Artery Research

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2992 articles
Conference Abstract

P8.16 WHITE MATTER LESIONS ARE ASSOCIATED WITH A SIGNIFICANT DECREASE IN THE METABOLISM OF THE BRAIN GREY-MATTER FROM OLDER HYPERTENSIVE PATIENTS

Antoine Verger, Anna Kearney-Schwartz*, Serge Bracard, Veronique Roch
Pages: 37 - 38
White matter lesions, described as leukoaraiosis, are frequently documented in older hypertensive patients, but their consequence on brain metabolism remains debated. This study aimed at characterizing the changes in brain metabolism, assessed by [18F]-fluorodesoxyglucose Positron Emission Tomography...
Research Article

Assessment of Arterial Stiffness Index Calculated from Accelerated Photoplethysmography

Tomoaki Murakami, Katsunori Asai, Yoshinori Kadono, Takeo Nishida, Hajime Nakamura, Haruhiko Kishima
Pages: 37 - 40
Objective: An Arterial Stiffness Index (ASI) can be obtained by measuring finger photoplethysmogram using the SB200 pulse oximeter, giving a level between 1 and 6. However, it was unclear whether this method accurately reflected arterial stiffness. Brachial–Ankle Pulse Wave Velocity (baPWV) is an established...
Review Article

Endothelial nitric oxide synthase in the vascular wall: Mechanisms regulating its expression and enzymatic function

Michael Demosthenous, Charalambos Antoniades, Dimitris Tousoulis, Marios Margaritis, Kyriakoula Marinou, Christodoulos Stefanadis
Pages: 37 - 49
Endothelial nitric oxide synthase (eNOS) is the main source of nitric oxide (NO) in the vascular wall, a molecule with anti-inflammatory, antithrombotic, vasorelaxant, antioxidant and finally antiatherogenic properties. eNOS is expressed in vascular endothelium, and it uses l-arginine as a substrate,...
Research Article

Vasoreactivity of thoracic aorta in Nigella Sativa supplemented and/or exercise trained rats

Rabia Latif, Al-Asoom LI
Pages: 38 - 42
Background: Nigella Sativa (NS) induced vasorelaxation of aortic rings upon direct exposure has been documented in literature. This study was conducted to determine whether 8 weeks Nigella Sativa supplementation and/or exercise training may alter vascular sensitivity of rat aorta in normal, healthy rats. Methods:...
Research Article

Assessment of the relationship between serum uric acid level and atherosclerosis burden in patients undergoing coronary angiography in Ekbatan (Farshchian) hospital, Hamadan 2015

Mohammadreza Bayanati, Soudabeh Keshtkar, Maryam Farhadian, Fatemeh Ashtarani
Pages: 38 - 41
Background: Nowadays, cardiac disease is the most widespread reason of death in most countries such as Iran. Some studies have correlated serum uric acid level with risk of death in the patients of acute coronary syndrome. The study aimed to determine if there is any correlation between serum uric level...
Short Communication

A new teaching model of the systemic circulation that incorporates reservoir characteristics

John V. Tyberg, J. Christopher Bouwmeester, Lindsay M. Burrowes, Kim H. Parker, Nigel G. Shrive, Jiun-Jr. Wang
Pages: 38 - 41
A hydraulic teaching model of the human systemic circulation is proposed, based on the principles of the reservoir-wave approach. Reservoir characteristics are portrayed by the arterial tall-and-narrow and venous short-and-wide columns, the relative compliances of which are signified by their diameters....
Research Article

Primary African American Endothelial Cells Exhibit Endothelial Dysfunction with an Exacerbated Inflammatory Profile and Blunted MMP-2 Activity

Marc D. Cook, Chenyi Ling, Heather Grimm, Adelola Adeyemo, Maitha Aldokhayyil, Kevin Heffernan, Bo Fernhall, Michael Brown
Pages: 38 - 46
Endothelial dysfunction is associated with the racial health disparity in vascular dysfunction in African Americans (AAs). Matrix Metalloproteinase (MMP)-2 is constitutively expressed in endothelial cells (EC) and is a biomarker that has been associated with hypertension, as its properties are involved...
Conference Abstract

1.1 DIASTOLIC LEFT VENTRICULAR FUNCTION IN RELATION TO CIRCULATING METABOLIC BIOMARKERS IN A GENERAL POPULATION

Zhen Yu Zhang*, Vannina Marrachelli, Lutgarde Thijs, Wen Yi Yang, Fang Fei Wei, Daniel Monleon, Lotte Jacobs, Tim Nawrot, Peter Verhamme, Jens-Uwe Voigt, Tatiana Kuznetsova, Josep Redón, Jan Staessen
Pages: 39 - 39
Background: The metabolic signature associated with subclinical diastolic left ventricular (LV) dysfunction in the general population is unknown. Objectives: This population study aimed at identifying a specific profile of circulating me-tabolites associated with asymptomatic diastolic LV dysfunction. Methods:...
Conference Abstract

1.2 AGE-DEPENDENT ASSOCIATION OF 24-HOUR PERIPHERAL AND CENTRAL PULSE PRESSURES WITH STROKE VOLUME

Giacomo Pucci*, Francesca Battista, Fabio Anastasio, Mariano Edoardo Crapa, Leandro Sanesi, Giuseppe Schillaci
Pages: 39 - 39
Objective: Pulse pressure (PP) is a complex physiologic trait affected by many variables, including LV contractility (reflected by stroke volume), arterial stiffness, and central-to-brachial amplification.The impact of age on the relationship between stroke volume and central or brachial PP has not been...
Conference Abstract

1.3 PAST SMOKERS DECELERATE VASCULAR AGING IN THE LONG TERM

Dimitrios Terentes-Printzios*, Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Athanasios Aggelis, Panagiotis Xaplanteris, Panagiota Pietri, Dimitrios Tousoulis
Pages: 39 - 40
Objectives: Smoking has an unfavorable effect on arterial properties. Vascular aging is an independent predictor of cardiovascular risk. We examined the effect of quitting smoking on the progression of arterial stiffness. Methods: 142 subjects (mean age 51.9 ± 10.8 years, 94 men) with no established...
Research Article

Anatomical characterization of the vertebral artery from a local study population using angiography by computed tomography

Gloria Patricia Baena-Caldas, Juan Felipe Orejuela Zapata, Ana María Granados Sánchez
Pages: 39 - 43
Purpose: Despite most anatomical variations of the vertebral artery (VA) related to the origin and intraforaminal entrance remain asymptomatic because of the collateral irrigation system, it is important to know their anatomical presentation in order to prevent complications than could be neurologically...
Case Report

