Artery Research

Volume 12, Issue C, December 2015
Conference Abstract

1. WHAT IS THE BEST METHOD TO EVALUATE RETINAL MICROCIRCULATION?

Joanna Harazny
Pages: 1 - 2
The microvasculature of retinal ganglion cell layer, which is the part of central nervous system, can be investigated non-invasively in human. For clinical routine the fluorescence angiography is used to test patency and leak of retinal or choroid vessels, and to determine the blood passage time through...
Conference Abstract

2. CD1 VASCULAR ADAPTATION TO EXTREME CONDITIONS: THE ROLE OF HYPOXIA

Rosa Maria Bruno*, Lorenzo Ghiadoni, Lorenza Pratali
Pages: 1 - 1
The study of vascular adaptation to extreme conditions, and in particular to hypoxia, represents a unique opportunity in cardiovascular physiology, with relevant translational implications. First, it has crucial clinical consequences for about 140 million people worldwide living at high altitude and...
Conference Abstract

3. CD2 CIRCADIAN BLOOD PRESSURE PROFILE AND TARGET ORGAN DAMAGE

Agnieszka Bednarek
Pages: 1 - 1
The 24-hour brachial ambulatory blood pressure measurement (ABPM) has the unique ability to provide information on 24-hour averaged blood pressure (BP), on nocturnal BP and day–night BP changes, as well as on 24-hour BP variability, which all provide independent prognostic information over that provided...
Conference Abstract

4. CD3 ALDOSTERONISM, HEART AND VESSELS

Aleksander Prejbisz
Pages: 1 - 1
It has been documented that absolute aldosterone excess in patients with primary aldosteronism (PA) has been associated with higher risk of heart, vascular and kidney damage independent on blood pressure and resulting in increased total cardiovascular risk. Structural (left ventricular hypertrophy) and...
Conference Abstract

5. RETINAL ARTERIOLAR STRUCTURE IN PRIMARY HYPERTENSION – REVIEW OF THE DATA

Andrzej Januszewicz
Pages: 2 - 2
Vascular dysfunction and remodelling due to elevated blood pressure constitutes an early step in the pathogenesis of atherosclerotic disease. Microvascular remodelling reduces tissue perfusion and impedes blood-tissue exchange. These processes could lead to inadequate perfusion and tissue hypoxia in...
Conference Abstract

6. SODIUM INTAKE IN RELATION TO CARDIOVASCULAR OUTCOME

Katarzyna Stolarz-Skrzypek
Pages: 2 - 2
The data associating blood pressure to salt intake in humans comes from randomized clinical trials of interventions on dietary salt intake and population studies. Generally, estimates from meta-analyses are similar to those derived from prospective population studies (1.7 mm Hg change in systolic blood...
Conference Abstract

7. P1.1 PHYSICAL ACTIVITY IS ASSOCIATED WITH FLOW-MEDIATED DILATATION IN FEMALES

Ulrika Ferberg*, Katya Matusevich, Gabriella Eliason, Maria Fernstom, Anita Hurtig-Wennlof
Pages: 3 - 3
Impairment of vascular endothelial function is an early sign of atherosclerosis. An active lifestyle is suggested to be positively associated with favorable endothelial function as opposed to a sedentary lifestyle. The aim of this ongoing study (Lifestyle, Biomarkers and Atherosclerosis Study) is to...
Conference Abstract

8. P1.2 NANOMECHANICAL ALTERATIONS IN THE ADVENTITIAL LAYER OF THE INTERNAL MAMMARY ARTERY OF PATIENTS WITH HIGH PWV

Zhuo Chang, Maria Lyck Hansen, Lars Melholt Rasmussen, Riaz Akhtar*
Pages: 3 - 3
Aim: Arterial stiffening occurs as part of the natural ageing process, and is thought to be related to the accumulation of collagen and degradation of elastin. However, little is known about how regional variations in arterial structure and mechanical properties contribute to arterial stiffening. This...
Conference Abstract

9. P1.3 A NEW DYNAMIC ORGAN BATH SETUP TO ASSESS ISOBARIC STIFFNESS PARAMETERS OF PERIODICALLY STRETCHED ISOLATED MOUSE AORTIC SEGMENTS

Arthur J.A. Leloup*, Cor E. Van Hove, Guido R.Y. De Meyer, Dorien M. Schrijvers, Gilles W. De Keulenaer, Paul Fransen
Pages: 3 - 4
Cyclic stretch is a major contributor of vascular function. However, isolated mouse aortas are frequently studied at low stretch frequency or even isometric conditions. Pacing experiments done in rodents and humans show that arterial compliance is highly cyclic stretch frequency-dependent. The Rodent...
Conference Abstract

10. P1.4 HEMODYNAMICS OF PULMONARY HYPERTENSION: APPLICATION OF THE RESERVOIR-WAVE APPROACH

Anukul Ghimire*, Mads Andersen, Lindsay Burrowes, J. Christopher Bouwmeester, Andrew Grant, Israel Belenkie, Nowell Fine, Barry Borlaug, John Tyberg
Pages: 4 - 4
Using the reservoir-wave approach, previously we characterized pulmonary vasculature mechanics with multiple interventions in a canine model. In the present study, we measured high-fidelity pulmonary arterial (PA) pressure, Doppler flow velocity, and pulmonary capillary wedge pressure in 11 patients...
Conference Abstract

11. P1.5 AGE AND HYPERTENSION STRONGLY REDUCE AORTIC VISCO-ELASTIC PROPERTIES IN RATS AT BASAL AND MATCHED BLOOD PRESSURE LEVELS

George Lindesay*, Christophe Ragonnet, Stefano Chimenti, Nicole Villeneuve, Christine Vayssettes-Courchay
Pages: 4 - 4
Age and hypertension are major causes of large artery stiffening, a cardiovascular risk factor for heart and kidney damage. Long term hypertension induces vascular remodeling, accelerating vascular aging. The aged Spontaneously Hypertensive Rat (SHR) model is recognized for human cardiovascular pathology...
Conference Abstract

12. P1.8 DEVELOPMENT OF A TECHNIQUE FOR DETERMINATION OF PULMONARY ARTERY PULSE WAVE VELOCITY IN HORSES

Gonçalo Silva*, Bruce Guest, Diego Gomez, Martine McGregor, John Runciman, Luis Arroyo
Pages: 4 - 4
Calcification of the tunica media of the main pulmonary arteries has been observed in a large proportion of young racehorses. In humans, medial calcification is the most important cause of increased arterial stiffness, and has been implicated in the pathogenesis of microvascular diseases. Pulse wave...
Conference Abstract

13. P1.9 PLATELET-LOCALIZED FXI PROMOTES A GLYCOPROTEIN IBα DEPENDENT FEEDBACK LOOP IN ARTERIAL HYPERTENSION AND VASCULAR INFLAMMATION

Jeremy Lagrange*, Sabine Kossmann, Moritz Ehlken, Brett Monia, Wolfram Ruf, Philip Wenzel
Pages: 4 - 5
Background: Interactions of platelets, leukocytes and the vessel wall play pivotal roles in activating coagulation and precipitating thrombosis. High levels of angiotensin II (ATII) cause arterial hypertension by a complex inflammatory pathway requiring leukocyte recruitment and reactive oxygen species...
Conference Abstract

14. P1.10 PULSE PRESSURE IN RELATION TO 24-HOUR URINARY SODIUM EXCRETION IN A SAMPLE OF HIGH-SALT INTAKE POPULATION

Adam Bednarski*, Katarzyna Stolarz-Skrzypek, Grzegorz Kielbasa, Agata Franczyk, Malgorzata Kloch-Badelek, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 5 - 5
Objectives: In recent years, many studies emphasized the role of arterial rigidity in the development of cardiovascular diseases. Pulse pressure in an easy-obtained, reproducible marker of arterial stiffness and an independent cardiovascular risk factor. On the other hand it was observed that sodium...
Conference Abstract

15. P1.11 SOLUBLE IL-6 RECEPTOR CONCENTRATIONS ARE ASSOCIATED WITH AUGMENTATION INDEX IN HEALTHY YOUNG MALES

Matthew Armstrong*, Cat Singh, Laura Watkeys, Linnet Thekkemuriyil, Jordan Tucker, Zoe Marshall, Richard Webb, Barry McDonnell
Pages: 5 - 5
Background: Augmentation Index (AIx) is considered a sensitive marker of arterial stiffness in young individuals. Increased levels of inflammatory markers such as interleukin-6 (IL-6) are associated with increased levels of arterial stiffness in older and diseased populations. However, little is known...
Conference Abstract

16. P1.12 IN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION ARTERIAL NARROWING IS LIMITED AND HETEROGENEOUS

Nina Rol*, Esther Timmer, Theo Faes, Harm Jan Bogaard, Anton Vonk Noordegraaf, Katrien Grünberg, Nico Westerhof
Pages: 5 - 5
Rationale: In severe idiopathic pulmonary arterial hypertension, iPAH, pulmonary vascular resistance is increased due to remodeling of the small (resistance) arteries. Most information on arterial remodeling is limited to assessments of averaged increases in wall thickness. Quantitative information on...
Conference Abstract

17. P1.13 CHANGES IN PULSE WAVE VELOCITY ALONE CANNOT PREDICT THE PULSE PRESSURE INCREASE WITH AGE

Berend Westerhof*, Thomas Weber, Siegfried Wassertheurer, Bernhard Hametner, Nico Westerhof
Pages: 5 - 6
Recently Weber et al. invasively obtained aortic Pulse Wave Velocity (PWV) as a function of age. [1] Systolic and diastolic aortic pressure were determined as well. PWV can be used to derive total arterial compliance, Ctot, as Ctot=k/PWV2. With Ctot and Stroke Volume (SV), aortic Pulse Pressure (PP)...
Conference Abstract

18. P1.14 ANALYSIS OF LEFT VENTRICULAR FILLING DYNAMICS

Lindsay Burrowes*, Alessandro Satriano, Richard Thompson, Nigel Shrive, John Tyberg
Pages: 6 - 6
Diastolic filling of the left ventricle (LV) occurs in two phases, early and late filling. Early filling, manifest as the “E-wave”, is thought to be substantially due to diastolic suction (DS), a phenomenon where the LV aspirates blood and fills itself, independent of atrial activity. Late filling, resulting...
Conference Abstract

19. P1.15 CONDITIONAL INACTIVATION OF INTEGRIN AV SUBUNIT IN VASCULAR SMOOTH MUSCLE CELLS REGULATES FIBROSIS IN VESSELS

Ekaterina Belozertseva*, Melusine Didelot, Amel Mohamadi, Zhenlin Li, Huguette Louis, Jean-Baptiste Michel, Véronique Regnault, Patrick Lacolley
Pages: 6 - 6
Integrin avb3 is expressed at high density in vascular smooth muscle cells (VSMCs). It functions as a receptor for adhesion proteins in VSMCs which phenotypic modulation plays a pivotal role in arteriosclerosis and atherosclerosis. The aim was to study the role of integrin avb3 in angiotensin II (Ang...
Conference Abstract

20. P1.17 THE VENTRICLE’S PROMINENT ROLE IN PRESSURE AMPLIFICATION; AN INCREMENTAL EXPERIMENTAL STUDY

Nicholas Gaddum*, Jordi Alastruey, Tobias Schaeffter, Phil Chowienczyk
Pages: 6 - 6
Despite central pressure’s predictive power of cardiovascular risk, brachial pressure is the clinical standard. However, amplified brachial systolic pressure varies significantly with age, and during therapy. Our aim was to modulate individual arterial and ventricular parameters in an experimental model...
Conference Abstract

21. P2.1 AGING AND STRUCTURAL ALTERATIONS OF SUBCUTANEOUS SMALL RESISTANCE ARTERIES IN HYPERTENSIVE PATIENTS

Carolina De Ciuceis, Claudia Rossini, Claudia Agabiti Rosei, Enzo Porteri, Alice Gavazzi, Stefano Caletti, Paola Pileri, Maria Antonietta Coschignano, Enrico Agabiti Rosei, Damiano Rizzoni*
Pages: 6 - 6
Background: It was proposed that early vascular ageing may be an important mechanism of vascular damage in large conductance arteries. However it is not known whether aging may also affect small resistance artery morphology. Patients and methods: For this reason, we investigated 100 patients with essential...
Conference Abstract

22. P2.2 RESISTANT HYPERTENSION AND STRUCTURAL ALTERATIONS OF SUBCUTANEOUS SMALL RESISTANCE ARTERIES

Claudia Agabiti Rosei, Carolina De Ciuceis, Claudia Rossini, Maria Lorenza Muiesan, Massimo Salvetti, Enzo Porteri, Alice Gavazzi, Anna Paini, Stefano Caletti, Maria Antonietta Coschignano, Paola Pileri, Enrico Agabiti Rosei, Damiano Rizzoni*
Pages: 6 - 7
Background: It is was suggested that, in resistant hypertension, the presence of particularly pronounced microvascular alterations may contribute to explain the relative lack of response to treatment. Similarly, in diabetic patients, the persistence of an altered microvascular structure, despite the...
Conference Abstract

23. P2.4 THE INFLUENCE OF ANTIHYPERTENSIVE TREATMENT ON ARTERIAL STIFFNESS, SHEAR STRESS AND ACTIVITY OF CHOSEN MATRIX METALLOPROTEINASES

Tomasz Pizon*, Marek Rajzer, Marta Rojek, Danuta Czarnecka
Pages: 7 - 7
Objective: Comparison of therapeuthic effects of chosen antihypertensive drugs on arterial stiffness, shear stress in carotid arteries and metalloproteinases activity, moreover analysis of relationship of these variables in the course of treatment. Design and method: 95 never treated patients with HT...
Conference Abstract

24. P2.5 SEX-DEPENDENT DIFFERENCES IN OBESITY INDICES AND INFLAMMATORY MARKERS IN NON-DIABETIC OBESE PATIENTS

Mariusz Stępień*, Anna Stępień, Rafał N. Wlazeł, Marek Paradowski, Maciej Banach, Jacek Rysz
Pages: 7 - 7
Background: The aim of the study was to asses sex-dependent differences of obesity indices and inflammatory markers in non-diabetic hypertensive obese patients. Material and methods: 40 females and 25 males aged 59.8 ±10.1 and 54.6±11.9 years, respectively, were enrolled into the study. Serum TNF-α,...
Conference Abstract

