Artery Research

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Volume 12, Issue C, December 2015, Pages 34 - 34

P7.19 ARTERIAL STIFFNESS AND DISEASE-RELATED ORGAN DAMAGE IN SYSTEMIC LUPUS ERYTHEMATOSUS

Authors
Giacomo Pucci*1, 2, Francesca Battista1, 2, Elena Bartoloni Bocci2, 3, Fabio Anastasio1, 2, Mariano Crapa1, 2, Leandro Sanesi1, 2, Roberto Gerli2, 3, Giuseppe Schillaci1, 2
1Unit of Internal Medicine, Terni University Hospital, Terni, Italy
2Department of Medicine, University of Perugia, Perugia, Italy
3Rheumatology Unit, Perugia Hospital, Perugia, Italy
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.322How to use a DOI?
Abstract

Hypothesis: increased arterial stiffness has been reported in subjects with systemic lupus erythematosus (SLE) compared with healthy controls. In SLE, indexes of organ damage are related to a poor clinical status and worse prognosis independently from the activity of the disease. Data are controversial about the association between SLE-related organ damage and arterial stiffness.

Methods: 40 subjects with history of SLE (mean age 45±12 years, 90% women) and a median disease duration of 12 years (IQR 5–19), underwent assessment of carotid-femoral pulse wave velocity (cf-PWV) by means of applanation tonometry (SphygmoCor). A comprehensive clinical, metabolic and immunological assessment was performed. Irreversible organ damage, not related to active inflammation, was assessed through the Systemic Lupus International Collaborating Clinics (SLICC) damage index.

Results: mean BP was 128/75±16/10 mmHg. 9 subjects (23%) were on anti-hypertensive treatment, 4 (10%) had had previous cardiovascular events, 17 (42%) were treated with steroids, 29 (71%) with hydroxychloroquine, 15 (37%) with other immunosuppressants. Median SLICC index was 2 (IQR 1–3), average cf-PWV was 7.5±1.9 m/s. cf-PWV significantly increased across SLICC damage index categories (F=3.141, p<0.019). The association between cf-PVW and SLICC index persisted after adjustment for age, sex, mean arterial pressure, height, heart rate, disease duration, anti-hypertensive treatment, number of drugs for SLE therapy, C-reactive protein and previous cardiovascular events (p=0.031).

Conclusions: in subjects with SLE under active treatment, SLICC damage index had a significant independent association with cf-PWV. Further studies are needed to explore the role of arterial stiffness as a predictor of disease-related organ damage in SLE.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
34 - 34
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.322How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Giacomo Pucci*
AU  - Francesca Battista
AU  - Elena Bartoloni Bocci
AU  - Fabio Anastasio
AU  - Mariano Crapa
AU  - Leandro Sanesi
AU  - Roberto Gerli
AU  - Giuseppe Schillaci
PY  - 2015
DA  - 2015/11/23
TI  - P7.19 ARTERIAL STIFFNESS AND DISEASE-RELATED ORGAN DAMAGE IN SYSTEMIC LUPUS ERYTHEMATOSUS
JO  - Artery Research
SP  - 34
EP  - 34
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.322
DO  - 10.1016/j.artres.2015.10.322
ID  - Pucci*2015
ER  -