High origin of radial artery from the axillary artery: Case report

Merve Özgür, Murat Gölpınar, Yasin Arifoğlu, Safiye Çavdar
Pages: 39 - 42
The axillary artery is the main artery supplying the shoulder region and is clinically important. In the present case we report an arterial variation of the left upper extremity of a 65 year-old female cadaver. The radial artery arose from the axillary artery 2.5 cm below the anterior humeral circumflex...
Short Communication

H. pylori-induced higher C-reactive protein in obese African Americans

Nuzhat R. Siddiqui, W. Timothy Garvey, Mohammad A. Khaled
Pages: 39 - 42
African Americans are more susceptible to develop insulin resistance, obesity, Type 2 diabetes, and coronary heart disease (CHD), and systemic inflammation is central to the pathophysiology of these chronic diseases. African Americans are also more likely to contract H. pylori (cagA) infections during...
Conference Abstract

1.4 CHILDHOOD DETERMINANTS OF EARLY ADULT ARTERIAL STIFFNESS IN DIFFERENT ETHNIC GROUPS

K.J. Cruickshank, L. Faconti*, M.J. Silva, O.R. Molaodi, Z.E. Enayat, A. Cassidy, A. Karamanos, U.M. Read, P. Dall, B. Stansfield, S. Harding
Pages: 40 - 40
Childhood determinants of aortic pulse wave velocity [PWV] are poorly understood. We tested how factors measured twice previously in childhood in the MRC ‘DASH’ study, particularly body mass (BMI) components and BP, affected PWV in young adults. Methods: Of 6643 London children, aged 11–13 y, from 51...
Conference Abstract

1.5 RELATION OF ARTERIAL STIFFNESS WITH LEFT VENTRICULAR DIASTOLIC FUNCTION IN GENERAL POPULATION

Wiktoria Wojciechowska*, Katarzyna Stolarz-Skrzypek, Agnieszka Olszanecka, Lukasz Klima, Jerzy Gasowski, Tomasz Grodzicki, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 40 - 40
Left ventricular diastolic function declines with aging and hypertension. It is well known that elevated blood pressure results in increased arterial stiffness. The study aims to determine the relationship between arterial stiffness and left ventricular diastolic function in general population. Methods:...
Conference Abstract

1.6 THE BODE INDEX PROGNOSTIC SCORE IS AN INDEPENDENT DETERMINANT OF ARTERIAL STIFFNESS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Marie Fisk*, Nichola Gale, Divya Mohan, Carmel M. McEniery, Julia Forman, Charlotte E. Bolton, William MacNee, John R. Cockcroft, Joseph Cheriyan, Ruth Tal-Singer, Michael I. Polkey, Ian B. Wilkinson
Pages: 40 - 40
Introduction: COPD is associated with increased cardiovascular risk, independent of established risk factors. Arterial stiffness is a surrogate of cardiovascular risk and we sought to determine its relationship with COPD severity and prognosis in the ERICA (Evaluation of role of inflammation in airways...
Conference Abstract

2.1 A METHOD FOR THE MEASUREMENT OF PRESSURE SENSITIVITY OF CAROTID-FEMORAL PULSE WAVE VELOCITY IN HUMANS

Mark Butlin, Alberto Avolio*
Pages: 40 - 41
Background: Carotid-femoral pulse wave velocity (cfPWV), a marker of cardiovascular disease, is modified by both blood pressure and changes in arterial wall properties. Current cfPWV measurement does not differentiate between effects of blood pressure and arterial wall properties. Animal studies show...
Research Article

Relationships between blood pressure variability and silent cerebral infarction in patients with primary hypertension

Xianglin Chi, Xingyao Wang, Zhaorong Guo, Honghao Man, Hongxiao Xu, Yingcui Wang, Chengyu Liu
Pages: 40 - 46
Aims: This study aimed to investigate the relationship between blood pressure variability and the incidence of silent cerebral infarction (SCI) in patients with primary hypertension. Methods: The 346 hospitalized patients with primary hypertension were divided into primary hypertension group (160 cases)...
Research Article

Importance of the aortic reservoir in determining the shape of the arterial pressure waveform – The forgotten lessons of Frank

Justin E. Davies, Nearchos Hadjiloizou, Debora Leibovich, Anura Malaweera, Jordi Alastruey-Arimon, Zachary I. Whinnett, Charlotte H. Manisty, Darrel P. Francis, Jazmin Aguado-Sierra, Rodney A. Foale, Iqbal S. Malik, Kim H. Parker, Jamil Mayet, Alun D. Hughes
Pages: 40 - 45
It has been recognised for nearly 200 years that the human pressure waveform changes in shape with ageing and disease. The shape of the pressure waveform has been explained in terms of two fundamental models: the Windkessel (reservoir) and wave theory. In its simplest form the Windkessel model satisfactorily...
Conference Abstract

2.2 RE-REFLECTION OF BACKWARD PROPAGATING WAVES LEADS TO AMPLIFICATION OF THE FORWARD PRESSURE WAVE IN WAVE SEPARATION ANALYSIS

Patrick Segers*, Liesbeth Taelman, Joris Degroote, Jan Vierendeels
Pages: 41 - 41
Introduction: In wave separation analysis, the pressure wave is decomposed into a single forward and backward component, which actually compounds all forward and backward propagating waves. We hypothesize that, in particular in presence of early reflections as in aortic coarctation, re-reflection of...
Conference Abstract

2.3 TESTING RIVA-ROCCI’S BASIC ASSUMPTIONS BY SYSTEMATIC REVIEW AND META-ANALYSIS TO DETERMINE THE TRUE DIFFERENCE BETWEEN AORTIC AND BRACHIAL INVASIVE BLOOD PRESSURE

Dean Picone*, Petr Otahal, Martin Schultz, James Sharman
Pages: 41 - 41
Background: The Riva-Rocci brachial blood pressure (BP) method purported to measure aortic BP, and this remains the cornerstone thesis of clinical BP measurement. However, few studies have confirmed this thesis with direct BP measurements. This study aimed to determine the true differences in aortic...
Conference Abstract

2.4 AMBULATORY AORTIC STIFFNESS, INDEPENDENTLY OF STATIC, ASSOCIATES WITH NARROWER RETINAL ARTERIOLAR CALIBERS IN HYPERTENSIVES: THE SAFAR STUDY