25. P2.6 PWV IS AN INDEPENDENT DETERMINANT OF COGNITIVE DYSFUNCTION IN CKD PATIENTS

Despina Karasavvidou*, Dimitrios Stagikas, Kosmas Pappas, Stylianos Lampropoulos, Cristos katsinas, Rigas kalaitzidis
Pages: 7 - 7
Objectives: In the general population aortic stiffening assessed by carotid femoral pulse wave velocity (cf-PWV) is associated with cognitive dysfunction (CO/DY). Data in chronic kidney disease (CKD) are limited. Our study tests the hypothesis that large artery stiffness and microvascular damage in CKD...
Conference Abstract

26. P2.7 AMELIORATION OF COGNITIVE FUNCTION IN HEMODIALYSIS PATIENTS IN ABSENT OF HYPOTENSIVES EPISODES

Despina Karasavvidou*, Eleni Triantafilidou, Dimitrios Valoukas, Dimitrios Makridis, Sygliti-Errieta Pelidou, Cristos katsinas
Pages: 7 - 8
Objective: Patients in hemodialysis frequently have cognitive dysfunction (CO/DY). Hemodialysis session often results in acute intravascular volume loss, fluid shifts, hypotensives episodes, decrease of cerebral perfusion and cerebral ischemia, all of which may cause transient deterioration of cognitive...
Conference Abstract

27. P2.9 A NOVEL SPECKLE TRACKING TECHNIQUE FOR INVESTIGATING REGIONAL MOTION OF THE CAROTID WALL: SPATIO-TEMPORAL VARIATION IN DISTENSION ASSOCIATES WITH PRESENCE OF CALCIFIED PLAQUE

Benyu Jiang*, Jing Wang, Tim Spector, Phil Philip J. Chowienczyk
Pages: 8 - 8
Background: Arterial calcification may lead to regional variation in distension imposing stresses on the arterial wall that predispose to plaque rupture. The objective of this study was to use a novel speckle tracking method to investigate regional motion of the carotid wall and to determine whether...
Conference Abstract

28. P2.10 EXAGGERATED EXERCISE BLOOD PRESSURE INDEPENDENTLY PREDICTS INCIDENT HYPERTENSION: A SYSTEMATIC REVIEW AND META-ANALYSIS

Martin Schultz*, Petr Otahal, Dean Picone, James Sharman
Pages: 8 - 8
Background: Exaggerated exercise blood pressure (EEBP) independently predicts cardiovascular (CV) events and mortality, but reasons underlying this increased CV risk are unclear. The association between an EEBP and incident hypertension (as a potential underlying risk factor) has been reported, but there...
Conference Abstract

29. P2.11 EXERCISE REVEALS DIFFERENTIAL COUPLING BETWEEN AORTIC HAEMODYNAMICS AND LEFT VENTRICULAR TWIST MECHANICS

Martin Schultz*, Justin Davies, Eric Stöhr
Pages: 8 - 8
Background: Hypertensive heart disease is characterised by raised left ventricular (LV) mass, a consequence of load-altered ventricular-arterial coupling. Prior to gains in LV mass, early functional changes in ventricular-arterial coupling must occur, however, these are difficult to detect from conventional...
Conference Abstract

30. P2.12 A NOVEL MARKER EXPRESSES THE EFFECT OF THE NONLINEARITY IN THE ARTERIAL PRESSURE-VOLUME RELATIONSHIP ON THE PULSE PRESSURE: CHARACTERISTICS AND PROGNOSTIC SIGNIFICANCE IN HYPERTENSIVE PATIENTS

Benjamin Gavish*, Michael Bursztyn
Pages: 8 - 9
Arterial pressure-volume relationship frequently deviates from the linearity expected from an ideal elastic tube. As a result, pulse pressure (PP) can be split into an ‘elastic’ component (elPP) and an excess value PP-elPP. We define the ratio (PP-elPP)/elPP as arterial nonlinearity marker (NLM). OBJECTIVE:...
Conference Abstract

31. P2.13 BLOOD PRESSURE PROFILE CHANGES BETWEEN 7TH AND 11TH YEAR OF LIFE IN CHILDREN BORN PREMATURELY WITH EXTREMELY LOW BIRTH WEIGHT IN COMPARISON TO CHILDREN BORN ON TIME

Maja Gilarska*, Malgorzata Klimek, Dorota Drozdz, Andrzej Grudzien, Przemko Kwinta
Pages: 9 - 9
There have been research trials analyzing the impact of prematurity on the prevalence of hypertension, however the prospective, long-time observation is uncommon. The aim of this study was to evaluate the prevalence of hypertension at the age of 7 and 11 years of regional cohort of preterms with birth...
Conference Abstract

32. P2.14 PARAMETERS OF ARTERIAL STIFFNESS IN OSTEOARTHRITIS PATIENTS AND IN HEALTHY CONTROLS

Kaspar Tootsi*, Aare Märtson, Mihkel Zilmer, Kaido Paapstel, Jaak Kals
Pages: 9 - 9
Osteoarthritis (OA) and cardiovascular diseases (CVD) are prevalent conditions and often co-exist. Vascular involvement in pathogenesis of CVD and OA gives reason to investigate arterial stiffness in OA. The aim of this study is to investigate the associations between OA and arterial stiffness. Arterial...
Conference Abstract

33. P2.15 IRRITABLE AFFECTIVE TEMPERAMENT IS A PREDICTOR OF PULSE WAVE VELOCITY, WHEREAS HYPERTHYMIC AFFECTIVE TEMPERAMENT DETERMINES AUGMENTATION INDEX IN CHRONIC HYPERTENSION

János Nemcsik*, Andrea László, Péter Torzsa, Beáta Kőrösi, Dániel Eörsy, Orsolya Cseprekál, András Tislér, Zsófia Nemcsik-Bencze, Xénia Gonda, Zoltán Rihmer
Pages: 9 - 9
Background: Affective temperaments (anxious, depressive, cyclothymic, irritable and hyperthymic) are subclinical manifestations of major mood disorders and there is cumulating evidence about their involvement is somatic disorders as well. The aim of our study was to evaluate the associations of affective...
Conference Abstract

34. P2.17 FEASIBILITY OF USING COMPLIOR ANALYSE TO MEASURE CENTRAL SYSTOLIC BLOOD PRESSURE DURING DIALYSIS

Mabrouk Brahimi, Martine Catherine, Nathalie Stocard, Rachid Mojaat, Charles Chazot, Sandrine Millasseau*, Denis Chemla
Pages: 9 - 10
Central systolic blood pressure (cSBP) could be helpful to monitor hypotension during dialysis. However most cSBP devices are based on peripheral estimates which might be unreliable during the specific hemodynamic state of dialysis. Complior Analyse (Alam Medical, France) presents the advantage of measuring...
Conference Abstract

35. P2.18 IMPACT OF CARDIOVASCULAR RISK FACTORS ON CAROTID STIFFNESS AND CAROTID INTIMA MEDIA THICKNESS – GENDER DIFFERENCES

Maria Loboz-Rudnicka*, Joanna Jaroch, Zbigniew Bociaga, Barbara Rzyczkowska, Ewa Kruszynska, Krystyna Loboz-Grudzien, Andrzej Szuba
Pages: 10 - 10
Background and purpose: Whether the influence of risk factors on carotid stiffness (CS) and carotid intima media thickness (CIMT) is modulated by gender is still unclear. The aim of our study was to examine the association between cardiovascular (CV) risk factors, CS and CIMT in men and women. Material...
Conference Abstract

36. P2.19 COMPARISON OF BRACHIAL AND CENTRAL BLOOD PRESSURES FROM 2 SPHYGMOCOR XCEL SYSTEMS EQUIPPED WITH A 2M AND 6M-LONG HOSE

S. Stoer, G. Soulat, S. Tavolaro, S. Millasseau, H. Khettab, P. Boutouyrie, S. Laurent, E. Mousseaux*
Pages: 10 - 10
Background and aim: Magnetic resonance imaging (MRI) provides excellent anatomical coverage for local and regional indices of aortic function and structure. However, blood pressure (BP) assessments is usually necessary for the calculation of these functional MRI parameters. Unfortunately, most pressure...
Conference Abstract

37. P2.20 PERIPHERAL ARTERY DISEASE DETECTED BY ANKLE-BRACHIAL INDEX IS ASSOCIATED TO CARDIAC AND CAROTID ABNORMALITIES IN PATIENTS WITH ARTERIAL HYPERTENSION AND DIABETES

José Pompeu Filho, Ricardo Silva, Rachel Andrade, Leiria Andrade Neto, João Falcão, Sandra Falcão, Luiz Bortolotto*
Pages: 10 - 10
Few studies evaluated cardiac or carotid abnormalities in patients with arterial hypertension and diabetes according to the presence of peripheral artery disease detected by abnormal ankle brachial index (ABI). For this purpose, we studied 99 diabetic hypertensive patients with abnormal (n=50, ABI≤0.9...
Conference Abstract

38. P3.1 SUB-MAXIMAL EXERCISE BLOOD PRESSURE RELATES TO LEFT VENTRICULAR MASS INDEX, BUT IS DEPENDENT ON LOW AEROBIC CAPACITY

Martin Schultz*, Dean Picone, Rachel Climie, Costan Magnussen, Leah Wright, Thomas Marwick, Alison Venn, James Sharman
Pages: 10 - 11
Background: Exaggerated blood pressure (BP) responses to sub-maximal exercise independently predict cardiovascular (CV) events, mortality and incident hypertension. The aim of this study was to explore relationships between exercise BP, left-ventricular (LV) structure and function and aerobic fitness...
Conference Abstract

39. P3.2 ROGOZA INDEX IN HEALHY VOLUNTEERS AS A FUNCTION OF AGE

Igor Posokhov
Pages: 11 - 11
Background: Recently, prof Anatoly N Rogoza proposed a new vascular index calculated from one-channel volume sphygmography of brachial artery, Rogoza’s Index or Rogoza Index. It may be useful as a new indicator of asymptomatic vascular damage associated with cardiovascular risk in patients with hypertension. Objective:...
Conference Abstract

40. P3.3 THE CKD273 URINARY PROTEOMIC BIOMARKER FOR EARLY DIAGNOSIS OF DIABETIC NEPHROPATHY DOES NOT INDICATE GENERALISED SUBCLINICAL VASCULAR DISEASE IN NORMOALBUMINURIC TYPE 2 DIABETIC PATIENTS

Gemma Currie*, Joanne Flynn, Morten Lindhardt, Harald Mischak, Peter Rossing, Christian Delles
Pages: 11 - 11
Background: Diabetic nephropathy (DN) is associated with cardiovascular disease. Microalbuminuria (MA), its traditional hallmark, reflects both renal and generalised vascular damage. We previously established a urinary proteomic classifier (CKD273) for early DN prediction that correlates with other biomarkers...
Conference Abstract

41. P3.4 PULSE WAVE REFLECTIONS AND THEIR DIURNAL CHANGES IN PATIENTS WITH MARFAN SYNDROME COMPARED TO HEALTHY CONTROLS

Bernhard Hametner*, Matthias Hillebrand, Ghazaleh Nouri, Stephanie Parragh, Jelena Köster, Kai Mortensen, Achim Schwarz, Yskert von Kodolitsch, Siegfried Wassertheurer
Pages: 11 - 11
Introduction: Patients with Marfan syndrome may suffer from a variety of symptoms, including changes of the cardiovascular system. The aim of this study was to perform ambulatory 24 hour blood pressure and pulse wave measurements in a group of Marfan patients and a group of healthy controls and to analyse...
Conference Abstract

42. P3.5 TYPE 2 DIABETES EXACERBATES CAROTID ARTERY ECHOGENICITY AND CENTRAL ARTERY STIFFNESS IN MIDDLE-AGED AND OLDER INDIVIDUALS

Kunihiko Aizawa*, Francesco Casanova, Dave Mawson, Salim Elyas, Damilola Adingupu, Kim Gooding, David Strain, Angela Shore, Phillip Gates
Pages: 11 - 12
Grey scale median of the common carotid artery intima-media complex (IM-GSM) characterizes the composition of the arterial wall and low IM-GSM reflects more generalized atherosclerotic vulnerability. However, it is unclear whether the presence of DM itself affects IM-GSM, similar to that observed with...
Conference Abstract

43. P3.6 EVALUATION OF DIFFERENT METHODS FOR DETERMINING THE TIME DELAY OF THE ARTERIAL PULSE WAVE: APPLICATION TO THE POPMETRE ®

Hasan Obeid*, Hakim Khettab, Magid Hallab, Pierre Boutouyrie, Stéphane Laurent
Pages: 12 - 12
Objective: Pulse Wave Velocity (PWV) can be measured between different sites. Here we used two different aspects to assess the PWV; the standard method Carotid-Femoral (CF) Sphygmocor (AtCorMedical – Australia) and the pOpmetre ® (Axelife SAS – France) which uses the Finger to Toe (FT) signals. The aim...
Conference Abstract

44. P3.7 ARTERIAL STIFFNESS IS ASSOCIATED WITH LOWER PERFORMANCE ON THE COGNITIVE TESTS AT DIFFERENT DOMAINS IN HYPERTENSIVE PATIENTS

Henrique Muela, Valéria Costa-Hong, Michel Machado, Natalia Moraes, Claudia Memoria, Monica Yasuda, Ricardo Nogueira, Ayrton Massaro, Edson Shu, Ricardo Nitrini, Luiz Bortolotto*
Pages: 12 - 12
Background: Cognitive impairment and elevated arterial stiffness are described in patients with arterial hypertension (AH), but its correlations are not well studied. Objectives: To study the cognitive function at different domains and arterial properties in patients with AH stage 1 to 3 compared to...
Conference Abstract

45. P3.8 ARTERIAL STIFFNESS AND LEFT ATRIAL VOLUME IN HYPERTENSIVE AND NORMOTENSIVE SUBJECTS

Marta Rojek, Marek Rajzer*, Danuta Czarnecka
Pages: 12 - 12
Aim: Investigation of relationship between arterial stiffness indices and LAVI in hypertensive and normotensive subjects. Material and methods: Patients were recruited among Morawica town inhabitants. Study group (AH) consisted of 41 untreated hypertensives (20 men). Control group (NonAH)consisted of...
Conference Abstract

46. P3.9 PROGRESSION OF ARTERIAL STIFFNESS AND VASCULAR LESIONS ACCORDING TO THE DEGREE OF GLYCEMIC ABNORMALITIES. A WARNING IN PATIENTS WITH METABOLIC SYNDROME

