P8.7 VASCULAR ENDOTHELIAL SENESCENCE AND METABOLIC SYNDROME

DOI

10.1016/j.artres.2015.10.329How to use a DOI?

Abstract

Objectives: Vascular aging and metabolic syndrome (MS) are both independent predictors of cardiovascular events. We examined whether MS accelerates the progression of vascular aging.

Methods: 142 subjects (mean age 51.9±10.8 years, 94 men) with no established cardiovascular disease were investigated in 2 examinations over a 2-year period (mean follow-up visit 1.84 years). MS was defined by the ATP III criteria. Subjects had at the beginning and end of the study determinations of carotid-femoral pulse wave velocity (PWV), aortic augmentation index corrected for heart rate (AIx75), brachial flow-mediated dilatation (FMD) and carotid intima-media thickness (cIMT). Based on these measurements the annual absolute changes were calculated.

Results: At baseline patients with MS compared with patients without MSs had lower values of FMD (6.0% vs. 7.0%, P=0.025), but there were no statistically significant differences for PWV (7.04m/s vs. 7.26m/s, P=0.242), AIx@75 (19.9% vs. 20.3%, P=0.846) and cIMT (0.68mm vs. 0.68mm, P=0.957). For the overall population, there were no statistically significant differences in the annual absolute changes of PWV, FMD, AIx75 and cIMT. However, when a subgroup of patients <60 years with more rapid progression of endothelial aging was investigated, MS was associated with almost 7 times higher annual change of FMD [−0.89% (95% CI:−1.50 to −0.28) in patients with MS vs. −0.13% (95% CI:−0.36 to 0.10) in patients without MS, P=0.032]. This difference was not evident in the other vascular biomarkers.

Conclusions: Presence of MS is associated with endothelial dysfunction as well as accelerated progression of endothelial dysfunction, especially in the younger subjects.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Dimitrios Terentes-Printzios*
AU  - Charalambos Vachopoulos
AU  - Nikolaos Ioakeimidis
AU  - Athanasios Aggelis
AU  - Panagiotis Xaplanteris
AU  - Panagiota Pietri
AU  - Dimitrios Tousoulis
PY  - 2015
DA  - 2015/11/23
TI  - P8.7 VASCULAR ENDOTHELIAL SENESCENCE AND METABOLIC SYNDROME
JO  - Artery Research
SP  - 35
EP  - 36
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.329
DO  - 10.1016/j.artres.2015.10.329
ID  - Terentes-Printzios*2015
ER  -