Differences in pulse pressure day variability between the brachial artery and the aorta in healthy subjects

Athanase D. Protogerou; Theodore G. Papaioannou; Petros P. Sfikakis; Jacques Blacher; Emmanouil Karatzis; John P. Lekakis; Dimitris Papadogiannis; Christodoulos Stefanadis; Michel E. Safar

doi:10.1016/j.artres.2011.11.001

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Differences in pulse pressure day variability between the brachial artery and the aorta in healthy subjects

Authors

Athanase D. Protogerou^a^{, *}^{, e}, Theodore G. Papaioannou^b^{, e}, Petros P. Sfikakis^a, Jacques Blacher^c, Emmanouil Karatzis^a, John P. Lekakis^d, Dimitris Papadogiannis^a, Christodoulos Stefanadis^b, Michel E. Safar^c

^aHypertension Center and Cardiovascular Research Laboratory, 1st Dept. of Propaedeutic Medicine, Laiko Hospital, Medical School, National and Kapodistrian University of Athens, 17 Agiou Thoma St., Goudi 11527, Athens, Greece

^bBiomedical Engineering Unit, First Dept. of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

^cParis Descartes University, AP-HP, Diagnosis and Therapeutic Center, Hôtel-Dieu, Paris, France

^dSecond Dept. of Cardiology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

^e

ADP and TGP contributed equally to the manuscript.

^*Corresponding author. Fax: +30 210 6461808. E-mail address: aprotog@med.uoa.gr (A.D. Protogerou).

Corresponding Author

Athanase D. Protogerou

Received 2 September 2011, Revised 12 November 2011, Accepted 16 November 2011, Available Online 21 December 2011.

DOI: 10.1016/j.artres.2011.11.001 How to use a DOI?
Keywords: Pulse pressure; Variability; Time-dependent variability; Arterial-dependent variability; Aortic blood pressure; Augmentation index; Pulse pressure amplification
Abstract: Objectives: To search for: (i) potential differences in the within-subject pulse pressure (PP) day time variability between the brachial artery and aorta; (ii) the presence of substantial day time variation in the aortic-to-brachial (AtB) PP disparity.

Background: Brachial blood pressure (BP) variability is a risk factor, but also a source of inaccuracy for the assessment of BP-related cardiovascular risk. PP differs substantially in simultaneous measurements at the brachial artery and the aorta; this is of clinical importance regarding accurate cardiovascular risk assessment and reduction strategies. Whether the brachial and the aortic PP time variability is similar, and whether the AtB PP disparity varies during the day is not known.

Methods: In 13 healthy volunteers hourly assessment of brachial and aortic PP was performed (8:00–19:00) under controlled conditions at home.

Results: Aortic PP day variability was consistently and significantly lower than brachial PP (assessed by: standard deviation, variance and time rate variation index, p < 0.05 for all). Individual AtB PP difference (brachial – aortic PP, mmHg) varied substantially within all the 13 subjects; a significant variation during the day in the AtB PP amplification (defined as brachial/aortic PP) was evident (p = 0.006).

Conclusions: By taking into account both time and arterial space, substantial physiological differences in PP variability between the brachial artery and the aorta were observed. These novel findings suggest that non-invasive 24-h aortic ambulatory BP monitoring is warranted in order to significantly improve CV risk assessment and reduction strategies. This possibility must be tested in future clinical studies.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 6 - 1
Pages: 34 - 40
Publication Date: 2011/12/21
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2011.11.001 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Athanase D. Protogerou
AU  - Theodore G. Papaioannou
AU  - Petros P. Sfikakis
AU  - Jacques Blacher
AU  - Emmanouil Karatzis
AU  - John P. Lekakis
AU  - Dimitris Papadogiannis
AU  - Christodoulos Stefanadis
AU  - Michel E. Safar
PY  - 2011
DA  - 2011/12/21
TI  - Differences in pulse pressure day variability between the brachial artery and the aorta in healthy subjects
JO  - Artery Research
SP  - 34
EP  - 40
VL  - 6
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.11.001
DO  - 10.1016/j.artres.2011.11.001
ID  - Protogerou2011
ER  -

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