Artery Research

Volume 12, Issue C, December 2015, Pages 7 - 7

P2.4 THE INFLUENCE OF ANTIHYPERTENSIVE TREATMENT ON ARTERIAL STIFFNESS, SHEAR STRESS AND ACTIVITY OF CHOSEN MATRIX METALLOPROTEINASES

Authors
Tomasz Pizon*1, Marek Rajzer2, Marta Rojek2, Danuta Czarnecka2
1Department of Observation and Internal Medicine, University Hospital, Cracow, Poland
21’st Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Cracow, Poland
Available Online 23 November 2015.
DOI
https://doi.org/10.1016/j.artres.2015.10.211How to use a DOI?
Abstract

Objective: Comparison of therapeuthic effects of chosen antihypertensive drugs on arterial stiffness, shear stress in carotid arteries and metalloproteinases activity, moreover analysis of relationship of these variables in the course of treatment.

Design and method: 95 never treated patients with HT stage 1 or 2 were randomized to 6 months monotherapy with: quinapril, amlodipine, hydrochlorothiazide, losartan or bisoprolol. Each therapeuthic group consisted of 19 patients (N=19). Before and then after 1, 3 and 6 months of treatment carotid-femoral pulse wave velocity (PWV) by using a Complior device, ultrasound of carotid arteries were performed. Blood samples for the measurement of whole blood viscosity were taken during each visit. Shear stress (SS) was calculated on the basis of Irace formula. Serum concentration of metalloproteinase 3 (MMP-3) and plasma concentration of tissue inhibitor of metalloproteinase 1 (TIMP-1) were measured at the initial visit and after 6 months of treatment.

Results: ANOVA for repeated measurements revealed for all groups significant decrease of PWV and MMP-3 concentration and increase of shear stress in carotid artery and TIMP-1 concentration (p<0.05). No between groups differences appeared in above effects (p>0.05).

Conclusion: Irrespectively of chosen drug we observed similar effect for PWV drop. Reduction of arterial stiffness as a result of antihypertensive therapy is strongly connected with shear stress increase that is secondary to blood flow velocity growth and changes in connective tissue metabolism.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
7 - 7
Publication Date
2015/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.1016/j.artres.2015.10.211How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Tomasz Pizon*
AU  - Marek Rajzer
AU  - Marta Rojek
AU  - Danuta Czarnecka
PY  - 2015
DA  - 2015/11
TI  - P2.4 THE INFLUENCE OF ANTIHYPERTENSIVE TREATMENT ON ARTERIAL STIFFNESS, SHEAR STRESS AND ACTIVITY OF CHOSEN MATRIX METALLOPROTEINASES
JO  - Artery Research
SP  - 7
EP  - 7
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.211
DO  - https://doi.org/10.1016/j.artres.2015.10.211
ID  - Pizon*2015
ER  -