Part of Springer Nature

Artery Research

Volume 20, Issue C, December 2017, Pages 1 - 7

LDL fatty acids composition as a risk biomarker of cardiovascular disease

Authors
Hashem Nayeria, *, Gholam Ali Naderib, Sedigheh Asgaric, Masoumeh Sadeghib, Maryam Boshtamc, Samaneh Mohamadzadehd, Nasim Babaknejada, e
aDepartment of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
bCardiovascular Research Institute, Cardiac Rehabilitation Center, Isfahan University of Medical Sciences, Isfahan, Iran
cCardiovascular Research Institute, Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
dFaculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
eDepartment of Biochemistry, Faculty of Science, Shahrekord University, Shahrekord, Iran
*Corresponding author. Department of Biochemistry, Falavarjan Branch, Islamic Azad University, P.O. Box 81465-1148, Isfahan, Iran. Fax: +98 031 33373435. E-mail addresses: hnaieri@gmail.com, Nayeri@iaufala.ac.ir (H. Nayeri).
Corresponding Author
Hashem Nayeri
Received 7 March 2017, Revised 9 June 2017, Accepted 3 August 2017, Available Online 1 September 2017.
DOI
https://doi.org/10.1016/j.artres.2017.08.001How to use a DOI?
Keywords
Fatty acids, Saturated fatty acids, Mono unsaturated fatty acids, Poly unsaturated fatty acids, LDL, ox-LDL, Coronary artery disease
Abstract

Objective: Fatty acid composition of Low-density lipoprotein (LDL) particle is an effective factor in LDL oxidation and atherosclerotic plaques formation. This study evaluates the relationship between LDL fatty acid composition and coronary artery disease (CAD).

Methods: 42 men with coronary artery disease (CAD-group) and 40 men without coronary artery disease (non-CAD-group) were selected. LDL fatty acid composition of blood samples was measured by gas chromatography.

Results: Ox-LDL was significantly high in CAD-group. Poly unsaturated fatty acids (PUFA) and PUFA/MUFA (Mono unsaturated fatty acids), linoleic acid and arachidonic acid were significantly higher in CAD-group than in non-CAD-group. In CAD-group, a reverse correlation was observed between oleic acid concentrations and ox-LDL levels and a direct correlation was seen between arachidonic acid concentrations and ox-LDL levels.

Conclusion: Composition of LDL is related to atherosclerosis and CAD. High levels of arachidonic and linoleic acids could increase LDL oxidation and atherosclerotic plaques formation. In addition, LDL arachidonic acid levels could be a better predictor of CAD.

Copyright
© 2017 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
1 - 7
Publication Date
2017/09
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.1016/j.artres.2017.08.001How to use a DOI?
Copyright
© 2017 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Hashem Nayeri
AU  - Gholam Ali Naderi
AU  - Sedigheh Asgari
AU  - Masoumeh Sadeghi
AU  - Maryam Boshtam
AU  - Samaneh Mohamadzadeh
AU  - Nasim Babaknejad
PY  - 2017
DA  - 2017/09
TI  - LDL fatty acids composition as a risk biomarker of cardiovascular disease
JO  - Artery Research
SP  - 1
EP  - 7
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.08.001
DO  - https://doi.org/10.1016/j.artres.2017.08.001
ID  - Nayeri2017
ER  -