Artery Research

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Volume 12, Issue C, December 2015, Pages 31 - 31

P7.5 RELATIONSHIPS BETWEEN 24 HOUR URINARY CORTISOL METABOLITES AND STRUCTURAL CARDIAC AND ARTERIAL INDICES IN PEOPLE WITH OR AT RISK OF TYPE 2 DIABETES

Authors
Charlotte Mills*1, 3, Luca Faconti1, 3, Hannah Crickmore1, Fahad Iqbal1, Anne Risser1, Doina Bobeica1, Lea Ghataore4, Virginia Govoni1, 3, Maria-Linda Casagrande1, 3, Andrew Webb2, 3, Norman Taylor4, Kennedy Cruickshank1, 3
1King’s College London, Division of Diabetes and Nutritional Sciences, London, UK
2King’s College London, British Heart Foundation Centre, Cardiovascular Division, Department of Clinical Pharmacology, London, UK
3Guy’s and St Thomas’ NHS Foundation Trust, NIHR Biomedical Research Centre, London, UK
4King’s College Hospital, Viapath, Department of Clinical Biochemistry, London, UK
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.309How to use a DOI?
Abstract

Objective: To assess if 24h urinary cortisol metabolite (UCM) profiles are related to structural cardiac and arterial parameters in those with or at risk of Type 2 diabetes mellitus (T2DM).

Design and method: 32 participants, 25-77 years, eGFR> 45 mL/min and no serious illness. Urine was collected over 24 hours. 2D echocardiography and arterial stiffness measures [aortic pulse wave velocity (aPWV) by Arteriograph and cardio-ankle vascular index (CAVI) by VaSera] were performed on the collection day. Steroids were extracted from urine and hydrolysed; derivatives were analysed by GC-MS.

Results: Seven UCMs were quantified [tetrahydrocortisol (THF), allo-tetrahydrocortisol (a-THF), tetrahydrocortisone (THE), α-cortol (α-col), β-cortol (β-col), α-cortolone (α-cone), β-cortolone (β-cone)].

Left ventricular mass index (LVMI) correlated positively with 24h cortisol:cortisone metabolites (THF+aTHF+αcol+βcol/THE+αcortolone+βcortolone) and negatively with α:β metabolites (αcol+αcortol/βcol+βcortol), when indexed for body surface area (BSA) and height (r=0.37, 0.48 and r=−0.34, −0.49 respectively). Further, there was a positive relationship between LVMIBSA and THF:THE (r=0.35). aPWV but not CAVI was also related to 24h cortisol:cortisone metabolites (r=0.45). All p<0.05.

Regression analysis including age, gender, systolic blood pressure (SBP), arterial stiffness (aPWV or CAVI) and body mass index (BMI; only for RWT), showed an independent association between THF:THE and LVMIBSA and LVMIheight and cortisol:cortisone metabolites with LVMIheight, p<0.02.

SBP, but not arterial stiffness, was also independently related to LVMIBSA and LVMIheight in all models.

Conclusion: Specific 24h UCMs and UCM ratios (from glucocorticoid/mineralocorticoid, 11βHSD and 20αHSD/20βHSD actions) may be structural cardiac biomarkers in those with or at risk of T2DM.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
12 - C
Pages
31 - 31
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.309How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Charlotte Mills*
AU  - Luca Faconti
AU  - Hannah Crickmore
AU  - Fahad Iqbal
AU  - Anne Risser
AU  - Doina Bobeica
AU  - Lea Ghataore
AU  - Virginia Govoni
AU  - Maria-Linda Casagrande
AU  - Andrew Webb
AU  - Norman Taylor
AU  - Kennedy Cruickshank
PY  - 2015
DA  - 2015/11/23
TI  - P7.5 RELATIONSHIPS BETWEEN 24 HOUR URINARY CORTISOL METABOLITES AND STRUCTURAL CARDIAC AND ARTERIAL INDICES IN PEOPLE WITH OR AT RISK OF TYPE 2 DIABETES
JO  - Artery Research
SP  - 31
EP  - 31
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.309
DO  - 10.1016/j.artres.2015.10.309
ID  - Mills*2015
ER  -