Artery Research

Volume 12, Issue C, December 2015, Pages 40 - 40

1.5 RELATION OF ARTERIAL STIFFNESS WITH LEFT VENTRICULAR DIASTOLIC FUNCTION IN GENERAL POPULATION

Authors
Wiktoria Wojciechowska*1, Katarzyna Stolarz-Skrzypek1, Agnieszka Olszanecka1, Lukasz Klima1, Jerzy Gasowski2, Tomasz Grodzicki2, Kalina Kawecka-Jaszcz1, Danuta Czarnecka1
1I Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University, Medical College, Krakow, Poland
2Department of Internal Medicine and Gerontology, Jagiellonian University, Medical College, Krakow, Poland
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.006How to use a DOI?
Abstract

Left ventricular diastolic function declines with aging and hypertension. It is well known that elevated blood pressure results in increased arterial stiffness. The study aims to determine the relationship between arterial stiffness and left ventricular diastolic function in general population.

Methods: We recruited 303 (mean age, 46.9 years; 167 women, 155 normotensives) members of randomly recruited families. Normotension and hypertension were diagnosed based on both office and ambulatory blood pressure measurements, or history of antihypertensive treatment. Pulse wave velocity (PWV), peripheral and central pulse pressure (pPP; cPP) were evaluated by means of pulse wave analysis. Left ventricle (LV) diastolic function was determined by measuring transmitral (early (E) and late (A) diastolic peak velocities and E/A ratio) and pulmonary (peak systolic (S) and diastolic (D) velocity and S/D ratio) flow velocities and diastolic velocities of septal and lateral mitral annulus (E′ wave and E/E′ ratio) obtained in tissue doppler. Additionaly we measured left atrium diameter (LAd).

Results: After adjusting for relatedness, pPP, cPP and PWV were negatively associated with E/A, and positively with E/E′ and S/D (P < 0.001). In multivariate analysis the most closely related parameters were: cPP with E/E′(β = 0.04, P = 0.001), cPP with S/D (β = −0.004, P = 0.011), and pPP with E/E′ (β = −0.03, P = 0.003). Additionally pPP was associated with LAd (β = 0.058, P = 0.011). In hypertensives pPP and cPP related both to E/E′ and S/D (p < 0.01).

Conclusions: Our study suggested that increased arterial stiffness as estimated by pulse pressure measurement might be considered as a determinant of left ventricular diastolic dysfunction.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
12 - C
Pages
40 - 40
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.006How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Wiktoria Wojciechowska*
AU  - Katarzyna Stolarz-Skrzypek
AU  - Agnieszka Olszanecka
AU  - Lukasz Klima
AU  - Jerzy Gasowski
AU  - Tomasz Grodzicki
AU  - Kalina Kawecka-Jaszcz
AU  - Danuta Czarnecka
PY  - 2015
DA  - 2015/11/23
TI  - 1.5 RELATION OF ARTERIAL STIFFNESS WITH LEFT VENTRICULAR DIASTOLIC FUNCTION IN GENERAL POPULATION
JO  - Artery Research
SP  - 40
EP  - 40
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.006
DO  - 10.1016/j.artres.2015.10.006
ID  - Wojciechowska*2015
ER  -