P1.13 CHANGES IN PULSE WAVE VELOCITY ALONE CANNOT PREDICT THE PULSE PRESSURE INCREASE WITH AGE
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Recently Weber et al. invasively obtained aortic Pulse Wave Velocity (PWV) as a function of age.  Systolic and diastolic aortic pressure were determined as well. PWV can be used to derive total arterial compliance, Ctot, as Ctot=k/PWV2. With Ctot and Stroke Volume (SV), aortic Pulse Pressure (PP) can be approximated from Ctot=SV/PP.
However, the PWV-derived value for Ctot predicted a larger PP increase with age than measured.  PWV increased from 5.6 to 12m/s between <40 and >80 years of age thus aortic compliance (Cao) decreased by a factor (12/5.6)2=4.6. Setting Ctot equal to Cao, PP would increase by the same factor, while measured PP increased from 50 to 90 mmHg. SV decreasing with age may play a role but certainly not a factor 2.
We hypothesize that Ctot is not equal to Cao as calculated form PWV: compliance of the conduit arteries, Cca, also contribute. This can be seen as follows. In the young Ctot=0.6, Cao=0.35 and Cca=0.25 (cgs units). At high age Cao reduces to 0.6/4.6=0.076 and Cca to 0.25/1.2=0.20, thus Ctot=0.28; about halved. PP then approximately doubles, in agreement with the pressure data.
In aging Ctot decreases considerably less than Cao since the relatively smaller changes in Cca play a role as well. Changes in aortic PWV alone cannot predict the PP increase as a function of age.
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TY - JOUR AU - Berend Westerhof* AU - Thomas Weber AU - Siegfried Wassertheurer AU - Bernhard Hametner AU - Nico Westerhof PY - 2015 DA - 2015/11 TI - P1.13 CHANGES IN PULSE WAVE VELOCITY ALONE CANNOT PREDICT THE PULSE PRESSURE INCREASE WITH AGE JO - Artery Research SP - 5 EP - 6 VL - 12 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2015.10.205 DO - https://doi.org/10.1016/j.artres.2015.10.205 ID - Westerhof*2015 ER -