Regional differences in the vascular response to CO2 among cerebral, ocular, and mesenteric vessels

A. Miyaji; T. Ikemura; Y. Hamada; N. Hayashi

doi:10.1016/j.artres.2015.08.001

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Volume 12, Issue C, December 2015, Pages 54 - 59

Regional differences in the vascular response to CO₂ among cerebral, ocular, and mesenteric vessels

Authors

A. Miyaji^a, T. Ikemura^b, Y. Hamada^a, N. Hayashi^a^{, *}

^aGraduate School of Decision Science and Technology, Tokyo Institute of Technology, Meguro, Tokyo 152-8852, Japan

^bFaculty of Sport Science, Waseda University, Tokorozawa, Saitama, 359-1192, Japan

^*Corresponding author. Tel./fax: +81 3 57343434. E-mail address: naohayashi@hum.titech.ac.jp (N. Hayashi).

Corresponding Author

N. Hayashi

Received 15 July 2015, Accepted 25 August 2015, Available Online 6 September 2015.

DOI: 10.1016/j.artres.2015.08.001 How to use a DOI?
Keywords: Cerebral circulation; Ocular circulation; CO2 reactivity; Endothelial function
Abstract: Background: It is well-known that cerebral and ocular vessels are highly sensitive to changes in the partial pressure of CO₂ (P_ETCO₂). However, it is unclear whether there are regional differences in the magnitude of the vascular response to CO₂ (CO₂ reactivity) in various vessels of a single individual, and whether there is a relationship in the CO₂ reactivity of specific vessels between different individuals.

Methods: We compared the CO₂ reactivity of the superior mesenteric artery (SMA), middle cerebral artery (MCA), retinal artery (RA), and retinal and choroidal vessels (RCV) during a 3-min inhalation of CO₂-rich air (5%) in 70 subjects.

Results: The blood flow velocities in the MCA, RA, and RCV significantly increased by 21 ± 2% (mean ± SE), 9 ± 1%, and 7 ± 2%, respectively (P < 0.05) during hypercapnia, whereas that in the SMA did not change significantly (−17 ± 11%). The CO₂ reactivity–the relative change in blood flow to a given change in P_ETCO₂–was significantly greater in the MCA (2.2 ± 0.2%/mmHg) than in the RA and RCV (0.9 ± 0.1%/mmHg and 0.8 ± 0.2%/mmHg, respectively). There was a weak correlation in the CO₂ reactivity only between RA and RCV (r = 0.43, P < 0.05).

Conclusion: These findings indicate that the CO₂ reactivity can vary even in cerebral and ocular vessels, although the correlation is weak.
Open Access: This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue

Journal: Artery Research
Volume-Issue: 12 - C
Pages: 54 - 59
Publication Date: 2015/09/06
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2015.08.001 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - A. Miyaji
AU  - T. Ikemura
AU  - Y. Hamada
AU  - N. Hayashi
PY  - 2015
DA  - 2015/09/06
TI  - Regional differences in the vascular response to CO2 among cerebral, ocular, and mesenteric vessels
JO  - Artery Research
SP  - 54
EP  - 59
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.08.001
DO  - 10.1016/j.artres.2015.08.001
ID  - Miyaji2015
ER  -

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