Pedro Forcada*, Carlos Castellaro, Jorge Chiabaut, Sergio Gonzalez, Carol Kotliar, Sebastian Obregon
Pages: 12 - 13
Introduction: Metabolic Syndrome (MS), is postulated as intermediate stage in the way to overt DBT, and probably the degree of vascular compromise in this stage could explain the higher proportion of CV complications in diabetics. If so, it should deserve an intensive prevention in MS to reduce DBT complications. Objective:...
Conference Abstract

47. P3.10 REGIONAL CAROTID MECHANICS IS SIGNIFICANTLY IMPAIRED IN PATIENTS ON HEMODIALYSIS

Oleg Kerbikov*, Ekaterina Borskaya, Irina Kaloshina, Anna Kaloshina, Olga Telnova, Natalia Ustyantseva, Maria Agakina
Pages: 13 - 13
Conference Abstract

50. P3.14 ASSOCIATION OF CAROTID INTIMA-MEDIA THICKNESS, ENDOTHELIAL FUNCTION AND AORTIC STIFFNESS WITH CARDIOVASCULAR EVENTS IN METABOLIC SYNDROME PATIENTS

Ligita Ryliskyte, Jurate Balsyte*, Jolita Badariene, Roma Puronaite, Rokas Navickas, Svetlana Solovjova, Kristina Ryliskiene, Jurgita Kuzmickiene, Aleksandras Laucevicius
Pages: 13 - 13
Conference Abstract

51. P3.15 CARDIAC PERFORMANCE VASCULAR PHYSIOLOGY AND ERECTILE STATUS; A QUESTION OF A HEALTHY DIET

Athanasios Angelis*, Nikolaos Ioakeimidis, Mahmoud Abderasoul, Ioanna Gourgouli, Konstantinos Aznaouridis, Dimitrios Terentes, Konstantinos Rokkas, Charalampos Vlachopoulos, Dimitrios Tousoulis
Pages: 13 - 14
Conference Abstract

52. P3.16 CENTRAL ARTERIAL STIFFNESS AND SYSTEMIC VASCULAR RESISTANCE INFLUENCE ON LEFT VENTRICULAR GEOMETRY AND DIASTOLIC FUNCTION IN ESSENTIAL HYPERTENSION

Athanasios Angelis*, Charalampos Vlachopoulos, Nikolaos Ioakimidis, Konstantinos Aznaouridis, Mahmoud Abdelrasoul, Christos Georgakopoulos, Ioannis Felekos, Konstantina Aggeli, Dimitrios Tousoulis
Pages: 14 - 14
Purpose: Vascular resistance remains a key determinant of arterial hypertension and target organ damage alters morbidity of the disease. Our aim is to investigate physiology and clinical relevance of the left ventricular and systemic vascular interaction in essential hypertension patients. Methods:...
Conference Abstract

53. P3.17 THE EFFECTS OF ALPHA 1-ADRENOCEPTOR-BLOCKADE BY DOXAZOSIN AND ANGIOTENSIN CONVERTING ENZYME-INHIBITION BY RAMIPRIL ON CENTRAL AND BRACHIAL BLOOD PRESSURE AND VASCULAR REACTIVITY IN MILD-TO-MODERATE HYPERTENSION: THE DOXAZOSIN RAMIPRIL STUDY

Andreas Jekell*, Majid Kalani, Thomas Kahan
Pages: 14 - 14
Objectives: To study whether inhibition of the renin-angiotensin-aldosterone system has effects on vascular function beyond blood pressure (BP) reduction alone. Methods: Mild-to-moderate hypertensive patients (age 54±12 years, 34% women) were randomized double-blind to ramipril (10 mg od, n=33) or doxazosin...
Conference Abstract

54. P3.18 COMPARISON OF STRUCTURAL AND FUNCTIONAL CAROTID AND AORTIC CHANGES IN DIABETES MELLITUS AND HYPERTENSION

Zbigniew Bociąga*, Joanna Jaroch, Ewa Kruszyńska, Maria Łoboz-Rudnicka, Barbara Rzyczkowska, Krystyna Łoboz-Grudzień
Pages: 14 - 14
Background: It is known that age, blood pressure and diabetes mellitus are determinants of arterial stiffness. There are no studies comparing impact of hypertension and diabetes on structural and functional carotid and aortic changes. Aim: The aim of the study was to evaluate structural and functional...
Conference Abstract

55. P3.19 ASSESSMENT OF CARDIOVASCULAR RISK IN HYPERTENSIVES WITH WHITE COAT EFFECT VS. PATIENTS WITH MASKED UNCONTROLLED HYPERTENSION

Anna Szyndler*, Beata Graff, Jacek Wolf, Katarzyna Polonis, Ewa Swierblewska, Katarzyna Kunicka, Marzena Chrostowska, Krzysztof Narkiewicz
Pages: 14 - 15
Background: According to current ESH guidelines cardiovascular risk assessment is recommended in vast majority of patients with hypertension. However the groups of patients exist where risk assessment may be challenging. Aim: The aim of our analysis was to compare risk factors, and target organ damage...
Conference Abstract

56. P3.21 ASSOCIATIONS OF INSULIN-LIKE GROWTH FACTOR AND ITS BINDING PROTEIN-2 AND 3 WITH BLOOD PRESSURE AND ARTERIAL STRUCTURE AND FUNCTION IN HYPERTENSIVE PERIMENOPAUSAL WOMEN

Agnieszka Olszanecka*, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 15 - 15
IGFs and their binding proteins are increasingly recognized as important in understanding the pathogenesis of cardiovascular disease. During the transition from premenopause to postmenopause, many women experience weight gain, hence we hypothesized that circulating growth hormones can play a role in...
Conference Abstract

57. P4.1 ARTERIAL STIFFNESS IN INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW

Luca Zanoli*, Stefania Rastelli, Jean-Philippe Empana, Pierre Boutouyrie, Stephane Laurent, Pietro Castellino
Pages: 15 - 15
Background: Arterial stiffness is increased with chronic inflammatory disorders. The reduction of inflammation by immunomodulatory therapy is associated with a restoration of arterial function. Objectives: To determine whether carotid-femoral pulse wave velocity (cf-PWV) is increased in subjects with...
Conference Abstract

58. P4.2 CORONARY RISK IN RELATION TO GENETIC VARIATION IN MEOX2 AND TCF15 IN A FLEMISH POPULATION

Wen-Yi Yang, Thibault Petit, Lutgard Thijs, Zhen-Yu Zhang, Lotte Jacobs, Azusa Hara, Fang-Fei Wei, Erika Salvi, Lorena Citterio, Yu-Mei Gu, Judita Knez, Nicholas Cauwenberghs, Matteo Barcella, Cristina Barlassina, Paolo Manuta, Tatiana Kuznetsova*, Daniele Cusi, Peter Verhamme, Aernout Luttun, Jan Staessen
Pages: 15 - 15
Aims: In mice, MEOX2/TCF15 heterodimers are highly expressed in heart endothelial cells and are involved in the transcriptional regulation of lipid transport. We investigated whether coronary heart disease (CHD) in humans is associated with variation in these genes. Methods and results: In 2027 participants...
Conference Abstract

59. P4.3 PHYSICAL ACTIVITY IS ASSOCIATED WITH LOWER ARTERIAL STIFFNESS IN OLDER ADULTS: RESULTS OF THE SAPALDIA 3 COHORT STUDY

Simon Endes*, Emmanuel Schaffner, Seraina Caviezel, Julia Dratva, Christine S. Autenrieth, Miriam Wanner, Brian Martin, Daiana Stolz, Marco Pons, Alexander Turk, Robert Bettschart, Christian Schindler, Nino Künzli, Nicole Probst-Hensch, Arno Schmidt-Trucksäss
Pages: 15 - 16
We examined cross-sectional associations of self-reported PA intensities with arterial stiffness in elderly Caucasians of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). Mixed central and peripheral arterial stiffness was measured oscillometrically by the cardio-ankle...
Conference Abstract

60. P4.4 INHIBITION OF ARTERIAL CALCIFICATION BY MATRIX GLA PROTEIN AS DETERMINANT OF RENAL FUNCTION IN THE GENERAL POPULATION

Fangfei Wei*, Nadja E.A. Drummen, Lutgarde Thijs, Lotte Jacobs, Marjo H.J. Knapen, Thibaut Petit, Wenyi Yang, Zhenyu Zhang, Yumei Gu, Tatiana Kuznetsova, Peter Verhamme, Pieter Evenepoel, Cees Vermeer, Jan A. Staessen
Pages: 16 - 16
Background: Carboxylation of matrix Gla protein (MGP), a vitamin K dependent process, activates the protein to a powerful inhibitor of arterial calcification. Circulating dephosphorylated and uncarboxylated MGP (dp-ucMGP) and total uncarboxylated MGP (t-ucMGP) are associated with macrovascular disease....
Conference Abstract

61. P4.5 VASCULAR HEALTH ASSESSMENT OF THE HYPERTENSIVE PATIENTS (VASOTENS) REGISTRY: RATIONALE, DESIGN AND METHODS OF AN INTERNATIONAL REGISTRY FOR AMBULATORY BLOOD PRESSURE AND ARTERIAL STIFFNESS TELEMONITORING

Stefano Omboni*, Igor N. Posokhov, Gianfranco Parati, Anatoli Rogoza, Alberto Avolio, Ernesto Cardona Muñoz, Lorenzo Ghiadoni, Vladimir Gorbunov, Elena Grigoricheva, Alexandra Konradi, Viktoria Korneva, Yulia Kotovskaya, Natalya Kulikova, Maria Lorenza Muiesan, Giuseppe Mulè, Iana Orlova, Carmine Savoia, Giuseppe Schillaci, Parounak Zelveian, Elena Zheleznyak
Pages: 16 - 16
Background: Ambulatory (A) blood pressure (BP), central BP and pulse wave velocity (PWV) are parameters recommended by hypertension guidelines for estimating BP control and vascular impairment. Recent advances in technology made available devices allowing combined non-invasive estimation of these parameters...
Conference Abstract

62. P4.6 GREATER CAROTID CIRCUMFERENTIAL WALL STRESS IS ASSOCIATED WITH INCIDENT CARDIOVASCULAR DISEASE IN INDIVIDUALS WITH TYPE 2 DIABETES – THE HOORN STUDY

Veronica Onete*, Ronald Henry, Miranda Schram, Jacqueline Dekker, Giel Nijpels, Coen Stehouwer
Pages: 16 - 17
Introduction: Arterial remodeling is an adaptive phenomenon aimed at maintaining circumferential wall stress (CWS) within operating limits. It is characterized by widening of the inter-adventitial diameter (IAD) and increases in intima-media thickness (IMT). This process is maladaptive when CWS increases...
Conference Abstract

63. P4.7 PLASMA COPPER AND CERULOPLASMIN IN RELATION TO CAROTID-FEMORAL PULSE WAVE VELOCITY

Katarzyna Stolarz-Skrzypek*, Joanna Platek, Halina Mrowiec, Stanislaw Walas, Wiktoria Wojciechowska, Lukasz Klima, Szczepan Zapotoczny, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 17 - 17
Copper participates in the redox mechanisms and is a cofactor of enzymes responsible for appropriate structure of elastic fibres. The aim of the study was to assess the relationship between plasma copper as well as ceruloplasmin concentrations and carotid-femoral pulse wave velocity (cfPWV). The study...
Conference Abstract

64. P4.8 ASSOCIATIONS OF MID-LIFE CARDIOVASCULAR RISK FACTORS WITH LATER LIFE COGNITIVE FUNCTION

Chloe Park*, Therese Tillin, Robert Stewart, Nish Chaturvedi, Alun Hughes
Pages: 17 - 17
Background: Mid-life cardiovascular risk factors may be detrimental to cognitive function in later life; however results are inconsistent. We investigated the impact of mid-life blood pressure, glucose, cholesterol and obesity on cognitive function. Methods: In a community based sample aged 49.6±6years:...
Conference Abstract

65. P4.9 ENDOTHELIN-1 IS LINKED WITH ARTERIAL STIFFNESS AND INTERLEUKIN-6 IN BLACK SOUTH AFRICAN WOMEN: THE SABPA STUDY

Christine Du Plooy, Ruan Kruger, Carina Mels, Hugo Huisman*
Pages: 17 - 17
Up-regulation of ET-1 activates inflammatory cells such as macrophages that release pro-inflammatory mediators such interleukin-6 which promote vascular inflammation and endothelial dysfunction, leading to arterial stiffness. Included in this study were 194 black and 197 white South-Africans. Cardiovascular...
Conference Abstract

66. P4.10 ASSOCIATION OF ARTERIAL STIFFNESS WITH BLOOD PRESSURE VARIABILITY

Wiktoria Wojciechowska*, Katarzyna Stolarz-Skrzypek, Agnieszka Olszanecka, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 17 - 18
Increase of arterial stiffness is an independent predictor of cardiovascular morbidity and mortality. Short term blood pressure (BP) variability is recognised as a marker and a risk factor for cardiovascular complications. The study aims to determine the relation between arterial stiffness and short...
Conference Abstract

67. P4.11 ENDOTHELIAL DYSFUNCTION IN URBANIZED AFRICANS WITH LOW PLASMA RENIN LEVELS: THE SABPA STUDY

Johannes van Rooyen*, Rijane Swart, Carina Mels
Pages: 18 - 18
Background and objectives: It is known that high renin levels could damage the vasculature and may cause retinal detachment, stroke, heart failure and kidney failure. The objective of this part of the SABPA study was to determine if renin levels in low and high renin participants could contribute to...
Conference Abstract

68. P4.12 REFERENCE VALUES OF CENTRAL BLOOD PRESSURE IN ADULTS USING A VALIDATED NON-INVASIVE OSCILLOMETRIC METHOD

Bela Benczur*, Renata Bocskei, Attila Cziraki, Miklos Illyes
Pages: 18 - 18
Central systolic pressure (csBP) is strongly correlated with cardiovascular outcomes than brachial pressure. However, until recently there weren’t widely accepted reference values of csBP established yet. The aim of this work was to determine this missing values of csBP assessed by oscillometric method....
Conference Abstract

69. P4.13 HERITABILITY AND OTHER DETERMINANTS OF LEFT VENTRICULAR DIASTOLIC FUNCTION IN THE FAMILY-BASED POPULATION STUDY

