Artery Research

Volume 20, Issue C, December 2017, Pages 108 - 108

P188 EFFECTS OF RADIOTHERAPY ON LARGE VESSELS IN HODGKIN LYMPHOMA SURVIVORS

Authors
Anna Paini1, Massimo Salvetti1, Michela Buglione2, Fabio Bertacchini1, Giulia Maruelli1, Francesca Trevisan2, Liliana Baushi2, Stefano Maria Magrini2, Maria Lorenza Muiesan1
1Internal Medicine, University of Brescia, Italy
2Radiation Oncology, University of Brescia, Italy
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.189How to use a DOI?
Abstract

New chemotherapeutic drugs and radiation therapy have significantly improved cancer patient’s survival, although the cardiovascular (CV) side effects of cancer treatment are increasingly important. In previous studies, an increased risk of cerebrovascular complications such as stroke and transient ischemic attack was described in patients undergoing neck radiotherapy.

Aim: To evaluate vascular carotid structural (IMT, plaque) and functional (carotid stiffness) damage, and changes in arterial stiffness (Carotido-femoral pulse wave velocity; cf- PWV) in Hodgkin Lymphoma survivors previously treated with radiotherapy.

Patients and methods: We enrolled206 Hodgkin lymphoma survivors (mean age 54±14years, 51%males, mean follow-up of9±6years).CV risk factors were investigated and atherosclerotic carotid damage was assessed by standard carotid ultrasound evaluation for intima-media thickness (IMT) measurement (MeanMax- IMT, CBMax, Tmax; n = 167); in 141 patients radiofrequency-based carotid stiffness analysis (distensibility; distensibility coefficient, DC; compliance coefficient; CC) was also performed.Cf-PWV measurement were obtained in 154 patients.

Results: A significant correlation between radiotherapy dose and: MeanMax-IMT (r = 0.20; p < 0.05), Tmax (r = 0.20; p < 0.05), distensibility (r = 0.24; p < 0.05), DC(r = 0.24; p < 0.05), CC(r = 0.24; p < 0.05) was observed. Patients were divided into 4 groups according to radiotherapy dose (Dose: 20–30; 31–36; 37–42;>42Gy). An increase in Tmax (1.27±0.61, 1.35±0.59, 1.46±0.69, 1.76±1.12 mm, p for trend <0.05) and in the prevalence of carotid plaque (29%, 31%, 47% and 55%, p for trend <0.05) was observed as related to dose-category. One-hundred-seventeen patients received neck irradiation (67 bilateral; 50 unilateral).In unilaterally irradiated patients, MeanMaxIMT was greater in the irradiated side as compared to unirradiated carotid artery and the difference reached statistical significance in the group of patients who received a high radiotherapy dose (0.97±0.35 vs 0.92±0.34 p < 0.05).Cf-PWV was significantly greater only in patients that received high dose (>42Gy), as compared to all the other dose groups (9.7±2.3 vs 8.3±2.2,8.0±1.5 and 8.3±1.4, p < 0.05).

Conclusions: In this large number ofHL survivors, carotid IMT, plaque prevalence and aortic and carotid stiffness were significantly related with radiotherapy doses. Carotid IMT, carotid and aortic stiffness were significantly higher in the irradiated carotid arteries, but only at doses >42Gy, suggesting that there may be a dose threshold for radiotherapy-induced carotid wall damage.

Open Access
This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

Journal
Artery Research
Volume-Issue
20 - C
Pages
108 - 108
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.189How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Anna Paini
AU  - Massimo Salvetti
AU  - Michela Buglione
AU  - Fabio Bertacchini
AU  - Giulia Maruelli
AU  - Francesca Trevisan
AU  - Liliana Baushi
AU  - Stefano Maria Magrini
AU  - Maria Lorenza Muiesan
PY  - 2017
DA  - 2017/12/06
TI  - P188 EFFECTS OF RADIOTHERAPY ON LARGE VESSELS IN HODGKIN LYMPHOMA SURVIVORS
JO  - Artery Research
SP  - 108
EP  - 108
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.189
DO  - 10.1016/j.artres.2017.10.189
ID  - Paini2017
ER  -