Artery Research

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Volume 20, Issue C, December 2017, Pages 69 - 69

P56 ASSOCIATION BETWEEN URIC ACID AND CARDIAC, VASCULAR AND RENAL TARGET ORGAN DAMAGE IN HYPERTENSIVES SUBJECTS

Authors
Alessandro Maloberti1, 2, Marisa Varrenti3, 2, Nicola Triglione1, 2, Lucia Occhi1, 2, Francesco Panzeri1, 2, Marta Alloni2, Luca Giupponi1, 2, Paola Vallerio2, Matteo Casati4, Guido Grassi1, Giuseppe Mancia1, Cristina Giannattasio1, 2
1Medicine and Surgery Department, Milano-Bicocca University, Milan, Italy
2Cardiology IV Unit, “A. De Gasperis” Department, Ospedale Niguarda Ca’ Granda, Milan, Italy
3Medicine and Surgery Department, Milano-Bicocca University, Milan, Italy
4Biochemical Laboratory, San Gerardo Hospital, Monza, Italy
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.078How to use a DOI?
Abstract

Background: To date no definitive results exist about the relationship of Serum Uric Acid (SUA) and TOD in HT subjects. We sought to determine if such an association exist between SUA and subclinical cardiac, vascular and renal alterations in HT.

Methods: We enrolled 632 consecutive outpatients, followed by the Hypertension Unit of S. Gerardo Hospital (Monza, Italy) affected by essential HT. We evaluated anamnestic data, clinical BP and laboratory data as well as TOD with cardiac echocardiography (both as LMVI and diastolic function – E/A), carotid ultrasound (IMT), arterial stiffness (PWV) and renal function analysis (creatinine and microalbumiuria).

Results: Age was 53.4±12.7 years, SBP/DBP were 140.5±18.8 and 85.1±13.1 mmHg and SUA was 5.2±1.4 mg/dL. Regarding TOD mean LVMI was 109.6±31.4g/m2, IMT 0.71±0.1 mm, PWV 8.5±2.2 m/s, while creatinine and microalbuminuria were 0.8±0.2 mg/dL and 25.4±126.1 mg/24h respectively. When subjects were divided into high and low SUA group (depending on the median SUA of 5.2 mg/dL), with similar age and BP values the first group showed significantly higher values of metabolic index (BMI, HDL chol, triglycerides and glucose, p < 0.001), LVMI (117.1±32.8 vs 102.1±28.1g/m2, p < 0.01), IMT (0.73±0.1 vs 0.70±0.1mm, p = 0.04), PWV (8.8±2.4 vs 8.3±2.1m/s, p = 0.01) and creatinine (0.9±0.2 vs 0.7±0.1 mg/dL, p < 0.01) and lower E/A (1,0±0.3 vs 1.1±0.3, p < 0.01). SUA showed significant correlation with sex, age, BMI, SBP, HDL chol, triglicerides, glucose, creatinine, IMT, LVMI and E/A. Regarding TOD only creatinine presents SUA as as significant determinant in logistic regression analysis.

Conclusion: In HT, SUA values correlate with metabolic derangements and with cardiac, vascular and renal TOD. The most significant correlation is with renal damage.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
69 - 69
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.078How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Alessandro Maloberti
AU  - Marisa Varrenti
AU  - Nicola Triglione
AU  - Lucia Occhi
AU  - Francesco Panzeri
AU  - Marta Alloni
AU  - Luca Giupponi
AU  - Paola Vallerio
AU  - Matteo Casati
AU  - Guido Grassi
AU  - Giuseppe Mancia
AU  - Cristina Giannattasio
PY  - 2017
DA  - 2017/12/06
TI  - P56 ASSOCIATION BETWEEN URIC ACID AND CARDIAC, VASCULAR AND RENAL TARGET ORGAN DAMAGE IN HYPERTENSIVES SUBJECTS
JO  - Artery Research
SP  - 69
EP  - 69
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.078
DO  - 10.1016/j.artres.2017.10.078
ID  - Maloberti2017
ER  -