Artery Research

Volume 12, Issue C, December 2015, Pages 25 - 25

P6.2 AORTIC-TO-BRACHIAL STIFFNESS GRADIENT INDEPENDENTLY PREDICTS KIDNEY FUNCTION: CASE-CONTROL COMPARISON BETWEEN PATIENTS WITH TYPE 2 DIABETES AND NON-DIABETIC CONTROLS

Authors
Dean Picone*1, Martin Schultz1, Rachel Climie1, Velandai Srikanth2, James Sharman1
1Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
2Stroke and Ageing Research Group, Monash Medical Centre, Dept. of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, Australia
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.286How to use a DOI?
Abstract

Background: A negative aortic-brachial stiffness gradient (ab-SG), whereby aortic pulse wave velocity (aPWV)≥brachial PWV (bPWV) predicts mortality independent of aPWV in dialysis patients. Patients with type 2 diabetes mellitus (T2DM) have increased risk of renal damage and exhibit haemodynamic abnormalities that may alter ab-SG. This study aimed to determine if there were differences in ab-SG among patients with T2DM compared with non-diabetic controls, and also to determine associations between ab-SG, aPWV and kidney function.

Methods: 60 patients with T2DM and 60 age- and sex-matched non-diabetic controls (58±8 years, 55% male both) had ab-SG measured by applanation tonometry, with ab-SG defined as the quotient of bPWV (carotid-to-radial) and aPWV (carotid-to-femoral). Kidney function was assessed by estimated glomerular filtration rate (eGFR).

Results: ab-SG was significantly lower in patients with T2DM (0.99±0.2 versus 1.2±0.3, p<0.001) and aPWV, but not bPWV, was significantly higher (p<0.001, p=0.25). 58% of patients with T2DM versus 27% of non-diabetic controls (χ2=11.0, p<0.001) had negative ab-SG (aPWV≥bPWV). ab-SG predicted eGFR in the entire cohort independent of age, sex, T2DM status and cardiovascular risk factors (β=17.0, p=0.005), whereas aPWV was a weaker correlate of eGFR (β=−0.15, p=0.22). Independent predictors of ab-SG were brachial and central pulse pressure (β=−0.008, p=0.005; β=−0.007, p=0.027) for patients with T2DM and heart rate (β=−0.012, p=0.007) and brachial pulse pressure (β=−0.012, p=0.026) for non-diabetic controls.

Conclusions: Patients with T2DM have reduced (negative) ab-SG. In the entire cohort, ab-SG predicted kidney function independent of aPWV, implying that negative ab-SG may have a pathophysiological function.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
12 - C
Pages
25 - 25
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.286How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Dean Picone*
AU  - Martin Schultz
AU  - Rachel Climie
AU  - Velandai Srikanth
AU  - James Sharman
PY  - 2015
DA  - 2015/11/23
TI  - P6.2 AORTIC-TO-BRACHIAL STIFFNESS GRADIENT INDEPENDENTLY PREDICTS KIDNEY FUNCTION: CASE-CONTROL COMPARISON BETWEEN PATIENTS WITH TYPE 2 DIABETES AND NON-DIABETIC CONTROLS
JO  - Artery Research
SP  - 25
EP  - 25
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.286
DO  - 10.1016/j.artres.2015.10.286
ID  - Picone*2015
ER  -