Artery Research

Volume 12, Issue C, December 2015, Pages 32 - 32

P7.11 PREDICTIVE VALUE OF ENDOTHEL DYSFUNCTION ASSESSED BY FLOW MEDIATED VASODILATATION AND ARTERIAL STIFFNESS PARAMETERES IN THROMBOTIC EVENTS OF PRIMARY ANTIPHOSPHOLIPID SYNDROME

Authors
Agnes Dioszegi*, Katalin Veres, Beata Kovacs, Viktor Banhegyi, Pal Soltesz
University of Debrecen, Clinical Center, Department of Internal Medicine, Division of Angiology, Debrecen, Hungary
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.314How to use a DOI?
Abstract

Primary antiphosphplipid sydrome (APS) is characterized by recurrent arterial or venous thrombosis and/or fetal loss in the presence of antiphospholipd antibodies. The authors in a longitudinal (2005–2015) follow-up study examined how the angiological and metabolic parameters have changed during the follow up. The aim was to define if there is any association with the latter thrombotic events and the changing of examined parameters and if the parameters have any predictive values in APS specific events.

In 2005 49 primary APS patient were enrolled. In 2015 26 patient participated in the follow up measurments, but we obtained clinical history from all of the patients. Endothel function was decribed by flow mediated vasodilatation (FMD), stiffness parameters (augmentation index, pulse wave velocity), carotis intima-media thickness (cIMT) were examined, and metabolic parameteres were also determined.

During the follow-up 28 patient suffered thromboembolic events, in 21 patients did not have any kind of thrmboembolic events. In the trombotic group the onset cIMT was significantly higher (0,73 mm vs.0,63; p=0,014) than in patients without thrombotic events. As for the other onset angiological parameters there were no significant difference between the thrombotic and non-thrombotic group. In the thrombotic group significantly more patient smoked (p=0,015). In the non-thrmbotic group the endothel function significantly improved (p=0,019) while in the trombotic group the cIMT significantly increased (p=0,05) during the 10 year follow-up.

The improvement of endothel function with pharmalogical and non –pharmacological meaures has positive clinical benefit. The abnormal stiffness parameters do not correlate with the clinical outcome.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
12 - C
Pages
32 - 32
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.314How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Agnes Dioszegi*
AU  - Katalin Veres
AU  - Beata Kovacs
AU  - Viktor Banhegyi
AU  - Pal Soltesz
PY  - 2015
DA  - 2015/11/23
TI  - P7.11 PREDICTIVE VALUE OF ENDOTHEL DYSFUNCTION ASSESSED BY FLOW MEDIATED VASODILATATION AND ARTERIAL STIFFNESS PARAMETERES IN THROMBOTIC EVENTS OF PRIMARY ANTIPHOSPHOLIPID SYNDROME
JO  - Artery Research
SP  - 32
EP  - 32
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.314
DO  - 10.1016/j.artres.2015.10.314
ID  - Dioszegi*2015
ER  -