Artery Research

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Volume 20, Issue C, December 2017, Pages 73 - 73

P66 ASSOCIATION BETWEEN URINARY SODIUM EXCRETION, ENDOTHELIAL FUNCTION AND ARTERIAL STIFFNESS IN NON-DIABETIC HYPERTENSIVE PATIENTS

Authors
Michelle Cunha, Ana Rosa Cunha, Bianca Cristina Marques, Jenifer D’El-Rei, Samanta Mattos, Ronaldo Gismondi, Wille Oigman, Mario Neves
State University of Rio de Janeiro, Brazil
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.088How to use a DOI?
Abstract

Background: High salt intake has been associated with structural and functional vascular changes.1

Objective: To correlate urinary sodium excretion with endothelial function and arterial stiffness in non-diabetic hypertensive patients.

Methods: Cross-sectional study with non-diabetic hypertensive patients, both genders, aged 45–65 years, submitted to office blood pressure measurement, 24-hour urine sampling, carotid-femoral pulse wave velocity (PWV; Complior Analysis), central hemodynamic parameters by applanation tonometry (SphygmoCor) and microvascular reactivity by Laser Speckle Contrast Analysis (Pericam PSI)2.

Results: Patients (n = 18) were divided according to the urinary sodium excretion (UrNa) median: group 1 (UrNa <165mEq/24h) and group 2 (UrNa≥165mEq/24h). The mean age was 56 years, 72% were women. Although not statistically significant, group 2 presented higher systolic blood pressure (SBP, 136±12 vs 144±20 mmHg, p = 0.382) and diastolic blood pressure (84±10 vs 87±10 mmHg, p = 0.523). Serum insulin (11±5 vs 20±12 mcU/ml, p = 0.072), HOMA-IR (2.6±1.2 vs 4.9±3.0, p = 0.069), C-Reactive protein (CRP, 0.12±0.35 vs 0.78±0.83 mg/dL, p = 0.058) and PWV (8.8±2.1 vs 10.8±2.3 m/s, p = 0.093) were also higher in group 2. There were no significant differences in aortic SBP (127±16 vs 132±20 mmHg, p = 0.556), and in the peak of microvascular reactivity (95.5±24.0 vs 83.4±45.1, p = 0.505). Group 2 presented a higher proportion of patients with HOMA-IR greater than 2.7 (37.5 vs 70.0%, p = 0.047), CRP greater than 0.4 mg/dl (12.5 vs 55.6%; p = 0.064) and PWV greater than 10m/s (25 vs 80%, p = 0.020).

Conclusion: Although without significant differences in blood pressure and endothelial function, hypertensive patients with higher urinary sodium excretion showed changes suggestive of insulin resistance and arterial stiffness.

Open Access
This is an open access article distributed under the CC BY-NC license.

References

1.F Huang, P Yu, Y Yuan, Q Li, F Lin, Z Gao, F Chen, and P Zhu, The relationship between sodium excretion and blood pressure, urine albumin, central retinal arteriolar equivalent, BMC Cardiovasc Disord, Vol. 16, No. 1, 2016, pp. 194.
2.GA1 Tew, M Klonizakis, H Crank, JD Briers, and GJ Hodges, Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function, Microvasc Res, Vol. 82, No. 3, 2011, pp. 326-32.
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Journal
Artery Research
Volume-Issue
20 - C
Pages
73 - 73
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.088How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Michelle Cunha
AU  - Ana Rosa Cunha
AU  - Bianca Cristina Marques
AU  - Jenifer D’El-Rei
AU  - Samanta Mattos
AU  - Ronaldo Gismondi
AU  - Wille Oigman
AU  - Mario Neves
PY  - 2017
DA  - 2017/12/06
TI  - P66 ASSOCIATION BETWEEN URINARY SODIUM EXCRETION, ENDOTHELIAL FUNCTION AND ARTERIAL STIFFNESS IN NON-DIABETIC HYPERTENSIVE PATIENTS
JO  - Artery Research
SP  - 73
EP  - 73
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.088
DO  - 10.1016/j.artres.2017.10.088
ID  - Cunha2017
ER  -