Artery Research

Volume 20, Issue C, December 2017, Pages 47 - 47

1.1 CENTRAL BLOOD PRESSURE, STATINS AND LDL-CHOLESTEROL: A MEDIATION ANALYSIS

Authors
Florence Lamarche1, Mohsen Agharazii2, Francois Madore1, Remi Goupil1
1Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada
2CHU de Québec, Hôtel-Dieu de Québec, Québec, QC, Canada
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.015How to use a DOI?
Abstract

Background: Central blood pressure (CBP) is a better predictor of cardiovascular burden than peripheral blood pressure (BP). While studies have suggested a reduction in peripheral BP with statins, it remains uncertain to what extent statins reduce CBP and whether this reduction is mediated through a decrease in LDL-cholesterol (LDL).

Methods: Of the 20,004 CARTaGENE participants, 17,011 had CBP and LDL measurements (n = 13,439 without, n = 3,133 with statins). Linear and logistic regression analyses were used to evaluate the association between CBP, LDL and statin use (after stratification for treatment indication for the latter). The impact of LDL on the association between statin use and CBP was determined by mediation analyses. All analyses were adjusted for age, sex, diabetes, cardiovascular disease, smoking, eGFR, BMI, uric acid, heart rate, anti-hypertensive agents and aspirin.

Results: Lower levels of LDL were associated with lower systolic and diastolic CBP in participants treated with (b = 0.098 and 0.125; p < 0.001) and without statins (b = 0.089 and 0.105; p < 0.001). Statin use as primary prevention (per ACC/AHA guidelines; n = 8,865) was also associated with lower systolic CBP, diastolic CBP and central pulse pressure (b = −0.091, −0.073 and −0.055; p < 0,001). Mediation analyses demonstrated that 15%, 46% and -22% of these effects were achieved through the concomitant changes in LDL (Table 1). In secondary prevention (n = 995), statins use was not associated with lower CBP, although the small sample size may lack power.

Conclusion: In this populational cohort, statin use as primary prevention is associated with lower CBP. These changes are mediated directly by statins but also indirectly through effects on LDL.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
47 - 47
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.015How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Florence Lamarche
AU  - Mohsen Agharazii
AU  - Francois Madore
AU  - Remi Goupil
PY  - 2017
DA  - 2017/12/06
TI  - 1.1 CENTRAL BLOOD PRESSURE, STATINS AND LDL-CHOLESTEROL: A MEDIATION ANALYSIS
JO  - Artery Research
SP  - 47
EP  - 47
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.015
DO  - 10.1016/j.artres.2017.10.015
ID  - Lamarche2017
ER  -