Artery Research

Volume 20, Issue C, December 2017
Research Article

1. LDL fatty acids composition as a risk biomarker of cardiovascular disease

Hashem Nayeri, Gholam Ali Naderi, Sedigheh Asgari, Masoumeh Sadeghi, Maryam Boshtam, Samaneh Mohamadzadeh, Nasim Babaknejad
Pages: 1 - 7
Objective: Fatty acid composition of Low-density lipoprotein (LDL) particle is an effective factor in LDL oxidation and atherosclerotic plaques formation. This study evaluates the relationship between LDL fatty acid composition and coronary artery disease (CAD). Methods: 42 men with coronary artery...
Short Communication

2. Sex differences in the LDL receptor knockout mouse model of atherosclerosis

Neel A. Mansukhani, Zheng Wang, Vera P. Shively, Megan E. Kelly, Janet M. Vercammen, Melina R. Kibbe
Pages: 8 - 11
Research Article

3. Associations between smoking and alcohol use and arterial elasticity in patients with newly diagnosed essential hypertension: A cross-sectional study

Noor-Ahmed Jatoi, Waleed-Ibrahim Al-Baker, Afnan Al-Muhanna, Fahad Al-Muhanna, Stella-Maria Kyvelou, Faisal Sharif
Pages: 12 - 18
Objective: To assess the relationship between smoking and alcohol use (separately and combined) on arterial stiffness in patients with essential hypertension. Materials and Methods: We assessed never-treated newly diagnosed patients with essential hypertension (n = 446) aged 18–80 years (52% males)....
Editorial

4. Obituary (Life-time achievement award Artery17) Giuseppe Schillaci (27/09/1961, 21/12/2016)

Giacomo Pucci, Kennedy J. Cruickshank, Lorenzo Ghiadoni, John R. Cockcroft
Pages: 19 - 21
Research Article

5. Abdominal aortic size and volume by computed tomography angiography in population of Ukraine: Normal values by age, gender, and body surface area

Andriy Nykonenko, Andrei Balyuta, Yevhen Haidarzhi, Yevgen Yermolayev, Ivan Pertsov, Olexandr Nykonenko
Pages: 22 - 26
Background: Computed tomography angiography (CTA) is a standard tool for investigation of the abdominal aorta diseases. Currently, there are only a few published scientific articles devoted to the study of the infrarenal aortic size without pathology. The aim of the current work was to examine the indicators...
Research Article

6. Effects of dietary modification with weight loss on central blood pressure during oral glucose tolerance test in overweight/obese men

Toru Yoshikawa, Hiroshi Kumagai, Kanae Myoenzono, Asako Zempo-Miyaki, Takehiko Tsujimoto, Kiyoji Tanaka, Seiji Maeda
Pages: 27 - 34
Background: Postprandial regulation of central systolic blood pressure (cSBP) is impaired by obesity-related disorders. The present study aimed to examine the effect of hypocaloric diet intervention on cSBP when performing oral glucose tolerance test (OGTT) in overweight/obese men and explore its mechanism. Methods:...
Guidelines

7. Validation of non-invasive central blood pressure devices: Artery society task force (abridged) consensus statement on protocol standardization

James E. Sharman, Alberto P. Avolio, Johannes Baulmann, Athanase Benetos, Jacques Blacher, C. Leigh Blizzard, Pierre Boutouyrie, Chen-Huan Chen, Phil Chowienczyk, John R. Cockcroft, J. Kennedy Cruickshank, Isabel Ferreira, Lorenzo Ghiadoni, Alun Hughes, Piotr Jankowski, Stephane Laurent, Barry J. McDonnell, Carmel McEniery, Sandrine C. Millasseau, Theodoros G. Papaioannou, Gianfranco Parati, Jeong Bae Park, Athanase D. Protogerou, Mary J. Roman, Giuseppe Schillaci, Patrick Segers, George S. Stergiou, Hirofumi Tomiyama, Raymond R. Townsend, Luc M. Van Bortel, Jiguang Wang, Siegfried Wassertheurer, Thomas Weber, Ian B. Wilkinson, Charalambos Vlachopoulos
Pages: 35 - 43
Brachial cuff blood pressure (BP) is clinically important, but may be an inaccurate substitute for central BP. Many non-invasive devices have been developed that purport to estimate central BP from peripheral artery sites, yet with no standardized guidelines; the accuracy testing of these new devices...
Conference Abstract

8. THE CLINICAL IMPORTANCE OF EXERCISE BLOOD PRESSURE

Martin G. Schultz
Pages: 44 - 44
Clinical exercise stress testing is a common medical test performed in cardiology and exercise physiology clinics the world over. Measurement of blood pressure (BP) during testing is mandated. Whilst systolic BP should normally rise with incremental exercise, and diastolic BP remains relatively stable,...
Conference Abstract

9. THE CENTRALITY OF THE HEART IN ITS RELATIONSHIP WITH THE ARTERIAL SYSTEM: WHERE IT ALL STARTS AND ENDS

Giacomo Pucci
Pages: 44 - 44
The interaction between the heart and large arteries represent a not fully understood process, which results from the integration of pressure wave generation, flow ejection, wave travel and reflection, and geometric mismatch between structures. Left ventricular (LV) mass and geometry, two independent...
Conference Abstract

10. STIFF VESSELS APPROACHED IN A FLEXIBLE WAY: ADVANCING QUANTIFICATION AND INTERPRETATION OF ARTERIAL STIFFNESS

Bart Spronck
Pages: 44 - 44
Introduction Although pulse wave velocity (PWV), a proxy of arterial stiffness, is a strong predictor of cardiovascular complications, it is confounded by blood pressure (BP) and heart rate at the time of examination. Furthermore, establishing whether an artery is stiffened or not does not inform a...
Conference Abstract

11. FETAL PROGRAMMING AND VASCULAR DYSFUNCTION

T.A. Meister, E. Rexhaj, S.F. Rimoldi, U. Scherrer, C. Sartori*
Pages: 45 - 45
Cardiovascular diseases are the main cause of mortality and morbidity in Western countries, but the underlying mechanisms are still poorly understood. Genetic polymorphisms, once thought to represent a major determinant of cardiovascular risk, individually and collectively, only explain a tiny fraction...
Conference Abstract

12. ENDOTHELIAL AUTOPHAGY AS A KEY MECHANISM IN ARTERIAL DISEASES

Pierre-Louis Tharaux
Pages: 45 - 45
Blood flow imposes shear stress on endothelial cells (ECs). ECs are able to convert these mechanical stimuli into intracellular signals that affect cellular function. As deregulated autophagy is associated with an acceleration of a variety of cardiovascular and metabolic diseases where impaired flow-mediated...
Conference Abstract

13. VASCULAR CALCIFICATION: FROM INNOCENT BYSTANDER TO CULPRIT RISK FACTOR

Leon J. Schurgers
Pages: 45 - 45
Vascular calcification was regarded as an innocent bystander in cardiovascular disease. It was considered to be the passive chemical nucleation of calcium and phosphate ions on cellular debris and therefore the end-stage of atherosclerosis. Currently, vascular calcification is understood to be an actively...
Conference Abstract

14. TARGETING VASCULAR SMOOTH MUSCLE CELL TO IMPROVE ARTERIAL STIFFNESS

Patrick Lacolley
Pages: 45 - 45
Hypertension and arterial aging engage a plethora of key signaling pathways that act in concert to induce vascular smooth muscle cell (VSMC) phenotypic changes leading to vascular degeneration and extracellular matrix (ECM) changes responsible for alterations of the mechanical properties of the vascular...
Conference Abstract

15. CENTRAL BLOOD PRESSURE MEASUREMENT AND VALIDATION: WHAT IS STILL NEEDED?

James E. Sharman
Pages: 45 - 45
Accurate measurement of blood pressure (BP) is a critical goal for appropriate diagnosis and management of high BP. The measurement reference standard is brachial cuff BP, but recent large-scale meta-analyses show major deficiencies in the accuracy of this method. Indeed, irrespective of cuff technique...
Conference Abstract

16. CENTRAL BP MEASUREMENT AND VALIDATION: THE ENGINEER’S POINT OF VIEW

Siegfried Wassertheurer
Pages: 46 - 46
The non-invasive assessment of aortic (central) pressure evolved as an emerging clinical research area over the last two decades. Several non-invasive methods and devices were developed to support these investigations. A variety of technical approaches and sites of peripheral signal acquisition have...
Conference Abstract

17. ARTERIAL HEMODYNAMICS AND WAVE REFLECTIONS

Patrick Segers, Alun Hughes
Pages: 46 - 46
Despite years of research, there are still some contentious aspects of arterial hemodynamics that have remained unresolved. These were discussed during a workshop entitled Arterial hemodynamics: past, present and future held in London on June 14 and 15, 2016, with keynote contributions by Nico Westerhof,...
Conference Abstract

18. CON: GLUCOSE IS THE MOST IMPORTANT TARGET FOR CARDIOVASCULAR PREVENTION IN DIABETES

Francesco Giorgino
Pages: 46 - 46
The overall impact of glucose-lowering on vascular complications and major clinical outcomes, including mortality, in type 2 diabetes is still an open issue. While intensive glucose control has undoubted benefit for microvascular endpoints, the relationship between glucose-lowering approaches and reduced...
Conference Abstract

19. THE METABOLIC-MICROVASCULAR DYSREGULATION SYNDROME

Coen D.A. Stehouwer
Pages: 46 - 46
Microvascular and metabolic physiology are inextricably linked. Thus, metabolic dysfunction impairs microvascular function and microvascular dysfunction impairs normal metabolism. The relationship is therefore reciprocal, justifying the concept of a ‘Metabolic-Microvascular Dysregulation Syndrome’. For...
Conference Abstract

20. 1.1 CENTRAL BLOOD PRESSURE, STATINS AND LDL-CHOLESTEROL: A MEDIATION ANALYSIS

Florence Lamarche, Mohsen Agharazii, Francois Madore, Remi Goupil
Pages: 47 - 47
Background: Central blood pressure (CBP) is a better predictor of cardiovascular burden than peripheral blood pressure (BP). While studies have suggested a reduction in peripheral BP with statins, it remains uncertain to what extent statins reduce CBP and whether this reduction is mediated through a...
Conference Abstract

21. 1.2 MASKED HYPERTENSION IS REVEALED BY EXAGGERATED SUBMAXIMAL EXERCISE BLOOD PRESSURE AMONG ADOLESCENTS FROM THE AVON LONGITUDINAL STUDY OF PARENTS AND CHILDREN (ALSPAC)

Zhengzheng Huang, James Sharman, Chloe Park, John Deanfield, Marietta Charakida, Abigail Fraser, Laura Howe, Debbie Lawlor, Nish Chaturvedi, George Smith, Alun Hughes, Martin Schultz
Pages: 47 - 47
Objectives: Masked hypertension (MH) is associated with hypertension-related markers of organ damage, but is undetectable by clinic (resting) BP. Exaggerated systolic BP response to submaximal exercise reveals MH in adults, but it is unknown whether this is the case during adolescence. We aimed to determine...
Conference Abstract

22. 1.3 DETERMINANTS OF CENTRAL AND PERIPHERAL PULSE PRESSURE IN A POPULATION OF HEALTHY ADOLESCENTS. THE MACISTE STUDY

Pucci Giacomo, Battista Francesca, D’Abbondanza Marco, Papi Francesco, Schillaci Giuseppe
Pages: 47 - 48
We aimed at evaluating the anthropometric and hemodynamic factors associated with central pulse pressure (cPP), peripheral pulse pressure (pPP) and central-to-peripheral PP amplification (PPamp) in healthy adolescents. We studied 459 subjects (boys 57%, 16.8 ± 1.5 y) attending the Liceo Donatelli High...
Conference Abstract

23. 1.4 A PROTEOMIC MARKER OF DIABETIC NEPHROPATHY IS ASSOCIATED WITH MORTALITY IN PATIENTS WITH TYPE 2 DIABETES

Gemma Currie, Sheon Mary, Bernt Johan von Scholten, Morten Kofod Lindhardt, Harald Mischak, William Mullen, Peter Rossing, Christian Delles
Pages: 48 - 48
Background: The urinary proteomic classifier CKD273 has been found to predict diabetic nephropathy development in advance of microalbuminuria. Whether it is also a determinant of mortality and cardiovascular disease in patients with established albuminuria is unknown. Methods: We studied 155 subjects...
Conference Abstract

24. 1.5 DESPHOSPHO-UNCARBOXYLATED MATRIX GLA PROTEIN IS A NOVEL CIRCULATING BIOMARKER PREDICTING DETERIORATION OF RENAL FUNCTION IN THE GENERAL POPULATION

Fangfei Wei, Sander Trenson, Lutgarde Thijs, Qi-Fang Huang, Zhen-Yu Zhang, Wen-Yi Yang, Paula Moliterno, Karel Allegaert, José Boggia, Stefan Janssens, Peter Verhamme, Cees Vermeer, Jan Staessen
Pages: 48 - 48
Background: Recent studies showing an inverse association between estimated glomerular filtration rate (eGFR), a microvascular trait, and inactive desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) support the hypothesis that after vitamin K dependent activation MGP is renoprotective, but were limited...
Conference Abstract

25. 1.6 PERIPHERAL AND CENTRAL AMBULATORY BLOOD PRESSURE IN RELATION TO ECG VOLTAGE

Wen-Yi Yang, Blerim Mujaj, Ljupcho Efremov, Zhen-Yu Zhang, Lutgarde Thijs, Fang-Fei Wei, Qi-Fang Huang, Aernout Luttun, Peter Verhamme, Tim Nawrot, Jose Boggia, Jan Staessen
Pages: 48 - 49
Background: The heart ejects in the central elastic arteries. No previous study addressed the question whether ECG voltages are more closely associated with central than with peripheral blood pressure (BP). Methods: Using the oscillometric Mobil-O-Graph 24 h PWA monitor, we measured brachial, central...
Conference Abstract

26. NAA1 NICOTINAMIDE RIBOSIDE SUPPLEMENTATION REDUCES AORTIC STIFFNESS AND BLOOD PRESSURE IN MIDDLE-AGED AND OLDER ADULTS

Christopher Martens, Blair Denman, Melissa Mazzo, Michael Armstrong, Nichole Reisdorph, Matthew McQueen, Michel Chonchol, Douglas Seals
Pages: 49 - 49
Purpose: Regular calorie restriction (CR) improves endothelial function and lowers aortic stiffness in older mice and humans; however, adherence to sustained CR remains poor, and possibly unsafe in normal weight older adults. Nicotinamide adenine dinucleotide (NAD+) is an important signaling molecule...
Conference Abstract

27. LAA1 HEMODYNAMIC AND STRUCTURAL ARTERIAL PARAMETERS’ ASSOCIATION WITH INTERINDIVIDUAL VARIATIONS OF BODY MASS INDEX IN CHILDHOOD AND ADOLESCENCE

Victoria Garcia, Santiago Curcio, Agustina Zinoveev, Gustavo Giachetto, Pedro Chiesa, Daniel Bia, Yanina Zócalo
Pages: 49 - 50
Background: Several works analyze arterial parameters’ (stiffness levels, wall thickness, etc.) association with variations of body mass index (BMI) in pediatric populations. However, none integrate different arterial parameters as comparable continuous (standardized) variables, in order to assess their...
Conference Abstract

28. 2.1 COGNITION IN RELATION TO THE RETINAL MICROCIRCULATION IN CHILDREN BORN PREMATURELY OR AT TERM

Fangfei Wei, Anke Raaijmakers, Zhen-Yu Zhang, Theun Pieter van Tienoven, Qi-Fang Huang, Wen-Yi Yang, Lutgarde Thijs, Harry Struijker-Boudier, Peter Verhamme, Karel Allegaert, Jan Staessen
Pages: 50 - 50
Background: The retinal microvasculature can be visualized noninvasively and mirrors the status of the cerebral vasculature. We therefore investigated in 93 prematurely born infants (birth weight < 1000 g) and 87 controls born at term whether neurocognitive performance at ∼11 years is associated with...
Conference Abstract

29. 2.2 HEART STRUCTURE AND VASCULAR FUNCTION IN YOUNG PATIENTS AFTER ENDOVASCULAR REPAIR FOR BLUNT THORACIC AORTIC INJURY