M. Kloch-Badełek*, V. Tikhonoff, L. Thijs, W. Sakiewicz, K. Stolarz-Skrzypek, K. Narkiewicz, J. Staessen, T. Kuznetsova, K. Kawecka-Jaszcz, D. Czarnecka
Pages: 18 - 18
Background: Understanding to what extent genetic factors influence diastolic Doppler indexes is an important issue in view of the relation of left ventricular (LV) diastolic dysfunction with outcome. We, therefore, investigated in nuclear families recruited from the general population the heritability...
Conference Abstract

70. P4.14 PREVALENCE OF DIASTOLIC LEFT VENTRICULAR DYSFUNCTION IN EUROPEAN POPULATIONS BASED ON CROSS-VALIDATED DIAGNOSTIC THRESHOLDS

M. Kloch-Badelek*, T. Kuznetsova, W. Sakiewicz, V. Tikhonoff, A. Ryabikov, M. Loster, K. Stolarz-Skrzypek, L. Thijs, K. Narkiewicz, J. Staessen, K. Kawecka-Jaszcz, D. Czarnecka
Pages: 18 - 18
Objective: Different diagnostic criteria limit comparisons between populations in the prevalence of diastolic left ventricular (LV) dysfunction. We aimed to compare across populations age-specific echocardiographic criteria for diastolic LV dysfunction as well as their correlates and prevalence. Methods:...
Conference Abstract

71. P4.15 BLOOD PRESSURE, BODY MASS INDEX AND ARTERIAL ELASTIC PROPERTIES IN YOUNG PEOPLE

Vasyl Yagensky
Pages: 19 - 19
Pulse wave velocity (PWV) is widely used for arterial stiffness assessment. Increased arterial stiffness is a predictor of cardiovascular risk in adults. There are limited data on PWV and its determinants in young people. Study was performed to compare PWV and its association with blood pressure (BP)...
Conference Abstract

72. P4.16 THE MYOTROPHOBLAST OF THE RAT PLACENTA: EX VIVO STUDY OF NITRIC OXIDE SYNTHASE INHIBITION

Ilana Ariel, Galina Skarzinski, Vitali Belzer, Wiessam Abu-Ahmad, Zaid Abassi, Michael Bursztyn*
Pages: 19 - 19
Introduction: Endovascular trophoblasts (EVasT) of the rat express smooth muscle (SM) proteins and contract ex vivo upon exposure to endothelin-1 (ET1). Contraction is mediated via ET1 receptors A and B (ETA, ETB). In vascular SM ETB, in variance from ETA, exerts relaxation through activation of nitric...
Conference Abstract

73. P4.17 ARTERIAL STIFFNESS IN YOUNG PATIENTS WITH PERIPHERAL ARTERIAL DISEASE

Mariella Catalano*, Giovanni Scandale, Gabriel Dimitrov, Marzio Minola, Martino Recchia, Francesca Galli, Gianni Carzaniga, Maria Carotta
Pages: 19 - 19
Increased arterial stiffness occurs in older patients with peripheral arterial disease (PAD). In this study we compared arterial stiffness and central hemodynamic parameters in young (< 60 years of age) PAD patients and controls. In 31 PAD patients with an ankle-brachial index (ABI≤ 0.9) and 42 controls,...
Conference Abstract

74. P4.18 THE ASSUMPTION THAT BLOOD PRESSURE DECREASES OVER CONSECUTIVE MEASUREMENTS IS FALSE: MAJOR IMPLICATIONS FOR HYPERTENSION DIAGNOSIS AND GUIDELINES

Panagiota Veloudi*, Leigh Blizzard, Velandai Srikanth, Martin Schultz, James E. Sharman
Pages: 19 - 19
Background: There is anecdotal belief that clinic blood pressure (BP) drops over consecutive measurements. This has led to guideline recommendations to discard the first BP reading, or take only one reading if systolic BP (SBP) <140 mmHg. However, the magnitude and direction of change in SBP over...
Conference Abstract

75. P4.19 CARDIOVASCULAR RISK FACTORS AND LEFT VENTRICULAR HYPERTROPHY IN CHILDREN WITH CHRONIC KIDNEY DISEASE

Dorota Drozdz*, Przemko Kwinta, Zbigniew Kordon, Katarzyna Zachwieja, Monika Miklaszewska, Krystyna Sztefko, Andrzej Rudzinski, Jacek Antoni Pietrzyk
Pages: 19 - 20
Cardiovascular diseases are substantial causes of mortality among patients with chronic kidney disease (CKD). The aim of the study was an assessment of the impact of cardiovascular risk factors on left ventricular hypertrophy (LVH) in children with CKD. Material and methods: The study was conducted...
Conference Abstract

76. P4.20 ASSESSMENT OF BODY COMPOSITION USING BIOELECTRICAL IMPEDANCE ANALYSIS AND BLOOD PRESSURE IN HEALTHY SCHOOL CHILDREN

Monika Latka, Dorota Drozdz*, Tomasz Drozdz, Kinga Wojtowicz, Przemko Kwinta, Jacek Antoni Pietrzyk
Pages: 20 - 20
Introduction: Bioimpedance analysis (BIA) is becoming more widely used in clinical practice to measure water body compartments. BIA allows to calculate: total body water (TBW), lean body mass (LBM), fat mass (FM), intra- and extracellular water (ICW, ECW). Aim: The aim of this study was to evaluate...
Conference Abstract

77. P4.21 MICROCIRCULATION EFFECTS OF OBESITY AND/OR DIET: A PRELIMINARY STUDY IN MICE

Nicole Di Lascio*, Francesca Lenzarini, Cristina Barsanti, Francesco Stea, Claudia Kusmic, Francesco Faita
Pages: 20 - 20
Obesity is becoming a global epidemic and is associated with cardiovascular disease. Genetic factors play a significant role in the disease etiology but less is known about the interaction between genes and diet composition. This study is aimed to investigate the effect of diet and/or genotype on microcirculation...
Conference Abstract

78. P5.1 FROM AORTIC FLOW VELOCITY TO CENTRAL PRESSURE: A NON-INVASIVE PROOF OF CONCEPT

Samuel Vennin*, Jordi Alastruey, Phil Chowienczyk
Pages: 20 - 20
Estimation of aortic and left ventricular (LV) pressure usually requires measurements that are difficult to acquire during the imaging required to obtain concurrent LV dimensions essential for determination of LV mechanical properties. We describe a novel method for deriving aortic pressure from the...
Conference Abstract

79. P5.2 FROM THE WAVE PROPAGATION MODEL TO A TRANSFER FUNCTION: A POSSIBILITY FOR PERSONALISATION

Bernhard Hametner*, Stephanie Parragh, Anita Gerstenmayer, Thomas Weber, Siegfried Wassertheurer
Pages: 20 - 21
Since aortic pressure cannot be measured noninvasively, pressure signals are often measured at more superficial arteries and a transfer function is applied to obtain a surrogate for the central pressure curve. These transformations are usually derived from measurements in a specific group of subjects...
Conference Abstract

80. P5.3 CHARACTERIZATION OF THE BIOMECHANICS OF THE RAT XENOGRAFT MODEL OF ABDOMINAL AORTIC ANEURYSM BY RING TEST

Louise Marais*, Jianping Dai, Eric Allaire, Mustapha Zidi
Pages: 21 - 21
Setting up new strategies to prevent the growth and fatal rupture of aneurysms remains a challenge. The rat xenograft model of abdominal aortic aneurysm (AAA) has been used to develop gene and cell therapies with the aim of countering the expansion of the diseased arterial wall. It is of primary importance...
Conference Abstract

81. P5.4 CENTRAL PRESSURE APPRAISAL: CLINICAL VALIDATION OF A SUBJECT-SPECIFIC MATHEMATICAL MODEL

Francesco Tosello, Andrea Guala*, Dario Leone, Carlo Camporeale, Giulia Bruno, Luca Ridolfi, Franco Veglio, Alberto Milan
Pages: 21 - 21
Increased blood pressure represents a major cardiovascular risk factor for western populations. Usually blood pressure is measured peripherally, but current evidence suggested that central blood pressure better predicts cardiovascular events. However, central blood pressure measurement is not feasible...
Conference Abstract

82. P5.5 COMPENSATORY EFFECT BETWEEN AORTIC STIFFENING AND REMODELLING DURING AGEING

Andrea Guala*, Carlo Camporeale, Luca Ridolfi
Pages: 21 - 21
The arterial tree exhibits a complex spatio-temporal wave pattern, whose healthy behaviour depends on a balance between mechanical and geometrical properties. Several clinical studies demonstrated that this balance progressively breaks down during ageing, when the aorta stiffens and remodels. This dual...
Conference Abstract

83. P5.6 CORONARY FLUID MECHANICS IN AN AGEING CARDIOVASCULAR SYSTEM

Andrea Guala*, Michele Scalseggi, Luca Ridolfi
Pages: 21 - 21
Coronary artery diseases are the most common type of cardiovascular diseases and have an increasing prevalence with age. Epidemiological studies demonstrated that coronary failure is associated with several pathologies (as atherosclerosis, hypertension, diabetes, endothelial dysfunction, renal insufficiency)....
Conference Abstract

84. P5.7 A DATABASE OF VIRTUAL HEALTHY SUBJECTS AS A NEW TOOL TO ASSESS PHYSIOLOGICAL INDEXES AND ALGORITHMS BASED ON WAVE PROPAGATION

Marie Willemet*, Phil Chowienczyk, Samuel Vennin, Jordi Alastruey
Pages: 22 - 22
Many physiological indexes and algorithms based on pulse wave analysis have been suggested in order to better understand the physiology of arterial hemodynamics (e.g. pulse wave velocity, transfer functions for central blood pressure derivation). Because these tools are most often computed from hemodynamic...
Conference Abstract

85. P5.8 TOWARDS IN VIVO BIAXIAL CHARACTERISATION OF CAROTID ARTERY MECHANICS

Robert Holtackers*, Bart Spronck, Maarten Heusinkveld, Geneviève Crombag, Jos Op ’t Roodt, Tammo Delhaas, Eline Kooi, Evelien Hermeling, Koen Reesink
Pages: 22 - 22
Background: The relative content and loading of collagen and elastin in the arterial wall determine in vivo longitudinal pre-stretch. Assessment of arterial distensibility at varying longitudinal pre-stretch could improve characterisation of arterial collagen-elastin matrix properties. We introduce a...
Conference Abstract

86. P5.9 CARDIAC AND ARTERIAL CONTRIBUTION TO BLOOD PRESSURE CHANGES WITH AGE

Elira Maksuti*, Nico Westerhof, Berend Westerhof, Michael Broomé, Nikos Stergiopulos
Pages: 22 - 22
During aging, systolic blood pressure (Ps) continuously increases over time, whereas diastolic pressure (Pd) first increases and then slightly decreases after middle-age. These pressure changes are usually explained by changes of the arterial system alone (increase in arterial stiffness and vascular...
Conference Abstract

87. P5.10 CHANGES IN MECHANICAL PROPERTIES OF FEMORAL ARTERY WALLS IN PIG MODEL OF ARTERIOSCLEROSIS

Robert Pasławski
Pages: 22 - 22
Arteriosclertic lesions leading to increased stiffnes of the walls. The goal of the research was to estimate changes in the mechanical properties of femoral artery in swine with experimentally induced arteriosclerotic changes by western type diet. Methods: 32 white female pigs (40 kg), were divided...
Conference Abstract

88. P5.11 ROLE OF PRESSURE-DEPENDENT ARTERIAL OMPLIANCE IN MODULATING THE PHASE OF WAVE REFLECTIONS: IMPLICATIONS FOR LV-AS COUPLING

Timothy Phan*, John Li
Pages: 22 - 23
Background: Arterial compliance is pressure-dependent due to the nonhomogeneous composition of the arterial wall. Wall distending pressure varies within each cardiac cycle, thus arterial compliance is dynamic and time-varying within any given cycle. As compliance is a component of the pulsatile load...
Conference Abstract

89. P5.13 ESTIMATION OF CENTRAL SYSTOLIC PRESSURE: ARE PERIPHERAL WAVEFORMS AND TRANSFER FUNCTION NECESSARY?

Denis Chemla*, Sandrine Millasseau, Edmund Lau, P. Attal, Alain Nittenberg
Pages: 23 - 23
Background and aim: The degree of systolic pressure amplification (SPamp) from aorta to brachial artery depends on a number of variables including age, gender, heart rate and arterial stiffness. It is admitted that central systolic blood pressure (cSBP) cannot be predicted with sufficient accuracy from...
Conference Abstract

90. P5.14 THIGH-CUFF BASED MEASUREMENT OF AORTIC PULSE WAVE VELOCITY: INITIAL TESTING OF A NOVEL VASERA PROTOTYPE DEVICE

Francisco Londoño*, Daime Campos, Shigeo Horinaka, Julio Chirinos, Patrick Segers
Pages: 23 - 23
Introduction: Fully automated cuff-based devices have been developed for the assessment of arterial stiffness via pulse wave velocity (PWV) measurement, such as the VaSera device (Fukuda Denshi). To date, measurements were confined to the heart-to-ankle segment, yielding PWV and stiffness indices that...
Conference Abstract

91. P5.15 EVALUATION OF AORTIC 18F-NAF TRACER UPTAKE DETECTED USING PET/CT IN PREDICTING AORTIC CALCIFICATION OVER A 4-YEAR FOLLOW-UP PERIOD

Marina Cecelja*, Amelia Moore, Ignac Fogelman, Michelle Frost, Phillip Chowienczyk
Pages: 23 - 23
Background: Uptake of 18F-sodium fluoride (18F-NaF) in the aortic wall may reflect metabolically active areas of calcification, an important predictor of cardiovascular morbidity and mortality when detected by computed tomography (CT). The aim of this project was to determine if 18F-NaF uptake in the...
Conference Abstract

92. P5.17 CAROTID PULSE PRESSURE ASSESSMENT BY MEANS OF AN ACCELEROMETRIC SENSOR

Nicole Di Lascio*, Vincenzo Gemignani, Rosa Maria Bruno, Elisabetta Bianchini, Francesco Stea, Lorenzo Ghiadoni, Francesco Faita
Pages: 23 - 24
Central pulse pressure (cPP) is increasingly investigated as possible independent predictor of cardiovascular risk and carotid pulse pressure (carPP) can be used as a surrogate marker of cPP. Despite its importance, carPP measurement remains challenging in clinical practice. The aim of this study was...
Conference Abstract

