Artery Research

Volume 20, Issue C, December 2017, Pages 65 - 65

P36 PULSE PRESSURE AMPLIFICATION AND ITS RELATIONSHIP WITH AGE IN YOUNG, APPARENTLY HEALTHY BLACK AND WHITE ADULTS: THE AFRICAN-PREDICT STUDY

Authors
Yolandi Breet1, 2, Alta Schutte1, 2, Hugo Huisman1, 2, Ruan Kruger1, 2, Johannes van Rooyen1, 2, Lebo Gafane-Matemane1, 2, Lisa Ware1
1Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa
2MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.066How to use a DOI?
Abstract

Background: Pulse pressure amplification (PPA), i.e. the amplification from central arteries to the periphery, is inversely related to arterial stiffness, organ damage and mortality. It is known that arterial stiffness is higher in black than white populations, but it is unclear if this is due to early vascular aging. We therefore investigated whether PPA declines earlier in young normotensive black South Africans, when compared to their white counterparts.

Methods: We included 875 black and white men and women from the African-PREDICT study (55% black, 41% men), aged 20–30 years, with no prior diagnosis of chronic disease, screened for normotensive clinic blood pressure (BP). We determined supine central PP (cPP), and supine brachial systolic – and diastolic BP, from which brachial PP (bPP) was calculated. PPA was defined as the ratio of the amplitude of the PP between these distal and proximal locations (bPP/cPP).

Results: We found the mean PPA to be lower in black compared to white participants (1.43 vs. 1.46; P = 0.013). In black adults PPA declined earlier with increasing age (P-trend < 0.001), with a weak trend in whites (P = 0.063) after adjustment for sex, socio-economic status, height and mean arterial pressure. In multivariable-adjusted regression, we found an independent inverse association between PPA and age only in the black group (β = −0.22, P < 0.001).

Conclusion: PPA declines earlier with age in normotensive black adults younger than 30 years, exemplifying early vascular aging which may predispose black individuals to future cardiovascular outcomes.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
20 - C
Pages
65 - 65
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.066How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Yolandi Breet
AU  - Alta Schutte
AU  - Hugo Huisman
AU  - Ruan Kruger
AU  - Johannes van Rooyen
AU  - Lebo Gafane-Matemane
AU  - Lisa Ware
PY  - 2017
DA  - 2017/12/06
TI  - P36 PULSE PRESSURE AMPLIFICATION AND ITS RELATIONSHIP WITH AGE IN YOUNG, APPARENTLY HEALTHY BLACK AND WHITE ADULTS: THE AFRICAN-PREDICT STUDY
JO  - Artery Research
SP  - 65
EP  - 65
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.066
DO  - 10.1016/j.artres.2017.10.066
ID  - Breet2017
ER  -