P4.9 ENDOTHELIN-1 IS LINKED WITH ARTERIAL STIFFNESS AND INTERLEUKIN-6 IN BLACK SOUTH AFRICAN WOMEN: THE SABPA STUDY

DOI

10.1016/j.artres.2015.10.253How to use a DOI?

Abstract

Up-regulation of ET-1 activates inflammatory cells such as macrophages that release pro-inflammatory mediators such interleukin-6 which promote vascular inflammation and endothelial dysfunction, leading to arterial stiffness.

Included in this study were 194 black and 197 white South-Africans. Cardiovascular variables were recorded using the Finometer and the Compliar. ET-1 and interleukin-6 were determined by recognized biochemical methods.

The participants were divided into black and white men and women due to significant interactions of ethnicity (F(391) = 6.78; p < 0.001) and gender (F(391) = 2.39; p < 0.05) on the association of ET-1 with systolic blood pressure.

No significant difference in ET-1 levels between black and white groups emerged. Black men and women had higher blood pressure and pulse wave velocity in comparison to white men and women (p < 0.05). C-reactive protein and interleukin-6 were higher in the black groups compared to the white group (all p < 0.05). A positive correlation (single) existed between ET-1 and interleukin-6 (r = 0.27; p = 0.007), systolic blood pressure (r = 0.27; p = 0.008), pulse pressure (r = 0.25; p = 0.014) and pulse wave velocity (r = 0.23; p = 0.026) in black women. After partial adjustments for BMI and GGT the correlation remains. With forward stepwise multiple regression ET-1 associated with interleukin-6 (adj.R²= 0.13, β=0.278, P=0.005) and measures of arterial stiffness.

ET-1 independently associated with systolic blood pressure, pulse pressure and interleukin-6 in black women. Our results suggest that adverse endothelial function is potentially driven by pro-inflammation.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Christine Du Plooy
AU  - Ruan Kruger
AU  - Carina Mels
AU  - Hugo Huisman*
PY  - 2015
DA  - 2015/11/23
TI  - P4.9 ENDOTHELIN-1 IS LINKED WITH ARTERIAL STIFFNESS AND INTERLEUKIN-6 IN BLACK SOUTH AFRICAN WOMEN: THE SABPA STUDY
JO  - Artery Research
SP  - 17
EP  - 17
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.253
DO  - 10.1016/j.artres.2015.10.253
ID  - DuPlooy2015
ER  -