Artery Research

Volume 20, Issue C, December 2017, Pages 97 - 98

P145 MEASUREMENT OF BLOOD PRESSURE DEPENDENCY OF CAROTID-FEMORAL PULSE WAVE VELOCITY

Authors
Mark Butlin1, Isabella Tan1, Fatemeh Shirbani1, Bart Spronck2, Alberto Avolio1
1Macquarie University, Australia
2Maastricht University, Netherlands
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.157How to use a DOI?
Abstract

Background: Carotid-femoral pulse wave velocity (cfPWV) is predictive of cardiovascular outcomes but clinical interpretation is confounded by blood pressure (BP) interaction. This study proposes a method for PWV pressure dependency measurement suitable for routine clinical or research use.

Methods: Carotid tonometry and thigh-cuff volumetric displacement allowed cfPWV measurement in the seated and supine position. Brachial oscillometry gave systemic BP. Solving simultaneous equations describing the seated and supine measurement gave hydrostatic BP change across the carotid-femoral arterial path and the pressure dependency of cfPWV. Stepwise multiple linear regression quantified the association of pressure dependency of cfPWV with demographic and cardiovascular parameters.

Results: Of 88 subjects (19 to 91 years, 41 female), 4 (4.5%) had an unexpected increase in cfPWV with decreased BP from seated to supine position. Cross-sectional analysis in the remaining cohort showed blood pressure dependency of cfPWV correlated with brachial pulse pressure (β = 0.40, p < 0.001), diastolic pressure (β = −0.33, p < 0.001), gender (β = 0.25 for female/male = 1/0, p = 0.010), and heart rate (β = 0.23, p = 0.033).

There was no correlation with supine cfPWV nor age. Average pressure dependency of cfPWV was 0.6±0.3 m/s per 10 mmHg (range of 0.09 to 1.5 m/s per 10 mmHg). Average change in transmural BP across the carotid-femoral arterial path was 20±7 mmHg (diastolic BP change 4±7 mmHg; hydrostatic BP change 16±2 mmHg).

Conclusions: Changing from seated to supine position imparts a BP change across the carotid- femoral arterial path, the majority of the effect being hydrostatic. Measuring cfPWV in these two stable BP positions allows calculation of the BP dependency of cfPWV.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
20 - C
Pages
97 - 98
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.157How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Mark Butlin
AU  - Isabella Tan
AU  - Fatemeh Shirbani
AU  - Bart Spronck
AU  - Alberto Avolio
PY  - 2017
DA  - 2017/12/06
TI  - P145 MEASUREMENT OF BLOOD PRESSURE DEPENDENCY OF CAROTID-FEMORAL PULSE WAVE VELOCITY
JO  - Artery Research
SP  - 97
EP  - 98
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.157
DO  - 10.1016/j.artres.2017.10.157
ID  - Butlin2017
ER  -