Artery Research

Volume 12, Issue C, December 2015, Pages 7 - 8

P2.7 AMELIORATION OF COGNITIVE FUNCTION IN HEMODIALYSIS PATIENTS IN ABSENT OF HYPOTENSIVES EPISODES

Authors
Despina Karasavvidou*1, Eleni Triantafilidou1, Dimitrios Valoukas1, Dimitrios Makridis1, Sygliti-Errieta Pelidou2, Cristos katsinas1
1Department of Nephrology, General Hospital of Ptolemaida, Ptolemaida, Greece
2Department of Neurology, University of Ioannina, Ioannina, Greece
Available Online 23 November 2015.
DOI
https://doi.org/10.1016/j.artres.2015.10.214How to use a DOI?
Abstract

Objective: Patients in hemodialysis frequently have cognitive dysfunction (CO/DY). Hemodialysis session often results in acute intravascular volume loss, fluid shifts, hypotensives episodes, decrease of cerebral perfusion and cerebral ischemia, all of which may cause transient deterioration of cognitive function. On the contrary, improvement in “uremic milieu” after a dialysis session can result in improved cognition. The aim of this study is to evaluate the effect of a single, random hemodialysis session on cognitive function, in absent of hypotensive episodes.

Method: Global cognitive function was assessed, pre-and post-dialysis by using the Mini Mental State Examination.

Results: Forty-eight patients participated in the study. The average age was 60.8±13.4 years. The mean dialysis vintage was 58±66 months. Patients received adequate renal replacement therapy and the mean urea reduction ratio was 72±6.6. At the onset and at the end of the study, no major hemodynamic changes were detecting (mean systolic/diastolic blood pressure (147.±20/78±11 vs 138±20/77±10 mmHg) according to our aforementioned criteria. Compared to pre- dialysis, an improvement in the test score was revealed after dialysis, paired t-test (p=0.03). Mean values of MMSE pre and post was 26.61 ± 3.24 and 28.86± 1.98 respectively (amelioration of 2.25 points).

Conclusions: Our results illustrate the better performance of cognitive function that can be observed after a single dialysis session, in absent of hypotensives episodes. These results may be used as a starting point, in an effort to evaluate the best possible time, pre or post dialysis, to provide medical advice to these patients.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
7 - 8
Publication Date
2015/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.1016/j.artres.2015.10.214How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Despina Karasavvidou*
AU  - Eleni Triantafilidou
AU  - Dimitrios Valoukas
AU  - Dimitrios Makridis
AU  - Sygliti-Errieta Pelidou
AU  - Cristos katsinas
PY  - 2015
DA  - 2015/11
TI  - P2.7 AMELIORATION OF COGNITIVE FUNCTION IN HEMODIALYSIS PATIENTS IN ABSENT OF HYPOTENSIVES EPISODES
JO  - Artery Research
SP  - 7
EP  - 8
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.214
DO  - https://doi.org/10.1016/j.artres.2015.10.214
ID  - Karasavvidou*2015
ER  -