93. P5.18 TRANSRADIAL APPROACH FOR VERTEBRAL ARTERY STENTING: SINGLE-CENTER EXPERIENCE

Damian Maciejewski*, Lukasz Tekieli, Anna Kablak-Ziembicka, Karolina Dzierwa, Piotr Paluszek, Andrzej Brzychczy, Grzegorz Lewinski, Magdalena Wojcik-Pedziwiatr, Roman Machnik, Piotr Pieniazek
Pages: 24 - 24
Objectives: Transradial vertebral artery (VA) angioplasty might be a viable alternative to the transfemoral approach in cases of peripheral artery disease or anatomical variations of the aortic arch. The purpose of our study was to evaluate the safety and efficacy of transradial stenting of symptomatic...
Conference Abstract

94. P5.19 TRANSRADIAL APPROACH FOR CAROTID ARTERY STENTING: SINGLE-CENTER EXPERIENCE

Damian Maciejewski*, Lukasz Tekieli, Anna Kablak-Ziembicka, Piotr Paluszek, Mariusz Trystula, Karolina Dzierwa, Magdalena Wojcik-Pedziwiatr, Roman Machnik, Grzegorz Lewinski, Piotr Pieniazek
Pages: 24 - 24
Objectives: The transfemoral approach is commonly used for carotid artery stenting (CAS) however in cases of severe peripheral vascular disease or unfavorable aortic arch anatomy, the transradial access remains a viable alternative. We report a series of patients with aorto-iliac disease or unsuccessful...
Conference Abstract

95. P5.20 MEASURE OF CHANGE IN CAROTID-RADIAL PULSE WAVE VELOCITY AFTER REACTIVE HYPERAEMIA

Hakim Khettab*, Benjamin Nayagom, Sandrine Millasseau, Stephane Laurent, Pierre Boutouyrie
Pages: 24 - 24
The recognized reference method for endothelial function assessment is brachial artery diameter echo-tracking during flow mediated dilation (FMD) induced by reactive hyperaemia (RH). From the Mons-Korteweg equation, FMD should also reduce upper limb pulse wave velocity (PWV). The aim of our study was...
Conference Abstract

96. P5.21 PERCUTANEOUS CORONARY INTERVENTIONS OF CHRONIC TOTAL OCCLUSIONS: GENDER DIFFERENCES – SINGLE CENTER EXPERIENCE

Leszek Bryniarski*, Slawomir Surowiec, Lukasz Klima, Michal Terlecki, Piotr Jankowski, Marek Rajzer, Piotr Kusak, Tadeusz Krolikowski, Adam Curylo, Dariusz Dudek, Danuta Czarnecka
Pages: 24 - 25
Background: Little is known about gender differences among patients undergoing percutaneous coronary intervention (PCI) for chronic total occlusion (CTO). Methods: A total of 242 patients underwent 255 procedures PCI of CTO in our center between January 2011 and January 2015. Demographic data, procedural...
Conference Abstract

97. P6.1 DIURNAL CHANGES IN PULSE PRESSURE AMPLIFICATION IN NORMOTENSIVE, HYPERTENSIVE DIPPER AND HYPERTENSIVE NON-DIPPER PATIENTS

Sandrine Millasseau, Yulia Kotovskaya, Jirar Topouchian, Igor Posokhov*
Pages: 25 - 25
Office central blood pressure (cBP) have been shown to better predict cardiovascular events than standard peripheral pressure. With Vasotens software and BPLab monitor (OOO Petr Telegin, Russia) is now possible to estimate central pressure over 24h. However to date, no data have shown that 24h monitoring...
Conference Abstract

98. P6.2 AORTIC-TO-BRACHIAL STIFFNESS GRADIENT INDEPENDENTLY PREDICTS KIDNEY FUNCTION: CASE-CONTROL COMPARISON BETWEEN PATIENTS WITH TYPE 2 DIABETES AND NON-DIABETIC CONTROLS

Dean Picone*, Martin Schultz, Rachel Climie, Velandai Srikanth, James Sharman
Pages: 25 - 25
Background: A negative aortic-brachial stiffness gradient (ab-SG), whereby aortic pulse wave velocity (aPWV)≥brachial PWV (bPWV) predicts mortality independent of aPWV in dialysis patients. Patients with type 2 diabetes mellitus (T2DM) have increased risk of renal damage and exhibit haemodynamic abnormalities...
Conference Abstract

99. P6.3 PLATELET ACTIVITY IN TEEN GIRLS WITH PRIMARY ARTERIAL HYPERTENSION

Indre Bauziene*, Kazys Simanauskas, Virginijus Sapoka, Vytautas Kasiulevicius, Kristina Ryliskiene, Reda Matuzeviciene, Augustina Jankauskiene, Tomas Rekasius
Pages: 25 - 25
Objective: Primary arterial hypertension (PAH) – a multifactorial disease. Its etiology, especially in children, still causes a lot of questions and diagnostic tests are not common in clinical practice. Even less is known of the variation in platelet activity in adolescents with PAH, this study was the...
Conference Abstract

100. P6.4 PLATELET ACTIVITY IN TEENAGE BOYS WITH PRIMARY ARTERIAL HYPERTENSION

Indre Bauziene*, Kazys Simanauskas, Virginijus Sapoka, Vytautas Kasiulevicius, Reda Matuzeviciene, Kristina Ryliskiene, Augustina Jankauskiene, Tomas Rekasius
Pages: 25 - 25
Objective: Primary arterial hypertenion for teen has caused a lot of debate today, there is too much uncertainty about platelet functional changes in patients with PAH. The objective was to evaluate platelet activity in healthy and suffering from PAH groups of 17–18 year old boys. Materials and methods:...
Conference Abstract

101. P6.5 EFFECTIVENESS OF FACEBOOK FOR PARTICIPANT RECRUITMENT INTO A BLOOD PRESSURE RANDOMISED CONTROLLED CLINICAL TRIAL

Erin Nash*, James Sharman
Pages: 26 - 26
Background: The cost of conventional advertising to recruit participants for clinical trials is expensive and can be ineffective. Social media may be a useful tool to improve participant recruitment. This study evaluated the use of Facebook advertising to recruit participants into a clinical trial. Methods:...
Conference Abstract

102. P6.6 NITROGLYCERIN IMPROVES SYSTOLIC MYOCARDIAL EFFICIENCY

Haotian Gu*, Henry Fok, Benyu Jiang, Manish Sinha, John Simpson, Phil Chowienczyk
Pages: 26 - 26
Introduction: Nitroglycerin (NTG) has a particularly marked action to reduce augmentation pressure (cAP), attributed to a reduction in timing or amplitude of pressure wave reflection. However, a recent study suggests that cAP is determined in large part by ventricular contraction/relaxation dynamics....
Conference Abstract

103. P6.7 DETERMINANTS FOR DIFFERENCES IN CENTRAL SYSTOLIC BLOOD PRESSURE CAUSED BY DIFFERENT CALIBRATION METHODS

Christopher Mayer, Martin Bauhofer, Bernhard Hametner, Christoph Schmaderer, Uwe Heemann, Siegfried Wassertheurer*, Marcus Baumann
Pages: 26 - 26
Introduction: There are known issues and ongoing discussions regarding calibration methods using peripheral mean and diastolic or peripheral systolic and diastolic pressure for the determination of central systolic blood pressure. The aim of this cross-sectional study is an analysis of determinants for...
Conference Abstract

104. P6.8 COMPARISON OF CENTRAL BLOOD PRESSURE ESTIMATED BY UPPER-ARM CUFF-BASED DEVICE WITH RADIAL TONOMETRY

Xiaoqing Peng*, Martin Schultz, Walter Abhayaratna, Michael Stowasser, James Sharman
Pages: 26 - 26
Background: New techniques that measure central blood pressure (BP) using an upper arm cuff-based approach require assessment for performance. The aim of this study was to compare a cuff-based device (CuffCBP) to estimate central BP indices [systolic BP, diastolic BP, pulse pressure (PP), augmentation...
Conference Abstract

105. P6.9 MEASURING ARTERIAL STIFFNESS USING POPMETRE® IN THE AFRICAN HETEROZYGOUS AND HOMOZYGOUS SICKLE CELL DISEASE

Valentine Ouédraogo, Hasan Obeid*, Magid Hallab, Isabelle Signolet, Mor Diaw, Amadou Ba, Georges Lefthériotis
Pages: 26 - 27
Aim: The sickle cell trait (SCT) is the heterozygous and benign form of the homozygous SC disease (SCD). Although SCT exhibits hemorheological disturbances and increased oxidative stress, its exact role in the development of cardiovascular disease in SCT remains to be determined. The present study sought...
Conference Abstract

106. P6.10 ALCOHOL INTAKE IS ASSOCIATED WITH 24-HOUR AORTIC BLOOD PRESSURE IN A YOUNG HEALTHY STUDENT COHORT

James Thomas*, Niamh Chapman, Laura Watkeys, Maria Kearney, Sue King, Eric Stohr, John Cockcroft, Margaret Munnery, Carmel McEniery, Barry McDonnell
Pages: 27 - 27
Objective: Increased brachial (bBP) and aortic blood pressure (aBP) have been linked to increased arterial stiffness and cardiovascular risk in older individuals. Literature suggests that increased alcohol intake is associated with increased BP both acutely and long term in older adults and heavy alcohol...
Conference Abstract

107. P6.11 THE FRAMINGHAM RISK SCORE IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Nichola Gale*, Margaret Munnery, Ali Albaratti, Dennis Shale, John Cockcroft
Pages: 27 - 27
Background: Patients with chronic obstructive pulmonary disease (COPD) have increased risk of cardiovascular (CV) events and mortality beyond that attributable to smoking. Increased arterial stiffness has been identified in COPD, however it prognostic value has not been established. The Framingham risk...
Conference Abstract

108. P6.12 AORTIC AND LOCAL CAROTID STIFFNESS: RELATIONSHIP WITH CARDIAC AND VASCULAR ORGAN DAMAGE IN A GENERAL POPULATION SAMPLE IN NORTHERN ITALY

Anna Paini*, Massimo Salvetti, Claudia Agabiti Rosei, Fabio Bertacchini, Giulia Maruelli, Giulia Rubagotti, Efrem Colonetti, Carlotta Donini, Elisa Casella, Enrico Agabiti Rosei, Maria Lorenza Muiesan
Pages: 27 - 27
Background: Carotid-femoral pulse wave velocity (aoPWV), the gold-standard measurement of arterial stiffness, has been found associated with cardiac and vascular organ damage. Less information is available with regard to the correlation between local carotid stiffness (CS) and cardiac and vascular preclinical...
Conference Abstract

109. P6.13 AMBULATORY AND OFFICE CENTRAL SYSTOLIC BLOOD PRESSURE IS MORE CLOSELY ASSOCIATED WITH LEFT VENTRICULAR MASS THAN AMBULATORY AND OFFICE PERIPHERAL SYSTOLIC BLOOD PRESSURE IN A YOUNG NORMOTENSIVE POPULATION

Maria Kearney*, James Thomas, Niamh Chapman, Laura Watkeys, Margaret Munnery, John Cockcroft, Rob Shave, Carmel McEniery, Eric Stöhr, Barry McDonnell
Pages: 27 - 28
Background: High blood pressure (BP) at a young age and increased left ventricular mass (LVM) are associated with increased risk of future cardiovascular mortality. In addition, ambulatory 24-hour central systolic BP (24cSBP) is more closely associated with LVM than either 24-hour peripheral SBP (24pSBP)...
Conference Abstract

110. P6.14 THE EFFECT OF PHYSICAL ACTIVITY ON 24-HOUR AUGMENTATION INDEX

Niamh Chapman*, James Thomas, Maria Kearney, Laura Watkeys, Margaret Munnery, John R. Cockcroft, Carmel M. McEniery, Eric J. Stohr, Barry J. McDonnell
Pages: 28 - 28
Introduction: Augmentation Index (AIx) is a surrogate measure of systemic arterial stiffness and wave reflections. Clinic measures of AIx are considered to be a sensitive measure of risk in young adults and are lower in individuals who take part in high levels of physical activity (PA). The development...
Conference Abstract

111. P6.15 ATTENUATION OF ARTERIAL STIFFNESS GRADIENT WITH AGE AND ITS IMPACT ON CENTRAL PULSE WAVE PROFILE IN DIALYSIS PATIENTS

Catherine Fortier, Marie-Pier Desjardins, David Turgeon, Karine Marquis, Marcel Lebel, Mohsen Agharazii*
Pages: 28 - 28
Background: Arterial stiffness has been considered as an index of vascular ageing. However, the relationship between age and stiffness of various segments of the arterial tree is heterogeneous. Moreover, the hemodynamic impact of vascular stiffness is thought to be related to the attenuation or even...
Conference Abstract

112. P6.16 LEFT VENTRICULAR GEOMETRY AND CAROTID VASCULAR DAMAGE IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY

M. Salvetti*, A. Paini, M.F. Cesana, A. Moreo, R. Facchetti, P. Faggiano, S. Carerj, G.F. Mureddu, N. Gaibazzi, F. Rigo, C. Giannattasio, M.L. Muiesan
Pages: 28 - 28
Background: Vascular structural(intima-media thickness, IMT) and functional(carotid stiffness, cPWV)alterations are related to different pattern of left ventricular (LV) geometry in general populations and in hypertensives. The relationship between vascular damage and LV geometry has not been analyzed...
Conference Abstract

113. P6.17 CARDIOVASCULAR RISK FACTORS CONTRIBUTE TO THE VARIANCE OF WALL-TO-LUMEN RATIO

Rytis Masiliunas*, Kristina Ryliskiene, Ligita Ryliskyte, Rokas Navickas, Jurgita Kuzmickiene, Jolita Badariene, Dalius Jatuzis, Aleksandras Laucevicius
Pages: 28 - 29
Background: Common carotid artery intima-media thickness (cIMT) is an accepted ultrasound marker of subclinical atherosclerosis. It is argued that increase in cIMT may also reflect nonatherosclerotic thickening, thus, lumen diameter could be taken into account. A common approach to account for lumen...
Conference Abstract

114. P6.18 CARDIOVASCULAR TARGET ORGAN DAMAGE IN PREMENOPAUSAL SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS AND IN CONTROLS; ARE THERE ANY DIFFERENCES?

