Artery Research

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Volume 12, Issue C, December 2015, Pages 24 - 24

P5.20 MEASURE OF CHANGE IN CAROTID-RADIAL PULSE WAVE VELOCITY AFTER REACTIVE HYPERAEMIA

Authors
Hakim Khettab*1, Benjamin Nayagom1, Sandrine Millasseau2, Stephane Laurent1, Pierre Boutouyrie1
1HEGP, APHP, Paris, France
2Pulse Wave Consulting, St Leu la Foret, France
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.283How to use a DOI?
Abstract

The recognized reference method for endothelial function assessment is brachial artery diameter echo-tracking during flow mediated dilation (FMD) induced by reactive hyperaemia (RH). From the Mons-Korteweg equation, FMD should also reduce upper limb pulse wave velocity (PWV). The aim of our study was to compare echo-tracking FMD with PWV changes after RH.

Brachial diameter was assessed by echo-tracking (MyLAb 70, Easote, Italy) before and after 7 min of ischemia induced by inflating a cuff on the right wirst 50mmHg above subject’s systolic blood pressure. Carotid-left radial and carotid-right radial PWVs were also simultaneously measured with Complior Analyse (Alam Medical, France) at baseline (in triplicate), 30sec, 1, 3 and 5 min end of ischemia.

Measurements were performed in 15 healthy subjects (10M/5F, 31±11 yrs). Maximum PWV changes happened 1min after cuff deflation in the ischemic arm (ΔPWV=2,1±1,4m/s, p<0,001) while changes in the control arm were non-significant.

Time after deflation ΔPWV ischemic arm ΔPWV control arm
30sec −0,6 ± 0,6 −0,2 ± 1,0
1min −2,1 ± 1,4 * −0,1 ± 1,1
3min −1,9 ± 1,4 * −0,1 ± 1,2
5min −1,7 ± 1,3 −0,7 ± 2,5
*

p<0,001

The maximal change in arterial diameter post-RH was 5,1±4,7%. There was no correlation between diameter change and ΔPWV (R=0,03, p=0,91).

While the use carotid-radial PWV seems promising to track changes post RH, further studies are needed to better understand this phenomena which is not related to diameter change.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
24 - 24
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.283How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Hakim Khettab*
AU  - Benjamin Nayagom
AU  - Sandrine Millasseau
AU  - Stephane Laurent
AU  - Pierre Boutouyrie
PY  - 2015
DA  - 2015/11/23
TI  - P5.20 MEASURE OF CHANGE IN CAROTID-RADIAL PULSE WAVE VELOCITY AFTER REACTIVE HYPERAEMIA
JO  - Artery Research
SP  - 24
EP  - 24
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.283
DO  - 10.1016/j.artres.2015.10.283
ID  - Khettab*2015
ER  -