P1.1 PHYSICAL ACTIVITY IS ASSOCIATED WITH FLOW-MEDIATED DILATATION IN FEMALES
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Impairment of vascular endothelial function is an early sign of atherosclerosis. An active lifestyle is suggested to be positively associated with favorable endothelial function as opposed to a sedentary lifestyle.
The aim of this ongoing study (Lifestyle, Biomarkers and Atherosclerosis Study) is to investigate associations between vascular endothelial function and physical activity level in 1000 non-smokers without know disease aged 18-25 years. Preliminary data from the 317 first subjects with complete data will be reported here.
Flow-mediated dilation was assessed in a. brachialis by high-resolution ultrasound (Vivid e9) before and after 5-minutes occlusion, and time spent active (at moderate or vigorous intensity level) or sedentary was assessed by accelerometry (ActiGraph wGT3X-BT).
Body fat (%)
Time spent active (min/day)
Time spent sedentary (min/day)
Flow Mediated Dilatation measures
Diameter, pre-stas (mm)
Increase, post-stas (mm)
Increase, post-stas (%)
Multiple regression analyses show that time spent active is statistically associated with diameter increase (mm) and percentage increase (adjusted for pre-stas diameter) in females (beta coefficient = 0,144; p=0,032 and beta-coefficient=0,135; p= 0,041, respectively) but not in males. Time spent sedentary did not show any associations with the flow-mediated dilatation variables in neither females nor males.
In conclusion, already in young adulthood, an active lifestyle is associated with higher flow-mediated dilatation as a measure of endothelial function.
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Cite this article
TY - JOUR AU - Ulrika Ferberg* AU - Katya Matusevich AU - Gabriella Eliason AU - Maria Fernstom AU - Anita Hurtig-Wennlof PY - 2015 DA - 2015/11 TI - P1.1 PHYSICAL ACTIVITY IS ASSOCIATED WITH FLOW-MEDIATED DILATATION IN FEMALES JO - Artery Research SP - 3 EP - 3 VL - 12 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2015.10.195 DO - https://doi.org/10.1016/j.artres.2015.10.195 ID - Ferberg*2015 ER -