Artery Research

Volume 12, Issue C, December 2015, Pages 8 - 8

P2.9 A NOVEL SPECKLE TRACKING TECHNIQUE FOR INVESTIGATING REGIONAL MOTION OF THE CAROTID WALL: SPATIO-TEMPORAL VARIATION IN DISTENSION ASSOCIATES WITH PRESENCE OF CALCIFIED PLAQUE

Authors
Benyu Jiang*1, Jing Wang1, Tim Spector2, Phil Philip J. Chowienczyk1
1King’s College London British Heart Foundation Centre, Department of Clinical Pharmacology, London, UK
22Department of Twin Research, King’s College, London, UK
Available Online 23 November 2015.
DOI
https://doi.org/10.1016/j.artres.2015.10.215How to use a DOI?
Abstract

Background: Arterial calcification may lead to regional variation in distension imposing stresses on the arterial wall that predispose to plaque rupture. The objective of this study was to use a novel speckle tracking method to investigate regional motion of the carotid wall and to determine whether this relates to subclinical disease.

Methods and results: Measurements were obtained on 256 subjects from the Twins UK cohort (mean ± SD age 62±10.2 years). The left carotid was imaged for an assessment of plaque and calcification. Speckle-tracking was then used to measure regional circumferential strain of the left common carotid in 6 separate 60° segments of the circumference of the arterial wall in a plaque free plane of the common carotid approximately 1 cm proximal to the bifurcation. Regional variation in circumferential strain around the circumference of the arterial wall was characterized by the standard deviation of circumferential strain and that of the time from onset of systole to peak circumferential strain in each segment. Spatio-temporal variation in circumferential strain characterized by variation in the time to peak circumferential strain was associated with age and presence of calcified plaque (regression coefficients 0.73 units/year and 14.2 increase for presence of calcified plaque, each P<0.001) independent of other confounding factors and of other measures of arterial wall damage such as carotid intima-media thickening, carotid distensibility and carotid-femoral pulse wave velocity.

Conclusion: Arterial ageing and calcification are associated with spatio-temporal variation in distension of the carotid artery.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
8 - 8
Publication Date
2015/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.1016/j.artres.2015.10.215How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Benyu Jiang*
AU  - Jing Wang
AU  - Tim Spector
AU  - Phil Philip J. Chowienczyk
PY  - 2015
DA  - 2015/11
TI  - P2.9 A NOVEL SPECKLE TRACKING TECHNIQUE FOR INVESTIGATING REGIONAL MOTION OF THE CAROTID WALL: SPATIO-TEMPORAL VARIATION IN DISTENSION ASSOCIATES WITH PRESENCE OF CALCIFIED PLAQUE
JO  - Artery Research
SP  - 8
EP  - 8
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.215
DO  - https://doi.org/10.1016/j.artres.2015.10.215
ID  - Jiang*2015
ER  -