Artery Research

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Volume 12, Issue C, December 2015, Pages 12 - 12

P3.7 ARTERIAL STIFFNESS IS ASSOCIATED WITH LOWER PERFORMANCE ON THE COGNITIVE TESTS AT DIFFERENT DOMAINS IN HYPERTENSIVE PATIENTS

Authors
Henrique Muela1, Valéria Costa-Hong1, Michel Machado2, Natalia Moraes3, Claudia Memoria3, Monica Yasuda2, Ricardo Nogueira2, Ayrton Massaro2, Edson Shu2, Ricardo Nitrini2, Luiz Bortolotto*1
1Heart Institute (Incor), University of São Paulo Medical School, São Paulo, São Paulo, Brazil
2Department of Neurology, University of São Paulo Medical School, São Paulo, São Paulo, Brazil
3Department of Psychology, University of São Paulo Medical School, São Paulo, São Paulo, Brazil
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.232How to use a DOI?
Abstract

Background: Cognitive impairment and elevated arterial stiffness are described in patients with arterial hypertension (AH), but its correlations are not well studied.

Objectives: To study the cognitive function at different domains and arterial properties in patients with AH stage 1 to 3 compared to normotensives and to evaluate the correlations between these variables.

Methods: We evaluated 162 subjects, 42 normotensives (44.7±11yrs,69%male,88%white) and 120 patients with stage 1–3 AH (51±11yrs,46%male,69%white) under treatment. The global cognitive function was assessed by Mini Mental State Examination(MMSE) and Montreal Cognitive Assessment(MoCA). was done A validated comprehensive battery of neuropsychological tests assessed the following main cognitive areas:memory, language, visuoperceptual and visuospatial, praxia, gnosia, executive function, attention, judgment. Pulse wave velocity(PWV) was measured by Complior® device. Carotid properties were assessed by radiofrequency ultrasound(WTS®). Central arterial pressure and augmentation index(AIx) were obtained using applanation tonometry(Sphygmocor®).

Results: Mean BP of the normotensive group (121.9±7/76.1±7 mmHg) was significantly lower than hypertensive patients (141.4±23/87.2±13 mmHg). Hypertensive group had worse performance in cognitive evaluation either by MMSE (27±2 vs. 28.6±1, p<0.05) or MoCA test (23.8±3 vs. 26.7±2, p<0.05). On the neuropsychological tests hypertensive patients had worse performance mainly in visuoperceptual and visuospatial capacities and executive function. On the multivariate regression analysis, the following independent associations were observed: PWV-memory, executive function and attention parameters; IMT-memory and executive function; AIx-all neuropsychological domains except memory.

Conclusions: Cognitive impairment at different domains was more frequent in patients with different stages of AH. Arterial functional and structural properties were diversely associated with cognitive performance at different domains.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
12 - 12
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.232How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Henrique Muela
AU  - Valéria Costa-Hong
AU  - Michel Machado
AU  - Natalia Moraes
AU  - Claudia Memoria
AU  - Monica Yasuda
AU  - Ricardo Nogueira
AU  - Ayrton Massaro
AU  - Edson Shu
AU  - Ricardo Nitrini
AU  - Luiz Bortolotto*
PY  - 2015
DA  - 2015/11/23
TI  - P3.7 ARTERIAL STIFFNESS IS ASSOCIATED WITH LOWER PERFORMANCE ON THE COGNITIVE TESTS AT DIFFERENT DOMAINS IN HYPERTENSIVE PATIENTS
JO  - Artery Research
SP  - 12
EP  - 12
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.232
DO  - 10.1016/j.artres.2015.10.232
ID  - Muela2015
ER  -