Artery Research

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Volume 6, Issue 1, March 2012, Pages 21 - 27

Hepatic arterial changes following iodized oil chemoembolization of hepatocellular carcinoma: Incidence and technical consequence

Authors
Ron C. Gabaa, *, Tamara R. Brodskyb, M. Grace Knuttinena, Benedictta O. Omenea, Charles A. Owensa, James T. Buia
aDepartment of Radiology, Interventional Radiology section, University of Illinois Medical Center at Chicago, 1740 West Taylor Street, MC 931, Chicago, IL 60612, United States
bAlbert Einstein College of Medicine at Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, United States
*Corresponding author. Tel.: +1 312 996 3971; fax: +1 312 355 2857. E-mail addresses: rongaba@yahoo.com, rgaba@uic.edu (R.C. Gaba).
Corresponding Author
Ron C. Gaba
Received 29 June 2011, Revised 16 August 2011, Accepted 19 August 2011, Available Online 7 September 2011.
DOI
10.1016/j.artres.2011.08.002How to use a DOI?
Keywords
Hepatic artery; Iodized oil; Chemoembolization; Hepatocellular carcinoma
Abstract

Objective: To describe the nature, incidence, and therapeutic consequence of hepatic arterial changes seen following transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).

Methods: In this retrospective study, 46 patients with HCC underwent ≥ 2 TACE treatment sessions between 2004 and 2010. All patients had hepatic angiography on days of treatment. Sequential angiographic studies were reviewed to assess for abnormalities in appearance of the hepatic vasculature. Angiographic abnormalities were graded in a binary fashion: present or absent. When present, abnormalities and effect on drug delivery were recorded.

Results: 123 (mean 2.7, range 2–5) successful lobar (n = 34), segmental (n = 88), or superselective (n = 1) TACE procedures were performed in 46 patients (M:F = 36:10, mean age 59 years). TACE was performed using 1:1 chemotherapy to iodized oil mixture without (n = 102) or with (n = 21) particle embolization. An abnormal angiographic appearance was identified in 21/46 (38%) patients and in 23/123 (19%) procedures, with first appearance after mean 1.5 (range 1–3) TACE sessions and mean 176 (range 27–509) days after initial TACE. Abnormalities included new vessel attenuation or stenosis (n = 10, 43%), slow flow (n = 2, 9%), and new vascular occlusions (n = 11, 48%). These vascular changes did not result in inability to perform repeat TACE in 16/16 (100%) cases where vascular changes were present and TACE was repeated to the same liver lobe.

Conclusion: While the hepatic vasculature is altered in many patients undergoing TACE, arterial abnormalities did not preclude therapy.Further investigation is warranted.

Copyright
© 2011 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
6 - 1
Pages
21 - 27
Publication Date
2011/09/07
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2011.08.002How to use a DOI?
Copyright
© 2011 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Ron C. Gaba
AU  - Tamara R. Brodsky
AU  - M. Grace Knuttinen
AU  - Benedictta O. Omene
AU  - Charles A. Owens
AU  - James T. Bui
PY  - 2011
DA  - 2011/09/07
TI  - Hepatic arterial changes following iodized oil chemoembolization of hepatocellular carcinoma: Incidence and technical consequence
JO  - Artery Research
SP  - 21
EP  - 27
VL  - 6
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.08.002
DO  - 10.1016/j.artres.2011.08.002
ID  - Gaba2011
ER  -