Artery Research

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Volume 4, Issue 2, June 2010, Pages 41 - 46

Shear stress, inflammation and Atherosclerosis

Authors
Rob Kramsa, *, Simon Cuhlmanna, b, Nicolas Foina, Paul Evansb
aDepartment of Bioengineering, Imperial College, London, UK
bBritish Heart Foundation Cardiovascular Unit, National Heart and Lung Institute, Imperial College, London, UK
*Corresponding author at: Department of Bioengineering, Room 3.15, Royal School of Mines, Imperial College, Exhibition Road, London SW7 2AZ, UK. Tel: +442075941473; fax: +442075949817 E-mail address: r.krams@imperial.ac.uk (R. Krams).
Corresponding Author
Rob Krams
Received 5 January 2009, Revised 27 July 2009, Accepted 29 March 2010, Available Online 28 April 2010.
DOI
10.1016/j.artres.2010.03.002How to use a DOI?
Keywords
Shear stress; Inflammation; Atherosclerosis
Abstract

Background: Atherosclerosis is the disease with one of the largest mortalities of the Western world. An important cause of this high mortality rate is rupture of atherosclerotic plaques and subsequent total blockage of the vessel by thrombus. Because, plaque rupture has been associated with a distinct plaque phenotype there is a growing need for understanding the pathogenesis of plaque composition. In this manuscript, we will discuss the new hypothesis that blood flow and lipid driven inflammation are intimately related to each other and that shear stress induced expression of chemokines and the resulting coordinated homing of inflammatory cells influence plaque composition in such a way that vulnerable plaque may be induced. As vulnerable plaques are intimately related to the high mortality of atherosclerosis, it re-emphasis the important role blood flow has in atherosclerosis.

Copyright
© 2010 Published by Elsevier B.V. on behalf of Association for Research into Arterial Structure and Physiology. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
4 - 2
Pages
41 - 46
Publication Date
2010/04/28
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.03.002How to use a DOI?
Copyright
© 2010 Published by Elsevier B.V. on behalf of Association for Research into Arterial Structure and Physiology. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Rob Krams
AU  - Simon Cuhlmann
AU  - Nicolas Foin
AU  - Paul Evans
PY  - 2010
DA  - 2010/04/28
TI  - Shear stress, inflammation and Atherosclerosis
JO  - Artery Research
SP  - 41
EP  - 46
VL  - 4
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.03.002
DO  - 10.1016/j.artres.2010.03.002
ID  - Krams2010
ER  -