Artery Research

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Volume 20, Issue C, December 2017, Pages 106 - 107

P185 CARDIO-ANKLE VASCULAR INDEX AND PLASMA LEVELS OF LEPTIN AND ADIPONECTIN IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Authors
Kwame Yeboah1, Richard NA. Owusu Mensah1, Dzifa Dey2, Vincent Boima2, J. Kennedy Cruickshank3
1Department of Physiology, School of Biomedical & Allied Health Sciences, University of Ghana, Accra, Ghana
2Department of Medicine & Therapeutics, School of Medicine & Dentistry, University of Ghana, Ghana
3Cardiovascular Medicine Group, Division of Diabetes and Nutrition, King’s College and King’s Health Partners, London, UK
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.186How to use a DOI?
Abstract

Objective: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease associated with vascular derangement [1]. Leptin and adiponectin are adipokines with immunomodulatory and vascular functions [2]. We studied the association between arterial stiffness and plasma leptin and adiponectin levels in SLE patients in Ghana.

Methods: In a case control design involving 80 SLE patients and 90 non-SLE controls, arterial stiffness was assessed by cardio-ankle vascular index (CAVI) and heart-ankle pulse wave velocity (haPWV) using Vasera 1500N. Circulating levels of leptin, adiponectin, insulin and C-reactive protein (CRP) were measured by ELISA.

Results: Compared to non-SLE controls, SLE patients had higher levels of CAVI (7.3±1.1 vs 6.1±1, p < 0.001), haPWV (7.7±1.3 vs 6.5±0.8 m/s, p = <0.001), insulin [76.8 (45.9–184.8) vs 39.8 (22.9–86.3) pmol/ml, p = 0.007], leptin [856.1 (364.8–1509.3) vs 426.7 (426.8 (84.7–1178.7) ng/ml, p = 0.039], adiponectin [1.1 (0.8–2.3) vs 1.6 (1.3–2.6) ng/ml, p = 0.039] and CRP [1.6 (0.8–2.2) vs 0.9 (0.6–1.2) mg/ml, p = 0.021]. In a partial correlation analysis with adjustment for age and BMI, CAVI was associated with leptin (r = 0.21, p = 0.031), CRP (r = 2.9, p < 0.001) and insulin (r = 0.18, p = 0.04), but not adiponectin (r = −0.15, p = 0.068).

Conclusion: In our study population, SLE patients have higher arterial stiffness, associated with low-grade inflammation and deranged circulating adipokine levels.

Open Access
This is an open access article distributed under the CC BY-NC license.

References

1.N Tiffin, B Hodkinson, and I Okpechi, Lupus in Africa: can we dispel the myths and face the challenges?, Lupus, Vol. 23, No. 1, 2014, pp. 102-111.
2.T-P Zhang, H-M Li, R-X Leng, X-P Li, X-M Li, H-F Pan, and D-Q Ye, Plasma levels of adipokines in systemic lupus erythematosus patients, Cytokine, Vol. 86, 2016, pp. 15-20.
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Journal
Artery Research
Volume-Issue
20 - C
Pages
106 - 107
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.186How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Kwame Yeboah
AU  - Richard NA. Owusu Mensah
AU  - Dzifa Dey
AU  - Vincent Boima
AU  - J. Kennedy Cruickshank
PY  - 2017
DA  - 2017/12/06
TI  - P185 CARDIO-ANKLE VASCULAR INDEX AND PLASMA LEVELS OF LEPTIN AND ADIPONECTIN IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
JO  - Artery Research
SP  - 106
EP  - 107
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.186
DO  - 10.1016/j.artres.2017.10.186
ID  - Yeboah2017
ER  -