A. Paini*, L. Andreoli, M. Salvetti, F. Dall’Ara, S. Piantoni, C. Donini, C. Agabiti Rosei, F. Bertacchini, D. Stassaldi, E. Agabiti Rosei, A. Tincani, M.L. Muiesan
Pages: 29 - 29
Background: In patients with Systemic lupus erythematosus (SLE) a greater prevalence of structural and functional cardiovascular (CV) alterations has been described, possibly explaining the higher incidence of CV events, as compared to subjects matched for age and sex. Aim of this study was to analyze...
Conference Abstract

115. P6.19 GENDER DIFFERENCES OF ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE IN PATIENTS WITH ARTERIAL HYPERTENSION AND THE INFLUENCE OF MENOPAUSE

Valéria Costa-Hong, Henrique Muela, Allan Sales, Luiz Bortolotto*
Pages: 29 - 29
Introduction: In general population women seems to have greater arterial stiffness and central blood pressure(BP), measured by augmentation index (AIx), than men, but in hypertension this condition is poorly studied. Objectives: To evaluate differences of central BP and arterial stiffness between men...
Conference Abstract

116. P6.20 ROLE OF ALTERED VASCULAR REACTIVITY IN THE PATHOPHYSIOLOGY OF ACUTE MOUNTAIN SICKNESS

Rosa Maria Bruno*, Guido Giardini, Sandro Malacrida, Bruna Catuzzo, Sabina Armenia, Lorenzo Ghiadoni, Raffaele Brustia, Paolo Laveder, Paolo Salvi, Emmanuel Cauchy, Lorenza Pratali
Pages: 29 - 29
Purpose: The aim of this study is to explore the physiological vascular adaptation to exposure to high altitude and to test the hypothesis that its impairment might play a role in the pathophysiology of acute mountain sickness (AMS). Methods: 34 healthy volunteers (age 38±11years, 13 women) were studied...
Conference Abstract

117. P7.1 INCREASED PLATELET REACTIVITY IS RESPONSIBLE OF MODIFICATIONS OF THROMBIN GENERATION IN PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSION

Jeremy Lagrange*, Yvonne Weihert, Susanne Karbach, Philip Wenzel
Pages: 29 - 30
Background: Hypertensive crisis is an extreme phenotype of increased blood pressure that can lead to organs failure and thrombotic complications. Recently, we were able to show an angiotensin II driven FXI-thrombin amplification loop leading to vascular injury in experimental hypertension. Objective:...
Conference Abstract

118. P7.2 VERY EARLY CLINICAL VASCULAR AND HEART MARKERS OF NEWLY RECOGNIZED HYPERTENSION IN MIDDLE AGE ADULTS

Olga Siga*, Jarosαaw Królczyk, Anna Dzieża-Grudnik, Jolanta Walczewska, Barbara Wizner, Tomasz Grodzicki
Pages: 30 - 30
The aim of this study was to evaluate vascular and echocardiographic markers of hypertension (HT) in subjects with newly diagnosed HT before treatment started. We studied 32 patients with newly diagnosed HT without pharmacological therapy (HT group) and 31 healthy ones (control group). ABPM were performed...
Conference Abstract

119. P7.3 RISK FACTORS CONTROL IN ELDERLY PATIENTS WITH PERIPHERAL ARTERY DISEASE

Barbara Gryglewska*, Dorota Studzinska
Pages: 30 - 30
Objective: The assessment of control of modifiable risk factors among elderly patients with peripheral artery disease (PAD) admitted to the hospital angiology ward. Methods: The results of treatment of dyslipidemia (DL), hypertension (HT), diabetes mellitus (DM) and prevalence of cigarette smoking were...
Conference Abstract

120. P7.4 MORNING CENTRAL BLOOD PRESSURE SURGE DOES NOT DIFFER BETWEEN MEN AND WOMEN

Agnieszka Bednarek*, Piotr Jankowski, Agnieszka Olszanecka, Adam Windak, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 30 - 31
Objective: Morning blood pressure (BP) surge is considered to be an independent risk factor for cardiovascular diseases. On the other hand, there is increasing evidence that central systolic pressure (CSP) is stronger correlated with target organ damage and cardiovascular events than peripheral systolic...
Conference Abstract

121. P7.5 RELATIONSHIPS BETWEEN 24 HOUR URINARY CORTISOL METABOLITES AND STRUCTURAL CARDIAC AND ARTERIAL INDICES IN PEOPLE WITH OR AT RISK OF TYPE 2 DIABETES

Charlotte Mills*, Luca Faconti, Hannah Crickmore, Fahad Iqbal, Anne Risser, Doina Bobeica, Lea Ghataore, Virginia Govoni, Maria-Linda Casagrande, Andrew Webb, Norman Taylor, Kennedy Cruickshank
Pages: 31 - 31
Objective: To assess if 24h urinary cortisol metabolite (UCM) profiles are related to structural cardiac and arterial parameters in those with or at risk of Type 2 diabetes mellitus (T2DM). Design and method: 32 participants, 25-77 years, eGFR> 45 mL/min and no serious illness. Urine was collected...
Conference Abstract

122. P7.7 TESTOSTERONE LEVELS IN HYPERTENSIVE PATIENTS WITH VASCULAR ORGAN DAMAGE

Dimitrios Terentes-Printzios*, Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Athanassios Angelis, Panagiota Pietri, Mahmoud Abdelrasoul, Christos Georgakopoulos, Dimitris Tousoulis
Pages: 31 - 31
Purpose: Testosterone levels are decreased in hypertensive patients compared to normotensive subjects with similar age. Measurements of carotid IMT or aortic stiffness are reasonable for detecting vascular organ damage (OD) in patients with arterial hypertension. We investigated whether low testosterone...
Conference Abstract

123. P7.8 THE RELATIONSHIP BETWEEN RENAL AND CEREBRAL BLOOD FLOW PULSATILITY

Laura Watkeys*, James Pearson, Barry McDonnell
Pages: 31 - 31
Introduction: Increased pulsatile flow has been implicated in the progression of microvascular damage. The pulsatile blood flow transmitted into both the brain and kidney are often assumed to be similar, however specific studies confirming these associations are lacking. Therefore, the aim of this study...
Conference Abstract

124. P7.10 MULTI-SITE ULTRASOUND ASSESSMENT OF ARTERIAL REMODELING AND DISTENSIBILITY IN MARATHON RUNNERS

Rosa Maria Bruno*, Elisabetta Bianchini, Nicole Di Lascio, Francesco Stea, Kristian Ujka, Alberto Marabotti, Erik Stroeken, Lorenzo Ghiadoni, Lorenza Pratali
Pages: 32 - 32
Objective: to investigate features of arterial remodeling and distensibility in marathon runners by a multi-site, non-invasive approach. Methods: 46 marathon runners (M) and 15 age-sex- and BMI matched sedentary (S) individuals were recruited (men 70 vs 67%, p=0.83; age 44±7 vs 43±6 years, p=0.62; BMI...
Conference Abstract

125. P7.11 PREDICTIVE VALUE OF ENDOTHEL DYSFUNCTION ASSESSED BY FLOW MEDIATED VASODILATATION AND ARTERIAL STIFFNESS PARAMETERES IN THROMBOTIC EVENTS OF PRIMARY ANTIPHOSPHOLIPID SYNDROME

Agnes Dioszegi*, Katalin Veres, Beata Kovacs, Viktor Banhegyi, Pal Soltesz
Pages: 32 - 32
Primary antiphosphplipid sydrome (APS) is characterized by recurrent arterial or venous thrombosis and/or fetal loss in the presence of antiphospholipd antibodies. The authors in a longitudinal (2005–2015) follow-up study examined how the angiological and metabolic parameters have changed during the...
Conference Abstract

126. P7.12 PULSE PRESSURE AND INTIMA MEDIA THICKNESS IN RELATION TO SERUM VITAMIN D CONCENTRATION IN A SAMPLE OF GENERAL POPULATION

Agata Franczyk*, Katarzyna Stolarz-Skrzypek, Agnieszka Olszanecka, Wiktoria Wojciechowska, Anna Wesoαowska, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 32 - 32
Objectives: Vitamin D regulates the renin-angiotensin-aldosterone system, inhibits proliferation of cardiomyocytes and vascular smooth muscles and has anti-inflammatory effects. We aimed to investigate the relation between serum vitamin D concentration and arterial structure and function in a sample...
Conference Abstract

127. P7.13 RELATION OF PARAMETERS OF VASCULAR STIFFNESS TO CARDIAC STRUCTURE AND FUNCTION IN PATIENTS AT RISK OF OR WITH TYPE 2 DIABETES

Luca Faconti*, Charlotte E. Mills, Virginia Govoni, Maria L. Casagrande, Andrew J. Webb, Kennedy J. Cruickshank
Pages: 32 - 33
Objective: To investigate the relationship between arterial function and cardiac, especially left ventricular (LV) diastolic, function, in people at risk of or with type 2 diabetes (T2DM). Design and method: 64 patients (48% non-European) participated in the study. Cardiac indices were obtained by 2-dimensional...
Conference Abstract

128. P7.14 SERUM INFLAMMATORY MARKERS ARE POOR PREDICTORS OF VASCULAR INFLAMMATION AND VASCULAR INFLAMMATION DOES NOT DETERMINE AORTIC STIFFNESS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Marie Fisk*, Divya Mohan, Joseph Cheriyan, Julia Forman, Carmel M. McEniery, John R. Cockcroft, Ruth Tal-Singer, Michael I. Polkey, Ian B. Wilkinson
Pages: 33 - 33
Background: COPD is independently associated with increased cardiovascular events. Arterial stiffening and systemic inflammation are postulated aetiological factors. We hypothesised that vascular inflammation links systemic inflammation with vascular stiffening and sought to test this in a cohort of...
Conference Abstract

129. P7.15 REACTIVE HYPEREMIA INDEX AND FLOW MEDIATED DILATION WITH UPPER- AND LOWER-ARM CUFF OCCLUSION: ARE THEY MEASURING THE SAME?

Lorenzo Ghiadoni*, Rosa Maria Bruno, Francesco Regoli, Giuseppe Penno, Stefano Taddei
Pages: 33 - 33
Objective: Methodological issues are major reasons preventing the use of endothelial function testing in clinical practice This study aimed to address the relationship between two non-invasive techniques, brachial artery flow-mediated dilation (FMD) and as reactive hyperemia index (RHI), comparing also...
Conference Abstract

130. P7.16 VALIDATION OF AN OSCILLOMETRIC BRACHIAL CUFF METHOD TO DERIVE CENTRAL BLOOD PRESSURE USING DIFFERENT CALIBRATION MODES

Martin Schultz*, Ahmad Qasem, Xiaoqing Peng, Dean Picone, J. Andrew Black, Nathan Dwyer, Phillip Roberts-Thomson, James Sharman
Pages: 33 - 33
Background: There is interest in measuring central blood pressure (BP) from non-invasive upper-arm cuff devices, the accuracy of which may be influenced by different calibration modes. The aim of this study was to determine the validity of an upper-arm cuff oscillometric device to estimate central BP...
Conference Abstract

131. P7.17 DISASSOCIATION OF BLOOD PRESSURE FROM AORTIC RESERVOIR CHARACTERISTICS BETWEEN THE AORTA AND RADIAL ARTERIES

Xiaoqing Peng*, Martin Schultz, Justin Davies, Dean Picone, Andrew Black, Nathan Dwyer, Phil Roberts-Thomson, James Sharman
Pages: 33 - 34
Background: Aortic reservoir pressure (RP) and excess pressure (XSP) predict cardiovascular events independent of clinic blood pressure (BP). It is unknown whether RP and XSP change in magnitude from the central to peripheral large arteries where conventional BP is measured. This information has implications...
Conference Abstract

132. P7.18 VALIDATION TESTING FOR THE NON-INVASIVE MEASUREMENT OF AORTIC RESERVOIR CHARACTERISTICS FROM BRACHIAL CUFF OSCILLOMERIC PRESSURE WAVEFORMS

Xiaoqing Peng*, Martin Schultz, Justin Davies, Dean Picone, Andrew Black, Nathan Dwyer, Phil Roberts-Thomson, James Sharman
Pages: 34 - 34
Background: Aortic reservoir pressure (RP) and excess pressure (XSP) derived non-invasively from radial tonometry independently predict cardiovascular events and mortality. However, whether RP and XSP can be derived non-invasively from brachial oscillometric cuff pressure waveforms has never been undertaken....
Conference Abstract

133. P7.19 ARTERIAL STIFFNESS AND DISEASE-RELATED ORGAN DAMAGE IN SYSTEMIC LUPUS ERYTHEMATOSUS

Giacomo Pucci*, Francesca Battista, Elena Bartoloni Bocci, Fabio Anastasio, Mariano Crapa, Leandro Sanesi, Roberto Gerli, Giuseppe Schillaci
Pages: 34 - 34
Hypothesis: increased arterial stiffness has been reported in subjects with systemic lupus erythematosus (SLE) compared with healthy controls. In SLE, indexes of organ damage are related to a poor clinical status and worse prognosis independently from the activity of the disease. Data are controversial...
Conference Abstract

134. P7.20 THE IMPACT OF OBSTRUCTIVE SLEEP APNEA ON ARTERIAL STIFFNESS IS INDEPENDENT OF GENDER IN PATIENTS WITH HYPERTENSION

Raimundo Jenner, Luiz Bortolotto*, Valéria Costa-Hong, Silvia Souza, Sandra Teixeira, Heno Lopes, Geraldo Lorenzi, Eduardo Krieger, Luciano Drager
Pages: 34 - 34
Introduction: In men with hypertension, obstructive sleep apnea (OSA) is associated with increased arterial stiffness. However, it is not clear if the impact of OSA on patients with hypertension is similar in women. Methods: We recruited consecutive patients with established diagnosis of hypertension...
Conference Abstract

135. P8.1 CENTRAL HEMODYNAMICS IN SYSTEMIC SCLEROSIS: A CASE-CONTROL STUDY

Francesca Battista*, Giacomo Pucci, Elena Bartoloni Bocci, Francesca Cannarile, Alessia Alunno, Fabio Anastasio, Roberto Gerli, Giuseppe Schillaci
Pages: 34 - 34
Background: Although a few studies have suggested an alteration in aortic stiffness in patients with systemic sclerosis (SS), a disease characterized by immunological and microvascular changes and by tissue fibrosis, the functional properties of the large arteries have been understudied in SS. Methods:...
Conference Abstract

136. P8.2 ARTERIAL WAVE REFLECTIONS: LOOKING BEYOND THE FIRST HARMONIC AND PRESSURE INFLECTION POINTS TO ASSESS LATE-SYSTOLIC VENTRICULAR LOADING

Timothy Phan*, John Li, Zoubair Ahmed, Ejaz Shah, Vandan Panchal, Julio Chirinos
Pages: 35 - 35
Background: Late-systolic ventricular loading is associated with impaired relaxation and adverse remodeling. Standard indices of relative wave reflections such as augmentation index (AIx) and reflection magnitude (RM) from wave separation analysis blend different times within the cardiac cycle and are...
Conference Abstract