Evaggelia K. Aissopou*, Antonios A. Argyris, Efthimia G. Nasothimiou, George D. Konstantonis, Konstantinos Tampakis, Nikolaos Tentolouris, Miltiadis Papathanassiou, Panagiotis G. Theodossiadis, Theodoros G. Papaioannou, Coen D.A. Stehouwer, Petros P. Sfikakis, Athanassios D. Protogerou
Pages: 41 - 42
Background: Arterial stiffness measured under static conditions reclassifies significantly cardiovascular (CV) risk and associates with organ damage, including narrower retinal arterioles. However, arterial stiffness exhibits diurnal variation, thus single static stiffness recordings do not correspond...
Research Article

Association between Irritable Affective Temperament and Nighttime Peripheral and Central Systolic Blood Pressure in Hypertension

Beáta Kőrösi, Dóra Batta, Xénia Gonda, Zoltán Rihmer, Zsófia Nemcsik-Bencze, Andrea László, Milán Vecsey-Nagy, János Nemcsik
Pages: 41 - 47
Background: Affective temperaments (depressive, anxious, cyclothymic, irritable and hyperthymic) have important role in psychopathology, but cumulating data support their involvement in vascular pathology, especially in hypertension as well. The aim of our study was to evaluate their associations with...
Research Article

Gut microbiota and vascular biomarkers in patients without clinical cardiovascular diseases

Daria Kashtanova, Olga Tkacheva, Anna Popenko, Lilit Egshatyan, Alexander Tyakht, Dmitry Alexeev, Yulia Kotovskaya, Ekaterina Plokhova, Sergey Boytsov
Pages: 41 - 48
The aim of this research was to study the association between the gut microbiota composition and arterial wall properties. The study included 92 participants, men and women aged 25–76 years old without clinical manifestation of chronic diseases but with the possible presence of cardiovascular risk factors....
Research Article

Loss of elastic fiber integrity compromises common carotid artery function: Implications for vascular aging

J. Ferruzzi, M.R. Bersi, R.P. Mecham, F. Ramirez, H. Yanagisawa, G. Tellides, J.D. Humphrey
Pages: 41 - 52
Competent elastic fibers endow central arteries with the compliance and resilience that are fundamental to their primary mechanical function in vertebrates. That is, by enabling elastic energy to be stored in the arterial wall during systole and then to be used to work on the blood during diastole, elastic...
Research Article

Central haemodynamics reveal significant potential for prevention in Black hypertensive patients born and living in sub-Saharan Africa

Birinus Ezeala-Adikaibe, Yan-Ping Liu, Daniel Lemogoum, Benedict C. Anisiuba, Marius K. Kamdem, Joseph Kaptue, Chinwuba K. Ijoma, Lutgarde Thijs, Augustine N. Odili, Kei Asayama, Jan A. Staessen, Jean-René M’Buyamba-Kabangu, Ifeoma I. Ulasi
Pages: 41 - 48
Background: Few studies assessed arterial stiffness in Black hypertensive patients born and living in sub-Saharan Africa, where cardiovascular disease reaches epidemic proportions. Methods: The Newer versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) trial is currently recruiting...
Review Article

Shear stress, inflammation and Atherosclerosis

Rob Krams, Simon Cuhlmann, Nicolas Foin, Paul Evans
Pages: 41 - 46
Background: Atherosclerosis is the disease with one of the largest mortalities of the Western world. An important cause of this high mortality rate is rupture of atherosclerotic plaques and subsequent total blockage of the vessel by thrombus. Because, plaque rupture has been associated with a distinct...
Conference Abstract

2.5 IN SINGLETONS BORN AT TERM, LOWER GESTATIONAL AGE IS ASSOCIATED WITH INCREASED AORTIC PULSE WAVE VELOCITY IN YOUNG ADULTHOOD: THE NORTHERN IRELAND YOUNG HEARTS PROJECT (NIYHP)

Isabel Ferreira*, Alison Gallagher, Liam Murray, Colin Boreham
Pages: 42 - 42
Decreases in the mean gestational age of babies born at term have been reported over the past decade in several developed countries, linked to increases in the rates of planned births by labour induction and/or pre-labour caesarean sections. In contrast to the effects of pre-term birth, the extent to...
Conference Abstract

2.6 PULSE WAVE VELOCITY AND GAIT PERFORMANCE IN OLDER SUBJECTS

Anna Skalska*, Malgorzata Fedyk-Lukasik, Paulina Fatyga, Tomasz Grodzicki
Pages: 42 - 42
Background: Arterial stiffening is an age-related change and is a well-known cardiovascular risk factor but its association with physical decline is rarely evaluated. The aim of this analysis was to assess the association of arterial stiffness as carotid-femoral pulse wave velocity (PWV) with gait performance...
Conference Abstract

3.1 PREDIABETES IS ASSOCIATED WITH IMPAIRED RETINAL VASODILATION: THE MAASTRICHT STUDY

Ben Sörensen*, Boy Houben, Tos Berendschot, Jan Schouten, Bram Kroon, Carla van der Kallen, Ronald Henry, Annemarie Koster, Pieter Dagnelie, Nicolaas Schaper, Miranda Schram, Coen Stehouwer
Pages: 42 - 42
Aim: Type 2 diabetes (DM2) causes microvascular dysfunction (MVD). In addition, MVD can contribute to insulin resistance, predisposing to DM2. This hypothesis predicts that MVD should be present in impaired glucose metabolism (IGM; prediabetes). However, population-based studies of MVD and glucose metabolism...
Conference Abstract

3.2 ORIGINS OF THE BACKWARD TRAVELING WAVE IN THE ARTERIAL TREE

Ye Li*, Henry Fok, Benyu Jiang, Sally Epstein, Marie Willemet, Jordi Alastruey, Kim Parker, Phil Chowienczyk
Pages: 42 - 43
Backward traveling waves, an important determinant of central haemodynamics, are usually regarded as being due to reflections from discontinuities in the arterial tree. However, consideration of a single tube model of the arterial with a single site of reflection shows that a backward pressure wave may...
Research Article

Validation of a Method to Estimate Stroke Volume from Brachial-cuff Derived Pressure Waveforms

Thomas Weber, Siegfried Wassertheurer, Jessica Middlemiss, Carmel Mary McEniery, Bernhard Hametner, Christopher Clemens Mayer, Ronald Karl Binder, Hans-Josef Feistritzer, Gert Klug, Bernhard Metzler
Pages: 42 - 47
Background: Steady state hemodynamics [Stroke Volume - SV, cardiac output, peripheral resistance (Rp)] have attracted researchers in hypertension for decades. However, due to technical difficulties, they never entered clinical medicine. Objective: To investigate the performance of a model-based algorithm,...
Research Article

Sleep restriction and its influence on blood pressure

Arbind Kumar Choudhary, Anup Kumar Dadarao Dhanvijay, Tanwir Alam, Sadawarte Sahebrao Kishanrao
Pages: 42 - 48
Sleep is a major modulator of cardiovascular function. Since it’s more difficult to maintain adequate sleep duration among night watchmen during their working schedule, so in this study, we hypothesized that, the short sleep duration (<3 h) for 7 days in their night shift schedule, may possibly influence...
Short Communication

Aggressive renal sympathetic denervation approach to treating resistant hypertension: A fresh start?

