P158 ASSOCIATION BETWEEN AMBULATORY ARTERIAL STIFFNESS INDEX, MARKERS OF BLOOD PRESSURE VARIABILITY AND INDICES OF SUBCLINICAL VASCULAR DAMAGE IN OBESE CHILDREN

DOI

10.1016/j.artres.2017.10.179How to use a DOI?

Abstract

Objective: Ambulatory Arterial Stiffness Index (AASI) and symmetric AASI (sAASI) have been proposed as indices of arterial stiffness obtained by 24-hour ambulatory blood pressure monitoring (ABPM). ABPM allows the analysis of indices of BP variability like day and night SD, BP dipping, weighted 24-h SD (wSD), average real variability (ARV). Aim of the present study was to address the relationship between these indices and other markers of vascular subclinical damage in children.

Design and Method: 45 obese children were included. Children underwent vascular measurements, including: (i) office and 24-hour ambulatory BP; (ii) brachial flow-mediated dilatation (FMD), carotid intima media thickness (cIMT), and distensibility (cDC); (iii) systemic arterial stiffness (SIDVP). From ABPM we calculate AASI, sAASI, ARV, SD, SD, systolic and diastolic dipping and wSD.

Results: ARV showed a significant correlation with SIDVP (r = 0.379; p = 0.023). AASI but not sAASI correlated with FMD (r = 0.361; p = 0.031). In the population divided in hypertensive (n = 11)/normotensive (n = 34), ARV was associated with SIDVP only in normotensive (r = 0.446; p = 0.015). In normotensive, z score-BMI was correlated with both sAASI and wSD (respectively 0.340; p = 0.049 and 0.423; p = 0.014), wSD correlated with FMD (r = 0.384; p = 0.048); in hypertensive children, ARV correlated with FMD (r = 0.828; p = 0.011; rspearman = 0.738; p = 0.037). No indices of BP variability correlated with cIMT or cDC.

Conclusions: BP variability, in particular ARV, shows a correlation with systemic but not local vascular stiffness in a sample of obese children, suggesting a relation between daily BP variability and arterial elastic properties. Further studies, especially perspective ones, are needed to clarify the pathophysiological significance of these relations.

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TY  - JOUR
AU  - Angela Tagetti
AU  - Sara Bonafini
AU  - Cristiano Fava
PY  - 2017
DA  - 2017/12/06
TI  - P158 ASSOCIATION BETWEEN AMBULATORY ARTERIAL STIFFNESS INDEX, MARKERS OF BLOOD PRESSURE VARIABILITY AND INDICES OF SUBCLINICAL VASCULAR DAMAGE IN OBESE CHILDREN
JO  - Artery Research
SP  - 104
EP  - 105
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.179
DO  - 10.1016/j.artres.2017.10.179
ID  - Tagetti2017
ER  -