Paola Vallerio, Ilenia D’Alessio, Alessandro Maloberti, Marisa Varrenti, Simone Maggioni, Valentina Cantu, Marco Carbonaro, Maria Cristina Ferrara, Elisa Spada, Bruno Palmieri, Alfredo Lista, Cristina Giannattasio
Pages: 50 - 50
Objective: Thoracic Endovascular Aortic Repair (TEVAR) currently represents the gold standard of treatment for Blunt Thoracic Aortic Injury (BTAI). Nevertheless, there is an ongoing debate surrounding its safety and efficacy and its subsequent CV effects. The present study is aimed at assessing heart...
Conference Abstract

30. 2.3 BIOMECHANICAL AND STRUCTURAL QUANTIFICATION OF VASCULAR DAMAGE: A UNIQUE INVESTIGATION OF STENT IMPLANTATION

Markus A. Geith, Gerhard Sommer, Thomas Schratzenstaller, Gerhard A. Holzapfel
Pages: 50 - 50
The most challenging complication after coronary stent implantation is in-stent restenosis [1], which is mainly caused by mechanically induced injuries due to overloading. From a biomechanical point of view, the processes occurring inside the arterial tissues during stent implantation (SI) is rather...
Conference Abstract

31. 2.4 BRACHIAL CUFF RESERVOIR CHARACTERISTICS AND END-ORGAN MARKERS OF CARDIOVASCULAR RISK IN AUSTRALIAN ADULTS: A CROSS-SECTIONAL STUDY

Xiaoqing Peng, Martin Schultz, Michael Cheung, Melissa Wake, Jonathan Mynard, David Burgner, Richard Liu, James Sharman
Pages: 51 - 51
Objective: Reservoir-excess pressure measured using tonometry methods predicts cardiovascular events, but the operator-dependency of tonometry is an impediment to widespread use. A cuff-based blood pressure device has been developed to derive reservoir-excess pressure from measured brachial pressure...
Conference Abstract

32. 2.5 NON-INVASIVE WAVE INTENSITY ANALYSIS IN THE AORTA AND INTERNAL CAROTID USING PHASE-CONTRAST MR ANGIOGRAPHY: THE EFFECT OF HYPERTENSION

Sandra Neumann, Mark Hamilton, Julian Paton, Angus Nightingale, Jonathan Brooks, Emma Hart, Giovanni Biglino
Pages: 51 - 51
Introduction: Hypertension is associated with stiffening of blood vessels, reduced arterial lumen and reduced cerebral blood flow; however, it is not known how lower cerebral blood flow relates to arterial structure or impacts on wave dynamics. We hypothesise increased backward wave energy and faster...
Conference Abstract

33. 2.6 BLOOD PRESSURE-INDEPENDENCE OF AORTIC-TO-BRACHIAL ARTERY STIFFNESS RATIO IS DEPENDENT ON DISEASE STATUS

Matthew K. Armstrong, Martin G. Schultz, Dean S. Picone, James E. Sharman
Pages: 51 - 52
Introduction: Aortic stiffness predicts cardiovascular mortality but is limited as a risk marker because it is dependent on blood pressure (BP). A potential solution is provided from the ratio of aortic-to-brachial artery stiffness (ab-ratio), which is purported to be a BP-independent risk marker among...
Conference Abstract

34. 2.7 THE GUT-DERIVED METABOLITE TRIMETHYLAMINE N-OXIDE INDUCES LARGE ELASTIC ARTERY STIFFENING AND ENDOTHELIAL DYSFUNCTION IN YOUNG MICE

Vienna Brunt, Rachel Gioscia-Ryan, Zachary Sapinsley, Melanie Zigler, James Richey, Douglas Seals
Pages: 52 - 52
The gut microbiome, an emerging mediator of host physiological function, is adversely altered by aging and many diseases, termed “gut dysbiosis.” One consequence of gut dysbiosis is elevated circulating levels of the gut-derived metabolite trimethylamine N-oxide (TMAO), which has been directly linked...
Conference Abstract

35. 2.8 INVASIVE STUDY FOR TESTING NON-INVASIVE METHODS OF AORTIC PRESSURE ESTIMATION

Andrea Guala, F. Tosello, D. Leone, L. Sabia, F. D’Ascenzo, T. Crea, C. Moretti, F. Gaita, F. Veglio, L. Ridolfi, A. Milan
Pages: 52 - 52
Purpose: Aortic blood pressure has a superior prognostic value with respect to the brachial pressure [ 1]. Nonetheless, the low efficacy of the most used non-invasive methods (i.e., approaches based on the generalized transfer function (GTF)) may hamper the detection of this superiority in population...
Conference Abstract

36. 3.1 INTEGRATED CENTRAL PRESSURE-STIFFNESS RISK SCORE: A NEW OPPORTUNITY FOR CARDIOVASCULAR RISK STRATIFICATION. FIRST RESULTS ON CHRONIC KIDNEY DISEASE PATIENTS

János Nemcsik, Orsolya Cseprekál, Ádám Tabák, Dóra Batta, József Egresits, István Kiss, András Tislér
Pages: 52 - 53
Background: The evaluation of arterial stiffness and central haemodynamics represent a new tool of cardiovascular (CV) risk stratification. Our aim was to create an integrated central pressure-stiffness risk score (ICPS score) which incorporate the predictive potential of identical parameters. Methods:...
Conference Abstract

37. 3.2 ASCENDING AND DESCENDING AORTA PULSE WAVE VELOCITY AND DISTENSIBILITY IN BICUSPID AORTIC VALVE PATIENTS

Andrea Guala, Jose Rodriguez-Palomares, Lydia Dux-Santoy, Gisela Teixido-Tura, Giuliana Maldonado, Nicolas Villalva, Filipa Valente, Laura Galian, Marina Huguet, Laura Gutierrez, Teresa Gonzalez, Ruben Fernandez, Augusto Sao-Aviles, David Garcia-Dorado, Artur Evangelista
Pages: 53 - 53
Purpose: Bicuspid aortic valve (BAV) is a cardiac congenital disease associated with ascending aorta (AAo) dilation. The study of the impact of aortic biomechanics in this population has been limited by technical difficulties. Contrasting results have been reported for distensibility while studies including...
Conference Abstract

38. 3.3 ASSESSMENT OF AORTIC MORPHOLOGY IN A BICUSPID AORTIC VALVE POPULATION

Froso Sophocleous, Benedetta Biffi, Elena Giulia Milano, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli, Chiara Bucciarelli-Ducci, Tom Gaunt, Silvia Schievano, Giovanni Biglino
Pages: 53 - 54
Background: Bicuspid aortic valve (BAV) is a congenital heart disease associated with aortic wall abnormalities and co-existing with other congenital defects (e.g. aortic coarctation). This study aimed to explore aortic shape features in a BAV population, identifying sub-groups with different aortic...
Conference Abstract

39. 3.4 RESERVOIR PRESSURE SEPARATION AT BRACHIAL, CAROTID AND RADIAL ARTERIES: A QUANTITATIVE COMPARISON AND EVALUATION

Michael Ebner, Kim Parker, Tom Vercauteren, Sébastien Ourselin, Siegfried Wassertheurer, Alun Hughes, Bernhard Hametner
Pages: 54 - 54
Background: At present, reservoir pressure parameters are derived from arterial pressure waveforms regardless of the location of measurement. However, a comparison between sites has not been made, and site-related differences may affect interpretation. In this study, we computed reservoir pressure waveform...
Conference Abstract

40. 3.5 HEART RATE DEPENDENCE OF REGIONAL AND LOCAL AORTIC PULSE WAVE VELOCITY IN RATS AS A FUNCTION OF BLOOD PRESSURE

Bart Spronck, Isabella Tan, Koen Reesink, Dana Georgevsky, Tammo Delhaas, Alberto Avolio, Mark Butlin
Pages: 54 - 54
Background: Pulse wave velocity (PWV) is quantified by time difference of arrival of the blood pressure (BP) wave at two sites along the arterial bed (transit time; TT-PWV), or by combining measured arterial pressure and diameter using the Bramwell-Hill equation (BH-PWV). Besides the dependence of PWV...
Conference Abstract

41. 3.6 NON-INVASIVE, MRI-BASED ESTIMATION OF PATIENT-SPECIFIC AORTIC BLOOD PRESSURE USING ONE-DIMENSIONAL BLOOD FLOW MODELLING

Jorge Mariscal Harana, Arna van Engelen, Torben Schneider, Mateusz Florkow, Peter Charlton, Bram Ruijsink, Hubrecht De Bliek, Israel Valverde, Marietta Carakida, Kuberan Pushparajah, Spencer Sherwin, Rene Botnar, Jordi Alastruey
Pages: 54 - 55
Background and objectives: Clinical evidence shows that central (aortic) blood pressure (CBP) is a better marker of cardiovascular risk than brachial pressure [1]. However, CBP can only be accurately measured invasively, through catheterisation. We propose a novel approach to estimate CBP non-invasively...
Conference Abstract

42. 3.7 CHANGES OF INTRINSIC STIFFNESS OF THE CAROTID ARTERIAL WALL DURING THE CARDIAC CYCLE MEASURED BY SHEAR WAVE ELASTOGRAPHY IN HYPERTENSIVES COMPARED TO NORMOTENSIVES

Louise Marais, Mathieu Pernot, Hakim Khettab, Michael Tanter, Emmanuel Messas, Mustapha Zidi, Stéphane Laurent, Pierre Boutouyrie
Pages: 55 - 55
Objective: Because measurement of arterial stiffness is highly dependent on blood pressure (BP), methods independent of BP are required. Shear wave elastography (SWE, Supersonic Imagine, Aix-en-Provence, France) enables to assess local tissue stiffness by tracking the propagation of shear waves generated...
Conference Abstract

43. 3.8 IMPLEMENTING FLUID-STRUCTURE INTERACTION COMPUTATIONAL AND EMPIRICAL TECHNIQUES TO ASSESS HEMODYNAMICS OF ABDOMINAL AORTIC ANEURYSMS

Hannah Safi, Nathan Phillips, Yiannis Ventikos, Richard Bomphrey
Pages: 55 - 56
An Abdominal Aortic Aneurysm (AAA) represents a degenerative disease process of the abdominal aorta that leads to a focal dilation and irreversible remodeling of the arterial wall [1]. The reliable assessment of AAA rupture risk in a clinical setting is crucial in decreasing related mortality without...
Conference Abstract

44. 4.1 PILOT STUDY ON THE PRECLINICAL VASCULAR DAMAGE IN BOLIVIAN PATIENTS WITH CHAGAS INDETERMINATE CHRONIC PHASE

Filippo Valbusa, Andrea Angheben, Verena Zerbato, Andrea Chiampan, Davide Agnoletti, Cristiano Fava, Zeno Bisoffi, Guido Arcaro
Pages: 56 - 56
Background: In Italy, the prevalence of seropositivity for Trypanosoma cruzi in immigrants from endemic countries is about 11.3% (30.7% for Bolivian immigrants). The disease acute phase is usually asymptomatic, often leading to chronic infection that may remain silent for life (chronic indeterminate...
Conference Abstract

45. 4.2 SEX-DEPENDENT EFFECTS OF PERIVASCULAR ADIPOSE TISSUE ON VASCULAR FUNCTION

Christian Delles, Sarah McNeilly, Sheon Mary, Adam Sheikh, Heather Small
Pages: 56 - 56
Background: Premenopausal women are relatively protected against hypertension compared to males. Estrogen levels have been identified as a potential underlying cause, but the pathophysiological mechanisms remain incompletely understood. We hypothesised that sex-dependent effects of perivascular adipose...
Conference Abstract

46. 4.3 ABNORMAL PRESSURE WAVE REFLECTION ACCELERATES THE DEVELOPMENT OF HYPERTENSION VIA THE INCREASE OF ARTERIAL STIFFNESS

Hirofumi Tomiyama, Akira Yamashina, Shunsuke Komatsu, Kazuki Shiina, Chisa Matsumoto, Shogen Fujii, Taishiro Chikamori
Pages: 56 - 56
Objectives: It is noted that not only arterial stiffness but also abnormal pressure wave reflection are risks for the development of hypertension. However, the association between arterial stiffness and pressure wave reflection in the development of hypertension has not been fully clarified. The present...
Conference Abstract

47. 4.4 MIDDLE CEREBRAL ARTERY PULSATILITY IN HEART FAILURE AND PATIENTS WITH CONTINUOUS-FLOW LEFT VENTRICULAR ASSIST DEVICES

Eric Stöhr, Francesco Castagna, James Pearson, Laura Watkeys, Samuel Trocio, Oksana Zatvarska, Timothy Crimmins, Alberto Pinsino, Paolo Colombo, Melana Yuzefpolskaya, Reshad Garan, Veli Topkara, Hiroo Takayama, Koji Takeda, Yoshifumi Naka, John Cockcroft, Joshua Willey, Barry McDonnell
Pages: 57 - 57
Background: High pulsatility index (PI) in the cerebral circulation has been associated with increased prevalence of stroke (1). Interestingly, heart failure (HF) patients implanted with continuous-flow left ventricular assist devices (CF-LVADs) have increased rates of stroke despite presenting with...
Conference Abstract

48. 4.5 THE EFFECT OF LUNG FUNCTION ON BLOOD PRESSURE AND VASCULAR INDICES FROM ADOLESCENCE TO EARLY ADULTHOOD IN A MULTI-ETHNIC COHORT

Yao Lu, Harding Seeromanie
Pages: 57 - 57
Given the significance of lung function (LF) for vascular health in adulthood, there are surprisingly few studies that have examined the interrelationships of their developmental trajectories. Both develop and decline over the life course, though LF peaks in the 20s, and both predict cardiovascular events...
Conference Abstract

49. 4.6 HIPPOCAMPAL CEREBRAL BLOOD FLOW DEPENDS ON SYSTEMIC ENDOTHELIAL FUNCTION IN INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT: THE TRAIN THE BRAIN-MIND THE VESSEL STUDY

Rosa Maria Bruno, Lorenza Pratali, Rosa Sicari, Francesco Stea, Nicoletta Berardi, Gloria Tognoni, Ubaldo Bonuccelli, Lorenzo Ghiadoni, Stefano Taddei, Danilo Scelfo, Laura Biagi, Michela Tosetti, Lamberto Maffei, Eugenio Picano
Pages: 57 - 58
Background: Dementia has been recently viewed as a predominantly vascular disorder. Indeed, reduced brain NO availability causes increased ß-amyloid deposition by several mechanisms, including hypoperfusion. Purpose: To investigate the relationship between cerebral blood flow in the hippocampal and...
Conference Abstract

50. 4.7 PARAMETERS OF THE RESERVOIR-WAVE APPROACH AND MORTALITY IN DIALYSIS POPULATION

Mohsen Agharazii, Catherine Fortier, Marie-Pier Desjardins, Martin Schultz, James Sharman
Pages: 58 - 58
Background: A new model has been proposed to explain hemodynamic consequences of arterial stiffness, which integrates both wave propagation and aortic reservoir function. The aim of this study was to assess the association between parameters of reservoir-wave analysis and all-cause mortality in a population...
Conference Abstract

51. 4.8 ARTERIAL STIFFNESS AND ITS RELATIONSHIP TO MORTALITY IN PATIENTS WITH PERIPHERAL ARTERY DISEASE

Gabriel Dimitrov, Giovanni Scandale, Martino Recchia, Edoardo Perilli, Marzio Minola, Gianni Carzaniga, Maria Carotta, Mariella Catalano
Pages: 58 - 58
Background and aim: Several studies (1,2) suggest that patients with peripheral artery disease (PAD) show an increase in arterial stiffness, nevertheless the impact on mortality is less documented. (3) Methods: 228 PAD patients mean age (68 ± 9 years) were followed-up for 4,8 ± 2 years. Anthropometric...
Conference Abstract

52. 5.1 EFFECTS OF THE SGLT-2 INHIBITOR EMPAGLIFLOZIN ON VASCULAR FUNCTION AND CENTRAL HEMODYNAMICS IN PATIENTS WITH TYPE 2 DIABETES

Christian Ott, Kristina Striepe, Agnes Jumar, Marina Karg, Markus Schneider, Dennis Kannenkeril, Roland Schmieder
Pages: 58 - 58
Background: The selective sodium-glucose cotransporter 2 (SGLT-2) inhibitor empagliflozin leads to improved cardiovascular, renal and heart failure outcome in secondary prevention. To better understand these effects, we examined vascular function and central hemodynamics. Methods: In this prospective,...
Conference Abstract

53. 5.2 REDUCED SUBLINGUAL ENDOTHELIAL GLYCOCALYX IN TYPE 1 DIABETICS WITH DIABETIC NEPHROPATHY

Signe Abitz Winther
Pages: 59 - 59
Background: Glycocalyx is a glycoprotein layer protecting the capillary endothelium. An impaired glycocalyx may precede the development of microvascular complications in diabetes. Capillaroscopy is a new method to estimate the dimensions of the glycocalyx by measuring the perfused boundary region (PBR)....
Conference Abstract

54. 5.3 HIGH FIT OLDER ADULTS MAINTAIN A SIMILAR ENDOTHELIAL RESPONSE TO ACUTE INFLAMMATION AS YOUNGER ADULTS

Elizabeth Schroeder, Abbi Lane-Cordova, Sushant Ranadive, Tracy Baynard, Bo Fernhall
Pages: 59 - 59
Inflammation is associated with an increased risk of cardiovascular events and reduced endothelial function. Higher cardiorespiratory fitness is associated with lower risk of cardiovascular events and improved vascular function. Whether fitness plays a role during acute inflammation is unknown. Purpose:...
Conference Abstract

55. 5.4 EFFECT OF ACUTE RESISTANCE EXERCISE ON ARTERIAL HEMODYNAMICS AND CEREBRAL BLOOD FLOW DYNAMICS: DOES SEX MATTER?

