Artery Research

Volume 20, Issue C, December 2017, Pages 56 - 56

4.1 PILOT STUDY ON THE PRECLINICAL VASCULAR DAMAGE IN BOLIVIAN PATIENTS WITH CHAGAS INDETERMINATE CHRONIC PHASE

Authors
Filippo Valbusa1, Andrea Angheben2, Verena Zerbato3, Andrea Chiampan4, Davide Agnoletti1, Cristiano Fava3, Zeno Bisoffi2, Guido Arcaro1
1Department of Internal Medicine, Sacro Cuore – Don Calabria Hospital, Negrar, Italy
2Department of Tropical Medicine, Sacro Cuore – Don Calabria Hospital, Negrar, Italy
3Department of Internal Medicine, University of Verona, Verona, Italy
4Department of Cardiology, Sacro Cuore – Don Calabria Hospital, Negrar, Italy
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.039How to use a DOI?
Abstract

Background: In Italy, the prevalence of seropositivity for Trypanosoma cruzi in immigrants from endemic countries is about 11.3% (30.7% for Bolivian immigrants).

The disease acute phase is usually asymptomatic, often leading to chronic infection that may remain silent for life (chronic indeterminate phase). Chagas heart disease is the most severe and frequent (20–30%) form of chronic phase; its pathophysiology shares similar mechanisms with the arterial impairment associated to other diseases (diabetes, hypertension, aging), leading to chronic inflammation and stiffening. In literature there are no data about the possible elastic arteries deterioration in Chagas disease. Our hypothesis was that early arterial compliance modifications might be found in the chronic indeterminate phase of Chagas disease.

Methods: 35 consecutive Bolivian subjects (21 with indeterminate Chagas disease, mean age [SD] 44.2 [8.2], 5 women, and 14 controls, mean age 40.2 [8.2], 5 women) accessing the service of Tropical Medicine were enrolled. Staging of the disease, laboratory assay, and hemodynamics (central and peripheral blood pressure [BP], aortic pulse wave velocity [PWV], carotid intima media thickness, cardiac ultrasound) were assessed.

Results: No clinical nor laboratory differences were found between the cases and controls. Peripheral and central BPs components were similar. Chagas patients presented higher PWV than controls (7.87 ± 1.29 vs 6.43 ± 1.12 m/s, p = 0.002), even when adjusting for age, mean BP, heart rate, body mass index, smoking status (p = 0.001).

Conclusion: Patients with Chagas indeterminate chronic phase presented higher arterial stiffness than controls, pointing out an early arterial involvement as the possible etiological mechanism underlying the increased cardiovascular risk in these patients.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
56 - 56
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.039How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Filippo Valbusa
AU  - Andrea Angheben
AU  - Verena Zerbato
AU  - Andrea Chiampan
AU  - Davide Agnoletti
AU  - Cristiano Fava
AU  - Zeno Bisoffi
AU  - Guido Arcaro
PY  - 2017
DA  - 2017/12/06
TI  - 4.1 PILOT STUDY ON THE PRECLINICAL VASCULAR DAMAGE IN BOLIVIAN PATIENTS WITH CHAGAS INDETERMINATE CHRONIC PHASE
JO  - Artery Research
SP  - 56
EP  - 56
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.039
DO  - 10.1016/j.artres.2017.10.039
ID  - Valbusa2017
ER  -