John R. Cockcroft
Pages: 33 - 33
Ian B. Wilkinson, Carmel M. McEniery, Giuseppe Schillaci, Pierre Boutouyrie, Patrick Segers, Anne Donald, Philip J. Chowienczyk,
Pages: 34 - 40
The last 15 years have seen an explosion of interest in large artery haemodynamics, and arterial stiffness in particular. A number of devices are now available to assess arterial stiffness, and although many are in routine use, they do not necessarily provide identical information. The aim of this statement...
Rob Krams, Simon Cuhlmann, Nicolas Foin, Paul Evans
Pages: 41 - 46
Background: Atherosclerosis is the disease with one of the largest mortalities of the Western world. An important cause of this high mortality rate is rupture of atherosclerotic plaques and subsequent total blockage of the vessel by thrombus. Because, plaque rupture has been associated with a distinct...
A. Chakera, S. Bunce, C. Heppenstall, J.C. Smith
Pages: 47 - 51
Background: Obesity is considered an important factor contributing to premature arterial stiffening in type 2 diabetes but it is uncertain whether weight loss through dietary modification leads to a reduction in arterial stiffness. Rimonabant is an anti-obesity drug which, through its pharmacological...
Youngju Choi, Seiji Maeda, Takeshi Otsuki, Asako Miyaki, Nobutake Shimojo, Mutsuko Yoshizawa, Hitoshi Shiraki, Ryuichi Ajisaka
Pages: 52 - 58
Background: Endurance exercise training decreases arterial stiffness, whereas high-intensity strength exercise training increases arterial stiffness. However, the mechanisms underlying the adaptations to the 2 types of exercise training remain unclear. Increased oxidative stress induces vasoconstriction...
Giulia Soloperto, Niall G. Keenan, Mary N. Sheppard, Jacques Ohayon, Nigel B. Wood, Dudley J. Pennell, Raad H. Mohiaddin, Xiao Yun Xu
Pages: 59 - 65
Background: Rupture of carotid plaques is an important cause of cerebrovascular events. Several factors, including wall shear stress (WSS), plaque morphology and peak cap stress, have been associated with plaque vulnerability. The aim of this study was to investigate the relationship between these factors...