Márcio Galindo Kiuchi, Luis Marcelo Rodrigues Paz, Shaojie Chen
Pages: 42 - 44
A multivariable analysis identified predictors of systolic blood pressure change in SYMPLICITY HTN-3 trial. Additional analyses examined the influence of medication changes, results in selected subgroups and procedural factors. Greater reductions in office and ambulatory systolic blood pressure, and...
Research Article

Gender difference in age-related carotid stiffness: A prospective study in Chinese diabetic patients

Bo Zhao, Yan-Ping Liu, Yifei Zhang, Yuhong Chen, Zhifang Yang, Ying Zhu, Weiwei Zhan
Pages: 42 - 47
Background: The reason for the particularly increased cardiovascular morbidity and mortality in diabetic women remains unclear. The purpose of our study was to prospectively investigate sex difference in carotid stiffness in elder Chinese patients with type-2 diabetes mellitus (T2DM). Methods: 109 T2DM...
Conference Abstract

3.3 AN EASY AND INTUITIVE WEB INTERFACE FOR THE ASSESSMENT OF MEASUREMENTS OF CAROTID-FEMORAL PULSE WAVE VELOCITY AND LOCAL ARTERIAL STIFFNESS RELATIVE TO THE REFERENCE VALUES DATABASE

Francisco Londoño*, Jelle Bossuyt, Patrick Segers, Luc Van Bortel
Pages: 43 - 43
Objective: The use of different devices and methods still hampers the widespread clinical use of the reference values for arterial stiffness. The aim of this work was therefore to create a web-based application that allows easy assessment - for different methodological approaches - of a given measured...
Conference Abstract

3.4 EVALUATION OF THE MUTUAL RELATIONSHIPS AMONG THE DEVELOPMENT OF HYPERTENSION, ARTERIAL STIFFENING AND RENAL FUNCTION DECLINE BASED ON REPEATED LONGITUDINAL MEASUREMENTS

Hirofumi Tomiyama*, Akira Yamashina
Pages: 43 - 43
Background: The mechanisms underlying the development of hypertension have not yet been fully clarified. The mutual relationships among the development of hypertension and the longitudinal changes of arterial stiffness and renal function, and also the effect of maintenance of a normal body weight on...
Conference Abstract

3.5 ASSOCIATION OF VASCULAR RISK FACTORS WITH BRAIN STRUCTURE AND FUNCTION

Chloe Park*, Therese Tillin, Robert Stewart, Nish Chaturvedi, Alun Hughes
Pages: 43 - 43
Background: Vascular risk factors have been associated with brain aging. We aimed to determine the associations between blood pressure (BP), atherosclerosis, arterial stiffness and microvascular damage with both structural and functional measures of the brain. Methods: A community-based sample of 1287...
Conference Abstract

3.6 AORTIC STIFFNESS IS RELATED TO CEREBRAL LESION GROWTH IN PATIENTS WITH ACUTE ISCHEMIC STROKE

Dariusz Gasecki*, Mariusz Kwarciany, Kamil Kowalczyk, Anna Gójska-Grymajło, Tomasz Nowicki, Edyta Szurowska, Pierre Boutouyrie, Stephane Laurent, Krzysztof Narkiewicz, Bartosz Karaszewski
Pages: 43 - 44
Objective: Cerebral lesion growth in acute ischemic stroke leads to secondary neurological deterioration and poor outcome. Whether cSBP and arterial stiffness are related to the early brain infarct growth in patients after ischemic stroke is unknown. Design and Methods: We enrolled 65 patients (43 males,...
Research Article

Study of atherosclerosis in abdominal aortic aneurysms of autopsied patients

Maria Helena Soares, Mariana Silva Oliveira, Aline Cristina Souza da Silva, Bianca Gonçalves Silva Torquato, Gabriela Ribeiro Juliano, Guilherme Ribeiro Juliano, Márcia Fernandes de Araújo, Camila Lourencini Cavellani, Lívia Ferreira Oliveira, Mara Lúcia Fonseca Ferraz, Vicente de Paula Antunes Teixeira
Pages: 43 - 48
Background: Any kind of change in the arterial wall as atherosclerosis, may be the etiologic agent of the formation of aneurysm in an artery. The aim of this study was to describe the morphological and morphometric characteristics of the aorta with aneurysm in autopsied patients in relation to age, gender,...
Research Article

Elevated levels of IL-6 and IL-9 in the sera of patients with AAA do not correspond to their production by peripheral blood mononuclear cells

Hamid Aria, Mehdi Kalani, Hossein Hodjati, Mehrnoosh Doroudchi
Pages: 43 - 52
Background: Abdominal Aortic Aneurysm (AAA) is the stable local dilatation of abdominal aorta. AAA is an inflammatory condition in which cytokines may play a pathogenic role. Methods: Peripheral Blood Mononuclear cells (PBMCs) were isolated from 5 men, with confirmed diagnosis of AAA and aortic dilation...
Conference Abstract

THE CLINICAL IMPORTANCE OF EXERCISE BLOOD PRESSURE

Martin G. Schultz
Pages: 44 - 44
Clinical exercise stress testing is a common medical test performed in cardiology and exercise physiology clinics the world over. Measurement of blood pressure (BP) during testing is mandated. Whilst systolic BP should normally rise with incremental exercise, and diastolic BP remains relatively stable,...
Conference Abstract

4.1 EFFECT OF ALISKIREN ON VASCULAR REMODELING IN SMALL RETINAL CIRCULATION

Christian Ott*, Agnes Jumar, Joanna Harazny, Stephanie Schmidt, Roland Schmieder
Pages: 44 - 44
Background: In hypertension changes in small arterial structure are characterized by an increased wall-to-lumen ratio (WLR). These adaptive processes are modulated by the renin angiotensin system. It is unclear whether direct renin inhibitors exert protective effects on small arteries in hypertensive...
Conference Abstract

THE CENTRALITY OF THE HEART IN ITS RELATIONSHIP WITH THE ARTERIAL SYSTEM: WHERE IT ALL STARTS AND ENDS

Giacomo Pucci
Pages: 44 - 44
The interaction between the heart and large arteries represent a not fully understood process, which results from the integration of pressure wave generation, flow ejection, wave travel and reflection, and geometric mismatch between structures. Left ventricular (LV) mass and geometry, two independent...
Conference Abstract