Alexander Rosenberg, Tommy Wee, Elizabeth Schroeder, Kanokwan Bunsawat, Georgios Grigoriadis, Garett Griffith, Bo Fernhall, Tracy Baynard
Pages: 59 - 60
High-intensity resistance exercise (RE) acutely increases arterial stiffness and blood pressure (BP), coupled with reduced cerebral blood flow velocity (CBFv) and greater flow pulsatility in the cerebral circulation, which may be detrimental to cerebral microvasculature. Because females have different...
Conference Abstract

56. 5.5 IMPACT OF PULMONARY ENDARTERECTOMY ON PULMONARY ARTERIAL WAVE PROPAGATION AND RESERVOIR FUNCTION

Junjing Su, Alun Hughes, Ulf Simonsen, Jens Erik Nielsen-Kudsk, Kim Parker, Luke Howard, Søren Mellemkjaer
Pages: 60 - 61
Background: Recent studies have demonstrated distinctive arterial wave characteristics in patients with chronic thromboembolic pulmonary hypertension (CTEPH)1. Therefore, we aimed to assess the impact of pulmonary endarterectomy (PEA) on pulmonary arterial wave propagation and reservoir function in CTEPH...
Conference Abstract

57. 5.6 LONGITUDINAL FOLLOW-UP OF ARTERIAL STIFFNESS IN PATIENTS WITH SEVERE PSORIASIS TREATED BY ANTI-IL12/IL-23 COMPARED TO ANTI-TNF ALPHA

Hakim Khettab, Manuelle Viguier, Idir Hamdidouche, Hervé Bachelez, Pierre Boutouyrie
Pages: 61 - 61
Patients with chronic severe psoriasis are at increased cardiovascular risk (CVR). Modern systemic treatments of psoriasis involve anti-TNF alpha (ATNF) and more recently introduced anti-IL12/IL-23 (ustekinumab, AIL12/23) which, by interfering with IL-17, a possibly vasculoprotective cytokine, may increase...
Conference Abstract

58. 5.7 SUBPOPULATIONS OF CIRCULATING T LYMPHOCYTES IN OBESE PATIENTS UNDERGOING BARIATRIC SURGERY

C. Agabiti Rosei, C. Rossini, F. Mittempergher, A. Titi, N. Portolani, C. De Ciuceis, S. Caletti, M.A. Coschignano, V. Trapletti, E. Porteri, P. Pileri, E. Agabiti Rosei, D. Rizzoni
Pages: 61 - 61
Objective: It has been previously demonstrated that T lymphocytes may be involved in the development of hypertension and microvascular remodeling, and that circulating T effector lymphocytes may be increased in hypertension. In particular, Th1 and Th17 lymphocytes may contribute to the progression of...
Conference Abstract

59. P2 LOCAL ABDOMINAL VERSUS THORACIC AORTA STIFFENING IN HYPERTENSIVE RATS UNDER EITHER NO RESTRICTION OR SALTED DIET

George Lindesay, Neila Malti, Christophe Ragonnet, Marc Isabelle, Nicole Villeneuve, Yvonnick Bézie, Christine Vayssettes-Courchay
Pages: 62 - 62
Background: Hypertensive humans exhibit reduced nitric oxide bioavailability and increased salt sensitivity, both of which are related to central artery stiffening. We studied the effect of 5 week NO restriction via L-NAME treatment in spontaneously hypertensive rats (SHR) and 5% salted diet in salt-sensitive...
Conference Abstract

60. P3 THE EXTENT OF ENDOTHELIAL DYSFUNCTION IN THE FEMORAL ARTERY IS SIMILAR IN THE JUVENILE MALE AND FEMALE SPONTANEOUSLY HYPERTENSIVE RATS

Peter Balis, Iveta Bernatova, Angelika Puzserova
Pages: 62 - 62
Objectives: Endothelial dysfunction (ED) plays an important role in the pathogenesis of hypertension. In this work, we studied sex differences in the endothelium-dependent relaxation (EDR) of the femoral artery (FA) and its nitric oxide (NO)-dependent and NO-independent components in peri-pubertal (7-week-old)...
Conference Abstract

61. P4 SOCIAL STRESS-INDUCED BLOOD PRESSURE INCREASE IN BORDERLINE HYPERTENSIVE RATS IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN THE RESISTANT ARTERIES

Angelika Puzserova, Ruzena Sotnikova, Jozef Torok, Anna Zemancikova, Iveta Bernatova
Pages: 62 - 63
Objectives: Several studies have observed that altered endothelial function is involved in the development of stress-induced hypertension. The aim of this study was to investigate the effects of chronic social stress (crowding) on endothelium-dependent relaxation (EDR) of the superior mesenteric artery...
Conference Abstract

62. P5 ERYTHROCYTE DEFORMABILITY AND NITRIC OXIDE PRODUCTION IN ANIMAL MODEL OF PRIMARY HYPERTENSION AND THEIR AGE-DEPENDENT CHANGES

Jana Radosinska, Peter Balis, Angelika Puzserova
Pages: 63 - 63
Objectives: Reduced deformability of red blood cells (RBC) plays an important role in etiology of various diseases including cardiovascular. The nitric oxide (NO) was identified as one of factors responsible for maintenance of RBC deformability. Reduced bioavailability of NO might be important in the...
Conference Abstract

63. P6 ANGIOTENSIN AT2 RECEPTOR AGONIST, COMPOUND 21, MAINTAINS VASCULAR INTEGRITY AND PREVENTS ABDOMINAL AORTIC ANEURYSM PROGRESSION IN THE RAT

Christoph Lange, Manuela Sommerfeld, Pawel Namsolleck, Ulrich Kintscher, Thomas Unger, Elena Kaschina
Pages: 63 - 63
The effects of the selective angiotensin AT2 receptor agonist, compound 21 (C21), on abdominal aortic aneurysm (AAA) formation were investigated in normotensive Wistar rats. AAA was induced by perfusion of isolated aortic segments with elastase (Anidjar/Dobrin model). Treatment with C21 (0.03 and 0.3...
Conference Abstract

64. P7 THE URINARY PEPTIDOMIC SIGNATURE OF AORTIC STIFFNESS REVEALS MOLECULAR PATHWAYS AND DRUG TARGETS

Zhen-Yu Zhang, Makis Izoidakis, Wen-Yi Yang, Lutgarde Thijs, Fang-Fei Wei, Qi-Fang Huang, Joost Schanstra, Jens-Uwe Voigt, Tatiana Kuznetsova, Peter Verhamme, Antonia Vlahou, Harald Mischak, Jan Staessen
Pages: 63 - 63
Background: Molecular pathways leading to stiffening of the central arteries are poorly understood. We searched for differentially expressed proteins by urinary peptidomic analysis in patients with arterial stiffness and healthy controls in a case–control study. Methods: To identify urinary peptides...
Conference Abstract

65. P8 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 LEVELS AND ARTERIAL FUNCTION

Losif Koutagiar, Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, John Skoumas, Nikitas Skliros, Magkas Nikolaos, Antigoni Miliou, Dimitrios Tousoulis
Pages: 63 - 64
Purpose/Background/Objectives: Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are modestly but significantly associated with increased risk of total cardiovascular events. Aortic stiffness and wave reflections are also important predictors of cardiovascular events. The aim of this pilot...
Conference Abstract

66. P9 THE PARTICIPATION OF NITRIC OXIDE AND HYDROGEN SULPHIDE SIGNALISATION IN VASOACTIVE RESPONSES OF RAT THORACIC AORTA IN CONDITION OF DEVELOPED SPONTANEOUS HYPERTENSION

Andrea Berenyiova, Angelika Puzserova, Marian Grman, Frantisek Kristek, Sona Cacanyiova
Pages: 64 - 64
Our previous study in young spontaneously hypertensive rats (SHR) confirmed a participation of nitric oxide (NO) and hydrogen sulphide (H2S) in probably inherent adaptive strategy of conduit arteries in condition of sustained hypertension. The aim of study was to confirm or refuse the compensatory mechanisms...
Conference Abstract

67. P10 LOSS OF ENDOTHELIUM-DEPENDENT REGULATION OF ARTERIAL WALL VISCOSITY IN ESSENTIAL HYPERTENSION

Frederic Roca, Jeremy Bellien, Michele Lacob, Robinson Joannides
Pages: 64 - 64
Background: Nitric oxide (NO) and epoxyeicosatrienoic acids (EETs) regulate arterial wall viscosity (AWV) in young subjects (1). During hypertension, characterised by a decrease in endothelium-derived NO and an early disappearance of EETs, AWV is not modified (2,3). We compared the role of NO and EETs...
Conference Abstract

68. P13 ARHGEF1/RHOA SIGNALING PARTICIPATE IN AGEING-INDUCED ARTERIAL STIFFNESS AND HYPERCOAGULABILITY

Camille Rouillon, Nathalie Mercier, Patrick Lacolley, Gervaise Loirand, Véronique Regnault
Pages: 65 - 65
The RhoA signaling pathway is a master regulator of mechanostransduction and plasticity of vascular smooth muscle cells (VSMCs) that controls arterial stiffening. The RhoA exchange factor Arhgef1 is causally involved in the development of angiotensin II-dependent hypertension. Our aim was to determine...
Conference Abstract

69. P35 SOLUBLE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS AND AGE-DEPENDENT ARTERIAL STIFFENING IN GENERAL POPULATION BASED PROSPECTIVE STUDY

Julius Gelžinský, Otto Mayer, Markéta Hronová, Petra Karnosová, Jitka Seidlerová, Jan Filipovský
Pages: 65 - 65
Background: Accumulation of advanced glycation end-products (AGEs) is one of pathophysiological processes, responsible for progressive stiffening of vessel wall. In contrast, soluble isoform of receptor for AGEs (sRAGE) act as “decoy” and physiological defense against circulating AGEs. We hypothesized...
Conference Abstract

70. P36 PULSE PRESSURE AMPLIFICATION AND ITS RELATIONSHIP WITH AGE IN YOUNG, APPARENTLY HEALTHY BLACK AND WHITE ADULTS: THE AFRICAN-PREDICT STUDY

Yolandi Breet, Alta Schutte, Hugo Huisman, Ruan Kruger, Johannes van Rooyen, Lebo Gafane-Matemane, Lisa Ware
Pages: 65 - 65
Background: Pulse pressure amplification (PPA), i.e. the amplification from central arteries to the periphery, is inversely related to arterial stiffness, organ damage and mortality. It is known that arterial stiffness is higher in black than white populations, but it is unclear if this is due to early...
Conference Abstract

71. P37 REFERENCE VALUES OF CARDIO-ANKLE VASCULAR INDEX IN A RANDOM SAMPLE OF A CAUCASIAN POPULATION

Peter Wohlfahrt, Renata Cífková, Narine Movsisyan, Šárka Kunzová, Jiří Lešovský, Martin Homolka, Vladimír Soška, Petr Dobšák, Francisco Lopez- Jimenez, Ondřej Sochor
Pages: 65 - 66
Objectives: Cardio-ankle vascular index (CAVI), a parameter of arterial stiffness, has been increasingly used for cardiovascular risk estimation. Currently used CAVI reference values are derived from the Japanese population. It is not clear whether the same reference values can be used in the Caucasian...
Conference Abstract

72. P38 ASCENDING AORTA DIMENSIONS AND CLINIC AND 24 HOURS BLOOD PRESSURE IN A GENERAL POPULATION IN NORTHERN ITALY: THE VOBARNO STUDY

Anna Paini, Massimo Salvetti, Fabio Bertacchini, Deborah Stassaldi, Claudia Agabiti Rosei, Carlo Aggiusti, Giulia Rubagotti, Giulia Maruelli, Chiara Arnoldi, Enrico Agabiti Rosei, Maria Lorenza Muiesan
Pages: 66 - 66
Conference Abstract

73. P39 LEFT VENTRICULAR STRUCTURE AND FUNCTION IN RELATION TO PERIPHERAL AND CENTRAL BLOOD PRESSURE IN A GENERAL POPULATION

Wenyi Yang, Ljupcho Efremov, Zhen-Yu Zhang, Nicholas Cauwenberghs, Lutgarde Thijs, Fang-Fei Wei, Qi-Fang Huang, Blerim Mujaj, Aernout Luttun, Peter Verhamme, Tatiana Kuznetsova, Jan Staessen
Pages: 66 - 66
Background: Central blood pressure (BP) is a predictor of target organ damage. No previous study addressed the question to what extent central compared with peripheral is related to left ventricular (LV) structure and function in a general population. Methods: In 577 Flemish recruited from the general...
Conference Abstract

74. P40 DOES ARTERIAL AGEING DIFFER BETWEEN EUROPEANS AND JAPANESE AND KOREAN PATIENT SAMPLES? RESULTS FROM CURRENT UK STUDIES

F.A. Kirkham, C. Mills, K. Nambiar, J. Timeyin, K.A. Davies, F. Kern, J.K. Cruickshank, C. Rajkumar
Pages: 66 - 67
Objective: Vascular stiffness has long been linked with the ageing process. However, it is only since the development of accurate methods for measuring arterial compliance that unravelling this relationship has become possible. Arterial stiffening over time appears to differ between ethnic groups and/or...
Conference Abstract

75. P41 MYOCARDIAL MECHANOENERGETIC EFFICIENCY INDEX (MMEI) AND ARTERIAL STIFFNESS: ASSOCIATION IN A GENERAL POPULATION IN NORTHER ITALY

Fabio Bertacchini, Massimo Salvetti, Anna Paini, Giulia Rubagotti, Deborah Stassaldi, Carlo Aggiusti, Giulia Maruelli, Chiara Arnoldi, Giovanni Saccà, Enrico Agabiti Rosei, Maria Lorenza Muiesan
Pages: 67 - 67
A non-invasive approach for the estimation of mechanical efficiency through the calculation of the ratio between stroke work and HR-pressure product has been recently proposed by de Simone et al. This index, which expresses the amount of blood pumped in a single beat in 1 second by the heart, may be...
Conference Abstract

76. P42 24-HOUR CENTRAL BLOOD PRESSURE IS MORE STRONGLY ASSOCIATED TO TARGET ORGAN DAMAGE THAN BRACHIAL BLOOD PRESSURE: FIRST RESULTS OF THE VASOTENS REGISTRY

Stefano Omboni, Igor N. Posokhov, Gianfranco Parati, Vitaliy S. Barkan, Ernesto Cardona Muñoz, Elena A. Grigoricheva, Irina E. Minyukhina, Maria Lorenza Muiesan, Giuseppe Mulè, Iana A. Orlova, Telmo Pereira
Pages: 67 - 68
Objective: In the present analysis of the VASOTENS study [1] baseline data, we checked whether organ damage of hypertension (TOD) i) is better associated with 24-hour central than peripheral BP and ii) is related to ambulatory arterial stiffness, estimated by pulse wave velocity (PWV) and augmentation...
Conference Abstract

77. P45 RENIN AT DIFFERENT PHYSICAL ACTIVITY LEVELS IN A BI-ETHNIC POPULATION: THE AFRICAN-PREDICT STUDY

Johannes van Rooyen, Hugo Huisman, Leonè Malan, Catharina Mels, Ruan Kruger, Lebo Gafane-Matemane, Shani Botha, Alta Schutte
Pages: 68 - 68
Background and objectives: It is widely accepted that regular physical exercise reduces the BP, particularly in hypertensive individuals. It is recommended in the prevention of hypertension to assist in BP control. The BP lowering mechanisms of exercise remain largely elusive, we therefore evaluated...
Conference Abstract

