Artery Research

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Volume 12, Issue C, December 2015, Pages 30 - 30

P7.2 VERY EARLY CLINICAL VASCULAR AND HEART MARKERS OF NEWLY RECOGNIZED HYPERTENSION IN MIDDLE AGE ADULTS

Authors
Olga Siga*, Jarosαaw Królczyk, Anna Dzieża-Grudnik, Jolanta Walczewska, Barbara Wizner, Tomasz Grodzicki
Department of Internal Medicine and Gerontology, Jagiellonian University Medical College/University Hospital, Cracow, Poland
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.306How to use a DOI?
Abstract

The aim of this study was to evaluate vascular and echocardiographic markers of hypertension (HT) in subjects with newly diagnosed HT before treatment started.

We studied 32 patients with newly diagnosed HT without pharmacological therapy (HT group) and 31 healthy ones (control group). ABPM were performed to exclude or confirm HT. Cardiovascular risk factors and pulse wave velocity (PWV) were assessed. Measurements of left ventricle, size of left atrium and parameters of diastolic function of left ventricle were measured using echocardiography. The student’s T-test, U Mann-Whitney and Chi2 tests were used to compare differences between groups.

There were no significant differences in cardiovascular risk factors (sex, age, total cholesterol level, HbA1c) between groups with exception of BMI (p<0,05). We observed significant differences between HT group and control group in PWV, LVMI, LAVI, IVSd, LVIDd, LVPWd, E/A, E/E′, although there were no such differences in IVRT, DcT and E′.

Control group
N=31
HT group
N=32
Men, n[%]
12[39]
19[59]
Age[year]
45±10
44±12,5
BMI[kg/m2]*
24±3,5
28,5±4,0
SBP[mmHg]*
119,4±9,5
142,3±15,0
DBP[mmHg]*
81,1±8,8
97,6±11,1
Total cholesterol[mmol/l]
5,1±1,0
5,5±0,9
HbA1c[%]
5,4±0,4
5,5±0,4
PWV[m/s]*
8,7±2,0
10,2±2,6
LVMI[g/m2]*
83,1±18,4
96,3±24,7
IVSd[mm]*
9,4±1,8
10,7±2,0
LVIDd[mm]*
46,4±4,4
49,4±4,7
LVPWd[mm]*
9,2±1,7
10,7±1,7
LAVI[ml/m2]*
16,9±6,2
22,2±6,5
IVRT[s]
0,097±0,024
0,094±0,017
DcT[s]
0,293±0,078
0,266±0,083
E/A*
1,3±0,3
1,1±0,3
E′[m/s]
10,7±2,1
9,2±3,3
E/E′*
8,3±2,3
9,7±2,7
*-

p<0,05

In the study group, increase in pulse wave velocity concomitant with changes in diastolic function characterize middle age patients with newly diagnosed hypertension. It is difficult to separate the effect of high blood pressure from the importance of overweight.

Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
30 - 30
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.306How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Olga Siga*
AU  - Jarosαaw Królczyk
AU  - Anna Dzieża-Grudnik
AU  - Jolanta Walczewska
AU  - Barbara Wizner
AU  - Tomasz Grodzicki
PY  - 2015
DA  - 2015/11/23
TI  - P7.2 VERY EARLY CLINICAL VASCULAR AND HEART MARKERS OF NEWLY RECOGNIZED HYPERTENSION IN MIDDLE AGE ADULTS
JO  - Artery Research
SP  - 30
EP  - 30
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.306
DO  - 10.1016/j.artres.2015.10.306
ID  - Siga*2015
ER  -