4.2 THE INHOMOGENEITY OF DIASTOLIC-SYSTOLIC RISE TIME OF THE DISTENSION WAVEFORM DISTRIBUTION IN THE COMMON CAROTID ARTERY IS ASSOCIATED WITH LIPID PRESENCE OF DISTAL PLAQUES

J. Steinbuch*, F.H.B.M. Schreuder, M.T.B. Truijman, A.A.J. de Rotte, M.I. Liem, E. Hermeling, A.P.G. Hoeks, W.H. Mess
Pages: 44 - 44
Objectives: Diastolic-systolic rise time characteristics of the distension waveform distribution, i.e., mean and inhomogeneity, might be modified by wave reflections from distal plaques. The aim of this study is to investigate the association between rise time characteristics for the common carotid artery...
Conference Abstract

STIFF VESSELS APPROACHED IN A FLEXIBLE WAY: ADVANCING QUANTIFICATION AND INTERPRETATION OF ARTERIAL STIFFNESS

Bart Spronck
Pages: 44 - 44
Introduction Although pulse wave velocity (PWV), a proxy of arterial stiffness, is a strong predictor of cardiovascular complications, it is confounded by blood pressure (BP) and heart rate at the time of examination. Furthermore, establishing whether an artery is stiffened or not does not inform a...
Conference Abstract

4.3 THE EFFECT OF GLYCAEMIC STATE TRANSITION ON ACCELERATED AORTIC STIFFENING: A LONGITUDINAL STUDY IN THE WHITEHALL II COHORT

Nanna B. Johansen*, Martin Shipley, Daniel R. Witte, Adam G. Tabak, Eric J. Brunner
Pages: 44 - 44
In 4,759 participants from the Whitehall II study, we examined the impact of glycaemic history on aortic stiffening. Assessment of aortic stiffness by carotid-femoral pulse wave velocity (PWV) was performed twice with a 4 year interval (2007–2009 and 2012–2013). At the first aortic stiffness assessment...
Conference Abstract

4.4 FORWARD AND BACKWARD WAVES AT THE AORTIC ROOT: STEADY-STATE AND WAVE RE-REFLECTION CONSIDERATIONS

Timothy Phan*, John Li, Vandan Panchal, Amer Syed, Ejaz Shah, Julio Chirinos
Pages: 44 - 45
Background: The assumption of steady-state oscillation is often overlooked when arterial pressure and flow waveforms are decomposed into backward (Pb) and forward waves (Pf). This has led to various misinterpretations including a significant reflection-free time during early-systole and attribution of...
Research Article

The acute effects of mental arithmetic, cold pressor and maximal voluntary contraction on arterial stiffness in young healthy subjects

Noor-Ahmed Jatoi, Stella-Maria Kyvelou, John Feely
Pages: 44 - 50
Background: Mental stress, dynamic exercise and cold pressor stimulation all increase blood pressure (BP); however, their effects on arterial stiffness are not well described. Methods: Twenty-three young healthy subjects (14 female/9 males), aged 18–30 years (23 ± 3 years), underwent mental arithmetic...
Research Article

The direct effect of leg position on calf blood flow measured by venous occlusion plethysmography☆

Julie H. Corrigan, Joanna Burns, Robert J. Huggett, Alan F. Mackintosh, David A.S.G. Mary
Pages: 44 - 48
Background: Venous occlusion plethysmography is commonly used to assess changes in calf blood flow (CBF). Although the leg is often positioned above the level of the heart to aid venous emptying during periods of cuff deflation, its direct effect on measured CBF is not known. We therefore planned to...
Conference Abstract

FETAL PROGRAMMING AND VASCULAR DYSFUNCTION

T.A. Meister, E. Rexhaj, S.F. Rimoldi, U. Scherrer, C. Sartori*
Pages: 45 - 45
Cardiovascular diseases are the main cause of mortality and morbidity in Western countries, but the underlying mechanisms are still poorly understood. Genetic polymorphisms, once thought to represent a major determinant of cardiovascular risk, individually and collectively, only explain a tiny fraction...
Conference Abstract

REMODELLING SMALL ARTERIES AND PHD TRAINING: A JOURNEY

Michael J. Mulvany
Pages: 45 - 45
Biomedical research is increasingly based on the efforts of PhD students. This talk will trace the development of the author’s research, and show how this experience can be used to optimize PhD training. The basis of the research has been that essential hypertension is associated with increased peripheral...
Conference Abstract

4.5 A SYSTEMATIC REVIEW AND META-ANALYSIS OF CENTRAL TO BRACHIAL BLOOD PRESSURE AMPLIFICATION IN PATIENTS TYPE 2 DIABETES MELLITUS

Rachel Climie*, Petr Otahal, Martin Schultz, James Fell, Velandai Srikanth, James Sharman
Pages: 45 - 45
Background: Brachial blood pressure (BP) may not reflect central BP due to systolic BP (SBP) amplification. Patients with type 2 diabetes mellitus (T2DM) elicit vascular irregularities that may affect SBP amplification or other central BP indices (including pulse pressure [PP], augmentation pressure...
Conference Abstract

ENDOTHELIAL AUTOPHAGY AS A KEY MECHANISM IN ARTERIAL DISEASES

Pierre-Louis Tharaux
Pages: 45 - 45
Blood flow imposes shear stress on endothelial cells (ECs). ECs are able to convert these mechanical stimuli into intracellular signals that affect cellular function. As deregulated autophagy is associated with an acceleration of a variety of cardiovascular and metabolic diseases where impaired flow-mediated...
Conference Abstract

STEM CELL THERAPY FOR CARDIOVASCULAR DISEASES

Jean Sebastien Silvestre
Pages: 45 - 45
Stem cell-based therapies for vascular regeneration in patients with cardiovascular ischemic diseases initially relied on a very simple concept: therapeutic stem/progenitor cells might differentiate into vascular cells, mainly of endothelial phenotype, increasing new vessel formation and tissue perfusion...
Conference Abstract

4.6 RELATIONSHIP OF CAROTID ARTERIAL FUNCTIONAL AND STRUCTURAL CHANGES TO LEFT ATRIAL VOLUME INUNTREATED HYPERTENSION

Joanna Jaroch*, Barbara Rzyczkowska, Zbigniew Bociaga, Olga Vriz, Caterina Driussi, Maria Loboz-Rudnicka, Krzysztof Dudek, Krystyna Loboz-Grudzien
Pages: 45 - 45
The contribution of arterial functional and structural changes to left ventricular (LV) diastolic dysfunction has been the area of latest research. There are some studies on the relationship of arterial stiffness (a.s.) and left atrial (LA) remodeling as a marker of diastolic burden. Little is known...
Conference Abstract

