Artery Research

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Volume 12, Issue C, December 2015, Pages 41 - 42

2.4 AMBULATORY AORTIC STIFFNESS, INDEPENDENTLY OF STATIC, ASSOCIATES WITH NARROWER RETINAL ARTERIOLAR CALIBERS IN HYPERTENSIVES: THE SAFAR STUDY

Authors
Evaggelia K. Aissopou*1, Antonios A. Argyris1, Efthimia G. Nasothimiou1, George D. Konstantonis1, Konstantinos Tampakis1, Nikolaos Tentolouris1, Miltiadis Papathanassiou2, Panagiotis G. Theodossiadis2, Theodoros G. Papaioannou3, Coen D.A. Stehouwer4, 5, Petros P. Sfikakis1, Athanassios D. Protogerou1, 5
1Hypertension Unit and Cardiovascular Research Laboratory, 1st Department of Propaedeutic Internal Medicine, Laiko Hospital, Athens, Greece
22nd Department of Ophthalmology, Attikon University Hospital, Athens, Greece
3Biomedical Engineering Unit, 1st Department of Cardiology, Hippokration Hospital, Athens, Greece
4Department of Medicine, Maastricht, The Netherlands
5Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.011How to use a DOI?
Abstract

Background: Arterial stiffness measured under static conditions reclassifies significantly cardiovascular (CV) risk and associates with organ damage, including narrower retinal arterioles. However, arterial stiffness exhibits diurnal variation, thus single static stiffness recordings do not correspond to the “usual” 24 hr, awake and asleep average arterial stiffness. We aimed to test the hypothesis that ambulatory 24 hr, awake and asleep aortic (a) pulse wave velocity (PWV) associate with retinal vessel calibers, independently of confounders and of static arterial stiffness, in hypertensive individuals free from diabetes and CV disease.

Methods: Digital retinal images were obtained (181 individuals, age: 53.9 ± 10.7 years, 55.2% men) and retinal vessel calibers were measured with validated software to determine central retinal arteriolar and venular equivalents (CRAE and CRVE, respectively); ambulatory (24 hr, awake, asleep) and static office aPWV were estimated by Mobilo-O-Graph; and static office carotid-femoral (cf) PWV by SphygmoCor.

Results: Regression analysis performed in 320 gradable retinal images showed that, after adjustment for confounders: (i) ambulatory aPWV was significantly associated with narrower retinal arterioles but not with venules; (ii) asleep aPWV had stronger associations with CRAE than awake aPWV; (iii) both ambulatory aPWV and cfPWV were associated mutually independently with narrower retinal arterioles; aPWV introduction in the model of cfPWV, improved model’s R2 (p = 0.012). Similar discriminatory ability of 24 hr aPWV and of cfPWV to detect the presence of retinal arteriolar narrowing was found.

Conclusion: Ambulatory aPWV, estimated by an operator-independent method, provides additional information to cfPWV regarding the associations of arterial stiffness with the retinal microcirculation.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
12 - C
Pages
41 - 42
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.011How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Evaggelia K. Aissopou*
AU  - Antonios A. Argyris
AU  - Efthimia G. Nasothimiou
AU  - George D. Konstantonis
AU  - Konstantinos Tampakis
AU  - Nikolaos Tentolouris
AU  - Miltiadis Papathanassiou
AU  - Panagiotis G. Theodossiadis
AU  - Theodoros G. Papaioannou
AU  - Coen D.A. Stehouwer
AU  - Petros P. Sfikakis
AU  - Athanassios D. Protogerou
PY  - 2015
DA  - 2015/11/23
TI  - 2.4 AMBULATORY AORTIC STIFFNESS, INDEPENDENTLY OF STATIC, ASSOCIATES WITH NARROWER RETINAL ARTERIOLAR CALIBERS IN HYPERTENSIVES: THE SAFAR STUDY
JO  - Artery Research
SP  - 41
EP  - 42
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.011
DO  - 10.1016/j.artres.2015.10.011
ID  - Aissopou*2015
ER  -