Artery Research

Volume 20, Issue C, December 2017, Pages 109 - 109

P192 ENDOTHELIAL DYSFUNCTION, ARTERIAL STIFFNESS IN LUNG TRANSPLANTED INDIVIDUALS

Authors
Renáta Marietta Böcskei1, Béla Benczúr2, Veronika Müller1, Noémi Eszes1, György Láng3, Attila Cziráki4, György Losonczy1, Anikó Bohács1
1Semmelweis University Budapest, Department of Pulmonology, Hungary
2Balassa János Hospital of Szekszárd, Hungary
3Medical University of Vienna, Austria
4University of Pécs, Department of Cardiology, Hungary
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.193How to use a DOI?
Abstract

Background: The immunosuppressive treatment after organ transplantation highly contribute to evolve cardiovascular comorbidities like hypertension, hyperlipidemia, diabetes and kidney diseases. The effect of hypertriglyceridemia could cause accelerated atherosclerosis. Previous smoking and excessive inflammatory response could increase the cardiovascular risk on those patients who were transplanted because of end-staged chronic obstructive pulmonary disease. Long term follow up needed on lung transplanted (LuTx) patient with cardiovascular risk assessment and to screen patients with vulnerable cardiovascular diseases. However, the correlation between LuTx patients and arterial stiffness is not investigated in the literature.

Method: We investigated the arterial stiffness parameters in 51 LuTx and 49 healthy individuals. The arterial stiffness parameters were measured with oscillometric method (Tensiomed Arteriograph). Aortic pulse wave velocity (aoPWV), augmentation index (Aix), central systolic blood pressure (cSBP) and aortic pulse wave reflection time (RT) were determined.

Results: We found increased aoPWV and Aix values in lung transplanted (LuTx) patients than in the healthy individuals. Significant higher aoPWV (8.45 vs 7.49 m/s; p = 0.045), and RT (120 vs 134 ms; p = 0,0004) were found. Patients who were transplanted because of COPD and lung fibrosis the aoPWV were significantly higher versus the patient who were transplanted because of cystic fibrosis or pulmonary hypertension.

Conclusion: We strongly recommend the long term cardiovascular follow up on lung transplanted patient, because of the common systemic atherogen effect of the frequent infection and immunsupressive therapy.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
109 - 109
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.193How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Renáta Marietta Böcskei
AU  - Béla Benczúr
AU  - Veronika Müller
AU  - Noémi Eszes
AU  - György Láng
AU  - Attila Cziráki
AU  - György Losonczy
AU  - Anikó Bohács
PY  - 2017
DA  - 2017/12/06
TI  - P192 ENDOTHELIAL DYSFUNCTION, ARTERIAL STIFFNESS IN LUNG TRANSPLANTED INDIVIDUALS
JO  - Artery Research
SP  - 109
EP  - 109
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.193
DO  - 10.1016/j.artres.2017.10.193
ID  - Böcskei2017
ER  -