VASCULAR CALCIFICATION: FROM INNOCENT BYSTANDER TO CULPRIT RISK FACTOR

Leon J. Schurgers
Pages: 45 - 45
Vascular calcification was regarded as an innocent bystander in cardiovascular disease. It was considered to be the passive chemical nucleation of calcium and phosphate ions on cellular debris and therefore the end-stage of atherosclerosis. Currently, vascular calcification is understood to be an actively...
Conference Abstract

ARTERIAL PROTEOMICS: LESSONS IN RELATION TO STIFFNESS, ANEURYSMS, DIABETES AND OTHER CONDITIONS

Lars Melholt Rasmussen
Pages: 45 - 45
Proteins are the main molecular components of the arterial wall. Alterations in the amounts of specific proteins in both the extracellular matrix and in vascular cells are believed to be associated with different arterial pathologies, however only sparse data is currently available, particularly in relation...
Conference Abstract

5.1 INERTIAL-VISCOELASTIC MINIMAL MODEL OF THE ARTERIAL SYSTEM RECONCILES ARTERIAL COMPLIANCE ESTIMATIONS

Timothy Phan*, John Li, Maheshwara Koppula, Izzah Vasim, Swapna Varakantam, Julio Chirinos
Pages: 45 - 45
Background: The arterial system is viscoelastic rather than purely elastic. There exist various methods to characterize the purely elastic nature of arterial compliance, each method yielding different values. The pulse pressure method (CPPM), estimating compliance by matching the pulse pressure (PP)...
Conference Abstract

TARGETING VASCULAR SMOOTH MUSCLE CELL TO IMPROVE ARTERIAL STIFFNESS

Patrick Lacolley
Pages: 45 - 45
Hypertension and arterial aging engage a plethora of key signaling pathways that act in concert to induce vascular smooth muscle cell (VSMC) phenotypic changes leading to vascular degeneration and extracellular matrix (ECM) changes responsible for alterations of the mechanical properties of the vascular...
Conference Abstract

WAVE POTENTIAL: A UNIFIED MODEL OF ARTERIAL WAVES, RESERVOIR PHENOMENA AND THEIR INTERACTION

Jonathan P. Mynard, Joseph J. Smolich
Pages: 45 - 46
Models of haemodynamics play a central role in current research directed to understanding and addressing cardiovascular disease. Although conventional windkessel and wave models are very useful, they are incompatible due to conflicting assumptions and neither comprehensively explain the basis and interdependencies...
Conference Abstract

5.2 SOLUBLE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS AND AORTIC STIFFNESS IN GENERAL POPULATION

Otto Mayer, Jan Filipovsky*, Jitka Seidlerova, Petra Karnosova, Peter Wohlfahrt, Renata Cifkova, Jindra Windrichova, Ondrej Topolcan
Pages: 45 - 46
It has been suggested that accumulation of advanced glycation end-products (AGE) is involved in several pathophysiological processes in the vessel wall. Soluble isoform of receptor for AGE (sRAGE) acts as a decoy for capturing circulating AGE, prevents them from binding to the cell-surface receptor and...
Conference Abstract

CENTRAL BLOOD PRESSURE MEASUREMENT AND VALIDATION: WHAT IS STILL NEEDED?

James E. Sharman
Pages: 45 - 45
Accurate measurement of blood pressure (BP) is a critical goal for appropriate diagnosis and management of high BP. The measurement reference standard is brachial cuff BP, but recent large-scale meta-analyses show major deficiencies in the accuracy of this method. Indeed, irrespective of cuff technique...
Research Article

The decrease of Tie-2 receptor phosphorylation in microvascular endothelial cells is involved in early brain injury after subarachnoid hemorrhage

Hua Gu, Yi-qi Wang, Chao-Hui Zhao, Xing-ming Zhong, Jian-guo Yang
Pages: 45 - 51
Purpose: Loose endothelial cells and the destruction of the blood–brain barrier (BBB) are one of the pathophysiological mechanisms of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Tie-2 receptor phosphorylation is important for maintaining integrity of microvascular endothelial cells...
Conference Abstract

CENTRAL BP MEASUREMENT AND VALIDATION: THE ENGINEER’S POINT OF VIEW

Siegfried Wassertheurer
Pages: 46 - 46
The non-invasive assessment of aortic (central) pressure evolved as an emerging clinical research area over the last two decades. Several non-invasive methods and devices were developed to support these investigations. A variety of technical approaches and sites of peripheral signal acquisition have...
Conference Abstract

VASCULAR DYSFUNCTION: AT THE HEART OF CARDIOVASCULAR DISEASE, COGNITIVE IMPAIRMENT AND DEPRESSIVE SYMPTOMS

Thomas van Sloten
Pages: 46 - 46
Vascular dysfunction may be an important pathway through which ageing and other factors, such as diabetes and obesity, can cause diseases of the heart and brain. Vascular dysfunction includes dysfunction of large arteries (due to arterial stiffness), the microcirculation (microvascular dysfunction) and...
Conference Abstract

5.3 THE INFLUENCE OF SEX AND AGE ON ARTERIAL FUNCTION IN RESPONSE TO AN ACUTE INFLAMMATORY STIMULUS

Alexander Rosenberg*, Abbi Lane-Cordova, Kanokwan Bunsawat, Sang Ouk Wee, Tracy Baynard, Bo Fernhall
Pages: 46 - 46
Background: Aging is associated with increased arterial stiffness and chronic low-grade inflammation. Acute inflammatory stimulus in the presence of low-grade chronic inflammation briefly increases the risk of cardiovascular events. The risk of cardiovascular events also increases substantially in older...
Conference Abstract

ARTERIAL HEMODYNAMICS AND WAVE REFLECTIONS

Patrick Segers, Alun Hughes
Pages: 46 - 46
Despite years of research, there are still some contentious aspects of arterial hemodynamics that have remained unresolved. These were discussed during a workshop entitled Arterial hemodynamics: past, present and future held in London on June 14 and 15, 2016, with keynote contributions by Nico Westerhof,...
Conference Abstract

