Artery Research

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Volume 12, Issue C, December 2015, Pages 18 - 18

P4.14 PREVALENCE OF DIASTOLIC LEFT VENTRICULAR DYSFUNCTION IN EUROPEAN POPULATIONS BASED ON CROSS-VALIDATED DIAGNOSTIC THRESHOLDS

Authors
M. Kloch-Badelek*1, T. Kuznetsova2, W. Sakiewicz3, V. Tikhonoff5, A. Ryabikov4, M. Loster1, K. Stolarz-Skrzypek1, L. Thijs2, K. Narkiewicz3, J. Staessen2, K. Kawecka-Jaszcz1, D. Czarnecka1
1The First Department of Cardiology and Hypertension, Jagiellonian University, Cracow, Poland
2The Studies Coordinating Centre, Division of Hypertension, University of Leuven, Leuven, Belgium
33-Hypertension Unit, Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland
4The Institute of Internal Medicine, Novosibirsk, Russia
5The Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.258How to use a DOI?
Abstract

Objective: Different diagnostic criteria limit comparisons between populations in the prevalence of diastolic left ventricular (LV) dysfunction. We aimed to compare across populations age-specific echocardiographic criteria for diastolic LV dysfunction as well as their correlates and prevalence.

Methods: We measured the E and A peaks of transmitral blood flow by pulsed wave Doppler and the e′ and a′ peaks of mitral annular velocities by tissue Doppler imaging (TDI) in 2 cohorts randomly recruited in Belgium (n = 782; 51.4% women; mean age, 51.1 years) and in Italy, Poland and Russia (n = 476; 55.7%; 44.5 years).

Results: In stepwise regression, the multivariable-adjusted correlates of the transmitral and TDI diastolic indexes were similar in the 2 cohorts and included sex, age, body mass index, blood pressure and heart rate. Similarly, cutoff limits for the E/A ratio (2.5th percentile) and E/e′ ratio (97.5th percentile) in 338 and 185 reference subjects free from cardiovascular risk factors respectively selected from both cohorts were consistent within 0.02 and 0.26 units (median across 5 age groups). The rounded 2.5th percentile of the E/A ratio decreased by ∼0.10 per age decade In these apparently healthy subjects. The reference subsample provided age-specific cut-off limits for normal E/A and E/e′ ratios. In the 2 cohorts combined, diastolic dysfunction groups 1 (impaired relaxation), 2 (possible elevated LV filling pressure) and 3.

Conclusion: The age-specific criteria for diastolic LV dysfunction were highly consistent across populations with an age-standardized prevalence of 22.4% vs. 25.1% (P=0.09).

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
18 - 18
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.258How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - M. Kloch-Badelek*
AU  - T. Kuznetsova
AU  - W. Sakiewicz
AU  - V. Tikhonoff
AU  - A. Ryabikov
AU  - M. Loster
AU  - K. Stolarz-Skrzypek
AU  - L. Thijs
AU  - K. Narkiewicz
AU  - J. Staessen
AU  - K. Kawecka-Jaszcz
AU  - D. Czarnecka
PY  - 2015
DA  - 2015/11/23
TI  - P4.14 PREVALENCE OF DIASTOLIC LEFT VENTRICULAR DYSFUNCTION IN EUROPEAN POPULATIONS BASED ON CROSS-VALIDATED DIAGNOSTIC THRESHOLDS
JO  - Artery Research
SP  - 18
EP  - 18
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.258
DO  - 10.1016/j.artres.2015.10.258
ID  - Kloch-Badelek*2015
ER  -