78. P46 ARTERIAL STIFFNESS IN RELATION TO BIRTH CHARACTERISTICS IN THE JAMAICAN 1986 BIRTH COHORT

Nadia Bennett, Trevor Ferguson, Novie Younger-Coleman, Marshall Tulloch-Reid, Renee Walters, Amanda Rousseau, Janeil Williams, Seeromanie Harding, J. Kennedy Cruickshank, Rainford Wilks
Pages: 68 - 68
Background: We tested the association between birthweight and arterial stiffness measured by aortic pulse wave velocity (PWV) and cardio-ankle vascular index (CAVI) in a birth cohort of 30 year old Jamaicans. Methods: Participants were from the 1986 Jamaica Birth Cohort. Arterial stiffness was measured...
Conference Abstract

79. P47 TETRAHYDROBIOPTERIN AND MARKERS OF OXIDATIVE STRESS IN A YOUNG BI-ETHNIC POPULATION: THE AFRICAN-PREDICT STUDY

Hugo Huisman, Carina Mels, Johannes Van Rooyen, Ruan Kruger, Carla Fourie, Lebo Gafane, Wayne Smith, Alta Schutte
Pages: 68 - 68
Background/Objectives: Tetrahydrobiopterin (BH4) is a cofactor for nitric oxide synthase (NOS). Oxidative stress, reported in black populations (1), may lead to the oxidation of BH4, the uncoupling of eNOS, decreased NO and increased superoxide levels (2,3). We compared BH4 and markers of oxidative stress...
Conference Abstract

80. P54 SEX DIFFERENCES IN AMBULATORY CENTRAL BLOOD PRESSURE AND PULSE WAVE REFLECTIONS IN UNTREATED PATIENTS

Bernhard Hametner, Christopher Clemens Mayer, Katy Whitelegg, Thomas Weber, Peter Fitscha, Siegfried Wassertheurer
Pages: 68 - 69
Objectives: Sex differences for parameters of arterial wave reflection and arterial stiffness were reported from single office measurements, but circadian patterns were not extensively investigated up to now. The aim of this study was to determine sex differences between day and night values of ambulatory...
Conference Abstract

81. P55 TARGET ORGAN DAMAGE AND BLOOD PRESSURE VARIABILITY IN HYPERTENSION

Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Athanasios Angelis, Nikolaos Loakeimidis, Panagiotis Xaplanteris, Christos Georgakopoulos, Evangelia Sigala, Losif Koutagiar, Angeliki Rigatou, Dimitrios Tousoulis
Pages: 69 - 69
Purpose/Background/Objectives: Hypertension is associated with several markers of subclinical target organ damage (TOD). Short-term blood pressure variability (SBPV) is a prognostic factor for cardiovascular events in hypertensives. We hypothesised that there is a relationship between SBPV and TOD in...
Conference Abstract

82. P56 ASSOCIATION BETWEEN URIC ACID AND CARDIAC, VASCULAR AND RENAL TARGET ORGAN DAMAGE IN HYPERTENSIVES SUBJECTS

Alessandro Maloberti, Marisa Varrenti, Nicola Triglione, Lucia Occhi, Francesco Panzeri, Marta Alloni, Luca Giupponi, Paola Vallerio, Matteo Casati, Guido Grassi, Giuseppe Mancia, Cristina Giannattasio
Pages: 69 - 69
Background: To date no definitive results exist about the relationship of Serum Uric Acid (SUA) and TOD in HT subjects. We sought to determine if such an association exist between SUA and subclinical cardiac, vascular and renal alterations in HT. Methods: We enrolled 632 consecutive outpatients, followed...
Conference Abstract

83. P57 ASSESSMENT OF PULSE WAVE VELOCITY AND ASSOCIATION TO TARGET ORGAN DAMAGE IN TREATMENT-NAïVE HYPERTENSIVE PATIENTS: A COMPARISON OF SPHYGMOCOR AND MOBIL-O-GRAPH

Enrique Rodilla, Jose Antonio Costa, Francisco Perez, Carmen Gonzalez, Jose Maria Pascual
Pages: 69 - 70
Introduction: Comparison of Mobil-O-Graph® with SphygmoCor® exclusively in treatment- naïve hypertensives has never been done. Aims of the study were to assess 1) intra- device agreement between both methods, 2) inter-device agreement between two surface measurements of SC (subtracted distance (cfPWVsub))...
Conference Abstract

84. P58 ARTERIAL STIFFNESS IS ASSOCIATED WITH LOWER PERFORMANCE ON THE COGNITIVE TESTS AT DIFFERENT DOMAINS IN HYPERTENSIVE PATIENTS

Henrique Muela, Valeria Costa-Hong, Michel Machado, Natalia Moraes, Claudia Memória, Monica Yassuda, Edson Shu, Ayrton Massaro, Ricardo Nitrini, Alfredo Mansur, Luiz Bortolotto
Pages: 70 - 70
Background: Cognitive impairment and elevated arterial stiffness are described in arterial hypertension (AH), but its correlations are not well studied. Objectives: To study the cognitive function at different domains and arterial properties in patients with AH stage 1 to 3 compared to normotensives...
Conference Abstract

85. P59 ARTERIAL STIFFNESS AND PERIPHERAL VASCULAR RESISTANCE IN OFFSPRING OF HYPERTENSIVE PARENTS – INFLUENCE OF GENDER AND OTHER CONFOUNDERS

Niels Henrik Buus, Rasmus Carlsen, Dinah Khatir, Hans Eiskjær, Michael John Mulvany, Karin Skov
Pages: 70 - 70
Aim: Established essential hypertension (EH) is associated with increased arterial stiffness and peripheral resistance, but the extent of vascular changes in persons genetically predisposed for EH is uncertain. Methods: Participants from the Danish Hypertension Prevention Project (DHyPP) (having two...
Conference Abstract

86. P60 PSYCHOLOGICAL DETERMINANTS OF TARGET ORGAN DAMAGE IN HYPERTENSIVE PATIENTS: FOCUS ON PULSE WAVE VELOCITY AND DEPRESSION

Andrea Greco, Alessandro Maloberti, Marisa Varrenti, Ilaria Bassi, Enrico Piccinelli, Francesco Panzera, Stephan Laurent, Pierre Boutouyrie, Massimo D’Addario, Anna Maria Annoni, Patrizia Steca, Cristina Giannattasio
Pages: 70 - 71
Objective: Prior studies have suggested that the principal determinants of arterial stiffening are age, BP and others CV risk factors such as dyslipidemia and diabetes. However, scanty data are available on the role of psychological factors on arterial stiffness. The aim of the current cross-sectional...
Conference Abstract

87. P61 PSYCHOLOGICAL DETERMINANTS OF TARGET ORGAN DAMAGE IN HYPERTENSIVE PATIENTS: FOCUS ON TYPE A PERSONALITY AND LEFT VENTRICULAR MASS INDEX

Andrea Greco, Alessandro Maloberti, Paola Sormani, Giulia Colombo, Luca Giupponi, Stephan Laurent, Pierre Boutouyrie, Massimo D’Addario, Anna Maria Annoni, Antonella Moreo, Cristina Giannattasio, Patrizia Steca
Pages: 71 - 71
Background: Increased Left Ventricular Mass Index (LVMI) is a well known risk factor for cardiac morbidity and mortality. Furthermore, it is widely recognized that clinical evolution and progression of established CV diseases are related to a range of psychological characteristics, which may partially...
Conference Abstract

88. P62 BLOOD PRESSURE LOWERING HALTS CAROTID ARTERY STIFFENING IN HYPERTENSIVE PATIENTS: THE CATOD STUDY

Siske Bos, Rosa Maria Bruno, Bart Spronck, Maarten Heusinkveld, Stefano Taddei, Lorenzo Ghiadoni, Koen Reesink
Pages: 71 - 72
Background: We anticipate that in vascular outpatients followed over time, measured changes in arterial stiffness will be the multifactorial result of pressure-dependence, ageing- related degeneration, wall stress homeostasis, and medical treatment. Carotid ultrasound enables assessment of carotid pulse...
Conference Abstract

89. P63 CAN BRAQUIAL OSCILLOMETRY IDENTIFY PREHYPERTENSION AMONG NORMOTENSIVE SUBJECTS?

Enrique Rodilla, Manuel Adell, Vicente Giner, Zeneida Perseguer, Jose Maria Pascual, Maria Teresa Climent
Pages: 72 - 72
Background and objective: Arterial stiffness (AS) reflects vascular damage. Our objective was to determine 1) the frequency of AS in community pharmacies, 2) if subjects with AS identified by brachial oscillometry have more CV risk factors than normal subjects, and 3) if the prevalence of AS varies upon...
Conference Abstract

90. P64 ARTERIAL STIFFNESS AND PULSE PRESSURE AMPLIFICATION IN ADULTS WITH ISOLATED SYSTOLIC HYPERTENSION

Rosa Maria Bruno, Francesco Faggioni, Daniele Simone, Stefano Taddei, Ugo Faraguna, Lorenzo Ghiadoni
Pages: 72 - 72
Background/aim: ISH is usually considered more prevalent in aged individuals and associated to increased large artery stiffness. This study is aimed at identifying determinants of ISH in adult individuals. Methods: 20 individuals <60 years, referred to the Outpatient Hypertension Unit for high blood...
Conference Abstract

91. P65 GENDER DIFFERENCES OF AORTIC WAVE REFLECTION AND INFLUENCE OF MENOPAUSE ON CENTRAL BLOOD PRESSURE IN PATIENTS WITH ARTERIAL HYPERTENSION

Valeria Costa-Hong, Henrique Muela, Thiago Macedo, Alan Sales, Luiz Bortolotto
Pages: 72 - 72
Background: Evidences suggest that central hemodynamics indexes are independent predictors of future cardiovascular events and all-cause mortality. Multiple factors have been pointed to have potential influence on central aortic function: height, heart rate, left ventricular ejection duration and blood...
Conference Abstract

92. P66 ASSOCIATION BETWEEN URINARY SODIUM EXCRETION, ENDOTHELIAL FUNCTION AND ARTERIAL STIFFNESS IN NON-DIABETIC HYPERTENSIVE PATIENTS

Michelle Cunha, Ana Rosa Cunha, Bianca Cristina Marques, Jenifer D’El-Rei, Samanta Mattos, Ronaldo Gismondi, Wille Oigman, Mario Neves
Pages: 73 - 73
Background: High salt intake has been associated with structural and functional vascular changes.1 Objective: To correlate urinary sodium excretion with endothelial function and arterial stiffness in non-diabetic hypertensive patients. Methods: Cross-sectional study with non-diabetic hypertensive patients,...
Conference Abstract

93. P73 THE ASSESSMENT OF PULMONARY ARTERY STIFFNESS IN COPD USING CARDIAC MRI THE Q/A METHOD

Nichola Gale, Sujoy Saikia, Margaret Munnery, John Cockcroft
Pages: 73 - 73
Background: Pulmonary artery distensibility and pulsatility has been studied in patients with COPD using cardiac MRI (CMRI) (1). However, pulmonary artery pulse wave velocity (PA- PWV) using ‘QA’ method (2) in CMRI has not been studied in this population. We hypothesized that patients with COPD have...
Conference Abstract

94. P74 WALL SHEAR RATE AND BRACHIAL ARTERY FLOW-MEDIATED DILATORY RESPONSE BETWEEN HEALTHY YOUNG AND OLDER POPULATIONS USING MULTI-GATE SPECTRAL DOPPLER ULTRASOUND

Kunihiko Aizawa, Sara Sbragi, Alessandro Ramalli, Piero Tortoli, Francesco Casanova, Carmela Morizzo, Clare Thorn, Angela Shore, Phillip Gates, Carlo Palombo
Pages: 73 - 73
Background: Ageing is associated with an impaired brachial artery flow-mediated dilatation (FMD) response and a reduced wall shear rate (WSR) stimulus may contribute to this response. However, a detailed analysis of the WSR-FMD response is lacking due to inherent difficulties of WSR estimation near the...
Conference Abstract

95. P75 SIGNS OF ACCELERATED CAROTID ATHEROSCLEROSIS IN EARLY TYPE 2 DIABETES ASSESSED BY MAGNETIC RESONANCE IMAGING

Esben Laugesen, Pernille Høyem, Samuel Thrysøe, Esben Hansen, Anders Mikkelsen, Bill Kerwin, L. Poulsen Per, K. Hansen Troels, Y. Kim Won
Pages: 74 - 74
Background: Ischemic stroke from carotid plaque embolism remains a major cause of morbidity and mortality in patients with type 2 diabetes (T2DM). However, the effect of T2DM on early carotid plaque burden and composition is sparsely elucidated. We assessed carotid plaque composition by carotid magnetic...
Conference Abstract

96. P76 PERIPHERAL BLOOD PRESSURE AND STIFFNESS INDEX ESTIMATION USING THE PPG SIGNAL MEASURED WITH THE pOpmètre DEVICE: CALIBRATION WITH THE CUFF BLOOD PRESSURE

Hasan Obeid, Hakim Khettab, Magid Hallab, Stephane Laurent, Pierre Boutouyrie
Pages: 74 - 74
Arterial stiffness may influence the contour of the peripheral pulse, suggesting that contour analysis of the digital volume pulse (DVP) might be used to estimate peripheral blood pressure and a stiffness index (SI). The objective is to establish a transfer function that estimates the peripheral blood...
Conference Abstract

97. P77 NEAR INFRARED SPECTROSCOPY (NIRS) CAN DETECT DIFFERENCES IN MICROVASCULAR REACTIVE HYPERAEMIA IN THE PRESENCE OF HYPERTENSION

Siana Jones, Chloe Park, Nish Chaturvedi, Alun Hughes
Pages: 74 - 74
Background: Hypertension has adverse effects on microvascular function but there are limited methods that permit non-invasive assessment of the microcirculation in man in vivo. We used Near Infrared Spectroscopy (NIRS) to assess microvascular reactive hyperaemia in skeletal muscle following a short period...
Conference Abstract

98. P78 LONGITUDINAL MICRO-ULTRASOUND ASSESSMENT OF THE OB/OB MOUSE MODEL: EVALUATION OF CARDIOVASCULAR, RENAL AND HEPATIC PARAMETERS

Nicole Di Lascio, Claudia Kusmic, Francesco Stea, Francesca Lenzarini, Cristina Barsanti, Arthur Leloup, Francesco Faita
Pages: 74 - 75
Purpose/Background/Objectives: Obesity is associated with increased risk factors for cardiovascular disease (CVD). Leptin-deficient mice (ob/ob) are widely employed to investigate obesity. This study is aimed at providing a micro-ultrasound (mUS) longitudinal evaluation of the ob/ob mouse in terms of...
Conference Abstract

99. P79 ULTRASONOGRAPHIC CHARACTERIZATION OF THE DB/DB MOUSE, AN ANIMAL MODEL OF METABOLIC ABNORMALITIES

Nicole Di Lascio, Chiara Rossi, Claudia Kusmic, Anna Solini, Francesco Faita
Pages: 75 - 75
Purpose/Background/Objectives: The availability of an animal model that, beside common blood parameters like hyperglycemia or high lipid levels, reliably mirrors organ damage occurring in metabolic diseases, is an urgent need. These animals have not been fully characterized in terms of cardiovascular,...
Conference Abstract

100. P80 IDENTIFICATION OF RADIAL VASCULAR WALL ABNORMALITIES BY VERY-HIGH FREQUENCY ULTRASOUND IN PATIENTS WITH FIBROMUSCULAR DYSPLASIA: THE FUCHSIA STUDY

Rosa Maria Bruno, Nicole Di Lascio, Daniela Guarino, Saverio Vitali, Piercarlo Rossi, Davide Caramella, Stephane Laurent, Pierre Boutouryie, Stefano Taddei, Lorenzo Ghiadoni, Francesco Faita
Pages: 75 - 75
Aim: This case-control study is aimed at identifying radial vascular wall abnormalities in patients with fibromuscular dysplasia (FMD). Methods: High-frequency ultrasound scans of radial arteries were obtained by VevoMD (70 MHz probe, FUJIFILM, VisualSonics). Radial wall showed two echogenic interfaces:...
Conference Abstract

101. P81 DISARRAY AND REMODELING OF THE RADIAL ARTERY IN WOMEN WITH SPONTANEOUS CORONARY ARTERY DISSECTION: THE FUCHSIA STUDY