ARTERIAL INFLAMMATION, BLOOD PRESSURE AND CENTRAL HEMODYNAMICS – THE ABC OF DIABETIC ANGIOPATHY

Simone Theilade
Pages: 46 - 46
Aim: In diabetes patients, we explored relationships between markers of diabetic angiopathy, diabetic complications and adverse outcome. Methods: Patients were recruited from 3 observational studies from Steno Diabetes Center, Denmark and one randomized, double-blind, international, multicentre study. We...
Conference Abstract

5.4 MATRIX GLA PROTEIN IN RELATION TO LEFT VENTRICULAR DIASTOLIC FUNCTION

Thibault Petit*, Zhen-Yu Zhang, Wen-Yi Yang, Fang-Fei Wei, Yu-Mei Gu, Juditha Knez, Nicholas Cauwenberghs, Yan-Ping Liu, Nadja Drummen, Lotte Jacobs, Lutgarde Thijs, Tatiana Kuznetsova, Stefan Janssens, Cees Vermeer, Jan A. Staessen
Pages: 46 - 46
Introduction: Matrix Gla Protein (MGP) is highly expressed in cardiomyocytes and is upregulated after acute and chronic pressure overload and in myocardial hypertrophy in mice and humans. However, no study addressed the relation between cardiac function and MGP in humans. Methods and results: In 767...
Conference Abstract

CON: GLUCOSE IS THE MOST IMPORTANT TARGET FOR CARDIOVASCULAR PREVENTION IN DIABETES

Francesco Giorgino
Pages: 46 - 46
The overall impact of glucose-lowering on vascular complications and major clinical outcomes, including mortality, in type 2 diabetes is still an open issue. While intensive glucose control has undoubted benefit for microvascular endpoints, the relationship between glucose-lowering approaches and reduced...
Conference Abstract

WHY DOES NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) CONTRIBUTE TO CARDIOVASCULAR OUTCOMES?

Hannele Yki-Järvinen
Pages: 46 - 47
Take home messages 1.Both ‘Metabolic NAFLD’ and the features of insulin resistance/the metabolic syndrome (MetS) increase the risk of cardiovascular disease (CVD), even independent of obesity 2.‘Metabolic NAFLD’ and insulin resistance share common pathophysiology, which may explain their link with...
Conference Abstract

5.5 MEASUREMENT OF ARTERIAL STIFFNESS BY ULTRAFAST ECHO: COMPARISON WITH ECHOTRACKING IN NORMOTENSIVE SUBJECTS AND HYPERTENSIVE PATIENTS

Louise Marais*, Mathieu Pernot, Hakim Khettab, Mickael Tanter, Emmanuel Messas, Mustapha Zidi, Stéphane Laurent, Pierre Boutouyrie
Pages: 46 - 46
Because measurement of arterial stiffness is highly dependent on blood pressure (BP), methods independent of BP are required. Ultrafast echography (UFE, Supersonic Imagine, Aix en Provence, France) makes use of very fast sampling rate (up to 10 kHz), so transient events such as pressure wave arrival...
Conference Abstract

THE METABOLIC-MICROVASCULAR DYSREGULATION SYNDROME

Coen D.A. Stehouwer
Pages: 46 - 46
Microvascular and metabolic physiology are inextricably linked. Thus, metabolic dysfunction impairs microvascular function and microvascular dysfunction impairs normal metabolism. The relationship is therefore reciprocal, justifying the concept of a ‘Metabolic-Microvascular Dysregulation Syndrome’. For...
Conference Abstract

5.6 ASSOCIATION BETWEEN ENDOGENOUS SERUM TESTOSTERONE CONCENTRATIONS AND AORTIC PRESSURES AND PULSE WAVE AMPLIFICATION INDICES IN ERECTILE DYSFUNCTION PATIENTS

Dimitrios Terentes-Printzios*, Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Panagiota Pietri, Athanassios Angelis, Ioanna Gourgouli, Christos Georgakopoulos, Christodoulos Stefanadis, Dimitrios Tousoulis
Pages: 46 - 47
Purpose: Erectile dysfunction (ED) is an independent predictor of future cardiovascular (CV) events. Aortic pressures (central) and low testosterone independently predict future CV events and mortality. The relationship between testosterone, central pressures and wave reflection indices in ED patients...
Conference Abstract

1.1 CENTRAL BLOOD PRESSURE, STATINS AND LDL-CHOLESTEROL: A MEDIATION ANALYSIS

Florence Lamarche, Mohsen Agharazii, Francois Madore, Remi Goupil
Pages: 47 - 47
Background: Central blood pressure (CBP) is a better predictor of cardiovascular burden than peripheral blood pressure (BP). While studies have suggested a reduction in peripheral BP with statins, it remains uncertain to what extent statins reduce CBP and whether this reduction is mediated through a...
Conference Abstract

CONSTITUENT BASED MODELLING OF ARTERIAL WALL MECHANICS

Lydia Aslanidou, Rodrigo Araujo Fraga da Silva, Patrick Segers, Nikos Stergiopulos
Pages: 47 - 47
In the preclinical setting, Angiotensin-II infusion has been the most popular model for mouse aneurysm research in the last 15 years. Nonetheless, little is known about the ascending aortic aneurysm pathobiology of this model and several lingering questions regarding the abdominal aortic aneurysm pathology...
Conference Abstract

01.01 ARTERIAL STIFFNESS IS INCREASED IN PAEDIATRIC HEART RECIPIENTS

E. Sharkey, A. Klinge, J. Allen, A. Murray, R. Kirk, J. O’Sullivan
Pages: 47 - 47
Conference Abstract

1.2 MASKED HYPERTENSION IS REVEALED BY EXAGGERATED SUBMAXIMAL EXERCISE BLOOD PRESSURE AMONG ADOLESCENTS FROM THE AVON LONGITUDINAL STUDY OF PARENTS AND CHILDREN (ALSPAC)

Zhengzheng Huang, James Sharman, Chloe Park, John Deanfield, Marietta Charakida, Abigail Fraser, Laura Howe, Debbie Lawlor, Nish Chaturvedi, George Smith, Alun Hughes, Martin Schultz
Pages: 47 - 47
Objectives: Masked hypertension (MH) is associated with hypertension-related markers of organ damage, but is undetectable by clinic (resting) BP. Exaggerated systolic BP response to submaximal exercise reveals MH in adults, but it is unknown whether this is the case during adolescence. We aimed to determine...
Conference Abstract

ARTERIAL STIFFNESS IN INFLAMMATORY DISEASE

Kaisa Maki-Petaja
Pages: 47 - 47
Many inflammatory conditions are associated with an increased risk of cardiovascular disease (CVD) and mortality. As well as accelerated atherosclerosis, increased plaque instability and endothelial dysfunction; arterial stiffness has been proposed as one of the potential mechanisms underlying the increased...
Conference Abstract

