Central and peripheral pulse wave velocities are associated with ankle–brachial pressure index

Valérie Lacroix; Marie Willemet; Robert Verhelst; Christophe Beauloye; Luc Jacquet; Parla Astarci; Alexandre Persu; Emilie Marchandise

doi:10.1016/j.artres.2011.08.003

<Previous Article In Issue

Next Article In Issue>

Volume 6, Issue 1, March 2012, Pages 28 - 33

Central and peripheral pulse wave velocities are associated with ankle–brachial pressure index

Authors

Valérie Lacroix^a^{, e}^{, *}, Marie Willemet^b^{, e}, Robert Verhelst^a, Christophe Beauloye^c, Luc Jacquet^d, Parla Astarci^a, Alexandre Persu^c, Emilie Marchandise^b

^aDepartment of Cardiovascular Surgery, Saint Luc University Hospital, Avenue Hippocrate,10, B-1200 Bruxelles, Belgium

^bDepartment of Mechanical Engineering, Avenue G Lemaître, 4, B-1348 Louvain-La-Neuve, Belgium

^cDepartment of Cardiology, Saint-Luc University Hospital, Avenue Hippocrate,10, B-1200 Bruxelles, Belgium

^dDepartment of Intensive Care Unit, Saint Luc University Hospital, Avenue Hippocrate,10, B-1200 Bruxelles, Belgium

^eFonds National de la Recherche Scientifique, rue d’Egmont 5, B-1000 Bruxelles, Belgium

^*Corresponding author. Service de Chirurgie cardio-vasculaire, Cliniques Universitaires Saint Luc, Avenue Hippocrate, 10/6107, B-1200 Bruxelles, Belgium. Tel.: +32 473 39 25 37; fax: +32 2 764 89 60. E-mail address: valerie.lacroix@uclouvain.be (V. Lacroix).

Corresponding Author

Valérie Lacroix

Received 28 July 2011, Revised 23 August 2011, Accepted 25 August 2011, Available Online 9 September 2011.

DOI: 10.1016/j.artres.2011.08.003 How to use a DOI?
Keywords: Pulse wave velocity; Arterial stiffness; Vascular disease; Atherosclerosis; Ankle–brachial index
Abstract: Background: Central Pulse Wave Velocity (PWV) is considered to be the gold standard measurement of arterial stiffness. In healthy subjects, cardiovascular risk factors such as age, hypertension, diabetes and end-stage renal disease are associated with increased central (Carotid–Femoral) and peripheral (Femoral–Ankle) PWV. However, little is known about PWV in patients with peripheral arterial disease and pathological Ankle–Brachial Index (ABI). The aim of this study was to study central and peripheral PWV in a population with various degree of peripheral arterial disease.

Methods: Central and peripheral PWV were measured in sixty-two hospitalized patients. Half were admitted for symptomatic peripheral vascular disease and the remainder for cardiac or carotid disease. The population was classified on basis of the Framingham-derived risk score for claudicants and on the ABI. For all patients, PWV was assessed on electrocardiogram-ultrasonographic images acquired at the four following sites: carotid, radial, femoral and tibial arteries.

Results: Carotid–Femoral PWV increased significantly with the Framingham-derived global risk score (p < 0.0001) but Femoral–Ankle PWV did not. With respect to the Ankle–Brachial Index, Carotid–Femoral and Femoral–Ankle PWV significantly increased (p = 0.05 and p = 0.02 respectively) with the severity of peripheral arterial scoring.

Conclusions: These results confirm that central PWV is the best indicator of general atherosclerosis, even in the presence of peripheral arterial disease. Both central and peripheral PWV can be considered as indicators of the severity of peripheral vascular disease.
Open Access: This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

<Previous Article In Issue

Next Article In Issue>

Journal: Artery Research
Volume-Issue: 6 - 1
Pages: 28 - 33
Publication Date: 2011/09/09
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2011.08.003 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Valérie Lacroix
AU  - Marie Willemet
AU  - Robert Verhelst
AU  - Christophe Beauloye
AU  - Luc Jacquet
AU  - Parla Astarci
AU  - Alexandre Persu
AU  - Emilie Marchandise
PY  - 2011
DA  - 2011/09/09
TI  - Central and peripheral pulse wave velocities are associated with ankle–brachial pressure index
JO  - Artery Research
SP  - 28
EP  - 33
VL  - 6
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.08.003
DO  - 10.1016/j.artres.2011.08.003
ID  - Lacroix2011
ER  -

download .riscopy to clipboard