Rosa Maria Bruno, Nicole Di Lascio, Abtehale Al Hussaini, Daniela Guarino, Saverio Vitali, Piercarlo Rossi, Davide Caramella, Bernardo Cortese, Francesco Faita, Stefano Taddei, Lorenzo Ghiadoni, David Adlam
Pages: 75 - 76
Background: Spontaneous coronary dissection (SCAD) may represent a manifestation of fibromuscular dysplasia (FMD); thus, preclinical lesions might be found in extracoronary vessels with similar size and wall ultrastructure, such as the radial artery. Methods: Two 5′-clips from the left radial artery...
Conference Abstract

102. P82 IMAGE-BASED CHARACTERIZATION OF PLAQUE LIPID CONCENTRATION CHANGES IN TIME AND THE ROLE OF STATIN THERAPY

Kristen Meiburger, Gianfranco Varetto, Pietro Rispoli, Filippo Molinari
Pages: 76 - 76
Introduction: Carotid artery atherosclerosis is an established risk factor for cerebrovascular events. Core lipid-rich plaques are considered at a higher risk of embolization compared to fibrous or calcified lesions. Contrast enhanced ultrasound (CEUS) is effective for studying carotid plaques, providing...
Conference Abstract

103. P83 A PILOT STUDY TO ASSESS PEAK SYSTOLIC VELOCITY AS A POSSIBLE MARKER OF ATHEROSCLEROTIC BURDEN USING ULTRASOUND

Carola Koenig, Mark Atherton, Marco Cavazzuti, Sudarshan Ramachandran, Corinna Gomm, Richard Strange, Ian Halliday, Torsten Schenkel
Pages: 76 - 76
Introduction: Ischemic heart disease (IHD) has been associated with lower peak systolic velocity (PSV) on penile Doppler measurements [1]. This study establishes whether carotid ultrasound (US) PSV was associated with computational fluid dynamics (CFD) outputs, which in turn may contribute to IHD pathogenesis. Methods:...
Conference Abstract

104. P84 HIGH-FRAME RATE VECTOR FLOW IMAGING: RELATIONSHIP BETWEEN CAROTID BIFURCATION GEOMETRY AND FLOW PATTERNS

A. Alfredo Goddi, L. Luca Aiani, Y. Yigang Du, X. Xujin He, Y. Yingying Shen, L. Lei Zhu
Pages: 76 - 77
Background: The laminar flow movement in straight arteries is affected by anatomical factors such as bifurcation, lumen diameter changes or plaques. As a consequence of the local deceleration, the detachment of the boundary layer from the wall develops a disturbed flow, which impacts hemodynamics. It...
Conference Abstract

105. P85 HIGH FRAME RATE DYNAMIC DISPLAY ULTRASOUND VECTOR FLOW IMAGING FOR QUANTITATIVE STUDIES OF HEMODYNAMICS OF CAROTID ARTERIES

Yigang Du, Xujin He, Yingying Shen, Lei Zhu, Alfredo Goddi
Pages: 77 - 77
Advanced atherosclerotic patients are faced with significant risks of stroke, which are very likely to cause death or irreversible physical disability. However, the growth of artery stenosis usually needs a very long development. Early diagnosis is necessary and requires detailed and accurate quantitative...
Conference Abstract

106. P120 A MODEL-BASED STUDY ON THE EVOLUTION OF BLOOD PRESSURE DURING AGEING

Stamatia Pagoulatou, Nikolaos Stergiopulos
Pages: 77 - 78
Background: Hypertension being a major risk factor of cardiovascular mortality, there is a pressing need to understand the ageing mechanisms that lead to the continuous increase of pulse pressure and systolic blood pressure over time. Alterations in both forward and backward waves with age have been...
Conference Abstract

107. P121 IDENTIFYING HAEMODYNAMIC DETERMINANTS OF PULSE PRESSURE: AN INTEGRATED NUMERICAL AND PHYSIOLOGICAL APPROACH

Samuel Vennin, Ye Li, Marie Willemet, Henry Fok, Haotian Gu, Peter Charlton, Jordi Alastruey, Phil Chowienczyk
Pages: 78 - 78
Purpose: Hypertension, the single biggest killer worldwide1, arises mainly as a result of an increase in central pulse pressure (PP)2, yet haemodynamic basis of that increase is still disputed. We examined the ability of a simple “reduced” model comprising a proximal characteristic impedance linked to...
Conference Abstract

108. P122 CALCULATING RESERVOIR PRESSURE WITH OR WITHOUT FLOW INFORMATION: SIMILARITY AND ALGORITHMIC SENSITIVITY AT RADIAL ARTERY

Michael Ebner, Kim Parker, Tom Vercauteren, Sébastien Ourselin, Siegfried Wassertheurer, Alun Hughes, Bernhard Hametner
Pages: 78 - 79
Background: Reservoir pressure is typically estimated from the pressure waveform information only. Comparability with estimates made using pressure and flow depend on assumptions, e.g. a proportional relationship between excess pressure and flow [1]. In this study, we compared (i) results using flow...
Conference Abstract

109. P123 RESERVOIR PRESSURE IS INDEPENDENTLY ASSOCIATED WITH 11–12 YEAR OLD’S KIDNEY FUNCTION: POPULATION-DERIVED STUDY

Xiaoqing Peng, Martin Schultz, Michael Cheung, Melissa Wake, Jonathan Mynard, David Burgner, Richard Liu, James Sharman
Pages: 79 - 79
Introduction: Reservoir pressure (RP) and excess pressure (XSP) independently predict cardiovascular events in adults, but have never been investigated as markers of cardiovascular risk among children. This study aimed to determine the association of RP and XSP with end-organ makers of cardiovascular...
Conference Abstract

110. P124 VALIDITY AND RELIABILITY OF PULSE WAVE ANALYSIS ESTIMATED BY A NOVEL WRIST-WORN TONOMETER

Luis Garcia-Ortiz, Jose Recio-Rodriguez, Cristina Agudo-Conde, Rita Salvado, Jose Maderuelo-Fernandez, Jesus Gonzalez-Sanchez, Emiliano Rodriguez- Sanches, Manuel Gómez-Marcos,
Pages: 79 - 79
Objective: To analyze the reliability and validity of Pulse Wave Analysis determined with the new wrist-worn tonometry. Methods: Cross sectional study including 254 subjects. Aged 51.9±13.4, being women 53%. Main measurements: Peripheral AIx (PAIx) and Central AIx (CAIx) by wrist-worn tonometry and...
Conference Abstract

111. P125 USE OF VASCULAR ADAPTATION IN RESPONSE TO MECHANICAL LOADING FACILITATES PERSONALISATION OF A ONE-DIMENSIONAL PULSE WAVE PROPAGATION MODEL

Maarten Heusinkveld, Koen Reesink, Theo Arts, Wouter Huberts, Tammo Delhaas
Pages: 79 - 80
Background: Mathematical modelling of pressure and flow waveforms in blood vessels using pulse wave propagation (PWP) models could support clinical decision-making. For a personalised model outcome, measurements of all modelled vessel radii and wall thicknesses are required. In clinical practice, however,...
Conference Abstract

112. P126 COMPARISON OF PULSE WAVE ANALYSIS ASSESSMENT METHODOLOGY IN ELDERLY MEN

Elizabeth Ellins, Kirsten Smith, Lucy Lennon, Olia Papacosta, Goya Wannamethee, Peter Whincup, Julian Halcox
Pages: 80 - 80
Background: Both the Sphygmocor (S) and Vicorder (V) devices can be used for pulse wave analysis (PWA). However, large studies comparing data from both devices are lacking. Methods: 1,722 men (78.5±4.7yrs) from the British Regional Heart Study underwent PWA with S and V devices. Brachial blood pressure...
Conference Abstract

113. P127 FLOW DYNAMICS AND ITS RELATION TO BICUSPID AORTOPATHY ASSESSED BY 4D FLOW CMR

Lydia Dux-Santoy Hurtado, Jose F. Rodriguez-Palomares, Andrea Guala, Raquel Kale, Gisela Teixido-Tura, Filipa Valente, Giuliana Maldonado, David Garcia- Dorado, Artur Evangelista
Pages: 80 - 81
Purpose: Different altered flow dynamics may influence ascending aorta (AAo) dilation morphotypes in bicuspid aortic valve (BAV) (1). Using 4D-flow CMR, we aimed to identify flow variables related to root or ascending dilation in BAV. Methods: One-hundred and one BAV patients (no severe valvular disease,...
Conference Abstract

114. P128 COMPARISON OF AUGMENTATION INDEX OBTAINED FROM HEM-9000AI AND MOBIL-O-GRAPH IN JAPANESE NORMOTENSIVE INDIVIDUALS

Masakazu Obayashi, Michihiro Kohno, Shigeki Kobayashi, Michiaki Kohno, Masafumi Yano
Pages: 81 - 81
Background: HEM-9000AI (HEM) is an established device for measurement of radial augmentation index (rAIx) used by applanation tonometry in Japan. Mobil-O-Graph (MOG) is a cuff-based oscillometric device for assessment of central aortic AIx (cAIx) and the usefulness to Europeans has been reported. We...
Conference Abstract

115. P129 SHORT-TERM REPEATABILITY OF NON-INVASIVE AORTIC PULSE WAVE VELOCITY MEASURES

Andrea Grillo, Paolo Salvi, Sandrine Millasseau, Matteo Rovina, Corrado Baldi, Francesco Moretti, Lucia Salvi, Andrea Faini, Renzo Carretta, Filippo Scalise, Gianfranco Parati
Pages: 81 - 82
Objective: To compare the short-term repeatability of aortic pulse wave velocity (PWV) measures obtained with non-invasive devices. Methods: In 102 patients planned to undertake a cardiac catheterization (65±13 years, 70.6% males) duplicate non-invasive measures of PWV, 15-minutes apart, were obtained...
Conference Abstract

116. P130 TEST-RETEST RELIABILITY FOR PULSE WAVE VELOCITY AND CARDIO-ANKLE VASCULAR INDEX AMONG AFRO-CARIBBEAN YOUNG ADULTS

Janeil M. Williams, Trevor S. Ferguson, Nadia R. Bennett, Amanda Rousseau, Renee Walters, Novie O. Younger-Coleman, Marshall K. Tulloch-Reid, Seeromanie Harding, J. Kennedy Cruickshank, Rainford J. Wilks
Pages: 82 - 82
Background: This study evaluated the test-retest reliability of carotid-femoral pulse wave velocity (PWV) and cardio-ankle vascular index (CAVI) among young adults in Jamaica. Methods: We recruited participants from the Jamaica 1986 Birth Cohort Study. PWV was measured using the Arteriograph device™...
Conference Abstract

117. P131 DETERMINANTS OF A NEW, NON-INVASIVE INDEX OF VENTRICULAR-ARTERIAL COUPLING AND MYOCARDIAL PERFORMANCE IN A GENERAL POPULATION SAMPLE

Nicholas Cauwenberghs, Jan D’hooge, Lutgarde Thijs, Jan A. Staessen, Tatiana Kuznetsova
Pages: 82 - 82
Background: The interaction between the heart and arteries (i.e. ventricular-arterial coupling, VAC) is a key determinant of cardiovascular performance. As such, VAC indexes might reflect the interplay between arterial stiffness and left ventricular (LV) dysfunction. In a community-based sample, we assessed...
Conference Abstract

118. P165 HIGHER BLOOD PRESSURE IN YOUTH IS ATTRIBUTABLE TO A COMBINATION OF HIGHER CARDIAC OUTPUT AND HIGHER TOTAL PERIPHERAL RESISTANCE

Alun Hughes, Chloe Park, Abigail Fraser, Laura Howe, Siana Jones, Debbie Lawlor, NIsh Chaturvedi, George Davey Smith
Pages: 82 - 83
Background: It has been proposed that high blood pressure (BP) in young people is due to high cardiac output (CO) with normal total peripheral resistance (TPR) – a hyperkinetic/hyperdynamic circulation. We investigated this in a large, population- based cohort of adolescents. Methods: The study was...
Conference Abstract

119. P166 HEAD-DOWN TILT BED-REST SIGNIFICANTLY INCREASES CENTRAL ARTERIAL STIFFNESS

Fouassier David, Hakim Khettab, Pierre Boutouyrie, Carole Leguy, Catalin Cristian
Pages: 83 - 83
The vascular system is subject to continual variation in mechanical stresses, both physiological and pathological. Vascular remodeling via changes in vessel wall properties, including thickness and stiffness, is a major feature of aging and cardiovascular disease. A more detailed understanding of the...
Conference Abstract

120. P167 PULSE PRESSURE AMPLIFICATION AND AUGMENTATION INDEX CHANGE IN OPPOSITE MANNER WITH ARTERIAL STIFFNESS INDEPENDENTLY OF SYSTEMIC RESISTANCE

Nicolaas Westerhof, Berend Westerhof
Pages: 83 - 83
Background: Pulse Pressure Amplification (PPA) is the increase in Pulse Pressure (PP) from proximal to distal arteries. The Augmentation Index (AIx) is the secondary increase in aortic pressure in systole relative to PP. With aging and increased arterial stiffness the PPA decreases while the AIx increases....
Conference Abstract

121. P168 ENDOTHELIAL REGULATION OF AWV IS IMPAIRED DURING INCREASE IN BLOOD FLOW IN ESSENTIAL HYPERTENSION

Frederic Roca, Jeremy Bellien, Michele Iacob, Robinson Joannides
Pages: 83 - 84
Background: Arterial wall viscosity (AWV) depends on endothelium-derived factors in physiological conditions (1,2). Hypertension is characterized by an altered FMD during sustained flow increase due to endothelial dysfunction (3). Whether NO and EETs regulate change in AWV during increase in flow in...
Conference Abstract

122. P170 SHORT-TERM EFFECTS OF TRANSCATHETER AORTIC VALVE IMPLANTATION ON AORTIC FUNCTION AND HEMODYNAMICS

Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Konstantinos Toutouzas, Georgios Latsios, Andreas Synetos, Georgios Trantalis, Fani Mitropoulou, Maria Drakopoulou, Konstantinos Stathogiannis, Vicky Penesopoulou, Konstantinos Kalogeras, Konstantinos Aznaouridis, Manolis Vavuranakis, Dimitrios Tousoulis
Pages: 84 - 84
Purpose/Background/Objectives: Aortic stiffness and hemodynamics are independent predictors of adverse cardiovascular events. Transcatheter aortic valve implantation (TAVI) is growingly used in elderly patients with aortic stenosis. We sought to investigate the effect of TAVI upon aortic vascular function...
Conference Abstract

123. P171 COMPLIANCE OF EXTREMELY DILATED MAIN PULMONARY ARTERIES IN PULMONARY ARTERIAL HYPERTENSION

Joanne Groeneveldt, Tijmen van der Wel, Tim Marcus, Frances De Man, Anton Vonk Noordegraaf, Nicolaas Westerhof, Berend Westerhof
Pages: 84 - 85
Background: Main pulmonary artery (MPA) dilation is a radiological sign of pulmonary hypertension (PH) and is an independent risk factor of sudden death (Żyłkowska et al, Chest 2012). Extreme MPA dilation is a rare consequence of PH. We hypothesize that the main pulmonary artery compliance is larger...
Conference Abstract

124. P172 VOLUNTARY LIQUORICE INGESTION INCREASES BLOOD PRESSURE VIA MULTIPLE MECHANISMS: INCREASED VOLUME LOAD, PERIPHERAL ARTERIAL RESISTANCE, AND DECREASED AORTIC COMPLIANCE

Elina J. Hautaniemi, Anna M. Tahvanainen, Jenni K. Koskela, Antti J. Tikkakoski, Mika Kähönen, Marko Uitto, Kalle Sipilä, Onni Niemelä, Jukka Mustonen, Ilkka H. Pörsti
Pages: 85 - 85
Objectives: Liquorice consumption elevates blood pressure [1–3], but the liquorice-induced haemodynamic changes in the upright position are unknown. We investigated haemodynamics after liquorice exposure in healthy volunteers during orthostatic challenge. Methods: Haemodynamics were recorded from 22...
Conference Abstract

125. P173 COUPLED NITROSO-SULFIDE SIGNALIZATION TRIGGERS SPECIFIC VASOACTIVE EFFECTS IN INTRARENAL ARTERIES OF PATIENTS WITH ARTERIAL HYPERTENSION

Sona Cacanyiova, Andrea Berenyiova, Frantisek Kristek, Marian Grman, Karol Ondrias, Jan Breza, Jan Breza
Pages: 85 - 85
In normotensive conditions, it has been confirmed that S-nitrosothiols, as a source of NO, interact with hydrogen sulfide (H2S) and create new substance/s with specific vasoactive effects. This interaction could represent new regulator pathway also in hypertension. The aim of the study was to investigate...
Conference Abstract