01.02 ARTERIAL STRUCTURE AND FUNCTION AND ENVIRONMENTAL EXPOSURE TO CADMIUM

R. Schutte, T. Nawrot, T. Richart, L. Thijs, H.A. Roels, L.M. Van Bortel, H. Struijker-Boudier, J.A. Staessen
Pages: 47 - 47
Conference Abstract

1.3 DETERMINANTS OF CENTRAL AND PERIPHERAL PULSE PRESSURE IN A POPULATION OF HEALTHY ADOLESCENTS. THE MACISTE STUDY

Pucci Giacomo, Battista Francesca, D’Abbondanza Marco, Papi Francesco, Schillaci Giuseppe
Pages: 47 - 48
We aimed at evaluating the anthropometric and hemodynamic factors associated with central pulse pressure (cPP), peripheral pulse pressure (pPP) and central-to-peripheral PP amplification (PPamp) in healthy adolescents. We studied 459 subjects (boys 57%, 16.8 ± 1.5 y) attending the Liceo Donatelli High...
Conference Abstract

01.03 CAROTID PLAQUE, ARTERIAL STIFFNESS GRADIENT, AND BENDING STRAIN IN HYPERTENSION

H.B. Beaussier, I.M. Masson, C.C. Collin, E.B. Bozec, B.L. Laloux, P.B. Boutouyrie, S.L. Laurent
Pages: 47 - 47
Research Article

Interaction of the blood components and plaque in a stenotic coronary artery

Alireza Karimi, Reza Razaghi
Pages: 47 - 61
Background: So far, in the stress calculation of the plaques, the blood has been simulated as a single component, and the role of the mechanical interaction between the red blood cells (RBCs), white blood cells (WBCs), and plasma with that of the plaque has been neglected. This study was aimed at proposing...
Research Article

The effects of weight loss using dietary manipulation and rimonabant therapy on arterial stiffness in type 2 diabetes

A. Chakera, S. Bunce, C. Heppenstall, J.C. Smith
Pages: 47 - 51
Background: Obesity is considered an important factor contributing to premature arterial stiffening in type 2 diabetes but it is uncertain whether weight loss through dietary modification leads to a reduction in arterial stiffness. Rimonabant is an anti-obesity drug which, through its pharmacological...
Conference Abstract

1.4 A PROTEOMIC MARKER OF DIABETIC NEPHROPATHY IS ASSOCIATED WITH MORTALITY IN PATIENTS WITH TYPE 2 DIABETES

Gemma Currie, Sheon Mary, Bernt Johan von Scholten, Morten Kofod Lindhardt, Harald Mischak, William Mullen, Peter Rossing, Christian Delles
Pages: 48 - 48
Background: The urinary proteomic classifier CKD273 has been found to predict diabetic nephropathy development in advance of microalbuminuria. Whether it is also a determinant of mortality and cardiovascular disease in patients with established albuminuria is unknown. Methods: We studied 155 subjects...
Conference Abstract

1.1 DIABETES AND CENTRAL BLOOD PRESSURE IN CORONARY PATIENTS

Piotr Jankowski, Dorota Debicka-Dabrowska, Malgorzata Kloch-Badelek, Leszek Bryniarski, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 48 - 48
Background: Relative (represented by pulsatility) as well as absolute (pulse pressure) changes of central blood pressure (BP) were shown to predict cardiovascular (CV) complications in coronary patients. However, the influence of diabetes (a major CV risk factor) on the values of BP-derived indices is...
Conference Abstract

01.04 NON INVASIVE EVALUATION OF ARTERIAL REMODELING IN PATIENTS WITH FABRY DISEASE AFTER ENZYME REPLACEMENT THERAPY

C.C. Collin, M.B. Briet, H.B. Beaussier, E.B. Bozec, B.L. Laloux, P.B. Boutouyrie, S.L. Laurent
Pages: 48 - 48
Conference Abstract

1.5 DESPHOSPHO-UNCARBOXYLATED MATRIX GLA PROTEIN IS A NOVEL CIRCULATING BIOMARKER PREDICTING DETERIORATION OF RENAL FUNCTION IN THE GENERAL POPULATION

Fangfei Wei, Sander Trenson, Lutgarde Thijs, Qi-Fang Huang, Zhen-Yu Zhang, Wen-Yi Yang, Paula Moliterno, Karel Allegaert, José Boggia, Stefan Janssens, Peter Verhamme, Cees Vermeer, Jan Staessen
Pages: 48 - 48
Background: Recent studies showing an inverse association between estimated glomerular filtration rate (eGFR), a microvascular trait, and inactive desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) support the hypothesis that after vitamin K dependent activation MGP is renoprotective, but were limited...
Conference Abstract

1.2 HOW DOES OBESITY INFLUENCE ARTERIAL STIFFNESS IN ASYMPTOMATIC ADULTS?

Bela Benczur, Renata Bocskei, Attila Cziraki
Pages: 48 - 48
Central obesity is an important cause of cardiovascular disease. It’s well-known that aortic pulse wave velocity (aoPWV) is a strong predictor of cardiovascular events. However the potential correlation between fat accumulation and increased arterial stiffness is poorly investigated. The aim of this...
Conference Abstract

1.6 PERIPHERAL AND CENTRAL AMBULATORY BLOOD PRESSURE IN RELATION TO ECG VOLTAGE

Wen-Yi Yang, Blerim Mujaj, Ljupcho Efremov, Zhen-Yu Zhang, Lutgarde Thijs, Fang-Fei Wei, Qi-Fang Huang, Aernout Luttun, Peter Verhamme, Tim Nawrot, Jose Boggia, Jan Staessen
Pages: 48 - 49
Background: The heart ejects in the central elastic arteries. No previous study addressed the question whether ECG voltages are more closely associated with central than with peripheral blood pressure (BP). Methods: Using the oscillometric Mobil-O-Graph 24 h PWA monitor, we measured brachial, central...
Conference Abstract

1.3 CENTRAL PRESSURES AND WAVE REFLECTIONS ARE INDEPENDENTLY ASSOCIATED WITH MAJOR ADVERSE CARDIOVASCULAR EVENTS IN MEN WITH ERECTILE DYSFUNCTION

Nikitas Skliros, Nikolaos Ioakeimidis, Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, Athanasios Aggelis, Dimitrios Toulousis
Pages: 48 - 49
Purpose: Erectile dysfunction (ED) confers an independent risk for cardiovascular events and total mortality. Central pressures and wave reflection indices independently predict cardiovascular events. Aim of this study is to investigate whether central haemodynamics predict major adverse cardiovascular...