Artery Research

Volume 12, Issue C, December 2015, Pages 9 - 9

P2.14 PARAMETERS OF ARTERIAL STIFFNESS IN OSTEOARTHRITIS PATIENTS AND IN HEALTHY CONTROLS

Authors
Kaspar Tootsi*1, Aare Märtson1, 2, Mihkel Zilmer3, Kaido Paapstel3, Jaak Kals4, 3
1Department of Traumatology and Orthopaedics, University of Tartu, Tartu, Estonia
2Clinic of Traumatology and Orthopaedics, Tartu University Hospital, Tartu, Estonia
3Institute of Biomedicine and Translational Medicine, Department of Biochemistry, Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia
4Department of Vascular Surgery, Tartu University Hospital, Department of Surgery, University of Tartu, Tartu, Estonia
Available Online 23 November 2015.
DOI
https://doi.org/10.1016/j.artres.2015.10.220How to use a DOI?
Abstract

Osteoarthritis (OA) and cardiovascular diseases (CVD) are prevalent conditions and often co-exist. Vascular involvement in pathogenesis of CVD and OA gives reason to investigate arterial stiffness in OA. The aim of this study is to investigate the associations between OA and arterial stiffness.

Arterial stiffness characteristics were measured with Sphygmocor device in 54 patients (age 62 ± 7,4 years (mean ± SD)) with end-stage osteoarthritis before knee and hip replacement and compared to 54 age and sex matched controls (61 ± 7,0 years). Independent Student’s t-test was used to compare the means. Correlation between variables was determined using Pearson’s correlation analysis and multiple regression analysis.

Aortic pulse wave velocity and augmentation index were increased in patients with OA compared to controls (8,8±1,6 m/s vs 7,9±1,5 m/s, p=0,004; 25,2±9,3% vs 21,2±10,4%, p= 0,04, respectively). The small artery elasticity index was significantly lower in OA patients than in healthy controls (3,2 (2,20–6,05)ml/mmHg×100 (median (interquartile range) vs 5,08 (3,1–8,39)ml/mmHg×100, p=0,007, respectively). The level of central systolic and diastolic blood pressure were related to LDL- cholesterol (r=0,42; p=0,002; r=0,37; p=0,006, respectively) and urea (r=0,51; p<0,001) and urea level was also associated with aortic pulse wave velocity in the patients (r=0,51; p<0,001)

This study shows that patients with OA have increased arterial stiffness compared to healthy controls. Potential link between arterial stiffening and OA could suggest that alterations are involved in OA pathogenesis and be responsible for increased cardiovascular risk in OA patients.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
9 - 9
Publication Date
2015/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.1016/j.artres.2015.10.220How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Kaspar Tootsi*
AU  - Aare Märtson
AU  - Mihkel Zilmer
AU  - Kaido Paapstel
AU  - Jaak Kals
PY  - 2015
DA  - 2015/11
TI  - P2.14 PARAMETERS OF ARTERIAL STIFFNESS IN OSTEOARTHRITIS PATIENTS AND IN HEALTHY CONTROLS
JO  - Artery Research
SP  - 9
EP  - 9
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.220
DO  - https://doi.org/10.1016/j.artres.2015.10.220
ID  - Tootsi*2015
ER  -