126. P174 HEMODYNAMIC AND AUTONOMIC EFFECTS OF LOW-DOSE GLYCERYL TRINITRATE USED TO TEST ENDOTHELIUM-INDEPENDENT VASODILATION OF THE BRACHIAL ARTERY

Lorenzo Ghiadoni, Stefano Taddei, Rosa Maria Bruno
Pages: 85 - 85
Background/Aim: Smooth muscle function is explored by sublingual glyceryl trinitrate (GTN) administration in vascular function protocols, in order to compare with endothelium- dependent vasodilation of the brachial artery by flow-mediated dilation (FMD). The aim of this study is to evaluate the hemodynamic...
Conference Abstract

127. P175 AN ACUTE BOUT OF PROLONGED SITTING IMPAIRS ENDOTHELIAL FUNCTION AND INCREASES PLASMA CONCENTRATIONS OF ENDOTHELIN-1 IN OVERWEIGHT/OBESE ADULTS: IMPLICATIONS FOR GLUCOSE AND INSULIN METABOLISM

Megan Grace, Rachel Climie, Michael Wheeler, Nina Eikelis, Joshua Carr, Francis Dillon, Neville Owen, Danny Green, Bronwyn Kingwell, David Dunstan
Pages: 85 - 86
Background: Compared to regular active breaks, prolonged uninterrupted sitting amplifies postprandial glucose and insulin in overweight/obese adults with and without type 2 diabetes; and impairs lower limb endothelial function (a predictor of cardiovascular disease) in healthy adults. However, the effects...
Conference Abstract

128. P176 ARTERIAL STIFFNESS AS A PART OF A GENERAL ABNORMALITY OF THE FIBROUS HEALING PROCESS

Pedro Forcada, Miguel Sangiovanni, Alejandra Camino, Wanda Pampinella, Oscar Montaña
Pages: 86 - 86
Environment There seems to be a common abnormality of the healing process in several diseases as COPD, liver esteatosis, and arterial stiffening. Objective: To asses the association of frequency between liver esteatosis and aortic stiffness by means of c-f PWV in patients included in a CV prevention...
Conference Abstract

129. P177 ASSOCIATIONS OF AMBULATORY PULSE PRESSURE COMPONENTS WITH HIPPOCAMPAL VOLUME, WHITE MATTER HYPERINTENSITIES AND BRAIN INFARCTS

Benjamin Gavish, Therese Tillin, Alun D. Hughes, Nishi Chaturvedi
Pages: 86 - 86
Background: Arterial stiffness is blood pressure (BP) dependent. Using 24-hour ambulatory BP monitoring (24hABPM) pulse pressure (PP) can be split into an ‘elastic’ part (elPP: ‘diastolic stiffness’), and a ‘stiffening’ part (stPP: ‘stiffness change during systole’). We investigated associations of elPP,...
Conference Abstract

130. P89 UPRIGHT POSTURE ENHANCES THE UNFAVOURABLE INFLUENCES OF BISOPROLOL ON CENTRAL BLOOD PRESSURE IN HYPERTENSIVE MIDDLE AGED MEN: A DOUBLE-BLINDED RANDOMIZED PLACEBO-CONTROLLED CROSS-OVER STUDY

Ilkka Pörsti, Lauri Suojanen, Antti Haring, Antti Tikkakoski, Arttu Eräranta, Heini Huhtala, Mika Kähönen, Kari Kivistö, Jukka Mustonen
Pages: 86 - 87
Objective: Treatment with beta-blockers is characterised by inferior reduction of central versus peripheral blood pressure. We examined changes in central and peripheral blood pressure, cardiac function, and vascular resistance during beta-blockade. Methods: Haemodynamics were investigated after 3 weeks...
Conference Abstract

131. P90 POSITIVE EFFECTS OF ANTIHYPERTENSIVE TREATMENT ON AORTIC STIFFNESS IN THE GENERAL POPULATION

Markéta Mateřánková
Pages: 87 - 87
Aortic stiffness is strongly related to age and mean arterial pressure (MAP). We investigated whether antihypertensive treatment modulates the association of the aortic pulse wave velocity (PWV) with age and with MAP in the general population. In the Czech post-MONICA, we measured the PWV in 735 subjects...
Conference Abstract

132. P91 GREEN TEA EXTRACT REDUCES LIPID PROFILE, PERCENTAGE OF AORTIC AUGMENTATION INDEX AND INCREASES SOLUBLE RAGE CONCENTRATIONS IN NORMOTENSIVE PATIENTS WITH TYPE 2 DIABETES MELLITUS: A RANDOMIZED, DOUBLE-BLINDED, AND PLACEBO- CONTROLLED TRIAL

Fernando Grover Páez, Patricia Quezada Fernandez, Mariana Rodriguez de la Cerda, David Cardona Müller, Jhonatan Trujillo Quiroz, Walter Trujillo Rangel, Marycruz Barocio Pantoja
Pages: 87 - 88
Background: Type 2 diabetes mellitus is associated with premature atherosclerosis and arterial stiffening by an accumulation of advanced glycation end-products in vessel wall (1). Green tea polyphenols are considered a cardioprotective substance and may be used as an adjuvant for diabetes treatment,...
Conference Abstract

133. P92 SIMULTANEOUS INVASIVE AND NONINVASIVE MONITORING OF CENTRAL BLOOD PRESSURE ON CRITICALLY ILL PATIENTS SUFFERING FROM CARDIOGENIC SHOCK TREATED WITH IABP

Bela Benczur, Adam Nemeth, Renata Bocskei, Attila Cziraki
Pages: 88 - 88
Intraaortic balloon counterpulsation (IABP) is a method of temporary mechanical circulatory support in patients suffering from cardiogenic shock to improves the balance of myocardial oxygen supply and demand by using systolic unloading and diastolic augmentation. Arteriograph is an invasively validated...
Conference Abstract

134. P93 ARE HEMODYNAMIC MEASURES ASSOCIATED WITH FRAILTY IN ELDERLY PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE IMPLANTATION?

Jeannette Goudzwaard, Marjo de Ronde-Tillmans, Nahid El Faquir, Nicolas van Mieghem, Mattie Lenzen, Peter de Jaegere, Francesco Mattace Raso
Pages: 88 - 88
Background: Aortic valve stenosis (AS) is common in the elderly and is associated with high morbidity and mortality, and leads to functional decline. The aim of this study was to investigate the possible relation between aortic stiffness, AS and frailty in older patients undergoing Transcatheter Aortic...
Conference Abstract

135. P94 DAPAGLIFLOZIN ACUTELY RESTORES ENDOTHELIAL DYSFUNCTION, REDUCES AORTIC STIFFNESS AND RENAL RESISTIVE INDEX IN TYPE 2 DIABETIC PATIENTS: A PILOT STUDY

Rosa Maria Bruno, Livia Giannini, Marta Seghieri, Edoardo Vitolo, Stefano Taddei, Lorenzo Ghiadoni, Anna Solini
Pages: 88 - 88
Objective: Sodium-glucose co-transporter-2 inhibitors reduce blood pressure and renal and cardiovascular events in patients with type 2 diabetes through not fully elucidated mechanisms. Aim of this study was to investigate whether dapagliflozin is able to acutely modify systemic and renal vascular function. Methods:...
Conference Abstract

136. P95 EFFECT OF CHRONIC INFLAMMATION INHIBITION WITH SALSALATE ON AORTIC STIFFNESS AND VASCULAR ENDOTHELIAL FUNCTION IN OLDER ADULTS: A RANDOMIZED CONTROLLED STUDY

Gary Pierce, Lyndsey DuBose, Amy Stroud, Nicholas Jensen, Lauren Wegman-Points, Seth Holwerda, William Haynes, Kaitlyn Dubishar, Jess Fiedorowicz
Pages: 88 - 89
Chronic activation of the proinflammatory transcription factor nuclear factor kappa-B (NFkB) is linked to age-associated vascular dysfunction. Acute inhibition of NFkB with high-dose salsalate (>4g), a non-acetylated salicylate known to block NFkB activation, improves aortic stiffness and endothelial...
Conference Abstract

137. P96 ACUTE EFFECT OF ELECTRONIC CIGARETTE SMOKING ON PULSE PRESSURE AMPLIFICATION IN YOUNG SMOKERS

Nikolaos Ioakeimidis, Dimitris Terentes-Printzios, Christos Georgakopoulos, Charalambos Vlachopoulos, Mohammed Abdelrassoul, Ioanna Gourgouli, Nikolaos Magkas, Dimitrios Tousoulis
Pages: 89 - 89
Purpose/Background/Objectives: We investigated the acute effect of electronic cigarette (EC) smoking on the aortic pressure waveform amplification. We also sought to compare the effect of EC and combustible cigarette (TC) smoking on central haemodynamics. Methods: We studied 24 smokers (age: 30±8 years)...
Conference Abstract

138. P98 EFFECT OF LONG-TERM ANDROGENIC TREATMENT ON THE STRUCTURAL AND FUNCTIONAL PROPERTIES OF THE GREAT ARTERIES OF FEMALE TRANSSEXUALS

Flavia Cunha, Luiz Bortolotto, Valeria Costa-Hong, Elaine Costa, Maria Sircilli, Tania Bachega, Berenice Mendonça, Sorahia Domenice
Pages: 89 - 89
Background: Androgens act directly on the vasculature through your connection to the androgen receptor in the vascular wall, and can promote changes in structural and functional vascular properties. Objective: To evaluate the structural and functional properties of large arteries in TF in prolonged...
Conference Abstract

139. P99 THE EFFECT OF L-ARGININE ON THE VASCULAR FUNCTION IN HEALTHY TRAINED AND SEDENTARY SUBJECTS

Ksenija Cankar, Tina Virtič, Polona Zaletel, Ziva Melik
Pages: 89 - 89
Background: The aim of our study was to determine whether the use of food supplement L-arginine improves vascular function, which could be beneficial in preventing the formation and development of cardiovascular diseases. We investigated differences between trained and sedentary subjects. Method: Measurements...
Conference Abstract

140. P100 TRIAL OF EXERCISE TO PREVENT HYPERTENSION IN YOUNG ADULTS (TEPHRA): RATIONALE AND PROTOCOL

Afifah Mohamed, Odaro Huckstep, Wilby Williamson, Charlotte Herdman, Yvonne Kenworthy, Konstantina Spagou, Linda Arnold, Polly Whitworth, Ashley Verburg, Holger Burchert, Adam J. Lewandowski, Paul Leeson
Pages: 89 - 90
Background: Hypertension or pre-hypertension in young adults is unusual and more often linked with an adverse family or pregnancy history, such as preterm birth, than hypertension which develops later in life1–4. Surprisingly, no trials have investigated whether lifestyle advice developed for blood pressure...
Conference Abstract

141. P106 AORTIC STIFFNESS AND CENTRAL SYSTOLIC PRESSURE ARE ASSOCIATED WITH ORTHOSTATIC HYPOTENSION IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Philip Rankin, Nikesh Parekh, Steve Holt, Chakravarthi Rajkumar
Pages: 90 - 90
Objective: Orthostatic hypotension (OH) is common cardiovascular problem affecting older adults, and is associated with falls, stroke and chronic kidney disease (CKD). This postural drop (PD) in blood pressure (BP) has been independently associated with increased aortic stiffness in older adults. Aortic...
Conference Abstract

142. P107 OSCILLOMETRIC MEASUREMENT OF 24-HOUR PULSE WAVE VELOCITY PREDICTS ALL- CAUSE MORTALITY IN PATIENTS WITH END-STAGE RENAL DISEASE: THE ISAR-STUDY

Julia Matschkal, Christopher C. Mayer, Siegfried Wassertheurer, Georg Lorenz, Susanne Angermann, Stephan Kemmner, Matthias Braunisch, Roman Günthner, Bernhard Haller, Marcus Baumann, Uwe Heemann, Christoph Schmaderer
Pages: 90 - 91
Objectives: Mortality rate in end-stage renal disease (ESRD) are still at a high level. Sarafidis et al. showed the predictive value of 48h PWV in patients undergoing hemodialysis [1], although recent studies using office measurement showed controversial predictive results. Aim of the present study was...
Conference Abstract

143. P108 IMPACT OF KIDNEY TRANSPLANTATION ON AORTIC STIFFNESS INDEX β0

Marie-Pier Desjardins, Aboubacar Sidibé, Catherine Fortier, Fabrice Mac-Way, Sacha De Serres, Richard Larivière, Bart Spronck, Mohsen Agharazii
Pages: 91 - 91
Purpose/ Background/ Objectives: We have shown that aortic stiffness improves as early as 3 months post-kidney transplantation (KTx). Aortic stiffness index β0, a blood pressure independent parameter, has been proposed to be a better indicator of vascular wall property. This study was designed to examine...
Conference Abstract

144. P109 PROGRESSION OF AORTIC ARCH CALCIFICATION AFTER KIDNEY TRANSPLANT AND ITS IMPORTANCE IN PREDICTING CARDIOVASCULAR RISK: SINGLE-CENTER 2-YEAR FOLLOW-UP STUDY

Agne Laucyte-Cibulskiene, Evelina Boreikaite, Gediminas Aucina, Migle Gudynaite, Ilona Rudminiene, Sigita Anisko, Loreta Vareikiene, Liutauras Gumbys, Nerijus Teresius, Dileta Valanciene, Ligita Ryliskyte, Laurynas Rimsevicius, Marius Miglinas, Kestutis Strupas
Pages: 91 - 92
Vascular calcification (VC) is linked to post-transplant cardiovascular events in the long term. We aimed to evaluate whether pretransplant chest X-ray based aortic arch calcification (AoAC) or pulse wave velocity measurement can better predict post- transplant cardiovascular or cerebrovascular events,...
Conference Abstract

145. P110 DIFFERENCES IN ARTERIAL STIFFNESS MEASURED BY CARDIO-ANKLE VASCULAR INDEX IN PATIENTS WITH NORMAL AND DECREASED RENAL FUNCTION

Marius Miglinas, Alvita Gincaite, Laurynas Rimsevicius, Ligita Ryliskyte, Jolita Badariene, Aleksandras Laucevicius
Pages: 92 - 92
Background: Arterial stiffness (AS) is a highly prognostic risk factor of cardiovascular diseases. The aim of this study was to investigate the relationships between cardio-ankle vascular index (CAVI) and eGFR in patients under the risk of cardiovascular disease. Methods: This was a retrospective study...
Conference Abstract

146. P111 ASSOCIATION AND CLINICAL RELEVANCE OF ABSENCE OF LOWER LIMB ARTERIAL PULSE AND CORONARY ARTERY DISEASE IN HEMODIALYSIS PATIENTS

Luiz Bortolotto, Felizardo Nataniel, Luis Gowdak, Henrique Muela, Flavio Paula, Elias David-Neto, Jose Jayme De Lima
Pages: 92 - 92
Objectives: To determine the association between PAD and DAC in patients treated by haemodialysis in the waiting list for renal transplantation and to assert the influence of that association on prognosis and clinical management. Methods: 1246 renal transplant candidates underwent coronary angiography....
Conference Abstract

147. P112 CENTRAL PULSE WAVE PARAMETERS ARE ASSOCIATED WITH VALVE CALCIFICATION IN PATIENTS WITH END-STAGE RENAL DISEASE ON MAINTENANCE HEMODIALYSIS

Maria Trukhanova, Nadezhda Manukhina, Dmitry Doroshenko, Svetlana Villevalde, Zhanna Kobalava
Pages: 92 - 93
Background: Arterial stiffness is known marker of poor cardiovascular prognosis. The aim if the study was to assess the incidence of valve calcification (VC) in patients with end- stage renal disease (ESRD) and its associations with clinical parameters of arterial stiffness. Methods: In 68 adults with...
Conference Abstract

148. P113 DIASTOLIC AMBULATORY BLOOD PRESSURE PARAMETERS ARE ASSOCIATED WITH VALVE CALCIFICATION IN PATIENTS WITH END-STAGE RENAL DISEASE ON MAINTENANCE HEMODIALYSIS

Maria Trukhanova, Nadezhda Manukhina, Dmitry Doroshenko, Svetlana Villevalde, Zhanna Kobalava
Pages: 93 - 93
Objective: Valve calcification (VC) is common in patients on hemodialysis and increases the risk of cardiovascular morbidity and mortality. The aim if the study was to evaluate the association between VC and 44-hour ambulatory blood pressure (ABP) variables. Materials and methods: In 68 patients with...
Conference Abstract

149. P114 ARTERIAL STIFFNESS IS ASSOCIATED WITH AMBULATORY BLOOD PRESSURE PARAMETERS IN PATIENTS ON MAINTENANCE HEMODIALISYS

