Artery Research

Volume 6, Issue 1, March 2012, Pages 41 - 48

Central haemodynamics reveal significant potential for prevention in Black hypertensive patients born and living in sub-Saharan Africa

Authors
Birinus Ezeala-Adikaibea, b, g, Yan-Ping Liub, g, Daniel Lemogoumc, g, Benedict C. Anisiubaa, g, Marius K. Kamdemc, g, Joseph Kaptuec, g, Chinwuba K. Ijomaa, g, Lutgarde Thijsb, g, Augustine N. Odilib, d, g, Kei Asayamab, g, Jan A. Staessenb, e, *, g, Jean-René M’Buyamba-Kabanguf, g, Ifeoma I. Ulasia, g
aDepartment of Medicine, College of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria
bStudies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Block D, Box 7001, BE-3000 Leuven, Belgium
cDepartment of Internal Medicine, College of Health Science, University of Abuja, Abuja, Nigeria
dDouala Cardiovascular Research Institute, Douala School of Medicine, Douala, Cameroon
eDepartment of Epidemiology, Maastricht University, Maastricht, The Netherlands
fHypertension Unit, Department of Internal Medicine, University of Kinshasa Hospital, Kinshasa, The Democratic Republic of the Congo
g

On behalf of the NOAAH investigators.

*Corresponding author. Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Block D, Box 7001, BE-3000 Leuven, Belgium. Tel.: +32 16 347104, +32 15 41 1747 (home), +32 47 632 4928 (mobile); fax: +32 16 347106 (office), +32 15 41 4542 (home). E-mail addresses: jan.staessen@med.kuleuven.be, ja.staessen@epid.unimaas.nl (J.A. Staessen).
Corresponding Author
Jan A. Staessen
Received 12 October 2011, Revised 21 November 2011, Accepted 23 November 2011, Available Online 14 December 2011.
DOI
10.1016/j.artres.2011.11.002How to use a DOI?
Keywords
Arterial stiffness; Augmentation index; Black Africans; Prevention; Pulse wave velocity
Abstract

Background: Few studies assessed arterial stiffness in Black hypertensive patients born and living in sub-Saharan Africa, where cardiovascular disease reaches epidemic proportions.

Methods: The Newer versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) trial is currently recruiting native African patients to compare the efficacy of various antihypertensive drugs given once daily as single-pill combinations. Two centres engaged in pulse wave analysis and measured carotid–femoral pulse wave velocity (PWV). Statistical methods included single and multiple linear regressions.

Results: Of 172 patients screened, 116 entered the ancillary study on central haemodynamics (51.3% women; mean age 52.7 years; untreated blood pressure 147.6/87.1mmHg). The augmentation indexes were higher (p<0.0001) in women than men, both peripherally (pAI, 11.1 vs. −10.6%) and centrally (cAI, 39.0 vs. 28.0%). PWV (8.91m/s) and central pulse pressure (cPP, 48.7mmHg) were similar (p>0.844) in both sexes. pAI and cAI increased with female sex and mean arterial pressure, but decreased with heart rate and body mass index. cPP increased with age and mean arterial pressure. PWV increased with age and mean arterial pressure. Patients with measurements above the age-specific thresholds determined in healthy Black South Africans amounted to 0 for cAI, 1 (1.2%) for cPP, and 11 (18.3%) for PWV.

Conclusion: NOAAH patients have measures of arterial stiffness similar to those of a healthy Black reference population with determinants as reported in the literature. Our observations highlight the potential for the prevention of irreversible arterial damage by timely treating sub-Saharan hypertensive patients to target blood pressure levels.

Copyright
© 2011 Published by Elsevier B.V. on behalf of Association for Research into Arterial Structure and Physiology. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
6 - 1
Pages
41 - 48
Publication Date
2011/12/14
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2011.11.002How to use a DOI?
Copyright
© 2011 Published by Elsevier B.V. on behalf of Association for Research into Arterial Structure and Physiology. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Birinus Ezeala-Adikaibe
AU  - Yan-Ping Liu
AU  - Daniel Lemogoum
AU  - Benedict C. Anisiuba
AU  - Marius K. Kamdem
AU  - Joseph Kaptue
AU  - Chinwuba K. Ijoma
AU  - Lutgarde Thijs
AU  - Augustine N. Odili
AU  - Kei Asayama
AU  - Jan A. Staessen
AU  - Jean-René M’Buyamba-Kabangu
AU  - Ifeoma I. Ulasi
PY  - 2011
DA  - 2011/12/14
TI  - Central haemodynamics reveal significant potential for prevention in Black hypertensive patients born and living in sub-Saharan Africa
JO  - Artery Research
SP  - 41
EP  - 48
VL  - 6
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.11.002
DO  - 10.1016/j.artres.2011.11.002
ID  - Ezeala-Adikaibe2011
ER  -