Artery Research

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Volume 12, Issue C, December 2015, Pages 40 - 40

1.6 THE BODE INDEX PROGNOSTIC SCORE IS AN INDEPENDENT DETERMINANT OF ARTERIAL STIFFNESS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Authors
Marie Fisk*1, Nichola Gale3, Divya Mohan2, Carmel M. McEniery1, Julia Forman1, Charlotte E. Bolton5, William MacNee6, John R. Cockcroft3, Joseph Cheriyan1, Ruth Tal-Singer4, Michael I. Polkey2, Ian B. Wilkinson1
1University of Cambridge & Cambridge University Hospital NHS Foundation Trust, Cambridge, UK
2Imperial College & Royal Brompton & Harefield NHS Foundation Trust, London, UK
3Wales Heart Research Institute, Cardiff University, Cardiff, UK
4GSK, PA, USA
5University of Nottingham, Nottingham, UK
6University of Edinburgh, Edinburgh, UK
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.007How to use a DOI?
Abstract

Introduction: COPD is associated with increased cardiovascular risk, independent of established risk factors. Arterial stiffness is a surrogate of cardiovascular risk and we sought to determine its relationship with COPD severity and prognosis in the ERICA (Evaluation of role of inflammation in airways disease) multi-site UK study: the largest cohort study focusing on cardiovascular manifestations in COPD.

Methods: Spirometry and haemodynamic measures (aortic pulse wave velocity (aPWV), augmentation index (AIx)) were performed in 729 COPD subjects aged ≥40 years. COPD severity was classified by BODE Index [BMI (low BMI worse prognosis), Obstruction (FEV1), Dyspnoea (mMRC score), Exercise tolerance (6-minute walk distance) high BODE index: worse outcome], a validated score based on clinical variables and an independent predictor of mortality in COPD.

Results: Mean aPWV was 10.3 (SD 2.6) m/s, AIx 27 (10)%. BODE correlated with aPWV (R = 0.2, p = 0.0001) and this was maintained when adjusted for study site, age, supine HR and MAP, years smoked and cardiovascular comorbidities (MI, stroke, diabetes, peripheral vascular disease), (β = 0.2, p = 0.0001). BODE was also a determinant of AIx when adjusted for site, age, seated HR and MAP, years smoked and cardiovascular comorbidities (β = 0.1, p = 0.02).

Conclusions: BODE is associated with arterial stiffness in COPD, independent of traditional risk factors. Its composite variables are not on the causal pathway for vascular stiffness, so its association likely reflects patient susceptibility to smoke injury in the lungs and vasculature. BODE may also enhance cardiovascular risk stratification in COPD, since its relationship with stiffness was independent of self-reported cardiovascular comorbidities.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
40 - 40
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.007How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Marie Fisk*
AU  - Nichola Gale
AU  - Divya Mohan
AU  - Carmel M. McEniery
AU  - Julia Forman
AU  - Charlotte E. Bolton
AU  - William MacNee
AU  - John R. Cockcroft
AU  - Joseph Cheriyan
AU  - Ruth Tal-Singer
AU  - Michael I. Polkey
AU  - Ian B. Wilkinson
PY  - 2015
DA  - 2015/11/23
TI  - 1.6 THE BODE INDEX PROGNOSTIC SCORE IS AN INDEPENDENT DETERMINANT OF ARTERIAL STIFFNESS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
JO  - Artery Research
SP  - 40
EP  - 40
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.007
DO  - 10.1016/j.artres.2015.10.007
ID  - Fisk*2015
ER  -