Artery Research

Volume 12, Issue C, December 2015, Pages 45 - 46

5.2 SOLUBLE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS AND AORTIC STIFFNESS IN GENERAL POPULATION

Authors
Otto Mayer1, Jan Filipovsky*1, Jitka Seidlerova1, Petra Karnosova1, Peter Wohlfahrt2, Renata Cifkova2, Jindra Windrichova1, Ondrej Topolcan1
1Charles University Medical School, Pilsen, Czech Republic
2Charles University 1st Medical School, Prague, Czech Republic
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.027How to use a DOI?
Abstract

It has been suggested that accumulation of advanced glycation end-products (AGE) is involved in several pathophysiological processes in the vessel wall. Soluble isoform of receptor for AGE (sRAGE) acts as a decoy for capturing circulating AGE, prevents them from binding to the cell-surface receptor and protects against the RAGE-AGE axis-elicited processes. We hypothesized that low sRAGE levels might be associated with increased arterial stiffness.

In a cross-sectional design, we analyzed 1077 subjects from the Czech population-based study (“Post-MONICA”). Aortic pulse wave velocity (aPWV) was measured using a Sphygmocor device. sRAGE concentrations were assessed in frozen samples by ELISA methods (R&D Systems).

Aortic PWV significantly (p <0.0001) increased across the sRAGE quartiles. After adjustment for all potential confounders, non-diabetic subjects in the bottom quartile of sRAGE (<918 pg/mL) had odds ratio of raised aortic PWV (≥9. m/sec, top quartile), 1.8 (95% CI: 1.19–2.72) with p = 0.006; the association was stronger when only hypertensive non-diabetic individuals were included: odds ratio 2.05 (95%CI: 1.26–3.32) with p = 0.004. In contrast, using similar regression models, low sRAGE was rejected as an independent predictor of raised aortic aPWV in diabetic or in normotensive subjects.

In conclusion, low circulating sRAGE was independently associated with increased arterial stiffness in a general population-based sample, but mainly in hypertensive non-diabetic patients. The lack of association in diabetics was probably due to low dispersion of sRAGE values and relatively small number of subjects (9% of the sample).

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Journal
Artery Research
Volume-Issue
12 - C
Pages
45 - 46
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.027How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Otto Mayer
AU  - Jan Filipovsky*
AU  - Jitka Seidlerova
AU  - Petra Karnosova
AU  - Peter Wohlfahrt
AU  - Renata Cifkova
AU  - Jindra Windrichova
AU  - Ondrej Topolcan
PY  - 2015
DA  - 2015/11/23
TI  - 5.2 SOLUBLE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS AND AORTIC STIFFNESS IN GENERAL POPULATION
JO  - Artery Research
SP  - 45
EP  - 46
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.027
DO  - 10.1016/j.artres.2015.10.027
ID  - Mayer2015
ER  -