Artery Research

Volume 12, Issue C, December 2015, Pages 11 - 11

P3.4 PULSE WAVE REFLECTIONS AND THEIR DIURNAL CHANGES IN PATIENTS WITH MARFAN SYNDROME COMPARED TO HEALTHY CONTROLS

Authors
Bernhard Hametner*1, Matthias Hillebrand2, Ghazaleh Nouri2, Stephanie Parragh1, 5, Jelena Köster3, Kai Mortensen3, Achim Schwarz4, Yskert von Kodolitsch2, Siegfried Wassertheurer1
1AIT Austrian Institute of Technology, Vienna, Austria
2Universitäres Herzzentrum Hamburg, Hamburg-Eppendorf, Germany
3Universitätsklinikum Schleswig-Holstein, Lübeck, Germany
4I.E.M. GmbH, Stolberg, Germany
5Vienna University of Technology, Vienna, Austria
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.229How to use a DOI?
Abstract

Introduction: Patients with Marfan syndrome may suffer from a variety of symptoms, including changes of the cardiovascular system. The aim of this study was to perform ambulatory 24 hour blood pressure and pulse wave measurements in a group of Marfan patients and a group of healthy controls and to analyse wave reflections.

Methods: All measurements were obtained with the Mobil-O-Graph device. Reflection magnitude (RM) was calculated with the inbuilt ARCSolver algorithms and averaged during daytime and nighttime. The study included 27 patients with Marfan syndrome and 27 healthy controls. Matching criteria were age (39 years mean in both groups), sex (14 female) and daytime brachial systolic blood pressure (119 mmHg mean in both groups). Patients with Marfan syndrome were significantly taller than controls (190 cm vs. 174 cm).

Results: Reflection magnitude increased significantly during night in both groups (Marfan: 57.8 day, 66.6 night; controls: 58.6 day, 68.7 night). Differences between groups were not significant both day and night. Correlations between RM and body height were positive in Marfan patients (R=0.36 day, R=0.33 night) but negative in controls (R=−0.47 day, R=−0.66 night), showing a significantly different trend (p<0.01).

Conclusions: There are similar levels and diurnal changes of reflection magnitude in patients with Marfan syndrome and healthy controls, but correlations of RM to body height are significantly different in Marfans and controls. This finding may relate to structural changes of the cardiovascular system associated with Marfan syndrome.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
12 - C
Pages
11 - 11
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.229How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Bernhard Hametner*
AU  - Matthias Hillebrand
AU  - Ghazaleh Nouri
AU  - Stephanie Parragh
AU  - Jelena Köster
AU  - Kai Mortensen
AU  - Achim Schwarz
AU  - Yskert von Kodolitsch
AU  - Siegfried Wassertheurer
PY  - 2015
DA  - 2015/11/23
TI  - P3.4 PULSE WAVE REFLECTIONS AND THEIR DIURNAL CHANGES IN PATIENTS WITH MARFAN SYNDROME COMPARED TO HEALTHY CONTROLS
JO  - Artery Research
SP  - 11
EP  - 11
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.229
DO  - 10.1016/j.artres.2015.10.229
ID  - Hametner*2015
ER  -