137. P8.3 RELATIONSHIP BETWEEN PULSE WAVE VELOCITY AND BIOPSY PROVEN RENAL MICROVASCULAR LESIONS

Rania Kheder-Elfekih*, Hela Jebali, Lamia Rais, Fatma Ben Moussa, Karim Zouaghi
Pages: 35 - 35
Aortic stiffness is associated to chronic kidney disease. Although it is well established that patients with chronic kidney disease have classical and non classical risk factors correlated to a high pulse wave velocity, there is no data on the deleterious effect of high pulse wave velocity on intra renal...
Conference Abstract

138. P8.5 MORNING CENTRAL BLOOD PRESSURE SURGE IS RELATED TO AGE

Agnieszka Bednarek*, Piotr Jankowski, Agnieszka Olszanecka, Adam Windak, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 35 - 35
Objective: Morning surge of peripheral blood pressure (BP) is considered to be an independent risk factor for cardiovascular diseases. However, morning central blood pressure surge (MCBPS) has not been analyzed so far. Therefore, the aim of study was to evaluate the variables independently associated...
Conference Abstract

139. P8.6 PULSATILE COMPONENT OF CENTRAL BLOOD PRESSURE AND THE RISK OF STROKE IN CORONARY PATIENTS. RESULTS FROM THE AORTIC BLOOD PRESSURE AND SURVIVAL STUDY

Piotr Jankowski*, Agnieszka Bednarek, Malgorzata Kloch-Badelek, Magdalena Loster, Leszek Bryniarski, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 35 - 35
Background: There is ongoing debate concerning the best blood pressure (BP) parameter predicting cardiovascular risk. The aim of the analysis was to investigate the relationship between central BP and stroke in patients undergoing coronary angiography. Methods: The study group consisted of 954 patients...
Conference Abstract

140. P8.7 VASCULAR ENDOTHELIAL SENESCENCE AND METABOLIC SYNDROME

Dimitrios Terentes-Printzios*, Charalambos Vachopoulos, Nikolaos Ioakeimidis, Athanasios Aggelis, Panagiotis Xaplanteris, Panagiota Pietri, Dimitrios Tousoulis
Pages: 35 - 36
Objectives: Vascular aging and metabolic syndrome (MS) are both independent predictors of cardiovascular events. We examined whether MS accelerates the progression of vascular aging. Methods: 142 subjects (mean age 51.9±10.8 years, 94 men) with no established cardiovascular disease were investigated...
Conference Abstract

141. P8.8 CENTRAL ARTERIAL STIFFNESS IN COPD

Ali Albarrati*, Nichola Gale, Maggie Munnery, Sujoy Saikia, Dennis Shale, John Cockcroft
Pages: 36 - 36
Introduction: Increased arterial stiffness is a marker of cardiovascular disease and suggested to beassociated with impaired lung function in chronic obstructive pulmonary disease (COPD). However, whether patients with mild COPD have increased arterial stiffness and what factors are linked to is still...
Conference Abstract

142. P8.9 EFFECT OF CARDIAC RESYNCHRONISATION THERAPY ON THE ARTERIAL STIFFNESS

Anna Przybyla*, Danuta Czarnecka
Pages: 36 - 36
Development of cardiac resynchronisation therapy (CRT) in recent years became a breakthrough in treatment of severe heart failure, as it improves exercise capacity, reduces a rate of hospitalisations due to heart failure exacerbation, and the mortality rate, as well as improves quality of patients’ life....
Conference Abstract

143. P8.10 EFFECTS OF BARIATRIC SURGERY ON ENDOTHELIAL FUNCTION IN EXTREMELY OBESE PATIENTS

Anna Dzieża-Grudnik*, Anna Gαuszewska, Krzysztof Rewiuk, Aleksander Kwater, Bartosz Zarzycki, Maαgorzata Fedyk-Łukasik, Barbara Gryglewska, Tomasz Grodzicki
Pages: 36 - 36
Introduction: Bariatric surgery in extremely obese patients has influence on metabolic variables and body weight however data about influence on flow-mediated dilatation (FMD) of brachial artery are inconsistent. The aim of the study was to assess the effect of bariatric surgery on endothelial function...
Conference Abstract

144. P8.11 EFFECT OF CARDIAC RESYNCHRONISATION THERAPY ON THE AUTONOMIC NERVOUS SYSTEM FUNCTION

Anna Przybyla*, Danuta Czarnecka
Pages: 36 - 36
Development of cardiac resynchronisation therapy (CRT) in recent years became a breakthrough in treatment of severe heart failure. The aim of this study was evaluation of CRT effect on the autonomous nervous system function. Methods: The study covered a group of 55 patients (45 men, 10 women; mean age...
Conference Abstract

145. P8.12 CAROTID ARTERY WAVE INTENSITY ANALYSIS IN HEALTHY HUMANS DURING EXERCISE

Nicola Pomella*, Eurico Wilhelm Neto, Christina Kolyva, Mark Rakobowchuk, Jose Gonzalez-Alonso, Ashraf William Khir
Pages: 37 - 37
Background: The study of wave reflections in the carotid artery may reveal the vasoactive response of the cerebral circulation to exercise, which is not yet fully characterised. Therefore, we aim to examine the effect of exercise on wave intensity parameters measured in the carotid artery of healthy...
Conference Abstract

146. P8.13 THE ROLE OF HYALURONAN IN AORTIC STIFFENING IN PATIENTS WITH RHEUMATOID ARTHRITIS

Kathleen Connolly*, Kaisa Maki-Petaja, Elizabeth Ribey, Chen Yen Ooi, Sarah Cleary, Ian Wilkinson
Pages: 37 - 37
Growing evidence shows that patients with rheumatoid arthritis (RA) have up to twice the risk of developing cardiovascular disease (CVD) compared to those without RA. Generally, these RA patients have higher levels of inflammation in their bodies, and this inflammation is thought to be the link between...
Conference Abstract

147. P8.14 ELASTIC MODULUS OF HUMAN AORTAS AS A MEASURE OF STIFFNESS

Kathleen Connolly*, Ashraf Khir, Ye Li, Yasmin Yasmin, Ian Wilkinson
Pages: 37 - 37
Background: Although arterial stiffness is of clinical interest, data on the elastic modulus of the human aortic wall are scarce. The aim of this work is to directly measure the elastic modulus of human aorta ex vivo. Methods: Using a standard tensiometer, we measured the elastic modulus (E) of human...
Conference Abstract

148. P8.15 THE RELATION BETWEEN ARTERIAL STIFFNESS-RELATED, AND STEADY BLOOD PRESSURE COMPONENTS AND LEFT ATRIAL VOLUME IN THE CONTEXT OF LEFT VENTRICULAR MASS INDEX

Marta Rojek, Jerzy Gasowski*, Marek Rajzer, Tomasz Pizon, Danuta Czarnecka
Pages: 37 - 37
Objective: To check of relation between blood pressure (BP) and arterial stiffness parameters and measures of left atrial volume to verify whether it is the arterial stiffness-related BP parameters or mean arterial pressure (MAP)that could be responsible for increase in risk of atrial fibrillation. Methods:...
Conference Abstract

149. P8.16 WHITE MATTER LESIONS ARE ASSOCIATED WITH A SIGNIFICANT DECREASE IN THE METABOLISM OF THE BRAIN GREY-MATTER FROM OLDER HYPERTENSIVE PATIENTS

Antoine Verger, Anna Kearney-Schwartz*, Serge Bracard, Veronique Roch
Pages: 37 - 38
White matter lesions, described as leukoaraiosis, are frequently documented in older hypertensive patients, but their consequence on brain metabolism remains debated. This study aimed at characterizing the changes in brain metabolism, assessed by [18F]-fluorodesoxyglucose Positron Emission Tomography...
Conference Abstract

150. 1.1 DIASTOLIC LEFT VENTRICULAR FUNCTION IN RELATION TO CIRCULATING METABOLIC BIOMARKERS IN A GENERAL POPULATION

Zhen Yu Zhang*, Vannina Marrachelli, Lutgarde Thijs, Wen Yi Yang, Fang Fei Wei, Daniel Monleon, Lotte Jacobs, Tim Nawrot, Peter Verhamme, Jens-Uwe Voigt, Tatiana Kuznetsova, Josep Redón, Jan Staessen
Pages: 39 - 39
Background: The metabolic signature associated with subclinical diastolic left ventricular (LV) dysfunction in the general population is unknown. Objectives: This population study aimed at identifying a specific profile of circulating me-tabolites associated with asymptomatic diastolic LV dysfunction. Methods:...
Conference Abstract

151. 1.2 AGE-DEPENDENT ASSOCIATION OF 24-HOUR PERIPHERAL AND CENTRAL PULSE PRESSURES WITH STROKE VOLUME

Giacomo Pucci*, Francesca Battista, Fabio Anastasio, Mariano Edoardo Crapa, Leandro Sanesi, Giuseppe Schillaci
Pages: 39 - 39
Objective: Pulse pressure (PP) is a complex physiologic trait affected by many variables, including LV contractility (reflected by stroke volume), arterial stiffness, and central-to-brachial amplification.The impact of age on the relationship between stroke volume and central or brachial PP has not been...
Conference Abstract

152. 1.3 PAST SMOKERS DECELERATE VASCULAR AGING IN THE LONG TERM

Dimitrios Terentes-Printzios*, Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Athanasios Aggelis, Panagiotis Xaplanteris, Panagiota Pietri, Dimitrios Tousoulis
Pages: 39 - 40
Objectives: Smoking has an unfavorable effect on arterial properties. Vascular aging is an independent predictor of cardiovascular risk. We examined the effect of quitting smoking on the progression of arterial stiffness. Methods: 142 subjects (mean age 51.9 ± 10.8 years, 94 men) with no established...
Conference Abstract

153. 1.4 CHILDHOOD DETERMINANTS OF EARLY ADULT ARTERIAL STIFFNESS IN DIFFERENT ETHNIC GROUPS

K.J. Cruickshank, L. Faconti*, M.J. Silva, O.R. Molaodi, Z.E. Enayat, A. Cassidy, A. Karamanos, U.M. Read, P. Dall, B. Stansfield, S. Harding
Pages: 40 - 40
Childhood determinants of aortic pulse wave velocity [PWV] are poorly understood. We tested how factors measured twice previously in childhood in the MRC ‘DASH’ study, particularly body mass (BMI) components and BP, affected PWV in young adults. Methods: Of 6643 London children, aged 11–13 y, from 51...
Conference Abstract

154. 1.5 RELATION OF ARTERIAL STIFFNESS WITH LEFT VENTRICULAR DIASTOLIC FUNCTION IN GENERAL POPULATION

Wiktoria Wojciechowska*, Katarzyna Stolarz-Skrzypek, Agnieszka Olszanecka, Lukasz Klima, Jerzy Gasowski, Tomasz Grodzicki, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 40 - 40
Left ventricular diastolic function declines with aging and hypertension. It is well known that elevated blood pressure results in increased arterial stiffness. The study aims to determine the relationship between arterial stiffness and left ventricular diastolic function in general population. Methods:...
Conference Abstract

155. 1.6 THE BODE INDEX PROGNOSTIC SCORE IS AN INDEPENDENT DETERMINANT OF ARTERIAL STIFFNESS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Marie Fisk*, Nichola Gale, Divya Mohan, Carmel M. McEniery, Julia Forman, Charlotte E. Bolton, William MacNee, John R. Cockcroft, Joseph Cheriyan, Ruth Tal-Singer, Michael I. Polkey, Ian B. Wilkinson
Pages: 40 - 40
Introduction: COPD is associated with increased cardiovascular risk, independent of established risk factors. Arterial stiffness is a surrogate of cardiovascular risk and we sought to determine its relationship with COPD severity and prognosis in the ERICA (Evaluation of role of inflammation in airways...
Conference Abstract

156. 2.1 A METHOD FOR THE MEASUREMENT OF PRESSURE SENSITIVITY OF CAROTID-FEMORAL PULSE WAVE VELOCITY IN HUMANS

Mark Butlin, Alberto Avolio*
Pages: 40 - 41
Background: Carotid-femoral pulse wave velocity (cfPWV), a marker of cardiovascular disease, is modified by both blood pressure and changes in arterial wall properties. Current cfPWV measurement does not differentiate between effects of blood pressure and arterial wall properties. Animal studies show...
Conference Abstract

157. 2.2 RE-REFLECTION OF BACKWARD PROPAGATING WAVES LEADS TO AMPLIFICATION OF THE FORWARD PRESSURE WAVE IN WAVE SEPARATION ANALYSIS

Patrick Segers*, Liesbeth Taelman, Joris Degroote, Jan Vierendeels
Pages: 41 - 41
Introduction: In wave separation analysis, the pressure wave is decomposed into a single forward and backward component, which actually compounds all forward and backward propagating waves. We hypothesize that, in particular in presence of early reflections as in aortic coarctation, re-reflection of...
Conference Abstract

158. 2.3 TESTING RIVA-ROCCI’S BASIC ASSUMPTIONS BY SYSTEMATIC REVIEW AND META-ANALYSIS TO DETERMINE THE TRUE DIFFERENCE BETWEEN AORTIC AND BRACHIAL INVASIVE BLOOD PRESSURE

Dean Picone*, Petr Otahal, Martin Schultz, James Sharman
Pages: 41 - 41
Background: The Riva-Rocci brachial blood pressure (BP) method purported to measure aortic BP, and this remains the cornerstone thesis of clinical BP measurement. However, few studies have confirmed this thesis with direct BP measurements. This study aimed to determine the true differences in aortic...
Conference Abstract

159. 2.4 AMBULATORY AORTIC STIFFNESS, INDEPENDENTLY OF STATIC, ASSOCIATES WITH NARROWER RETINAL ARTERIOLAR CALIBERS IN HYPERTENSIVES: THE SAFAR STUDY

Evaggelia K. Aissopou*, Antonios A. Argyris, Efthimia G. Nasothimiou, George D. Konstantonis, Konstantinos Tampakis, Nikolaos Tentolouris, Miltiadis Papathanassiou, Panagiotis G. Theodossiadis, Theodoros G. Papaioannou, Coen D.A. Stehouwer, Petros P. Sfikakis, Athanassios D. Protogerou
Pages: 41 - 42
Background: Arterial stiffness measured under static conditions reclassifies significantly cardiovascular (CV) risk and associates with organ damage, including narrower retinal arterioles. However, arterial stiffness exhibits diurnal variation, thus single static stiffness recordings do not correspond...
Conference Abstract

