Artery Research

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Volume 12, Issue C, December 2015, Pages 16 - 16

P4.4 INHIBITION OF ARTERIAL CALCIFICATION BY MATRIX GLA PROTEIN AS DETERMINANT OF RENAL FUNCTION IN THE GENERAL POPULATION

Authors
Fangfei Wei*1, Nadja E.A. Drummen4, Lutgarde Thijs1, Lotte Jacobs1, Marjo H.J. Knapen4, Thibaut Petit1, Wenyi Yang1, Zhenyu Zhang1, Yumei Gu1, Tatiana Kuznetsova1, Peter Verhamme2, Pieter Evenepoel3, Cees Vermeer4, Jan A. Staessen1, 4
1Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium
2Centre for Molecular and Vascular Biology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium
3Laboratory of Nephrology, Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium
4R&D Group VitaK, Maastricht University, Maastricht, The Netherlands
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.248How to use a DOI?
Abstract

Background: Carboxylation of matrix Gla protein (MGP), a vitamin K dependent process, activates the protein to a powerful inhibitor of arterial calcification. Circulating dephosphorylated and uncarboxylated MGP (dp-ucMGP) and total uncarboxylated MGP (t-ucMGP) are associated with macrovascular disease. The association with microcirculatory disease remains unknown.

Methods: In 1174 randomly recruited Flemish (51.4% women; mean age, 38.2 years), we studied the estimated glomerular filtration rate (eGFR) and microalbuminuria, as prototypes of microcirculatory traits, in relation to dp-ucMGP and t-ucMGP. In multivariable linear and logistic regressions, we expressed effect sizes for a doubling of the biomarkers, while accounted for anthropometric characteristics, lifestyle, risk factors and use of medications.

Results: Among all participants, geometric means of dp-ucMGP and t-ucMGP were 3.68 mg/L and 45.2 mg/L, respectively. In relation to dp-ucMGP (figure), eGFR decreased by 1.57 mL/min/1.73 m2 (p=0.015), while the risk of renal dysfunction (eGFR <60 mL/min/1.73 m2) increased by 19% (p=0.022) with a 43% trend in the same direction (p=0.069) for microalbuminuria (albumin-to-creatinine ratio ≥3.5 mg/mmol in women and ≥2.5 mg/mmol in men). In relation to t-ucMGP (figure), eGFR increased by 1.89 mL/min/1.73 m2 (p=0.041) with no changes in the risks of renal dysfunction or microalbuminuria (p≥0.12).

Conclusion: In the general population, eGFR is inversely correlated with dp-ucMGP, a marker of vitamin K deficiency, whereas the opposite is the case for t-ucMGP, a marker of prevalent arterial calcification.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
16 - 16
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.248How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Fangfei Wei*
AU  - Nadja E.A. Drummen
AU  - Lutgarde Thijs
AU  - Lotte Jacobs
AU  - Marjo H.J. Knapen
AU  - Thibaut Petit
AU  - Wenyi Yang
AU  - Zhenyu Zhang
AU  - Yumei Gu
AU  - Tatiana Kuznetsova
AU  - Peter Verhamme
AU  - Pieter Evenepoel
AU  - Cees Vermeer
AU  - Jan A. Staessen
PY  - 2015
DA  - 2015/11/23
TI  - P4.4 INHIBITION OF ARTERIAL CALCIFICATION BY MATRIX GLA PROTEIN AS DETERMINANT OF RENAL FUNCTION IN THE GENERAL POPULATION
JO  - Artery Research
SP  - 16
EP  - 16
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.248
DO  - 10.1016/j.artres.2015.10.248
ID  - Wei*2015
ER  -