Artery Research

Volume 20, Issue C, December 2017, Pages 54 - 54

3.5 HEART RATE DEPENDENCE OF REGIONAL AND LOCAL AORTIC PULSE WAVE VELOCITY IN RATS AS A FUNCTION OF BLOOD PRESSURE

Authors
Bart Spronck1, Isabella Tan2, Koen Reesink1, Dana Georgevsky2, Tammo Delhaas1, Alberto Avolio2, Mark Butlin2
1CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands
2Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Australia
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.035How to use a DOI?
Abstract

Background: Pulse wave velocity (PWV) is quantified by time difference of arrival of the blood pressure (BP) wave at two sites along the arterial bed (transit time; TT-PWV), or by combining measured arterial pressure and diameter using the Bramwell-Hill equation (BH-PWV). Besides the dependence of PWV on BP, TT-PWV also depends on heart rate (HR). The present study aimed to also quantify the dependence of BH-PWV’s on HR, as a function of diastolic BP (DBP).

Methods: Adult anaesthetised rats (n = 24) were randomly paced at 300–500 bpm, at 50-bpm steps. At each step, aortic TT-PWV (two pressure-tip catheters) and BH-PWV (pressure-tip catheter and ultrasound wall-tracking; abdominal aorta) were measured simultaneously, across a pharmacologically induced DBP range of 60–110 mmHg.

Data from 9142 heart beats was analysed using mixed-effects modelling.

Results: HR dependence of TT-PWV increased from 0.03 m/s/100 bpm at DBP = 60 mmHg to 0.06 m/s/100 bpm at DBP = 110 mmHg (both p ≤ 0.023). HR dependence of BH-PWV was 0.11 m/s/100 bpm at DBP = 60 and 85 mmHg, but paradoxically decreased to 0 at DBP = 110 mmHg (p = 0.686). This decrease in dependence is explicable in that standard BH-PWV uses an approximate derivative of pressure to diameter, which overestimates PWV with increasing pulse pressure (PP). PP decreases as HR increases, potentially causing a BH-PWV decrease with HR. This effect can be overcome by estimating the full pressure-diameter curve for each HR, and calculating the true derivative at DBP, yielding a BH-PWV that no longer shows significant HR dependence (p ≥ 0.076 at all DBPs).

Conclusions: BH-PWV and TT-PWV show a different HR dependence, affected by DBP.

Open Access
This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

Journal
Artery Research
Volume-Issue
20 - C
Pages
54 - 54
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.035How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Bart Spronck
AU  - Isabella Tan
AU  - Koen Reesink
AU  - Dana Georgevsky
AU  - Tammo Delhaas
AU  - Alberto Avolio
AU  - Mark Butlin
PY  - 2017
DA  - 2017/12/06
TI  - 3.5 HEART RATE DEPENDENCE OF REGIONAL AND LOCAL AORTIC PULSE WAVE VELOCITY IN RATS AS A FUNCTION OF BLOOD PRESSURE
JO  - Artery Research
SP  - 54
EP  - 54
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.035
DO  - 10.1016/j.artres.2017.10.035
ID  - Spronck2017
ER  -