Artery Research

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Volume 20, Issue C, December 2017, Pages 51 - 51

2.4 BRACHIAL CUFF RESERVOIR CHARACTERISTICS AND END-ORGAN MARKERS OF CARDIOVASCULAR RISK IN AUSTRALIAN ADULTS: A CROSS-SECTIONAL STUDY

Authors
Xiaoqing Peng1, Martin Schultz1, Michael Cheung2, 3, 4, Melissa Wake2, 3, 5, Jonathan Mynard2, 3, 4, David Burgner2, 3, 6, Richard Liu3, James Sharman1
1Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia
2The University of Melbourne, Parkville, Victoria, Australia
3Murdoch Children’s Research Institute, Parkville, Victoria, Australia
4The Royal Children’s Hospital, Melbourne, Victoria, Australia
5The University of Auckland, Grafton, Auckland, New Zealand
6Monash University, Clayton, Victoria, Australia
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.026How to use a DOI?
Abstract

Objective: Reservoir-excess pressure measured using tonometry methods predicts cardiovascular events, but the operator-dependency of tonometry is an impediment to widespread use. A cuff-based blood pressure device has been developed to derive reservoir-excess pressure from measured brachial pressure waveforms, but whether this method is independently associated with cardiovascular risk has never been investigated and this was the aim of this study.

Methods: 1874 adult participants (age 43.7 ± 5.2 years, 11% male) from the Longitudinal Study of Australian Children’s Child Health CheckPoint study had reservoir pressure (RP) and excess pressure (XSP) derived from the brachial pressure waveform measured using cuff oscillometry (SphygmoCor XCEL, AtCor Medical, Sydney).

Central hemodynamics (augmentation index and central blood pressure) were estimated from the central pressure waveform. Carotid intima-media thickness (cIMT, n = 1467) and carotid-to-femoral pulse wave velocity (cf-PWV, n = 1674) were measured as end-organ markers of cardiovascular risk.

Results: XSP and RP were associated with cIMT after adjusting for age, sex, waist-to-hip ratio, heart rate (HR) and central hemodynamic indices (β = 0.070, p = 0.027 and β = 0.052, p = 0.047). RP was also significantly associated with cf-PWV after adjusting for the same variables as above (β = 0.128, p < 0.001). The additional reservoir-excess pressure variables in a model that originally included the Framingham risk score and HR strengthened the evidence for associations with cIMT and cf-PWV (p < 0.001 for all R2 changes).

Conclusion: Cuff-based measures of reservoir-excess pressure are significantly associated with end-organ markers of cardiovascular risk independent of traditional risk factors. This cuff method may provide additional information to improve cardiovascular risk stratification.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
51 - 51
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.026How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Xiaoqing Peng
AU  - Martin Schultz
AU  - Michael Cheung
AU  - Melissa Wake
AU  - Jonathan Mynard
AU  - David Burgner
AU  - Richard Liu
AU  - James Sharman
PY  - 2017
DA  - 2017/12/06
TI  - 2.4 BRACHIAL CUFF RESERVOIR CHARACTERISTICS AND END-ORGAN MARKERS OF CARDIOVASCULAR RISK IN AUSTRALIAN ADULTS: A CROSS-SECTIONAL STUDY
JO  - Artery Research
SP  - 51
EP  - 51
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.026
DO  - 10.1016/j.artres.2017.10.026
ID  - Peng2017
ER  -