Artery Research

Volume 12, Issue C, December 2015, Pages 18 - 18

P4.11 ENDOTHELIAL DYSFUNCTION IN URBANIZED AFRICANS WITH LOW PLASMA RENIN LEVELS: THE SABPA STUDY

Authors
Johannes van Rooyen*, Rijane Swart, Carina Mels
North-West University and HART, North West Province, South Africa
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.255How to use a DOI?
Abstract

Background and objectives: It is known that high renin levels could damage the vasculature and may cause retinal detachment, stroke, heart failure and kidney failure. The objective of this part of the SABPA study was to determine if renin levels in low and high renin participants could contribute to endothelial dysfunction.

Methods: This part of the SABPA study consisted of 113 black urbanized Africans (men and women) from the same socio-economic status (school teachers) from South Africa. The participants were stratified into low (<6.18 pg/ml) and high (≥6.18 pg/ml) renin levels. Blood pressure and other variables were determined with known methods. Active renin levels were determined with a radio-immunometric assay (Renin III Generation, CIS bio-international, Cedex, France). The Von Willebrand Factor (vWF) was analysed with ELISA assay. (DAKO, SA). A calorimetric method were used for urine creatinine and a turbidimetric method for albumin measurement.

Results: In single regression analysis, renin levels associated negatively with the Von Willebrand Factor (r=−0.3756; p=0.016) only in the low renin African men. With partial regression analysis after adjustment for age and BMI, the association remained. Renin levels also associated negatively (r=−0.4846; p=0.002) with systolic blood pressure only in low renin men. No associations could be encountered with markers of inflammation (IL-6; CRP and TNF-α) as well as stiffness.

Conclusion: The results revealed that renin causing endothelial dysfunction in low renin African men and may lead to high blood pressure in later life.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
18 - 18
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.255How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Johannes van Rooyen*
AU  - Rijane Swart
AU  - Carina Mels
PY  - 2015
DA  - 2015/11/23
TI  - P4.11 ENDOTHELIAL DYSFUNCTION IN URBANIZED AFRICANS WITH LOW PLASMA RENIN LEVELS: THE SABPA STUDY
JO  - Artery Research
SP  - 18
EP  - 18
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.255
DO  - 10.1016/j.artres.2015.10.255
ID  - vanRooyen*2015
ER  -