P2.14 PARAMETERS OF ARTERIAL STIFFNESS IN OSTEOARTHRITIS PATIENTS AND IN HEALTHY CONTROLS
- https://doi.org/10.1016/j.artres.2015.10.220How to use a DOI?
Osteoarthritis (OA) and cardiovascular diseases (CVD) are prevalent conditions and often co-exist. Vascular involvement in pathogenesis of CVD and OA gives reason to investigate arterial stiffness in OA. The aim of this study is to investigate the associations between OA and arterial stiffness.
Arterial stiffness characteristics were measured with Sphygmocor device in 54 patients (age 62 ± 7,4 years (mean ± SD)) with end-stage osteoarthritis before knee and hip replacement and compared to 54 age and sex matched controls (61 ± 7,0 years). Independent Student’s t-test was used to compare the means. Correlation between variables was determined using Pearson’s correlation analysis and multiple regression analysis.
Aortic pulse wave velocity and augmentation index were increased in patients with OA compared to controls (8,8±1,6 m/s vs 7,9±1,5 m/s, p=0,004; 25,2±9,3% vs 21,2±10,4%, p= 0,04, respectively). The small artery elasticity index was significantly lower in OA patients than in healthy controls (3,2 (2,20–6,05)ml/mmHg×100 (median (interquartile range) vs 5,08 (3,1–8,39)ml/mmHg×100, p=0,007, respectively). The level of central systolic and diastolic blood pressure were related to LDL- cholesterol (r=0,42; p=0,002; r=0,37; p=0,006, respectively) and urea (r=0,51; p<0,001) and urea level was also associated with aortic pulse wave velocity in the patients (r=0,51; p<0,001)
This study shows that patients with OA have increased arterial stiffness compared to healthy controls. Potential link between arterial stiffening and OA could suggest that alterations are involved in OA pathogenesis and be responsible for increased cardiovascular risk in OA patients.
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TY - JOUR AU - Kaspar Tootsi* AU - Aare Märtson AU - Mihkel Zilmer AU - Kaido Paapstel AU - Jaak Kals PY - 2015 DA - 2015/11 TI - P2.14 PARAMETERS OF ARTERIAL STIFFNESS IN OSTEOARTHRITIS PATIENTS AND IN HEALTHY CONTROLS JO - Artery Research SP - 9 EP - 9 VL - 12 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2015.10.220 DO - https://doi.org/10.1016/j.artres.2015.10.220 ID - Tootsi*2015 ER -