Artery Research

Volume 12, Issue C, December 2015, Pages 39 - 39

1.2 AGE-DEPENDENT ASSOCIATION OF 24-HOUR PERIPHERAL AND CENTRAL PULSE PRESSURES WITH STROKE VOLUME

Authors
Giacomo Pucci*1, 2, Francesca Battista1, 2, Fabio Anastasio1, 2, Mariano Edoardo Crapa1, 2, Leandro Sanesi1, 2, Giuseppe Schillaci1, 2
1Unit of Internal Medicine, Terni University Hospital, Terni, Italy
2Department of Medicine, University of Perugia, Perugia, Italy
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.003How to use a DOI?
Abstract

Objective: Pulse pressure (PP) is a complex physiologic trait affected by many variables, including LV contractility (reflected by stroke volume), arterial stiffness, and central-to-brachial amplification.The impact of age on the relationship between stroke volume and central or brachial PP has not been investigated.

Methods: 3765 untreated hypertensive adults (men 56%, age 50 ± 12 years) underwent 24-hour ambulatory BP monitoring (SpaceLabs) and M-mode echocardiography. In a subset of 982 subjects in whom central PP was measured by applying a transfer function to radial pulse wave (SphygmoCor), we also estimated central office (or 24 h) PP by regression equations based on office (or 24 h) PP and MAP, heart rate, age, height and sex (R2 = 0.92 between estimated and measured central PP).The same equations were then applied to the original population to obtain estimated central PP.

Results: Stroke volume had a significant direct association with both brachial and central 24 h PP up to the age of 39 years. The above relationship weakened with age and became mostly non-significant after the age of 40 (all r < 0.10). Similar, although weaker, trends were observed for office PP (both brachial and central).

Conclusions: 24-h PP has a strong direct association with LV stroke volume in the young only, and might more exclusively depend on arterial stiffness later in life. Since the above relationship was also observed with estimated central PP, it may not depend on PP amplification. The “young” and “old” pathophysiological patterns of PP may help to explain the increasingly adverse prognostic value of PP observed with advancing age.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
39 - 39
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.003How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Giacomo Pucci*
AU  - Francesca Battista
AU  - Fabio Anastasio
AU  - Mariano Edoardo Crapa
AU  - Leandro Sanesi
AU  - Giuseppe Schillaci
PY  - 2015
DA  - 2015/11/23
TI  - 1.2 AGE-DEPENDENT ASSOCIATION OF 24-HOUR PERIPHERAL AND CENTRAL PULSE PRESSURES WITH STROKE VOLUME
JO  - Artery Research
SP  - 39
EP  - 39
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.003
DO  - 10.1016/j.artres.2015.10.003
ID  - Pucci*2015
ER  -