160. 2.5 IN SINGLETONS BORN AT TERM, LOWER GESTATIONAL AGE IS ASSOCIATED WITH INCREASED AORTIC PULSE WAVE VELOCITY IN YOUNG ADULTHOOD: THE NORTHERN IRELAND YOUNG HEARTS PROJECT (NIYHP)

Isabel Ferreira*, Alison Gallagher, Liam Murray, Colin Boreham
Pages: 42 - 42
Decreases in the mean gestational age of babies born at term have been reported over the past decade in several developed countries, linked to increases in the rates of planned births by labour induction and/or pre-labour caesarean sections. In contrast to the effects of pre-term birth, the extent to...
Conference Abstract

161. 2.6 PULSE WAVE VELOCITY AND GAIT PERFORMANCE IN OLDER SUBJECTS

Anna Skalska*, Malgorzata Fedyk-Lukasik, Paulina Fatyga, Tomasz Grodzicki
Pages: 42 - 42
Background: Arterial stiffening is an age-related change and is a well-known cardiovascular risk factor but its association with physical decline is rarely evaluated. The aim of this analysis was to assess the association of arterial stiffness as carotid-femoral pulse wave velocity (PWV) with gait performance...
Conference Abstract

162. 3.1 PREDIABETES IS ASSOCIATED WITH IMPAIRED RETINAL VASODILATION: THE MAASTRICHT STUDY

Ben Sörensen*, Boy Houben, Tos Berendschot, Jan Schouten, Bram Kroon, Carla van der Kallen, Ronald Henry, Annemarie Koster, Pieter Dagnelie, Nicolaas Schaper, Miranda Schram, Coen Stehouwer
Pages: 42 - 42
Aim: Type 2 diabetes (DM2) causes microvascular dysfunction (MVD). In addition, MVD can contribute to insulin resistance, predisposing to DM2. This hypothesis predicts that MVD should be present in impaired glucose metabolism (IGM; prediabetes). However, population-based studies of MVD and glucose metabolism...
Conference Abstract

163. 3.2 ORIGINS OF THE BACKWARD TRAVELING WAVE IN THE ARTERIAL TREE

Ye Li*, Henry Fok, Benyu Jiang, Sally Epstein, Marie Willemet, Jordi Alastruey, Kim Parker, Phil Chowienczyk
Pages: 42 - 43
Backward traveling waves, an important determinant of central haemodynamics, are usually regarded as being due to reflections from discontinuities in the arterial tree. However, consideration of a single tube model of the arterial with a single site of reflection shows that a backward pressure wave may...
Conference Abstract

164. 3.3 AN EASY AND INTUITIVE WEB INTERFACE FOR THE ASSESSMENT OF MEASUREMENTS OF CAROTID-FEMORAL PULSE WAVE VELOCITY AND LOCAL ARTERIAL STIFFNESS RELATIVE TO THE REFERENCE VALUES DATABASE

Francisco Londoño*, Jelle Bossuyt, Patrick Segers, Luc Van Bortel
Pages: 43 - 43
Objective: The use of different devices and methods still hampers the widespread clinical use of the reference values for arterial stiffness. The aim of this work was therefore to create a web-based application that allows easy assessment - for different methodological approaches - of a given measured...
Conference Abstract

165. 3.4 EVALUATION OF THE MUTUAL RELATIONSHIPS AMONG THE DEVELOPMENT OF HYPERTENSION, ARTERIAL STIFFENING AND RENAL FUNCTION DECLINE BASED ON REPEATED LONGITUDINAL MEASUREMENTS

Hirofumi Tomiyama*, Akira Yamashina
Pages: 43 - 43
Background: The mechanisms underlying the development of hypertension have not yet been fully clarified. The mutual relationships among the development of hypertension and the longitudinal changes of arterial stiffness and renal function, and also the effect of maintenance of a normal body weight on...
Conference Abstract

166. 3.5 ASSOCIATION OF VASCULAR RISK FACTORS WITH BRAIN STRUCTURE AND FUNCTION

Chloe Park*, Therese Tillin, Robert Stewart, Nish Chaturvedi, Alun Hughes
Pages: 43 - 43
Background: Vascular risk factors have been associated with brain aging. We aimed to determine the associations between blood pressure (BP), atherosclerosis, arterial stiffness and microvascular damage with both structural and functional measures of the brain. Methods: A community-based sample of 1287...
Conference Abstract

167. 3.6 AORTIC STIFFNESS IS RELATED TO CEREBRAL LESION GROWTH IN PATIENTS WITH ACUTE ISCHEMIC STROKE

Dariusz Gasecki*, Mariusz Kwarciany, Kamil Kowalczyk, Anna Gójska-Grymajło, Tomasz Nowicki, Edyta Szurowska, Pierre Boutouyrie, Stephane Laurent, Krzysztof Narkiewicz, Bartosz Karaszewski
Pages: 43 - 44
Objective: Cerebral lesion growth in acute ischemic stroke leads to secondary neurological deterioration and poor outcome. Whether cSBP and arterial stiffness are related to the early brain infarct growth in patients after ischemic stroke is unknown. Design and Methods: We enrolled 65 patients (43 males,...
Conference Abstract

168. 4.1 EFFECT OF ALISKIREN ON VASCULAR REMODELING IN SMALL RETINAL CIRCULATION

Christian Ott*, Agnes Jumar, Joanna Harazny, Stephanie Schmidt, Roland Schmieder
Pages: 44 - 44
Background: In hypertension changes in small arterial structure are characterized by an increased wall-to-lumen ratio (WLR). These adaptive processes are modulated by the renin angiotensin system. It is unclear whether direct renin inhibitors exert protective effects on small arteries in hypertensive...
Conference Abstract

169. 4.2 THE INHOMOGENEITY OF DIASTOLIC-SYSTOLIC RISE TIME OF THE DISTENSION WAVEFORM DISTRIBUTION IN THE COMMON CAROTID ARTERY IS ASSOCIATED WITH LIPID PRESENCE OF DISTAL PLAQUES

J. Steinbuch*, F.H.B.M. Schreuder, M.T.B. Truijman, A.A.J. de Rotte, M.I. Liem, E. Hermeling, A.P.G. Hoeks, W.H. Mess
Pages: 44 - 44
Objectives: Diastolic-systolic rise time characteristics of the distension waveform distribution, i.e., mean and inhomogeneity, might be modified by wave reflections from distal plaques. The aim of this study is to investigate the association between rise time characteristics for the common carotid artery...
Conference Abstract

170. 4.3 THE EFFECT OF GLYCAEMIC STATE TRANSITION ON ACCELERATED AORTIC STIFFENING: A LONGITUDINAL STUDY IN THE WHITEHALL II COHORT

Nanna B. Johansen*, Martin Shipley, Daniel R. Witte, Adam G. Tabak, Eric J. Brunner
Pages: 44 - 44
In 4,759 participants from the Whitehall II study, we examined the impact of glycaemic history on aortic stiffening. Assessment of aortic stiffness by carotid-femoral pulse wave velocity (PWV) was performed twice with a 4 year interval (2007–2009 and 2012–2013). At the first aortic stiffness assessment...
Conference Abstract

171. 4.4 FORWARD AND BACKWARD WAVES AT THE AORTIC ROOT: STEADY-STATE AND WAVE RE-REFLECTION CONSIDERATIONS

Timothy Phan*, John Li, Vandan Panchal, Amer Syed, Ejaz Shah, Julio Chirinos
Pages: 44 - 45
Background: The assumption of steady-state oscillation is often overlooked when arterial pressure and flow waveforms are decomposed into backward (Pb) and forward waves (Pf). This has led to various misinterpretations including a significant reflection-free time during early-systole and attribution of...
Conference Abstract

172. 4.5 A SYSTEMATIC REVIEW AND META-ANALYSIS OF CENTRAL TO BRACHIAL BLOOD PRESSURE AMPLIFICATION IN PATIENTS TYPE 2 DIABETES MELLITUS

Rachel Climie*, Petr Otahal, Martin Schultz, James Fell, Velandai Srikanth, James Sharman
Pages: 45 - 45
Background: Brachial blood pressure (BP) may not reflect central BP due to systolic BP (SBP) amplification. Patients with type 2 diabetes mellitus (T2DM) elicit vascular irregularities that may affect SBP amplification or other central BP indices (including pulse pressure [PP], augmentation pressure...
Conference Abstract

173. 4.6 RELATIONSHIP OF CAROTID ARTERIAL FUNCTIONAL AND STRUCTURAL CHANGES TO LEFT ATRIAL VOLUME INUNTREATED HYPERTENSION

Joanna Jaroch*, Barbara Rzyczkowska, Zbigniew Bociaga, Olga Vriz, Caterina Driussi, Maria Loboz-Rudnicka, Krzysztof Dudek, Krystyna Loboz-Grudzien
Pages: 45 - 45
The contribution of arterial functional and structural changes to left ventricular (LV) diastolic dysfunction has been the area of latest research. There are some studies on the relationship of arterial stiffness (a.s.) and left atrial (LA) remodeling as a marker of diastolic burden. Little is known...
Conference Abstract

174. 5.1 INERTIAL-VISCOELASTIC MINIMAL MODEL OF THE ARTERIAL SYSTEM RECONCILES ARTERIAL COMPLIANCE ESTIMATIONS

Timothy Phan*, John Li, Maheshwara Koppula, Izzah Vasim, Swapna Varakantam, Julio Chirinos
Pages: 45 - 45
Background: The arterial system is viscoelastic rather than purely elastic. There exist various methods to characterize the purely elastic nature of arterial compliance, each method yielding different values. The pulse pressure method (CPPM), estimating compliance by matching the pulse pressure (PP)...
Conference Abstract

175. 5.2 SOLUBLE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS AND AORTIC STIFFNESS IN GENERAL POPULATION

Otto Mayer, Jan Filipovsky*, Jitka Seidlerova, Petra Karnosova, Peter Wohlfahrt, Renata Cifkova, Jindra Windrichova, Ondrej Topolcan
Pages: 45 - 46
It has been suggested that accumulation of advanced glycation end-products (AGE) is involved in several pathophysiological processes in the vessel wall. Soluble isoform of receptor for AGE (sRAGE) acts as a decoy for capturing circulating AGE, prevents them from binding to the cell-surface receptor and...
Conference Abstract

176. 5.3 THE INFLUENCE OF SEX AND AGE ON ARTERIAL FUNCTION IN RESPONSE TO AN ACUTE INFLAMMATORY STIMULUS

Alexander Rosenberg*, Abbi Lane-Cordova, Kanokwan Bunsawat, Sang Ouk Wee, Tracy Baynard, Bo Fernhall
Pages: 46 - 46
Background: Aging is associated with increased arterial stiffness and chronic low-grade inflammation. Acute inflammatory stimulus in the presence of low-grade chronic inflammation briefly increases the risk of cardiovascular events. The risk of cardiovascular events also increases substantially in older...
Conference Abstract

177. 5.4 MATRIX GLA PROTEIN IN RELATION TO LEFT VENTRICULAR DIASTOLIC FUNCTION

Thibault Petit*, Zhen-Yu Zhang, Wen-Yi Yang, Fang-Fei Wei, Yu-Mei Gu, Juditha Knez, Nicholas Cauwenberghs, Yan-Ping Liu, Nadja Drummen, Lotte Jacobs, Lutgarde Thijs, Tatiana Kuznetsova, Stefan Janssens, Cees Vermeer, Jan A. Staessen
Pages: 46 - 46
Introduction: Matrix Gla Protein (MGP) is highly expressed in cardiomyocytes and is upregulated after acute and chronic pressure overload and in myocardial hypertrophy in mice and humans. However, no study addressed the relation between cardiac function and MGP in humans. Methods and results: In 767...
Conference Abstract

178. 5.5 MEASUREMENT OF ARTERIAL STIFFNESS BY ULTRAFAST ECHO: COMPARISON WITH ECHOTRACKING IN NORMOTENSIVE SUBJECTS AND HYPERTENSIVE PATIENTS

Louise Marais*, Mathieu Pernot, Hakim Khettab, Mickael Tanter, Emmanuel Messas, Mustapha Zidi, Stéphane Laurent, Pierre Boutouyrie
Pages: 46 - 46
Because measurement of arterial stiffness is highly dependent on blood pressure (BP), methods independent of BP are required. Ultrafast echography (UFE, Supersonic Imagine, Aix en Provence, France) makes use of very fast sampling rate (up to 10 kHz), so transient events such as pressure wave arrival...
Conference Abstract

179. 5.6 ASSOCIATION BETWEEN ENDOGENOUS SERUM TESTOSTERONE CONCENTRATIONS AND AORTIC PRESSURES AND PULSE WAVE AMPLIFICATION INDICES IN ERECTILE DYSFUNCTION PATIENTS

Dimitrios Terentes-Printzios*, Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Panagiota Pietri, Athanassios Angelis, Ioanna Gourgouli, Christos Georgakopoulos, Christodoulos Stefanadis, Dimitrios Tousoulis
Pages: 46 - 47
Purpose: Erectile dysfunction (ED) is an independent predictor of future cardiovascular (CV) events. Aortic pressures (central) and low testosterone independently predict future CV events and mortality. The relationship between testosterone, central pressures and wave reflection indices in ED patients...
Research Article

180. Design and progress of a factorial trial testing the effect of spironolactone and inorganic nitrate on arterial function in people at risk of or with type 2 diabetes

Charlotte E. Mills, Virginia Govoni, Maria Linda Casagrande, Luca Faconti, Andrew J. Webb, J. Kennedy Cruickshank
Pages: 48 - 53
Background: Arterial stiffness (AS), as pulse wave velocity (PWV), is a powerful independent predictor of cardiovascular events and commonly complicates type 2 diabetes (T2D). This trial aims to test if AS, measured by the VaSera machine as cardio-ankle vascular index (CAVI) and by Arteriograph measuring...
Research Article

181. Regional differences in the vascular response to CO2 among cerebral, ocular, and mesenteric vessels

A. Miyaji, T. Ikemura, Y. Hamada, N. Hayashi
Pages: 54 - 59
Background: It is well-known that cerebral and ocular vessels are highly sensitive to changes in the partial pressure of CO2 (PETCO2). However, it is unclear whether there are regional differences in the magnitude of the vascular response to CO2 (CO2 reactivity) in various vessels of a single individual,...