3.6 AORTIC STIFFNESS IS RELATED TO CEREBRAL LESION GROWTH IN PATIENTS WITH ACUTE ISCHEMIC STROKE

Dariusz Gasecki*; Mariusz Kwarciany; Kamil Kowalczyk; Anna Gójska-Grymajło; Tomasz Nowicki; Edyta Szurowska; Pierre Boutouyrie; Stephane Laurent; Krzysztof Narkiewicz; Bartosz Karaszewski

doi:10.1016/j.artres.2015.10.019

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Volume 12, Issue C, December 2015, Pages 43 - 44

3.6 AORTIC STIFFNESS IS RELATED TO CEREBRAL LESION GROWTH IN PATIENTS WITH ACUTE ISCHEMIC STROKE

Authors

Dariusz Gasecki*¹, Mariusz Kwarciany¹, Kamil Kowalczyk¹, Anna Gójska-Grymajło¹, Tomasz Nowicki², Edyta Szurowska², Pierre Boutouyrie³, Stephane Laurent³, Krzysztof Narkiewicz⁴, Bartosz Karaszewski¹

¹Dept. of Neurology for Adults, Medical University of Gdansk, Gdansk, Poland

²Dept. of Radiology, Mecical University of Gdansk, Gdansk, Poland

³Dept. of Pharmacology, HEGP, APHP, Université Paris-Descartes, INSERM U970, Paris, France

⁴Hypertension Unit, Dept. of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland

Available Online 23 November 2015.

DOI: 10.1016/j.artres.2015.10.019 How to use a DOI?
Abstract: Objective: Cerebral lesion growth in acute ischemic stroke leads to secondary neurological deterioration and poor outcome. Whether cSBP and arterial stiffness are related to the early brain infarct growth in patients after ischemic stroke is unknown.

Design and Methods: We enrolled 65 patients (43 males, age 62.9 ± 12.2 years, mean ± SD) with acute ischemic stroke (NIHSS at admission 6.0 ± 4.6 points). Carotid-femoral pulse wave velocity (CF-PWV), central systolic blood pressure (cSBP) and central augmentation index (cAIx) were measured (Sphygmocor®) within few (5 ± 2) days after stroke onset. Serial brain MRI were analysed. Cerebral lesion growth was assessed on diffusion-weighted imaging (DWI) by comparing baseline and follow-up scans. Marked cerebral lesion growth was determined as the highest tertile in a standardized measure of DWI lesion volume increase, and compared with the lowest tertile used as the reference group. Data were analysed with multivariate logistic regression.

Results: CF-PWV was higher in patients with marked cerebral lesion growth than that in patients of the reference group (10.9 ± 3.1 vs. 9.1 ± 1.9 m/s, P = 0.035). By contrast, cAIx, as well as none of central and peripheral BP-derived parameters were significantly associated with cerebral lesion growth in univariate analysis. In multivariable regression logistic model, CF-PWV predicted cerebral lesion growth with an odds ratio of 1.43 [1.00–2.04], independently of age, and peripheral pulse pressure.

Conclusions: Increased aortic stiffness is independently associated with cerebral lesion growth in patients with acute ischemic stroke. Its deleterious effect is more important than that of BP.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 12 - C
Pages: 43 - 44
Publication Date: 2015/11/23
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2015.10.019 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Dariusz Gasecki*
AU  - Mariusz Kwarciany
AU  - Kamil Kowalczyk
AU  - Anna Gójska-Grymajło
AU  - Tomasz Nowicki
AU  - Edyta Szurowska
AU  - Pierre Boutouyrie
AU  - Stephane Laurent
AU  - Krzysztof Narkiewicz
AU  - Bartosz Karaszewski
PY  - 2015
DA  - 2015/11/23
TI  - 3.6 AORTIC STIFFNESS IS RELATED TO CEREBRAL LESION GROWTH IN PATIENTS WITH ACUTE ISCHEMIC STROKE
JO  - Artery Research
SP  - 43
EP  - 44
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.019
DO  - 10.1016/j.artres.2015.10.019
ID  - Gasecki*2015
ER  -

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