LDL fatty acids composition as a risk biomarker of cardiovascular disease
- https://doi.org/10.1016/j.artres.2017.08.001How to use a DOI?
- Fatty acids, Saturated fatty acids, Mono unsaturated fatty acids, Poly unsaturated fatty acids, LDL, ox-LDL, Coronary artery disease
Objective: Fatty acid composition of Low-density lipoprotein (LDL) particle is an effective factor in LDL oxidation and atherosclerotic plaques formation. This study evaluates the relationship between LDL fatty acid composition and coronary artery disease (CAD).
Methods: 42 men with coronary artery disease (CAD-group) and 40 men without coronary artery disease (non-CAD-group) were selected. LDL fatty acid composition of blood samples was measured by gas chromatography.
Results: Ox-LDL was significantly high in CAD-group. Poly unsaturated fatty acids (PUFA) and PUFA/MUFA (Mono unsaturated fatty acids), linoleic acid and arachidonic acid were significantly higher in CAD-group than in non-CAD-group. In CAD-group, a reverse correlation was observed between oleic acid concentrations and ox-LDL levels and a direct correlation was seen between arachidonic acid concentrations and ox-LDL levels.
Conclusion: Composition of LDL is related to atherosclerosis and CAD. High levels of arachidonic and linoleic acids could increase LDL oxidation and atherosclerotic plaques formation. In addition, LDL arachidonic acid levels could be a better predictor of CAD.
- © 2017 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - JOUR AU - Hashem Nayeri AU - Gholam Ali Naderi AU - Sedigheh Asgari AU - Masoumeh Sadeghi AU - Maryam Boshtam AU - Samaneh Mohamadzadeh AU - Nasim Babaknejad PY - 2017 DA - 2017/09 TI - LDL fatty acids composition as a risk biomarker of cardiovascular disease JO - Artery Research SP - 1 EP - 7 VL - 20 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2017.08.001 DO - https://doi.org/10.1016/j.artres.2017.08.001 ID - Nayeri2017 ER -