Artery Research

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Volume 20, Issue C, December 2017, Pages 79 - 79

P123 RESERVOIR PRESSURE IS INDEPENDENTLY ASSOCIATED WITH 11–12 YEAR OLD’S KIDNEY FUNCTION: POPULATION-DERIVED STUDY

Authors
Xiaoqing Peng1, Martin Schultz1, Michael Cheung2, 3, 4, Melissa Wake2, 3, 5, Jonathan Mynard2, 3, 4, David Burgner2, 3, 6, Richard Liu3, James Sharman1
1Menzies Institute for Medical Research, University of Tasmania, Hobart, Tas, Australia
2The University of Melbourne, Parkville, Victoria, Australia
3Murdoch Children’s Research Institute, Parkville, Victoria, Australia
4The Royal Children’s Hospital, Melbourne, Victoria, Australia
5The University of Auckland, Grafton, Auckland, New Zealand
6Monash University, Clayton, Victoria, Australia
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.105How to use a DOI?
Abstract

Introduction: Reservoir pressure (RP) and excess pressure (XSP) independently predict cardiovascular events in adults, but have never been investigated as markers of cardiovascular risk among children. This study aimed to determine the association of RP and XSP with end-organ makers of cardiovascular risk related to kidney function and large artery pre-atherosclerosis.

Methods: Participants were 1874 11–12 year-old children (50% male) from the Longitudinal Study of Australian Children’s Child Health CheckPoint study. Brachial blood pressure was measured by cuff oscillometric device (SphygmoCor XCEL, AtCor, Sydney). The same device was used to derive reservoir pressure (RP) and excess pressure (XSP) from the brachial pressure waveform. Kidney function was determined from estimated glomerular filtration rate (eGFR, n = 926) and large artery pre-atherosclerosis was determined from carotid intima media thickness (cIMT, n = 1131) using ultrasound.

Results: The eGFR was significantly correlated with RP peak (r = −0.109, p = 0.001), RP integral (r = −0.136, p < 0.001), XSP peak (r = 0.096, p = 0.004) and XSP integral (r = 0.102, p = 0.002). The RP (whether expressed as peak or integral) was significantly associated with eGFR after adjusting for sex, waist-to-hip ratio, heart rate and brachial BP indices (RP peak β = −0.079, p = 0.02, partial R2 = 0.006 and RP integral β = −0.079, p = 0.02, partial R2 = 0.007). XSP was not independently associated with eGFR after adjusting for the above variables. Neither RP nor XSP were significantly associated with cIMT.

Conclusion: Independent of conventional risk factors, RP was significantly associated with kidney function among a large population of Australian children. The non-invasive method to derive RP using an oscillometric cuff device could provide useful clinical information in children.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
20 - C
Pages
79 - 79
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.105How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Xiaoqing Peng
AU  - Martin Schultz
AU  - Michael Cheung
AU  - Melissa Wake
AU  - Jonathan Mynard
AU  - David Burgner
AU  - Richard Liu
AU  - James Sharman
PY  - 2017
DA  - 2017/12/06
TI  - P123 RESERVOIR PRESSURE IS INDEPENDENTLY ASSOCIATED WITH 11–12 YEAR OLD’S KIDNEY FUNCTION: POPULATION-DERIVED STUDY
JO  - Artery Research
SP  - 79
EP  - 79
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.105
DO  - 10.1016/j.artres.2017.10.105
ID  - Peng2017
ER  -