Maria Trukhanova, Nadezhda Manukhina, Dmitry Doroshenko, Svetlana Villevalde, Zhanna Kobalava
Pages: 93 - 93
Introduction: Arterial stiffness is a principal pathogenetic mechanism of aortic systolic blood pressure (SBP) augmentation, left ventricular hypertrophy and sudden cardiac death. The aim of the study was to evaluate the association between parameters of pulse wave and 44-hour ambulatory blood pressure...
Conference Abstract

150. P115 ALBUMIN-TO-CREATININE RATIO IS ASSOCIATED WITH TARGET ORGAN DAMAGE IN HYPERTENSION

Losif Koutagiar, Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, Nikolaos Loakeimidis, Christos Georgakopoulos, Konstantinos Aznaouridis, Panagiotis Xaplanteris, Athanasios Angelis, Dimitrios Tousoulis
Pages: 93 - 93
Purpose/Background/Objectives: Hypertension is associated with higher cardiovascular risk as well as several markers of subclinical target organ damage (TOD). Albumin to creatinine ratio (ACR) in urine has been recognised as an independent risk factor for cardiovascular events. We hypothesised that there...
Conference Abstract

151. P135 PRECISION CALIBRATION OF PERIPHERAL PRESSURE WAVEFORMS USING INTRA-ARTERIAL BLOOD PRESSURE REVEALS THE NEED FOR IMPROVED WAYS TO ACCURATELY ESTIMATE AORTIC BLOOD PRESSURE

Dean S. Picone, Martin G. Schultz, Xiaoqing Peng, J. Andrew Black, Nathan Dwyer, Philip Roberts-Thomson, James E. Sharman
Pages: 93 - 94
Background: Estimating aortic blood pressure (BP) non-invasively requires peripheral waveform calibration using cuff systolic (SBP) and diastolic (DBP). Accuracy of estimated aortic BP has never been determined when peripheral waveforms are precision calibrated using peripheral intra-arterial SBP/DBP....
Conference Abstract

152. P136 ALTERED ADVENTITIAL COLLAGEN FIBRIL MECHANICS AND MORPHOLOGY WITH HIGH PULSE WAVE VELOCITY

Zhuo Chang, Maria Lyck Hansen, Lars Melholt Rasmussen, Riaz Akhtar
Pages: 94 - 94
Background: Arterial stiffening, occurring as part of the natural aging process of the artery, is well- established as a powerful predictor of cardiovascular disease. However, little is known about how localised changes in the extracellular matrix and mechanical properties of arterial tissue contribute...
Conference Abstract

153. P137 NUMERICAL ASSESSMENT AND COMPARISON OF PULSE WAVE VELOCITY METHODS PRESUMING TO MEASURE AORTIC STIFFNESS

Hasan Obeid, Gilles Soulat, Elie Mousseaux, Stephane Laurent, Nikolaos Stergiopulos, Pierre Boutouyrie, Patrick Segers
Pages: 94 - 94
Recently several methods have been proposed as tools to measure aortic pulse wave velocity (aPWV). The carotid-femoral pulse wave velocity (cf-PWV), the current clinical gold standard method for the noninvasive assessment of aPWV, uses the carotid–femoral pulse transit time (cf-PTT) to derive cf-PWV....
Conference Abstract

154. P138 CAN PULSE WAVE VELOCITY BE MEASURED IN THE FETAL ASCENDING AORTA?

Madalina Negoita, Arianna Laoreti, Tarek F. Antonios, Asma Khalil, Ashraf W. Khir
Pages: 94 - 95
Background: Routine ultrasound exams are conducted to assess fetus development. Heart defects and cardiac function are the main areas investigated in an ultrasound assessment. However, prenatal assessment of the fetal arterial stiffness is yet to be established in the ascending aorta. Aim: To investigate...
Conference Abstract

155. P139 COMPARISON OF EJECTION DURATIONS DERIVED FROM RADIAL AND BRACHIAL PRESSURE WAVES

Andreas Bauer, Bernhard Hametner, Thomas Weber, Siegfried Wassertheurer
Pages: 95 - 95
Purpose: The ejection duration (ED) is an important indicator of ventricular function as well as ventriculo-arterial coupling. Thus, the non-invasive oscillometric determination of ED from arterial pressure waves could enhance methods of pulse wave analysis. The aim of this work was to test and to validate...
Conference Abstract

156. P140 COMPARISON OF DOPPLER AND OSCILLOMETRIC METHODS OF ASSESSING ANKLE-BRACHIAL INDEX IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Kwame Yeboah, Mensah Owusu, N.A. Rchard, Dzifa Dey, Vincent Boima, J. Kennedy Cruickshank
Pages: 95 - 95
Conference Abstract

157. P141 COMPARISON BETWEEN TECHNIQUES OF EVALUATION MICROVASCULAR MORPHOLOGY: THE GOLD-STANDARD LOCALLY INVASIVE MICROMYOGRAPHY VS. THREE NON-INVASIVE TECHNIQUES. PRELIMINARY DATA

C. De Ciuceis, S. Caletti, M.A. Coschignano, C. Rossini, S. Duse, F. Docchio, S. Pasinetti, F. Zambonardi, F. Semeraro, G. Sansoni, C. Agabiti Rosei, P. Pileri, E. Agabiti Rosei, D. Rizzoni
Pages: 95 - 96
Objective: The gold standard technique of evaluation microvascular morphology in human is generally considered the measure of media to lumen ratio (M/L) of subcutaneous small vessels obtained by local biopsies and evaluated by wire or pressure micromyography. However, non-invasive techniques for the...
Conference Abstract

158. P142 AORTIC ROOT STIFFNESS AND MECHANICAL PROPERTIES OF HEALTHY ADULTS

Madalina Negoita, Alun D. Hughes, Kim H. Parker, Ashraf W. Khir
Pages: 96 - 96
Background: Arterial stiffness, often expressed in terms of pulse wave velocity (PWV), is an important risk factor for cardiovascular disease. PWV can be determined locally and non-invasively, by means of ultrasound. Aim: To assess PWV, local compliance (Cs), distensibility (Ds) and Young’s modulus...
Conference Abstract

159. P143 VALIDITY OF PULSE WAVE VELOCITY AND AUGMENTATION INDEX MEASUREMENTS IN PATIENTS WITH ATRIAL FIBRILLATION

Rogier Caluwe, An S. De Vriese, Bruno Van Vlem, Francis Verbeke
Pages: 96 - 97
Background: Individualized weighing of the risk-benefit of anticoagulation is recommended in patients with atrial fibrillation (AF) that have low established risk scores or, conversely, are at increased risk for bleeding1. Parameters of arterial stiffness and wave reflection could improve risk stratification,...
Conference Abstract

160. P144 ASCENDING AND DESCENDING THORACIC AORTA PU-LOOPS FOR THE ESTIMATION OF LEFT VENTRICULAR AFTERLOAD

Alex Hong, Jona Joachim, Cedric Buxin, Sandrine Millasseau, Arthur Le Gall, Joaquim Mateo, Etienne Gayat, Fabrice Vallée
Pages: 97 - 97
Introduction: Pressure-Velocity (PU) loops obtained in the descending thoracic aorta (PU-loopsdes) could estimate left ventricular afterload with two remarkable angles: β and GALA (Global Afterload Angle) [1].The aim of this study is to compare PU-loops measured in the ascending aorta (PU-loopsasc) versus...
Conference Abstract

161. P145 MEASUREMENT OF BLOOD PRESSURE DEPENDENCY OF CAROTID-FEMORAL PULSE WAVE VELOCITY

Mark Butlin, Isabella Tan, Fatemeh Shirbani, Bart Spronck, Alberto Avolio
Pages: 97 - 98
Background: Carotid-femoral pulse wave velocity (cfPWV) is predictive of cardiovascular outcomes but clinical interpretation is confounded by blood pressure (BP) interaction. This study proposes a method for PWV pressure dependency measurement suitable for routine clinical or research use. Methods:...
Conference Abstract

162. P146 METHODOLOGICAL ASPECTS AND DETERMINANTS OF HYPEREMIA-MEDIATED SLOWING IN PULSE WAVE VELOCITY: A GENERAL POPULATION STUDY

Nicholas Cauwenberghs, Yenthel Heyrman, Judita Knez, Lutgarde Thijs, Jan A. Staessen, Tatiana Kuznetsova
Pages: 98 - 98
Background: Recent studies proposed that deceleration in pulse wave velocity (PWV) following hyperemia might reflect arterial distensibility and endothelial function. We therefore investigated methodological aspects and clinical determinants of newly proposed indexes of such flow-mediated slowing (FMS)...
Conference Abstract

163. P18 THE ASSOCIATION BETWEEN METABOLIC SYNDROME COMPONENTS, ARTERIAL MARKERS OF EARLY ATHEROSCLEROSIS AND LEFT VENTRICULAR DIASTOLIC DYSFUNCTION

Svetlana Solovjova, Roma Puronaite, Aiste Jakstaite, Ligita Ryliskyte, Jelena Celutkiene, Aleksandras Laucevicius
Pages: 98 - 98
Background: The aim of the study was to evaluate the relationship between MetS components and arterial stiffness in concert with left ventricular diastolic dysfunction (LVDD) in patients with high risk of cardiovascular disease. Methods: A study was carried among 436 subjects (aged 53,8±6, 37,2% men)...
Conference Abstract

164. P19 INFLUENCE OF BRACHIAL ARTERY STIFFNESS ON FLOW-MEDIATED DILATATION IN HEALTHY YOUNG AND OLDER POPULATIONS

Kunihiko Aizawa, Sara Sbragi, Alessandro Ramalli, Piero Tortoli, Francesco Casanova, Carmela Morizzo, Clare Thorn, Angela Shore, Phillip Gates, Carlo Palombo
Pages: 98 - 98
Background: Increased brachial artery (BA) stiffness has previously been shown to affect the magnitude of FMD response in patients with high cardiovascular risk. However, it is unclear whether increased BA stiffness explains the diminished FMD response typically observed in a healthy older population....
Conference Abstract

165. P20 AUGMENTATION INDEX ASSOCIATES WITH IMPAIRED EARLY VENTRICULAR EJECTION

Haotian Gu, Gerry Carr-White, John Chambers, Phil Chowienczyk
Pages: 98 - 99
Background: Previously regarded as a measure of pressure wave reflection, central augmentation index (cAI) may be influenced by the pattern of early ventricular ejection. We examined the relationship of cAI to first-phase ejection-fraction (EF1), a measure of ventricular ejection up to the time of the...
Conference Abstract

166. P21 REDUCTION OF CARDIAC PRE-LOAD HAS ANTITHETICAL EFFECTS ON BLOOD PRESSURE AND ARTERIAL STIFFNESS: IS BLOOD PRESSURE THE MAIN DETERMINANT OF WITHIN-SUBJECT VARIATION IN PULSE WAVE VELOCITY?

Luca Faconti, Bushra Farukh, Andrii Boguslavskyi, Phil Chowienczyk
Pages: 99 - 99
Objective: Blood pressure (BP) is considered the most important determinant of within-subject variation in pulse wave velocity (PWV) and the possibility of altering arterial stiffness independently of BP is still a matter of debate. When investigating acute effects of a reduction in cardiac pre-load,...
Conference Abstract

167. P22 CIRCADIAN VARIATIONS IN THE CARDIOVASCULAR SYSTEM

Thomas Weber, Siegfried Wasserheurer, Arno Schmidt-Trucksäss, Enrique Rodilla Sala, Piotr Jankowski, Maria Lorenza Muisan, Cristina Giannatasio, Ian Wilkinson, Joerg Kellermair, Bernhard Hametner, Jose Maria Pascual, Robert Zweiker, Danuta Czarnecka, Anna Paini, Massimo Salvetti, Allessandro Maloberti, Peter Fitscha, Kai Mortensen, Elisabeth Wagner, Carmel McEniery, Cornelia Ablasser
Pages: 99 - 99
Background: Comprehensive information on 24-hour profiles of pulsatile as well as steady-state hemodynamics in humans is not available yet. Methods: In 693 healthy individuals (352 men) free from antihypertensive drugs, we performed 24-hour blood pressure (BP) monitoring with a validated oscillometric...
Conference Abstract

168. P23 PREDICTION OF TOTAL AND CAUSE-SPECIFIC MORTALITY INCIDENCE AS WELL AS CARDIOVASCULAR MORBIDITY BY USE OF NON-INVASIVE MEASUREMENT OF CAROTID- FEMORAL PULSE WAVE VELOCITY AS A MEASURE OF ARTERIAL STIFFNESS

Peter Nilsson, Mikael Gottsäter, Abd al-Hakim Fatehali
Pages: 100 - 100
Objective: Arterial stiffness (AS) increases with age and predicts total mortality and total cardiovascular (CV) events. It has also been shown that positive family history (FH+) of cardiometabolic disease influences AS. We aimed to: 1) examine if AS predicts total mortality among elderly subjects, as...
Conference Abstract

169. P24 SEX-SPECIFIC PULSE WAVE VELOCITY CUT-OFFS IMPROVE SURVIVAL ANALYSIS IN PATIENTS WITH SUSPECTED CORONARY ARTERY DISEASE

Christopher C. Mayer, Bernhard Hametner, Katy Whitelegg, Thomas Weber, Siegfried Wassertheurer
Pages: 100 - 100
Objectives: There is evidence for sex and age influences on pulse wave velocity (PWV). Guidelines suggest a sex-independent cut-off for PWV. It is not obvious that an age- and blood-pressure-independent cut-off is suitable in different populations [1, 2]. Thus, the aim is to investigate the suitability...
Conference Abstract

170. P25 VASCULAR AGING IS ASSOCIATED WITH THE SEVERITY OF CEREBRAL WHITE MATTER LESION LOAD

Lisanne Tap, Annegreet van Opbroek, Wiro Niessen, Marion Smits, Francesco Mattace- Raso
Pages: 100 - 101
Background: Blood pressure (BP) levels and aortic stiffness are associated with the presence of cerebal small vessel disease, whereas little is known on the possible association of BP levels, aortic stiffness and the severity of cerebral small vessel disease. In a pilot study we investigated whether...
Conference Abstract

171. P27 REPLACED RIGHT HEPATIC ARTERY AND INTERLOBAR BRIDGE OF LIVER WITH UNUSUAL ARTERIAL SUPPLY OF IVTH SEGMENT

Mehtap Yuksel, Turan Koc, Sezgin Ilgi
Pages: 101 - 101
A replaced right hepatic artery (rRHA) arising from the superior mesenteric artery and an interlobar parenchymal bridge over the sagittal fissure of liver have been observed on a 64 year old formalin-fixed male cadaver in the anatomy laboratory. As we followed a detailed segmental anatomy, encountered...
Conference Abstract

172. P28 DETERMINANTS OF ARTERIAL STIFFNESS AS MARKER OF EARLY VASCULAR AGING IN PHYSICIANS POPULATION

Elena Shavarova, Eldar Kazahmedov, Artemiy Orlov, Zhanna Kobalava
Pages: 101 - 101
Objective: To analyze determinants of arterial stiffness in physician’s population. Methods: Observational multicenter study of doctor’s vascular health conducted in 12 Russian cities (VICTORIA study). Demographics; smoking status; anamnesis of arterial hypertension (AH) with/without therapy, medications,...
Conference Abstract

173. P29 TOTAL LONGITUDINAL DISPLACEMENT (TLOD) OF THE COMMON CAROTID ARTERY (CCA) DOES NOT DIFFER BETWEEN PATIENTS WITH MODERATE OR HIGH CARDIOVASCULAR RISK (CV) AND PATIENTS AFTER ACUTE MYOCARDIAL INFARCTION (AMI)

Urtė Gargalskaitė, Pranas Šerpytis, Karolis Azukaitis, Rokas Navickas, Vilma Dzenkeviciute, Jolita Badariene, Zaneta Petrulioniene, Kristijonas Česas
Pages: 101 - 101
Background: Total longitudinal displacement (tLoD) of the common carotid artery (CCA) wall is a novel ultrasound marker of vascular function that can be evaluated using modified speckle tracking techniques. Decreased CCA tLoD has already been shown to be associated with diabetes and was shown to predict...
Conference Abstract

174. P30 THE ROLE OF NOVEL BIOMARKERS IN ARTERIAL STIFFNESS, AND IN PREDICTING FURTHER VASCULAR EVENTS AFTER TIA AND LACUNAR STROKE

Esme Girdwood, Manuela Mengozzi, Eva Bunting, Jean Timeyin, Pietro Ghezzi, Chakravarthi Rajkumar
Pages: 101 - 102
Objective: To explore the role of biomarkers (hsCRP, sRANKL, PRDX1 and EPO) in arterial stiffness and in predicting further vascular events. Methods: Patients from the ongoing ASIST study each attended a laboratory visit within fourteen days of their diagnosed TIA or lacunar stroke. Arterial stiffness...
Conference Abstract

175. P150 ARTERIAL STIFFNESS AND PROGRESSION OF CEREBRAL WHITE MATTER LESIONS IN ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES AND MATCHED CONTROLS: A 5-YEAR COHORT STUDY

Kristian Løkke Funck, Esben Laugesen, Pernille Høyem, Brian Stausbøll-Grøn, Won Kim, Leif Østergaard, Dora Zeidler, Troels Krarup Hansen, Per Løgstrup Poulsen
Pages: 102 - 102
Aim: Stroke is a frequent and feared complication in patients with type 2 diabetes. Arterial stiffness may improve current suboptimal risk prediction of stroke. However, studies in diabetes populations are lacking. We investigated the association between arterial stiffness progression (carotid-femoral...
Conference Abstract

176. P151 CENTRAL PULSE PRESSURE IS ASSOCIATED WITH AORTIC-BRACHIAL STIFFNESS MISMATCH IN PATIENTS WITH ARTERIAL HYPERTENSION AND DIABETES MELLITUS

Elena Troitskaya, Ekaterina Starostina, Zhanna Kobalava
Pages: 102 - 102
Background: Central pulse pressure (PP) is a surrogate measure of arterial stiffness (AS) and a predictor of cardiovascular events in type 2 diabetes mellitus (T2DM). AS gradient reflects the vascular ageing. The aim of the study: To evaluate the associations between 24-h central PP and parameters of...
Conference Abstract

177. P152 MICROALBUMINURIA IN NEWLY DIAGNOSED DIABETES MELLITUS: NOT ONLY ABOUT BLOOD PRESSURE OR ARTERIAL STIFFNESS

Barbara Nikolaidou, Eleni Gavriilaki, Eugene Gkaliagkousi, Ioanna Zografou, Areti Triantafyllou, Antonios Lazaridis, Stella Douma
Pages: 102 - 103
Background: Diabetes mellitus (DM) and hypertension (EH) are both associated with micro- and macro-vascular damage. Microalbuminuria is a recognized marker of sub-clinical target organ damage in both DM and EH. However, it’s determinants in newly diagnosed DM with or without EH remain unclear. Methods:...
Conference Abstract

178. P153 MARKER OF TYPE VI COLLAGEN FORMATION (PRO-C6) IS ASSOCIATED WITH HIGHER ARTERIAL STIFFNESS IN TYPE 1 DIABETES

Tine Willum Hansen, Daniel G.K. Rasmussen, Simone Theilade, Signe H. Nielsen, Morten A. Karsdal, Federica Genovese, Peter Rossing
Pages: 103 - 103
Aim: Arterial stiffening reflects fragmentation and loss of elastin fibers and accumulation of stiffer collagen fibers in the media of large arteries. We evaluated associations between carotid-femoral pulse wave velocity (cfPWV) and a marker of collagen type VI formation (Pro-C6) and a marker of collagen...
Conference Abstract

179. P154 VASCULAR STRUCTURE AND FUNCTION IN RELATION TO WEIGHT EXCESS AND BLOOD PRESSURE IN A SAMPLE OF OBESE CHILDREN

Sara Bonafini, Angela Tagetti, Francesco Dalle Vedove, Sara Raimondi, Alice Giontella, Paolo Cavarzere, Rossella Gaudino, Pietro Minuz, Claudio Maffeis, Franco Antoniazzi, Cristiano Fava
Pages: 103 - 103
Objective: To investigate the influence of weight excess and blood pressure (BP) on vascular structure and function in a sample of obese children. Methods: We measured office and ambulatory BP (ABPM), carotid intima-media thickness (cIMT), endothelial function by the Flow Mediated Dilation (FMD) technique,...
Conference Abstract

180. P155 CORRELATION OF SOLUBLE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS AND S100-A1 ON ARTERIAL STIFFNESS IN NORMOTENSIVE PATIENTS WITH DIABETES

Patricia Quezada Fernandez, Fernando Grover Páez, Becerra Ramos, Carlos, Jhonatan Trujillo Quiros, Walter Trujillo Rangel, Sánchez Rodríguez Sánchez Rodríguez, David Cardona Müller, Mayra Jimenez Cázarez
Pages: 103 - 104
Background: Accumulation of advanced glycation end products (AGEs) are involved in several pathophysiological processes in the vessel wall, that may cause premature atherosclerosis and arterial stiffening (1). A soluble form of RAGE (sRAGE), which is a splice variant of full-length RAGE has been considered...
Conference Abstract

181. P156 DURATION OF DIABETES MELLITUS IS A SIGNIFICANT PREDICTOR OF ARTERIAL STIFFNESS IN PATIENTS WITH ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUS

Elena Troitskaya, Ekaterina Starostina, Zhanna Kobalava
Pages: 104 - 104
Background: Diabetic complications increase with disease duration but little is known about the relationships between aortic stiffness and diabetes duration. Aim: to assess associations of diabetes mellitus (DM) duration and parameters of arterial stiffness in patients with arterial hypertension (AH)...
Conference Abstract

182. P157 RETINAL ARTERIOLAR FUNCTION, ENDOTHELIAL DYSFUNCTION AND ARTERIAL STIFFNESS IN PATIENTS WITH TYPE 2 DIABETES

Jonathan Baier, Søren Tang Knudsen, Line Petersen, Kristian Løkke Funck, Liv Vernstrøm Hald, Toke Bek, Per Løgstrup Poulsen, Esben Laugesen
Pages: 104 - 104
Background: Crosstalk between large and small arteries has been suggested to partake in the microvascular complication development in patients with type 2 diabetes mellitus (T2DM). Yet, data are scarce. In the present study, we aimed to elucidate the crosstalk between large and small arteries in T2DM. Methods:...
Conference Abstract

183. P158 ASSOCIATION BETWEEN AMBULATORY ARTERIAL STIFFNESS INDEX, MARKERS OF BLOOD PRESSURE VARIABILITY AND INDICES OF SUBCLINICAL VASCULAR DAMAGE IN OBESE CHILDREN

Angela Tagetti, Sara Bonafini, Cristiano Fava
Pages: 104 - 105
Objective: Ambulatory Arterial Stiffness Index (AASI) and symmetric AASI (sAASI) have been proposed as indices of arterial stiffness obtained by 24-hour ambulatory blood pressure monitoring (ABPM). ABPM allows the analysis of indices of BP variability like day and night SD, BP dipping, weighted 24-h...
Conference Abstract

184. P159 ASSOCIATION BETWEEN PULSE WAVE VELOCITY AND APNEA-HYOPPNEA INDEX IN PATIENTS WITH TYPE 2 DIABETES AND OBSTRUCTIVE SLEEP APNEA

Christoffer Krogager, Anne Margereta Banghøj, Per Løgstrup Poulsen, Lise Tarnow, Esben Laugesen, Klavs Würgler Hansen
Pages: 105 - 105
Introduction: Obstructive sleep apnea (OSA) is associated with increased cardiovascular (CV) risk. OSA is highly prevalent among patients with type-2 diabetes (T2D). Patients with T2D have increased risk of cardiovascular events, and have an increased aortic stiffness. Continuous Positive Airway Pressure...
Conference Abstract

185. P160 VASCULAR ABNORMALITIES AND HAEMODYNAMIC PATTERN IN OBESE YOUNG ADULTS

Pedro Forcada, Jorge Chiabaut Svane, Sergio Gonzalez, Carol Kotliar, Sebastian Obregon, Carlos Castellaro
Pages: 105 - 105
Background: Obesity is linked to a higher prevalence of risk factors, metabolic and inflammatory pathways conducting to increased vascular disease and CV risk. Objective: To assess vascular disarrangements and haemodynamic patterns in obese young subjects (O) compared with matched lean (L) controls,...
Conference Abstract

186. P161 ROLES OF ANGIOPOIETINS 1 AND 2 ON ARTERIAL FUNCTION DURING A TREATMENT TRIAL IN PEOPLE WITH OR AT RISK OF DIABETES

K. Parkin, G. Slee, R. Gray, A. Webb, C. Mills, J.K. Cruickshank
Pages: 105 - 105
Background/ Objective: Vascular growth factors angiopoietin-1 (Ang1) and -2 (Ang2) regulate vascular permeability and inflammation, Ang2 likely as Ang1’s selective antagonist. Their role before or in type 2 diabetes (pre-&T2D) is unknown. We hypothesised that higher circulating Ang1 and lower Ang2...
Conference Abstract

187. P182 ARTERIES IN PATIENTS WITH HUNTINGTON’S DISEASE

Ziva Melik, Jan Kobal, Ksenija Cankar, Janja Pretnar, Marjan Zaletel, Lucijan Kobal, Natasa Teran
Pages: 105 - 106
Background: Huntington’s disease (HD) is a neurodegenerative disorder leading to the progressive death of neurons in various brain regions. Although it is a disease of the central nervous system (CNS), mortality surveys indicate that heart disease is one of the mayor causes of death in HD patients. The...
Conference Abstract

188. P183 INCREASED ARTERIAL STIFFNESS IS ASSOCIATED WITH POORER LEFT VENTRICULAR STRUCTURE AND FUNCTION IN ADOLESCENCE

Hannah Taylor, Alun Hughes, Marietta Charakida, Nishi Chaturvedi, George Davey- Smith, John Deanfield, Abigail Fraser, Laura Howe, Debbie Lawlor, Chloe Park
Pages: 106 - 106
Introduction: Increased arterial stiffness (AS) in adults causes increased left ventricular (LV) afterload, putting additional strain on the heart. Long-term, this can lead to an adverse cardiovascular phenotype and AS has been found to be a determinant of CVD, independent of traditional cardiovascular...
Conference Abstract

189. P184 INCREASED ARTERIAL STIFFNESS IS ASSOCIATED WITH HIGH INFLAMMATORY ACTIVITY IN RHEUMATOID ARTHRITIS

Sergey Velmakin, Elena Troitskaya, Svetlana Villevalde, Zhanna Kobalava
Pages: 106 - 106
Conference Abstract

190. P185 CARDIO-ANKLE VASCULAR INDEX AND PLASMA LEVELS OF LEPTIN AND ADIPONECTIN IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Kwame Yeboah, Richard NA. Owusu Mensah, Dzifa Dey, Vincent Boima, J. Kennedy Cruickshank
Pages: 106 - 107
Objective: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease associated with vascular derangement [1]. Leptin and adiponectin are adipokines with immunomodulatory and vascular functions [2]. We studied the association between arterial stiffness and plasma leptin and adiponectin levels...
Conference Abstract

191. P186 IMPACT OF OBESITY ON VASCULAR STRUCTURE AND FUNCTION IN INDIVIDUALS WITH MULTIPLE SCLEROSIS

Thessa Hilgenkamp, Garett Griffith, Robert Motl, Tracy Baynard, Bo Fernhall
Pages: 107 - 107
Background: Cardiovascular disease is a leading cause of disease progression and death in multiple sclerosis (MS). Obesity has a negative impact on vascular structure and function, but whether this contributes to worse vascular function similarly in individuals with MS and controls is unknown. Aim:...
Conference Abstract

192. P187 IN SEVERE AORTIC STENOSIS, DECREASED SYSTEMIC VASCULAR RESISTANCE IS ASSOCIATED WITH A LARGER, THICKER WALLED VENTRICLE EXCEPT FOR THE SEPTUM

Anish Bhuva, Thomas Treibel, Georgia Doumou, Antonio De Marvao, Carlo Biffi, Timothy Dawes, Siana Jones, Declan O’Regan, James Moon, Alun Hughes, Charlotte Manisty
Pages: 107 - 107
Background: The ventricle in aortic stenosis (AS) is influenced by both valvular and vascular factors. The importance of afterload on left ventricular (LV) remodeling is not completely understood. Traditional imaging techniques which rely on geometric assumptions may not assess regional remodeling accurately. Aim:...
Conference Abstract

193. P188 EFFECTS OF RADIOTHERAPY ON LARGE VESSELS IN HODGKIN LYMPHOMA SURVIVORS

Anna Paini, Massimo Salvetti, Michela Buglione, Fabio Bertacchini, Giulia Maruelli, Francesca Trevisan, Liliana Baushi, Stefano Maria Magrini, Maria Lorenza Muiesan
Pages: 108 - 108
New chemotherapeutic drugs and radiation therapy have significantly improved cancer patient’s survival, although the cardiovascular (CV) side effects of cancer treatment are increasingly important. In previous studies, an increased risk of cerebrovascular complications such as stroke and transient ischemic...
Conference Abstract

194. P189 IDENTIFYING PTPN14-DEPENDENT MECHANISMS THAT INFLUENCE CLINICAL MANIFESTATIONS OF HEREDITARY HEMORRHAGIC TELANGIECTASIA

Ons Mamai
Pages: 108 - 108
Hereditary Hemorrhagic Telangiectasia (HHT) is a genetic disorder caused predominantly by loss of a single allele of ENG (HHT1) or ACVRL1 (HHT2). Global incidence is about 1 in 5,000. Clinical manifestations include cutaneous, mucosal and/or gastrointestinal (GI) tract telangiectases that can cause severe...
Conference Abstract

195. P190 CARDIOVASCULAR DISEASE IN AXIAL SPONDYLOARTHRITIS

Tatyana Khan, Aliakhunova Mavjuda
Pages: 108 - 108
Objectives: To estimate the state of the brachiocephalic trunk in patients with axial spondyloarthritis (SpA) and the relationship of changes with the clinical manifestations of the underlying disease. Material and methods: 55 patients with a diagnosis of axial spondyloarthritis were examined. The average...
Conference Abstract

196. P191 AORTIC STIFFNESS AND INFLAMMATION IN INFLAMMATORY BOWEL DISEASES: AN INDIVIDUAL PARTICIPANT DATA META-ANALYSIS

Luca Zanoli, Pierre Boutouyrie, Pasquale Fatuzzo, Kadir Ozturk, Maria Cappello, Eleni Theocharidou, Pietro Castellino, Stephane Laurent
Pages: 108 - 109
Importance: The finding that aortic pulse wave velocity (aPWV) is increased may explain why patients with inflammatory bowel disease (IBD) have an increased cardiovascular risk despite the low prevalence of classic cardiovascular risk factors. Objective: To determine why these patients have an increased...
Conference Abstract

197. P192 ENDOTHELIAL DYSFUNCTION, ARTERIAL STIFFNESS IN LUNG TRANSPLANTED INDIVIDUALS

Renáta Marietta Böcskei, Béla Benczúr, Veronika Müller, Noémi Eszes, György Láng, Attila Cziráki, György Losonczy, Anikó Bohács
Pages: 109 - 109
Background: The immunosuppressive treatment after organ transplantation highly contribute to evolve cardiovascular comorbidities like hypertension, hyperlipidemia, diabetes and kidney diseases. The effect of hypertriglyceridemia could cause accelerated atherosclerosis. Previous smoking and excessive...
Conference Abstract

198. P193 CAROTID ATHEROSCLEROSIS, AORTIC STIFFNESS AND PENILE VASCULAR DAMAGE IN PATIENTS WITH ERECTILE DYSFUNCTION: RELATION TO LOW DENSITY LIPOPROTEIN LEVELS AND STATIN THERAPY

Nikolaos Ioakeimidis, Charalambos Vlachopoulos, Athanasios Angelis, Dimitrios Terentes- Printzios, Christos Georgakopoulos, Konstantinos Aznaouridis, Iosif Koutagiar, John Skoumas, Skliros, Dimitrios Tousoulis
Pages: 109 - 109
Purpose/Background/Objectives: Aim of the study is to examine the possible differentiation of aortic stiffness, carotid atherosclerosis and penile vascular function among patients with erectile dysfunction (ED) according to cholesterol level and statin therapy. Methods: We measured carotid intima-media...
Conference Abstract

199. P194 CARDIOVASCULAR RESPONSES TO INCREASED PRESSURE DURING HEALTHY PREGNANCY

Victoria L. Meah, Rob E. Shave, Karianne Backx, Eric Stöhr
Pages: 109 - 110
A long-standing question is whether pregnant females, who bear an increased biological stress, experience exacerbated cardiovascular responses during physiological challenge. At rest, pregnant females have reduced blood pressure, increased cardiac output, heart rate and stroke volume (1), with reported...